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Katelyn T Gause et al.
ACS nano, 9(3), 2433-2444 (2015-02-26)
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a whole cell vaccine approach has significant biosafety issues. Particle-based systems have shown particular efficacy due to their inherent immunogenicity. In some cases
K Heileman et al.
Biomicrofluidics, 9(4), 044125-044125 (2015-09-05)
Human pancreatic islets are seldom assessed for dynamic responses to external stimuli. Thus, the elucidation of human islet functionality would provide insights into the progression of diabetes mellitus, evaluation of preparations for clinical transplantation, as well as for the development
Shuai Lin et al.
Reproduction (Cambridge, England), 156(5), 429-437 (2018-11-08)
Decidualization is required for the successful establishment of pregnancy in rodents and primates. Fatty acid desaturase 3 (Fads3) belongs to the fatty acid desaturase family, which is a crucial enzyme for highly unsaturated fatty acid biosynthesis. However, the expression, regulation
Johanna C van den Beukel et al.
Obesity (Silver Spring, Md.), 23(8), 1671-1679 (2015-07-17)
Brown adipose tissue (BAT) can generate heat by burning fatty acids, a process mediated by uncoupling protein 1 (UCP1). White adipose tissue (WAT) depots can gain BAT-like properties, and various studies have suggested that females have more active BAT or
A Novell et al.
Journal of chromatography. A, 1384, 124-132 (2015-02-11)
A monolithic silica gel chromatographic matrix was derivatized repetitively with an octaproline-derived chiral selector (CS). The increasingly derivatized column was tested after each derivatization reaction. The enantioseparation ability, resolution and efficiency were found to depend on the content of CS
V Matiller et al.
Reproduction in domestic animals = Zuchthygiene, 49(5), 813-823 (2014-08-13)
Cystic ovarian disease (COD) is one of the main causes of infertility in dairy cattle. It has been shown that intra-ovarian factors may contribute to follicular persistence. Transforming growth factor-beta (TGFB) isoforms are important paracrine and autocrine signalling molecules that
B I Tamba et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 46-55 (2015-02-15)
The current progress in pharmaceutical nanotechnology field has been exploited in the design of functionalized radiolabelled nanoparticles that are able to deliver radionuclides in a selective manner to improve the outcome of diagnosis and treatment. Silica nanoparticles (SNPs) have been
Natalia Barkalina et al.
Nanomedicine (London, England), 10(10), 1539-1553 (2015-05-27)
This study aimed to investigate the effects of actively targeting mesoporous silica nanoparticles (MSNPs) toward mammalian sperm with a cell-penetrating peptide (C105Y), with subsequent analysis of binding rates and nano-safety profiles. Boar sperm were exposed in vitro to C105Y-functionalized MSNPs
Hong-Min Meng et al.
Analytical chemistry, 86(24), 12321-12326 (2014-11-18)
Glutathione (GSH) serves vital cellular biological functions, and its abnormal levels are associated with many diseases. To better understand its physiological and pathological functions, efficient methods for monitoring of GSH in living systems are desired. Although quite a few small
Rosamar Eulira Fontes Rezende et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 39, 110-115 (2015-09-17)
Kaposi's sarcoma (KS) is the most common neoplasm among HIV-infected individuals. The frequency of involvement of KS in the gastrointestinal (GI) tract and the associated epidemiological, immune, endoscopic, and histopathological features in HIV-infected patients, were evaluated in this study. A
Mohammad Yahya Hanafi-Bojd et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 248-258 (2014-12-17)
Recent studies with inorganic nanoparticles modified with functional groups have demonstrated improvement in drug delivery into cancer cells. In the present study, we prepared, characterized, and evaluated mesoporous silica nanoparticles (MSNs) as carriers for epirubicin hydrochloride (EPI) in order to
J Li et al.
British journal of cancer, 101(4), 691-698 (2009-08-13)
Retinoic acid-regulated nuclear matrix-associated protein (RAMP) is a WD40 repeat-containing protein that is involved in various biological functions, but little is known about its role in human cancer. This study aims to delineate the oncogenic role of RAMP in gastric
Cristina Potrich et al.
Lab on a chip, 14(20), 4067-4075 (2014-09-02)
There is an increasing interest in circulating microRNAs (miRNAs) as potential minimally invasive diagnostic biomarkers in oncology. Considerable efforts are being made in the development of lab-on-a-chip devices for biomedical applications to purify and detect miRNAs from biological fluids. Here
Siddharth Jambhrunkar et al.
Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29)
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2
Feng Tan et al.
Environmental science & technology, 49(15), 9256-9263 (2015-06-30)
Microcystin-LR (MCLR) is one of the most commonly detected and toxic cyclic heptapeptide cyanotoxins released by cyanobacterial blooms in surface waters, for which sensitive and specific detection methods are necessary to carry out its recognition and quantification. Here, we present
Jan Michels et al.
Zoology (Jena, Germany), 118(3), 141-146 (2015-01-28)
Copepods belong to the dominant marine zooplankton taxa and play an important role in particle and energy fluxes of the marine water column. Their mandibular gnathobases possess tooth-like structures, so-called teeth. In species feeding on large proportions of diatoms these
Christopher G England et al.
PloS one, 10(6), e0129172-e0129172 (2015-06-06)
Nanoparticle uptake and distribution to solid tumors are limited by reticuloendothelial system systemic filtering and transport limitations induced by irregular intra-tumoral vascularization. Although vascular enhanced permeability and retention can aid targeting, high interstitial fluid pressure and dense extracellular matrix may
Shakiba Shahabi et al.
ACS applied materials & interfaces, 7(25), 13821-13833 (2015-06-02)
To study the importance of the surface charge for cellular uptake of silica nanoparticles (NPs), we synthesized five different single- or multifunctionalized fluorescent silica NPs (FFSNPs) by introducing various ratios of amino and sulfonate groups into their surface. The zeta
Chunfeng Wang et al.
Materials science & engineering. C, Materials for biological applications, 45, 261-269 (2014-12-11)
Lipase from Candida rugosa (CRL) was chemically and physically immobilized onto four types of rod-shaped mesoporous silica (RSMS). RSMS prepared using surfactant P123 and poly(ethylene glycol) as co-templates was functionalized with (3-aminopropyl)triethoxysilane (APTES) to obtain P-RSMS by post-synthesis grafting. Tetraethoxysilane
Zhengyu Ma et al.
PloS one, 9(11), e112292-e112292 (2014-11-11)
Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that
Hong Yang et al.
Journal of colloid and interface science, 369(1), 317-322 (2012-01-10)
Ordered MCM-41-type mesoporous silica nanoparticles (MSNs) with pore size of 2.6 nm were synthesized and were further modified with various amounts of 3-aminopropyltriethoxysilane (APTES), respectively, by a direct co-condensation method. These amine functionalized mesoporous silica nanoparticles (Am-MSNs) were employed to
Jian Hua Chen et al.
Journal of hazardous materials, 248-249, 285-294 (2013-02-13)
In this study, we prepared 3-aminopropyl-triethoxysilane (APTEOS) functionalized sodium alginate (SA) porous membrane adsorbent (APTEOS/SA) and tested its adsorption performance for removing of Cr(III) ions. The physico-chemical properties of the pristine and Cr(III) ions loaded APTEOS/SA were investigated by FT-IR
Tong-Song Wang et al.
Biology open, 4(7), 893-902 (2015-05-24)
The prevalence of diabetes is increasing worldwide with the trend of patients being young and creating a significant burden on health systems, including reproductive problems, but the effects of diabetes on embryo implantation are still poorly understood. Our study was
Isabelle Bonnet et al.
Nucleic acids research, 36(12), 4118-4127 (2008-06-12)
The restriction endonuclease EcoRV can rapidly locate a short recognition site within long non-cognate DNA using 'facilitated diffusion'. This process has long been attributed to a sliding mechanism, in which the enzyme first binds to the DNA via nonspecific interaction
Real-time observation of a single DNA digestion by lambda exonuclease under a fluorescence microscope field.
Matsuura S, et al.
Nucleic Acids Research, 29, E79-E79 (2001)
Amy S Rasson et al.
Journal of molecular biology, 427(4), 824-839 (2014-09-23)
The most recently identified class of actin nucleators, WASp homology domain 2 (WH2) nucleators, use tandem repeats of monomeric actin-binding WH2 domains to facilitate actin nucleation. WH2 domains are involved in a wide variety of actin regulatory activities. Structurally, they
Ália Dos Santos et al.
Nucleic acids research, 49(1), 340-353 (2020-12-18)
DNA double-strand breaks drive genomic instability. However, it remains unknown how these processes may affect the biomechanical properties of the nucleus and what role nuclear mechanics play in DNA damage and repair efficiency. Here, we have used Atomic Force Microscopy
Nikul G Patel et al.
Acta biomaterialia, 8(7), 2559-2567 (2012-04-06)
The ability to harvest cell sheets grown on thermoresponsive polymers, such as poly(N-isopropylacrylamide) (pNIPAAm), has been widely studied for use in tissue engineering applications. pNIPAAm is of special interest because of the phase change that it undergoes in a physiologically
Séverine Hamann et al.
PloS one, 4(8), e6616-e6616 (2009-08-13)
Pathogenesis in the Rpe65(-/-) mouse model of Leber's congenital amaurosis (LCA) is characterized by a slow and progressive degeneration of the rod photoreceptors. On the opposite, cones degenerate rapidly at early ages. Retinal degeneration in Rpe65(-/-) mice, showing a null
Hokyung Song et al.
Materials science & engineering. C, Materials for biological applications, 48, 663-672 (2015-01-13)
Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly effective for some types of "wounds"
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