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Kantamas Apitanyasai et al.
Developmental and comparative immunology, 53(1), 234-243 (2015-06-27)
The viral responsive protein, PmHHAP, plays an important role in the control of hemocyte homeostasis in shrimps during viral infection. In this study, we further investigate the role of PmHHAP in the regulation of hemocyte apoptosis. RNA interference (RNAi) mediated
Fabrizio Angius et al.
BMC microbiology, 15, 74-74 (2015-04-19)
Human Herpesvirus 8 (HHV8), the causative agent of Kaposi's sarcoma, induces an intense modification of lipid metabolism and enhances the angiogenic process in endothelial cells. In the present study, neutral lipid (NL) metabolism and angiogenesis were investigated in HHV8-infected HUVEC
Yong Qin et al.
International journal of clinical and experimental pathology, 7(11), 7536-7544 (2015-01-01)
DAPK1 can induce apoptosis in several cells; to determine the effect of DAPK1 would provide a new potential therapeutic strategy for treating pancreatic cancer. The aim of the present study was to investigate the effect of DAPK1 gene on proliferation
Maureen A Bjerke et al.
Developmental biology, 394(2), 340-356 (2014-08-17)
Collective cell movements are integral to biological processes such as embryonic development and wound healing and also have a prominent role in some metastatic cancers. In migrating Xenopus mesendoderm, traction forces are generated by cells through integrin-based adhesions and tension
Melissa J Alldred et al.
The Journal of comparative neurology, 523(1), 61-74 (2014-08-19)
Down syndrome (DS) is the most prevalent cause of intellectual disability (ID). Individuals with DS show a variety of cognitive deficits, most notably in hippocampal learning and memory, and display pathological hallmarks of Alzheimer's disease (AD), with neurodegeneration of cholinergic
Yau-Hung Chen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(1), 246-254 (2015-07-03)
Aristolochic acid (AA) nephropathy is complicated with early onset and severe anemia. The molecular pathological mechanism of AA-induced anemia remains unclear. The aim of this study was to evaluate the putative pathological roles of the erythropoietin receptor (EPOR) in AA-induced
Sorina Morar-Mitrica et al.
mAbs, 7(4), 792-803 (2015-06-16)
The physical and chemical integrity of a biopharmaceutical must be maintained not only during long-term storage but also during administration. Specifically for the intravenous (i.v.) delivery of a protein drug, loss of stability can occur when the protein formulation is
Gilbert Eriani et al.
PloS one, 10(6), e0130042-e0130042 (2015-06-13)
Aminoacyl-tRNA synthetases (AARSs) constitute a family of RNA-binding proteins, that participate in the translation of the genetic code, by covalently linking amino acids to appropriate tRNAs. Due to their fundamental importance for cell life, AARSs are likely to be one
Hong Wang et al.
Methods (San Diego, Calif.), 81, 34-40 (2015-03-22)
In-depth quantitative profiling of the proteome and sub-proteomes of tumor cells has relevance to tumor classification, the development of novel therapeutics, and of prognostic and predictive markers and to disease monitoring. In particular the tumor cell surface represents a highly
Elizabeth Rodríguez-Bies et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(1), 33-43 (2014-02-06)
Aging affects many biochemical, cellular, and physiological processes in the organisms. Accumulation of damage based on oxidized macromolecules is found in many age-associated diseases. Coenzyme Q (Q) is one of the main molecules involved in metabolic and antioxidant activities in
Juliano Rodrigues Sangalli et al.
PloS one, 9(6), e101022-e101022 (2014-06-25)
Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic
Jason W-L Eng et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 30(8), 540-546 (2014-11-29)
Researchers studying the murine response to stress generally use mice housed under standard, nationally mandated conditions as controls. Few investigators are concerned whether basic physical aspects of mouse housing could be an additional source of stress, capable of influencing the
Jun-Hui Choi et al.
Biochimie, 115, 177-186 (2015-06-16)
The objectives of the present study were to investigate whether kaempferol affects pro-coagulant proteinase activity, fibrin clot formation, blood clot and thrombin (or collagen/epinephrine)-stimulated platelet activation, thrombosis, and coagulation in ICR (Imprinting Control Region) mice and SD (Sprague-Dawley) rats. Kaempferol
Águeda González-Rodríguez et al.
Molecular nutrition & food research, 59(8), 1431-1442 (2015-03-27)
Mice with deletion of insulin receptor substrate (IRS) 2 develop hyperglycaemia, impaired hepatic insulin signaling and elevated gluconeogenesis. Protein tyrosine phosphatase 1B (PTP1B) inhibition by resveratrol improves peripheral insulin sensitivity of these mice. Although resveratrol activates Sirtuin1 (Sirt1), the mechanisms
Anna Golunova et al.
Biomacromolecules, 16(4), 1146-1156 (2015-03-03)
The ability to tailor mechanical properties and architecture is crucial in creating macroporous hydrogel scaffolds for tissue engineering. In the present work, a technique for the modification of the pore size and stiffness of acrylamide-based cryogels is demonstrated via the
Takashi Ohta et al.
Journal of neuropathology and experimental neurology, 73(10), 908-915 (2014-09-06)
Gemistocytic astrocytoma (World Health Organization grade II) is a rare variant of diffuse astrocytoma that is characterized by the presence of neoplastic gemistocytes and has a significantly less favorable prognosis. Other than frequent TP53 mutations (>80%), little is known about
M Taniguchi et al.
Cell death & disease, 6, e1717-e1717 (2015-04-10)
We previously reported that IL-2 deprivation induced acid sphingomyelinase-mediated (ASM-mediated) ceramide elevation and apoptosis in an NK/T lymphoma cell line KHYG-1. However, the molecular mechanism of ASM-ceramide-mediated apoptosis during IL-2 deprivation is poorly understood. Here, we showed that IL-2 deprivation
James A Carroll et al.
Journal of virology, 89(4), 2388-2404 (2014-12-17)
Gliosis is often a preclinical pathological finding in neurodegenerative diseases, including prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these diseases are not understood. To expand our knowledge of the neuroinflammatory response in prion diseases, we assessed
Raif Eren Ayata et al.
BioMed research international, 2015, 630461-630461 (2015-03-20)
Angiogenesis is a fundamental process in healing, tumor growth, and a variety of medical conditions. For this reason, in vitro angiogenesis is an area of interest for researchers. Additionally, in vitro angiogenesis is important for the survival of prevascularized tissue-engineering
Kristian Syberg et al.
Journal of toxicology and environmental health. Part A, 78(6), 369-380 (2015-03-04)
Assessment of genotoxic properties of chemicals is mainly conducted only for single chemicals, without taking mixture genotoxic effects into consideration. The current study assessed mixture effects of the three known genotoxic chemicals, 2,4-dichlorophenoxyacetic acid (2,4-D), acrylamide (AA), and maleic hydrazide
Razika Hussein et al.
Biochimica et biophysica acta, 1849(8), 940-954 (2015-05-20)
Rho factor dependent transcription termination (RTT) is common within the coding sequences of bacterial genes and it acts to couple transcription and translation levels. Despite the importance of RTT for gene regulation, its effects on mRNA and protein concentrations have
Grégoire Millet et al.
PloS one, 9(5), e95092-e95092 (2014-05-07)
This study examined the effects of intermittent hypoxic training (IHT) on skeletal muscle monocarboxylate lactate transporter (MCT) expression and anaerobic performance in trained athletes. Cyclists were assigned to two interventions, either normoxic (N; n = 8; 150 mmHg PIO2) or hypoxic (H;
Gillian Browne et al.
Journal of cellular physiology, 230(10), 2522-2532 (2015-03-25)
Runx1 is a transcription factor essential for definitive hematopoiesis, and genetic abnormalities in Runx1 cause leukemia. Runx1 is functionally promiscuous and acts as either an oncogene or tumor suppressor gene in certain epithelial cancers. Recent evidence suggests that Runx1 is
Emad Omer Hama-Ali et al.
Molecular biology reports, 42(5), 917-925 (2014-11-17)
Oil palm breeding has been progressing very well in Southeast Asia, especially in Malaysia and Indonesia. Despite this progress, there are still problems due to the difficulty of controlled crossing in oil palm. Contaminated/illegitimate progeny has appeared in some breeding
Nam-Gyun Kim et al.
The Journal of cell biology, 210(3), 503-515 (2015-07-29)
The Hippo pathway is involved in the regulation of contact inhibition of proliferation and responses to various physical and chemical stimuli. Recently, several upstream negative regulators of Hippo signaling, including epidermal growth factor receptor ligands and lysophosphatidic acid, have been
Suzana Reis Evangelista et al.
International journal of food microbiology, 210, 102-112 (2015-06-30)
The evaluation of the microbiota present during coffee wet fermentation was done in two distinct regions of Minas Gerais, Brazil: one farm in the South of Minas Gerais (Lavras=L) and another farm in the savannah region (Monte Carmelo=MC). The yeast
Loreen R Stromberg et al.
Journal of microbiological methods, 116, 1-7 (2015-06-21)
Certain Shiga toxin-producing Escherichia coli (STEC) are virulent human pathogens that are most often acquired through contaminated food. The United States Department of Agriculture, Food Safety and Inspection Service has declared several serogroups of STEC as adulterants in non-intact raw
Danielle Hagstrom et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(1), 270-285 (2015-06-28)
Traditional toxicology testing has relied on low-throughput, expensive mammalian studies; however, timely testing of the large number of environmental toxicants requires new in vitro and in vivo platforms for inexpensive medium- to high-throughput screening. Herein, we describe the suitability of the asexual
Asif Khurshid Qazi et al.
Cancer letters, 359(1), 47-56 (2015-01-03)
Deregulation of PI3K signalling pathway is strongly involved in pathology of cancer and development of resistance in tumour cells. Here, we report that pharmacologically active vasicinone analogue, RLX (7, 8, 9, 10-Tetrahydroazepino [2, 1-b] quinazolin-12-(6H)-on), exhibited potent anticancer activities both
Mathieu L Viger et al.
ACS nano, 8(5), 4815-4826 (2014-04-11)
Near-infrared (NIR) light-triggered release from polymeric capsules could make a major impact on biological research by enabling remote and spatiotemporal control over the release of encapsulated cargo. The few existing mechanisms for NIR-triggered release have not been widely applied because
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