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Showing 1-30 of 43 results for "A2429" within Papers
Emily A Voigt et al.
NPJ vaccines, 7(1), 136-136 (2022-11-04)
mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death. However, limitations in these vaccines have been recognized due to their requirement for cold storage, short durability
Liliana M G Pereira et al.
Infection and immunity, 82(12), 5270-5285 (2014-10-08)
AIP56 (apoptosis-inducing protein of 56 kDa) is a metalloprotease AB toxin secreted by Photobacterium damselae subsp. piscicida that acts by cleaving NF-κB. During infection, AIP56 spreads systemically and depletes phagocytes by postapoptotic secondary necrosis, impairing the host phagocytic defense and
Taolan Zhang et al.
Oncology reports, 45(1), 337-348 (2021-01-09)
Breast cancer is the most frequently diagnosed malignancy and leading cause of cancer-related deaths among women worldwide. Tumor recurrence, or metastasis, is caused by cancer stem cells and has a dismal prognosis for breast cancer patients. Thus, targeting breast cancer
Hailong Qi et al.
Vaccines, 10(3) (2022-03-27)
SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1) cell strategy for improved
Arnar Gudjonsson et al.
Journal of immunology (Baltimore, Md. : 1950), 198(7), 2785-2795 (2017-02-24)
Targeting Ags to conventional dendritic cells can enhance Ag-specific immune responses. Although most studies have focused on the induction of T cell responses, the mechanisms by which targeting improves Ab responses are poorly understood. In this study we present data
F D Camargo et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 2(5), 496-504 (2000-11-18)
The utility of adenoviral vectors is limited by immune responses to adenoviral antigens. We sought to develop immune-competent mice in which the immune response to adenoviral antigens was selectively absent. To do so, we generated mice that were transgenic for
Grzegorz Młynarczyk et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 86(4), 201-207 (2019-05-28)
Collagenases are enzymes starting collagen degradation. The role of collagenases in renal carcinoma development is not well understood. Evaluation of collagen content and collagenase expression and activity in human kidney cancers. Collagen content was measured by the hydroxyproline assay. The
Simone Mester et al.
mAbs, 13(1), 1893888-1893888 (2021-03-12)
Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is that
Targeting influenza virus hemagglutinin to Xcr1+ dendritic cells in the absence of receptor-mediated endocytosis enhances protective antibody responses
Gudjonsson A, et al.
Journal of Immunology, 198(7), 2785-2795 (2017)
Ana F Dias et al.
The Journal of biological chemistry, 292(37), 15287-15300 (2017-08-03)
A remarkable property of the machinery for import of peroxisomal matrix proteins is that it can accept already folded proteins as substrates. This import involves binding of newly synthesized proteins by cytosolic peroxisomal biogenesis factor 5 (PEX5) followed by insertion
Specific IgG for cat allergens in patients with allergic conjunctivitis.
Miyama A, et al.
International Ophthalmology, 35(4), 575-586 (2015)
Cláudio F Costa et al.
Antioxidants (Basel, Switzerland), 12(6) (2023-06-28)
Peroxisomes serve as important centers for cellular redox metabolism and communication. However, fundamental gaps remain in our understanding of how the peroxisomal redox equilibrium is maintained. In particular, very little is known about the function of the nonenzymatic antioxidant glutathione
Gábor Oroszlán et al.
Frontiers in immunology, 8, 1821-1821 (2018-01-13)
Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation. The lectin pathway of the complement system is initiated by mannose-binding lectin
Complement-fixing IgG1 constitutes a new subclass of mouse IgG.
P L Ey et al.
Nature, 281(5731), 492-493 (1979-10-11)
Gunnveig Grodeland et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 3221-3231 (2013-08-21)
New influenza A viruses with pandemic potential periodically emerge due to viral genomic reassortment. In the face of pandemic threats, production of conventional egg-based vaccines is time consuming and of limited capacity. We have developed in this study a novel
Louise Bjerkan et al.
Frontiers in immunology, 12, 720550-720550 (2021-11-05)
Targeted delivery of antigen to antigen presenting cells (APCs) is an efficient way to induce robust antigen-specific immune responses. Here, we present a novel DNA vaccine that targets the Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5), a leading blood-stage antigen
Gunnveig Grodeland et al.
Journal of immunology (Baltimore, Md. : 1950), 197(9), 3575-3585 (2016-09-28)
It has been difficult to translate promising results from DNA vaccination in mice to larger animals and humans. Previously, DNA vaccines encoding proteins that target Ag to MHC class II (MHC-II) molecules on APCs have been shown to induce rapid
Olivier Diaz et al.
The Journal of general virology, 87(Pt 10), 2983-2991 (2006-09-12)
Hepatitis C virus (HCV) in cell culture has a density comparable to that of other members of the family Flaviviridae, whereas in vivo infectious particles are found partially in low-density fractions, associated with triacylglycerol (TG)-rich lipoproteins (TRLs). In the blood
Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells
Akkaraju S, et al.
The Journal of Experimental Medicine, 186(12), 2005-2012 (1997)
Giuseppe Giannini et al.
Bioorganic & medicinal chemistry, 27(15), 3248-3253 (2019-06-19)
Tenatumomab is an anti-tenascin murine monoclonal antibody previously used in clinical trials for delivering radionuclides to tumors by both pre-targeting (biotinylated Tenatumomab within PAGRIT) and direct 131Iodine labeling approaches. Here we present the synthesis and in vitro characterization of three
S Akkaraju et al.
The Journal of experimental medicine, 186(12), 2005-2012 (1998-02-12)
Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. To study how
Xiaogang Wang et al.
Nature communications, 9(1), 1379-1379 (2018-04-13)
Secretion of extracellular vesicles (EVs), a process common to eukaryotes, archae, and bacteria, represents a secretory pathway that allows cell-free intercellular communication. Microbial EVs package diverse proteins and influence the host-pathogen interaction, but the mechanisms underlying EV production in Gram-positive
Max Renner et al.
Nature immunology, 19(11), 1248-1256 (2018-10-17)
Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and dengue hemorrhagic fever is often associated with secondary heterologous infections. Antibody-dependent enhancement (ADE) may drive higher viral
Tor Kristian Andersen et al.
NPJ vaccines, 4, 9-9 (2019-02-19)
Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been unclear. We have here investigated the
Celien Lismont et al.
Antioxidants & redox signaling, 30(1), 22-39 (2017-06-09)
Peroxisomes are ubiquitous, single-membrane-bounded organelles that contain considerable amounts of enzymes involved in the production or breakdown of hydrogen peroxide (H2O2), a key signaling molecule in multiple biological processes and disease states. Despite this, the role of this organelle in
Pedro Humberto Castro et al.
Journal of experimental botany, 69(19), 4633-4649 (2018-07-28)
Post-translational modifiers such as the small ubiquitin-like modifier (SUMO) peptide act as fast and reversible protein regulators. Functional characterization of the sumoylation machinery has determined the key regulatory role that SUMO plays in plant development. Unlike components of the SUMO
Algirdas Grevys et al.
Nature communications, 9(1), 621-621 (2018-02-13)
Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based therapeutics has the potential to improve their efficacies, but there is
The specificity of targeted vaccines for APC surface molecules influences the immune response phenotype
Grodeland G, et al.
Testing, 8(11), e80008-e80008 (2013)
Marcel Zocher et al.
International immunology, 15(7), 789-796 (2003-06-17)
Antigen-specific B cells are key players in many autoimmune diseases through the production of autoreactive antibodies that can cause severe tissue damage and malfunction. We have designed and expressed a fusion protein, referred to as MOG-Fc, composed of the extracellular
Peter Szodoray et al.
Cell reports, 36(6), 109525-109525 (2021-08-12)
Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD45 phosphatase activity (CD45 PA). In this
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