Showing 1-30 of 31 results for "


K Yamano et al.
Parasite immunology, 31(8), 481-487 (2009-08-04)
Parasitic helminths express various antigenic carbohydrates, which often account for serological cross-reactions. In serodiagnosis, it is essential to inspect cross-reactivity between the target parasite and other parasites in order to assess diagnostic performance. Our previous study showed that the Galbeta1-6Gal...
Young Chan Kim et al.
Viruses, 11(5) (2019-05-06)
Chikungunya fever is a debilitating disease caused by Chikungunya virus (CHIKV) that can result in long-lasting arthralgias. The early diagnosis of CHIKV relies on PCR during the acute infection phase to allow differential diagnosis with other co-circulating arboviruses such as...
Jari Kankaanpää et al.
Neurobiology of disease, 33(3), 467-472 (2009-01-10)
Lipoprotein oxidation may play an important role in the pathogenesis of Alzheimer's Disease (AD), and therefore, we investigated cerebrospinal fluid (CSF) antibodies to oxidized low-density lipoprotein (OxLDL) in patients with AD and other neurodegenerative dementias. IgM and IgG antibody titers...
Recent trends in research on congenital toxoplasmosis.
E Petersen et al.
International journal for parasitology, 31(2), 115-144 (2001-03-10)
Dieter Palmberger et al.
Journal of biotechnology, 153(3-4), 160-166 (2011-04-12)
In recent years there has been an increase in both availability and demand for therapeutic monoclonal antibodies. Currently, most of these antibodies are produced by stably transfected mammalian cells. In this study we evaluated the use of different baculoviral insect...
Susanne Jacobsson et al.
Vaccine, 27(42), 5755-5759 (2009-08-06)
The IgG antibody levels directed against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis, were examined in order to investigate the extent of natural immunisation against these antigens in different age groups. As a comparison, the IgG antibody...
Dalgys Martínez et al.
International journal of molecular sciences, 20(12) (2019-06-27)
The house dust mite (HDM) Dermatophagoides pteronyssinus is an important risk factor for asthma and rhinitis. Allergen specific immunotherapy that is based on recombinant proteins has been proposed for the safer and more efficient treatment of allergic diseases. The aim...
James N Arnold et al.
Journal of immunology (Baltimore, Md. : 1950), 173(11), 6831-6840 (2004-11-24)
Analysis of the glycosylation of human serum IgD and IgE indicated that oligomannose structures are present on both Igs. The relative proportion of the oligomannose glycans is consistent with the occupation of one N-linked site on each heavy chain. We...
Hani A Al-Shobaili et al.
Disease markers, 33(1), 19-34 (2012-06-20)
This study was undertaken to investigate the role of lipid oxidative-by-product 4-hydroxy-2-nonenal (HNE)-modified human serum albumin (HSA), chromatin, reactive oxygen species (ROS)-modified chromatin and nitric oxide (NO)-modified chromatin in systemic lupus erythematosus (SLE). HSA was modified by HNE. Immunogenicity of...
Lee Aun Tan et al.
Protein & cell, 1(11), 1033-1049 (2010-12-15)
Complement proteins in blood recognize charged particles. The anionic phospholipid (aPL) cardiolipin binds both complement proteins C1q and factor H. C1q is an activator of the complement classical pathway, while factor H is an inhibitor of the alternative pathway. To...
Julia Whitehouse et al.
Vaccine, 34(15), 1792-1799 (2016-02-28)
Staphylococcus aureus is a pathogen which causes life-threatening infection, the incidence of which rises during adult life. This, together with the emergence of drug-resistant strains and the expansion of more susceptible elderly populations, represents the rationale for the ongoing development...
F Cataldo et al.
Minerva pediatrica, 42(12), 509-514 (1990-12-01)
IgG are the most common isotype of Ig and include four subclasses which differ from one another in the following ways: their initial amino acid sequence, their physical and chemical properties and the different serum concentrations reached with age. Every...
C Akisu et al.
Parasite (Paris, France), 13(4), 321-326 (2007-02-09)
Many serological tests are widely used in the diagnosis of cystic echinococcosis (CE), caused by the larval stages of Echinococcus granulosus. The present study was carried for differentiation between hepatic and pulmonary cystic echinococcosis by Western Blotting (WB). A total...
Young Chan Kim et al.
Virology journal, 15(1), 193-193 (2018-12-28)
Zika virus (ZIKV) has become a global threat with immediate need for accurate diagnostics, efficacious vaccines and therapeutics. Several ZIKV envelope (Env)-based vaccines have been developed recently. However, many commercially available ZIKV Env are based on the African lineage and...
Maria V Carroll et al.
Molecular immunology, 46(16), 3367-3378 (2009-08-25)
Mycobacterium tuberculosis is the leading cause of infectious disease in humans in the world. It evades the host immune system by being phagocytosed by macrophages and residing intracellularly. Complement-dependent opsonisation of extracellular mycobacteria may assist them to enter macrophages. This...
Alexander D Douglas et al.
Nature communications, 10(1), 1953-1953 (2019-04-28)
Malaria vaccine design and prioritization has been hindered by the lack of a mechanistic correlate of protection. We previously demonstrated a strong association between protection and merozoite-neutralizing antibody responses following vaccination of non-human primates against Plasmodium falciparum reticulocyte binding protein...
Christian Loch et al.
Journal of pharmaceutical sciences, 103(2), 517-526 (2013-12-07)
Intravitreal injections and drug-loaded implants are current approaches to treat diseases of the posterior eye. To investigate the release of active agents and their distribution in the vitreous body, a new test system was developed that enables a realistic simulation...
Markus Sack et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21(8), 1655-1664 (2007-03-01)
We report the production of an important human therapeutic antibody in plant cell suspension cultures and the functional analysis of that antibody, including a comparison with the same antibody produced in CHO cells. We established transgenic tobacco BY2 suspension cell...
Andreas Maccani et al.
Biotechnology journal, 9(4), 526-537 (2014-01-07)
Chinese hamster ovary (CHO) cells are currently the workhorse of the biopharmaceutical industry. However, yeasts such as Pichia pastoris are about to enter this field. To compare their capability for recombinant protein secretion, P. pastoris strains and CHO cell lines...
Meng-Yun Chou et al.
The Journal of clinical investigation, 119(5), 1335-1349 (2009-04-14)
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of oxidized lipoproteins and apoptotic cells. Adaptive immune responses to various oxidation-specific epitopes play an important role in atherogenesis. However, accumulating evidence suggests that these epitopes are also recognized by...
Lysibodies are IgG Fc fusions with lysin binding domains targeting Staphylococcus aureus wall carbohydrates for effective phagocytosis.
Raz, et al.
Proceedings of the National Academy of Sciences of the USA, 114, 4781-4786 (2018)
James N Arnold et al.
The Journal of biological chemistry, 280(32), 29080-29087 (2005-06-16)
The glycoprotein IgM is the major antibody produced in the primary immune response to antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a single J chain, which is absent in the hexamer. The...
Rodrigo Lorenzi et al.
Annals of clinical biochemistry, 51(Pt 2), 248-257 (2013-08-29)
The soluble form of the receptor for advanced glycation end-products (sRAGE) has been studied in various diseases. It is not clear why sRAGE levels vary between studies, with controversial results. What also remains to be determined is whether receptor for...
D A Heim et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 1(6), 533-544 (2000-08-10)
Host immune responses against foreign transgenes may be a major obstacle to successful gene therapy. To clarify the impact of an immune response to foreign transgene products on the survival of genetically modified cells, we studied the in vivo persistence...
M Medhane et al.
Scandinavian journal of immunology, 79(4), 267-275 (2014-01-05)
Meningococcal meningitis is a significant global health challenge, especially for sub-Saharan area: the African meningitis belt. Neisseria meningitidis of serogroup A (MenA) is responsible for the large number of epidemics that have been recorded in these countries. To determine the...
Ali Akyol et al.
Seizure, 16(3), 233-237 (2007-01-24)
Increased seropositivity for Toxoplasma gondii and Toxocara canis have been observed in epileptic patients. Our aim is to determine whether there is any relationship between these agents and epilepsy in our cryptogenic epilepsy group. We studied specific IgG antibodies against...
B E V Oftedal et al.
Scandinavian journal of immunology, 74(3), 327-333 (2011-05-04)
Autoantibodies against interleukin (IL)-17A, IL-17F and IL-22 have recently been described in patients with autoimmune polyendocrine syndrome type I (APS I), and their presence is reported to be highly correlated with chronic mucocutaneous candidiasis (CMC). The aim of this study...
Qiu-Hua Gu et al.
Journal of the American Society of Nephrology : JASN, 31(6), 1282-1295 (2020-05-24)
Antiglomerular basement membrane (anti-GBM) disease is associated with HLA-DRB1*1501 (the major predisposing genetic factor in the disease), with α3127-148 as a nephritogenic T and B cell epitope. Although the cause of disease remains unclear, the association of infections with anti-GBM...