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A2835

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Rahul Bhattacharyya et al.
Free radical research, 51(7-8), 723-738 (2017-09-06)
In this study, we demonstrated that the cytotoxicity of the protoberberine alkaloids such as coralyne, berberine and jatrorrhizine to several human cancer cell lines can be improved significantly in combination with UVA exposure. However, the phototoxic property of coralyne was...
Shitu Chen et al.
Translational oncology, 13(2), 441-451 (2020-01-09)
Vemurafenib, an inhibitor of mutant BRAF activity, is a promising anticancer agent for patients with BRAF-mutant metastatic melanoma. However, it is less effective in BRAF-mutant thyroid cancer, and the reason for this discrepancy is not yet fully elucidated. By RNA...
Ying Sun et al.
Chemico-biological interactions, 289, 57-67 (2018-04-27)
Chrysophanol, a major anthraquinone component occurring in many traditional Chinese herbs, is accepted as important active component with various pharmacological actions such as antibacterial and anticancer activity. Previous studies demonstrated that exposure to chrysophanol induced cytotoxicity, but the mechanisms of...
Li-Hua Mu et al.
Biological & pharmaceutical bulletin, 42(2), 194-200 (2018-11-23)
Seventeen 13,28-epoxy triterpenoid saponins obtained from Ardisia gigantifolia STAPF. were evaluated their anti-proliferative activities on MCF-7 cells. The structure-activity relationship analysis indicated that CH3 group at C-30, four saccharide units with L-rhamnose at R6 in the sugar units are crucial...
Rong Gao et al.
Oncoimmunology, 7(6), e1438108-e1438108 (2018-06-07)
Our previous studies have confirmed that tumor cell-released autophagosomes (TRAP) could induce the differentiation of B cells into IL-10+ regulatory B cells (Bregs) with suppressive activities on T lymphocytes. However, the mechanism of TRAP-mediated immune suppression is still largely unclear....
Shu-Chen Chu et al.
Brain research, 1721, 146329-146329 (2019-07-12)
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator responding to hypoxia. Amphetamine (AMPH), however, can activate HIF-1 under normoxic conditions, which is associated with the co-activation of oxidative stress. Hypothalamic neuropeptides and anti-oxidative enzymes have been found to participate in...
Chenyang Shi et al.
Pharmacology, 105(9-10), 598-608 (2020-02-03)
Although Platycodin D (PLD) is the main active saponin of Platycodon grandiflorum (PG) and responsible for multiple therapeutic benefits, including antioxidant and antiaging, only few direct demonstrations have been reported on the role of PLD in antiaging process. The present...
Michelle Erin Miller et al.
PloS one, 11(3), e0151584-e0151584 (2016-03-18)
Meis1 is recognized as an important transcriptional regulator in hematopoietic development and is strongly implicated in the pathogenesis of leukemia, both as a Hox transcription factor co-factor and independently. Despite the emerging recognition of Meis1's importance in the context of...
Ji-Yun Kim et al.
Cells, 9(3) (2020-03-11)
Curcumin, a hydrophobic polyphenol of turmeric, has a variety of biological functions as a herbal supplement, but its poor gastric absorption rate is one of the major factors limiting its oral bioavailability. In the present study, we have investigated the...
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Seungyeon Lee et al.
Free radical biology & medicine, 126, 133-141 (2018-08-11)
Cold atmospheric plasma (CAP) has gained attention for use in cancer treatment owing to its ability to preferentially induce cancer cell death; however, the involved molecular mechanism remains to be elucidated. Herein, an epigenetic effect of CAP on cancer cells...
Yujiao Fu et al.
Molecular pharmacology, 88(1), 161-170 (2015-02-27)
The timely resolution of inflammation prevents continued tissue damage after an initial insult. In the brain, the death of activated microglia by apoptosis has been proposed as one mechanism to resolve brain inflammation. How microglial death is regulated after activation...
Qianying Yang et al.
Journal of animal science and biotechnology, 11, 7-7 (2020-01-21)
Implantation failure limits the success of in vitro fertilization and embryo transfer (IVF-ET). Well-organized embryo-maternal crosstalk is essential for successful implantation. Previous studies mainly focused on the aberrant development of in vitro fertilized (IVF) embryos. In contrast, the mechanism of...
Chunxiao Zhang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 50, 217-224 (2018-03-24)
Hematotoxicity of benzene is derived mainly from its active metabolite, 1,4-Benzoquinone (1,4-BQ), which induces cell apoptosis and mitochondrial damage. Damaged mitochondria are degraded through a specialized autophagy pathway, called mitophagy, which is driven by PINK1/Parkin signaling. However, whether mitophagy is...
Hui-Ru Wang et al.
Oxidative medicine and cellular longevity, 2021, 6667355-6667355 (2021-03-23)
We previously found that marine sponge-derived manoalide induced antiproliferation and apoptosis of oral cancer cells as well as reactive species generations probed by dichloro-dihydrofluorescein diacetate (DCFH-DA) and MitoSOX Red. However, the sources of cellular and mitochondrial redox stresses and the...
Payel Bhattacharjee et al.
Plant molecular biology, 93(4-5), 511-532 (2017-01-01)
Genome-wide analysis was carried out to identify and analyze differential expression pattern of tomato membrane bound NAC transcription factors (SlNACMTFs) during stresses. Two biotic-stress-related SlNACMTFs have been characterized to elucidate their regulatory function. NAC transcription factors are known regulators of...
Cecilia Roux et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4326-4335 (2019-02-17)
The combination of immune checkpoint blockade with chemotherapy is currently under investigation as a promising strategy for the treatment of triple negative breast cancer (TNBC). Tumor-associated macrophages (TAMs) are the most prominent component of the breast cancer microenvironment because they...
Chun-Yan Jian et al.
Molecular medicine reports, 16(6), 9457-9463 (2017-11-21)
Doxorubicin (DOX) has been widely used to treat cancers as a first‑line antitumor drug. However, it causes severe, irreversible, dose‑dependent cardiotoxicity. To evaluate the protective effects of naringin (NRG) on cardiotoxicity, the authors investigated the molecular mechanism of the p38MAPK...
Seon-Mi Yu et al.
International journal of molecular medicine, 35(2), 325-332 (2014-12-02)
Dedifferentiation and inflammation are major features of cartilage degeneration during the pathogenesis of osteoarthritis (OA). Thymoquinone (TQ) is the major compound of black seed oil isolated from Nigella sativa with various beneficial or harmful effects on several diseases; however, its...
Yawei Wu et al.
International journal of molecular sciences, 21(9) (2020-05-10)
To gain more valuable genomic information about betalain biosynthesis, the full-length transcriptome of pitaya pulp from 'Zihonglong' (red pulp) and 'Jinghonglong' (white pulp) in four fruit developmental stages was analyzed using Single-Molecule Real-Time (SMRT) sequencing corrected by Illumina RNA-sequence (Illumina...
Jean-François Gélinas et al.
Scientific reports, 7(1), 10198-10198 (2017-09-02)
The development of lentiviral-based therapeutics is challenged by the high cost of current Good Manufacturing Practices (cGMP) production. Lentiviruses are enveloped viruses that capture a portion of the host cell membrane during budding, which then constitutes part of the virus...
Bai Yu et al.
Neurotoxicology, 51, 58-66 (2015-09-28)
This study was designed to examine the differential protection of pre- versus post-treatment with three different antioxidants, curcumin (CUR), Trolox, and N-acetylcysteine (NAC), on acrylonitrile (AN)-induced cytotoxicity in primary rat astrocytes. Primary astrocyte cultures were treated with CUR, Trolox and...
Kanikkai Raja Aseer et al.
Free radical biology & medicine, 108, 874-895 (2017-05-14)
Secreted protein acidic and rich in cysteine (SPARC) is known to play a previously unappreciated role in diabetes, but its precise mechanism in liver/hepatocyte pathology remains unknown. Inhibition of SPARC is critical in resolving candidate pathogenic events such as production...
Toshiyuki Matsunaga et al.
Chemico-biological interactions, 279, 10-20 (2017-11-08)
9,10-Phenanthrenequinone (PQ), a major quinone component in diesel exhaust particles, is considered to provoke damage of respiratory and vascular cells through highly producing reactive oxygen species (ROS), but little is known about its pathophysiological role in neuronal cell damage. In...
Doumet Georges Helou et al.
Journal of immunology (Baltimore, Md. : 1950), 202(8), 2189-2194 (2019-03-10)
Neutrophils are essential during contact hypersensitivity (CHS), a common skin allergic disease. NF-E2-related factor-2 (Nrf2) is a key regulator of redox balance and skin homeostasis playing a protective role in CHS. In this study, we investigated Nrf2 role in neutrophil...
Jiaojiao Wu et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(12), 1902933-1902933 (2020-07-01)
Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep-tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for...
Weirong Wang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 206-215 (2019-01-03)
Vascular complications are major causes of disability and death in people with diabetes mellitus (DM). Nitric oxide (NO) supplement may help prevent vascular complications and is an attractive treatment option for DM. Hydroxytyrosol (HT) is a major polyphenol in olive oil....
Xiaoyang Kong et al.
Oncology reports, 37(6), 3423-3432 (2017-05-13)
Although the patients with t(8;21) acute myeloid leukemia (AML) have a favorable prognosis compared with other non-acute promyelocytic leukemia AML patients, only ~50% patients with this relatively favorable subtype can survive for 5 years and refractory/relapse is common in clinical practice....
Ryusuke Hosoda et al.
The Journal of pharmacology and experimental therapeutics, 376(3), 385-396 (2020-12-19)
Resveratrol affords protection against reactive oxygen species (ROS)-related diseases via activation of SIRT1, an NAD+-dependent deacetylase. However, the low bioavailability of resveratrol limits its therapeutic applications. Since piceatannol is a hydroxyl analog of resveratrol with higher bioavailability, it could be...
Dmitrij Rekhter et al.
Science (New York, N.Y.), 365(6452), 498-502 (2019-08-03)
The phytohormone salicylic acid (SA) controls biotic and abiotic plant stress responses. Plastid-produced chorismate is a branch-point metabolite for SA biosynthesis. Most pathogen-induced SA derives from isochorismate, which is generated from chorismate by the catalytic activity of ISOCHORISMATE SYNTHASE1. Here...
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