Showing 1-30 of 141 results for "

a3156

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Edwin A Pena et al.
Environmental toxicology and chemistry, 34(9), 1946-1958 (2015-04-14)
Raw menhaden fish oil was developed for biomonitoring polycyclic aromatic hydrocarbons (PAHs) using fluorescence spectroscopy. Menhaden (Genus Brevoortia) were collected in 2010 and/or 2011 from Delaware Bay, New Jersey, USA; James River, Virginia, USA; Vermillion Bay, Louisiana, USA (VBLA); and...
Iwona Radziejewska et al.
Clinical and experimental medicine, 11(2), 81-88 (2010-10-19)
It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of...
Balázs Rada et al.
Journal of immunology (Baltimore, Md. : 1950), 181(7), 4883-4893 (2008-09-20)
The dual oxidase-thiocyanate-lactoperoxidase (Duox/SCN(-)/LPO) system generates the microbicidal oxidant hypothiocyanite in the airway surface liquid by using LPO, thiocyanate, and Duox-derived hydrogen peroxide released from the apical surface of the airway epithelium. This system is effective against several microorganisms that...
Fiona Kate Elizabeth McDuff et al.
PloS one, 6(3), e17854-e17854 (2011-03-23)
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic fusion protein, Nucleophosmin-ALK (NPM-ALK). Whilst much is known...
Vidmantas Petraitis et al.
Antimicrobial agents and chemotherapy, 53(6), 2382-2391 (2009-03-25)
We studied the antifungal activity of anidulafungin (AFG) in combination with voriconazole (VRC) against experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits and further explored the in vitro and in vivo correlations by using Bliss independence drug interaction analysis....
Carla Pereira et al.
Marine drugs, 9(11), 2236-2255 (2011-12-14)
Phage therapy may represent a viable alternative to antibiotics to inactivate fish pathogenic bacteria. Its use, however, requires the awareness of novel kinetics phenomena not applied to conventional drug treatments. The main objective of this work was to isolate bacteriophages...
Valerie P J Saw et al.
The American journal of pathology, 175(6), 2406-2415 (2009-11-17)
Interleukin-13 (IL-13) is the dominant effector cytokine of fibrosis in pulmonary and liver disease. Excessive conjunctival fibrosis in the immunobullous disease ocular mucous membrane pemphigoid (MMP) causes blindness; the pathogenesis of scarring in this disease is incompletely understood. To determine...
Bradley P Dixon et al.
PloS one, 6(1), e16595-e16595 (2011-02-10)
Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly increased risk of malignancy, and the bladder microenvironment may play a role in this carcinogenesis. Investigating the influences of the bladder microenvironment...
J Allen Crow et al.
Biochimica et biophysica acta, 1801(1), 31-41 (2009-09-19)
Two major isoforms of human carboxylesterases (CEs) are found in metabolically active tissues, CES1 and CES2. These hydrolytic enzymes are involved in xenobiotic and endobiotic metabolism. CES1 is abundantly expressed in human liver and monocytes/macrophages, including the THP1 cell line;...
Naomi J Logsdon et al.
PloS one, 6(11), e28127-e28127 (2011-12-02)
Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV antiviral immune responses, and contributes to lifelong persistence within infected hosts....
Gayathri Kanika et al.
Journal of biochemical and molecular toxicology, 29(8), 349-359 (2015-03-17)
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine...
Philip J Johnson et al.
Journal of biomedical materials research. Part A, 92(1), 152-163 (2009-01-24)
The purpose of this study was to evaluate the effects of fibrin scaffolds on subacute rat spinal cord injury (SCI). Long-Evans rats were anesthetized and underwent a dorsal hemisection injury; two weeks later, the injury site was re-exposed, scar tissue...
Nabanita De et al.
PLoS biology, 6(3), e67-e67 (2008-03-28)
Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger. Tight regulation of cellular c-di-GMP concentration is governed by diguanylate cyclases and phosphodiesterases...
Dominik Ho et al.
Biophysical journal, 96(11), 4661-4671 (2009-06-03)
Force-based ligand detection is a promising method to characterize molecular complexes label-free at physiological conditions. Because conventional implementations of this technique, e.g., based on atomic force microscopy or optical traps, are low-throughput and require extremely sensitive and sophisticated equipment, this...
Sujin Park et al.
Histochemistry and cell biology, 153(2), 89-99 (2019-11-14)
Autophagy is a degradative cellular process that can be both non-selective and selective and begins with the formation of a unique smooth double-membrane phagophore which wraps around a portion of the cytoplasm. Excess and damaged organelles and cytoplasmic protein aggregates...
Ana Carolina Vieira et al.
PloS one, 6(2), e17411-e17411 (2011-03-03)
Endogenous electric fields and currents occur naturally at wounds and are a strong signal guiding cell migration into the wound to promote healing. Many cells involved in wound healing respond to small physiological electric fields in vitro. It has long...
Daniel Gotthardt et al.
World journal of gastroenterology, 15(46), 5821-5826 (2009-12-10)
To investigate whether the secretion of phosphatidylcholine (PC) in intestinal mucus occurs by apical secretion or via basolateral excretion and to determine its subsequent passage across the tight junctions to the apical mucus. We addressed this question using the polarized...
Carl Pc Chen et al.
Proteome science, 9, 65-65 (2011-10-13)
Proteome analysis is frequently applied in identifying the proteins or biomarkers in knee synovial fluids (SF) that are associated with osteoarthritis and other arthritic disorders. The 2-dimensional gel electrophoresis (2-DE) is the technique of choice in these studies. Disease biomarkers...
Christopher J Alexander et al.
Cerebellum (London, England), 18(3), 406-421 (2019-02-08)
While mixed primary cerebellar cultures prepared from embryonic tissue have proven valuable for dissecting structure-function relationships in cerebellar Purkinje neurons (PNs), this technique is technically challenging and often yields few cells. Recently, mouse embryonic stem cells (mESCs) have been successfully...
Florence Teulé et al.
Nature protocols, 4(3), 341-355 (2009-02-21)
The extreme strength and elasticity of spider silks originate from the modular nature of their repetitive proteins. To exploit such materials and mimic spider silks, comprehensive strategies to produce and spin recombinant fibrous proteins are necessary. This protocol describes silk...
Livia Lai et al.
PLoS pathogens, 7(10), e1002296-e1002296 (2011-10-25)
Eimeria spp. are a highly successful group of intracellular protozoan parasites that develop within intestinal epithelial cells of poultry, causing coccidiosis. As a result of resistance against anticoccidial drugs and the expense of manufacturing live vaccines, it is necessary to...
Luis E F Almeida et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(40), 12702-12710 (2009-10-09)
cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response element-binding protein (CREB). However, in mouse cortical neuron cultures, prior to synaptogenesis, neither cAMP nor dopamine, which acts via cAMP, stimulated CREB-dependent gene...
Liuba Taccola et al.
International journal of nanomedicine, 6, 1129-1140 (2011-06-24)
It has recently been demonstrated that zinc oxide nanoparticles (ZnO NPs) induce death of cancerous cells whilst having no cytotoxic effect on normal cells. However, there are several issues which need to be resolved before translation of zinc oxide nanoparticles...
Poornima Bhupathy et al.
Journal of molecular and cellular cardiology, 47(5), 723-729 (2009-07-28)
Sarcolipin (SLN) has emerged as an important regulator of the atrial sarcoplasmic reticulum (SR) Ca2+ transport. The inhibitory effect of SLN on cardiac SR Ca2+ ATPase (SERCA) pump can be relieved by beta-adrenergic stimulation, which indicates that SLN is a...
The role of fresh cow's milk in iron deficiency: I. Albumin turnover in infants with iron deficiency anemia
Woodruff C W and Clark J L
American Journal of Diseases of Children, 124(1), 18-23 (1972)
M Geldof et al.
British journal of pharmacology, 154(6), 1369-1378 (2008-05-22)
The pharmacokinetic-pharmacodynamic (PK-PD) correlation of fluvoxamine 5-HT transporter (SERT) occupancy was determined in rat frontal cortex ex vivo. Rats (n=47) with permanent arterial and venous cannulas received a 30 min intravenous infusion of fluvoxamine (1 or 7.3 mg kg(-1)). At...
Yongtae Kim et al.
PloS one, 6(1), e14624-e14624 (2011-02-10)
Embryonic development is guided by a complex and integrated set of stimuli that results in collective system-wide organization that is both time and space regulated. These regulatory interactions result in the emergence of highly functional units, which are correlated to...
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of...
Edgars Liepinsh et al.
British journal of pharmacology, 157(8), 1549-1556 (2009-07-15)
Mildronate [3-(2,2,2-trimethylhydrazinium) propionate] is an anti-ischaemic drug whose mechanism of action is based on its inhibition of L-carnitine biosynthesis and uptake. As L-carnitine plays a pivotal role in the balanced metabolism of fatty acids and carbohydrates, this study was carried...
Chad Slawson et al.
Molecular biology of the cell, 19(10), 4130-4140 (2008-07-26)
O-linked beta-N-acetylglucosamine (O-GlcNAc) is a highly dynamic intracellular protein modification responsive to stress, hormones, nutrients, and cell cycle stage. Alterations in O-GlcNAc addition or removal (cycling) impair cell cycle progression and cytokinesis, but the mechanisms are not well understood. Here...