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Qinglin Han et al.
Molecular medicine reports, 16(5), 7591-7596 (2017-09-26)
The aim of the present study was to investigate the effects of cobalt nanoparticles (CoNPs) on the proliferation and differentiation of human osteoblasts in vitro, and to investigate the molecular mechanisms via which CoNPs affect proliferation and differentiation of osteoblasts. The
Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide
Lee M, et al.
Neurobiology of Aging, 30(10), 1523-1534 (2009)
Amanda R Lowery et al.
International journal of nanomedicine, 1(2), 149-154 (2007-08-29)
Consisting of a silica core surrounded by a thin gold shell, nanoshells possess an optical tunability that spans the visible to the near infrared (NIR) region, a region where light penetrates tissues deeply. Conjugated with tumor-specific antibodies, NIR-absorbing immunonanoshells can
Federica Riva et al.
Cancer immunology research, 7(6), 874-885 (2019-04-26)
Chronic inflammation, including that driven by autoimmunity, is associated with the development of B-cell lymphomas. IL1R8 is a regulatory receptor belonging to the IL1R family, which negatively regulates NF-κB activation following stimulation of IL1R or Toll-like receptor family members. IL1R8
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Sheila R Costford et al.
American journal of physiology. Endocrinology and metabolism, 306(12), E1341-E1353 (2014-04-25)
Chronic low-grade inflammation is an important contributor to the development of insulin resistance, a hallmark of type 2 diabetes mellitus (T2DM). Obesity and high-fat feeding lead to infiltration of immune cells into metabolic tissues, promoting inflammation and insulin resistance. We
Rama K Mallampalli et al.
JCI insight, 5(2) (2020-01-31)
Our integrative genomic and functional analysis identified transforming acidic coiled-coil-containing protein 2 (TACC2) as a chronic obstructive pulmonary disease (COPD) candidate gene. Here, we found that smokers with COPD exhibit a marked decrease in lung TACC2 protein levels relative to
Elisa Gorostieta-Salas et al.
Oxidative medicine and cellular longevity, 2021, 6682336-6682336 (2021-08-27)
Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment promotes cellular senescence. CRM1 (exportin-1/XPO1) exports hundreds
Yuanyi Zhang et al.
Oncology letters, 15(2), 2590-2594 (2018-02-13)
Activin A is a pleiotropic cytokine belonging to the transforming growth factor β superfamily. Abnormal expression of activin A is associated with tumorigenesis. Multiple myeloma is characterized by the development of osteolytic disease, which ultimately leads to cachexia. However, the
Pradeep Kumar Reddy Cingaram et al.
PloS one, 10(10), e0139219-e0139219 (2015-10-02)
The interactions of transition metals with the prion protein (PrP) are well-documented and characterized, however, there is no consensus on their role in either the physiology of PrP or PrP-related neurodegenerative disorders. PrP has been reported to protect cells from
Helen Hoffmeister et al.
The Journal of cell biology, 192(4), 631-645 (2011-02-16)
Polycystin-2 (also called TRPP2), an integral membrane protein mutated in patients with cystic kidney disease, is located in the primary cilium where it is thought to transmit mechanical stimuli into the cell interior. After studying a series of polycystin-2 deletion
Moonhee Lee et al.
The Journal of biological chemistry, 286(48), 41230-41245 (2011-10-13)
Previous studies indicate that astrocytes are the brain cells that express acidic fibroblast growth factor (aFGF) and that the expression is increased upon activation. However, there has been no study investigating the significance of this phenomenon. Here we report that
Vladimir P Baklaushev et al.
Drug delivery, 22(3), 276-285 (2014-01-21)
Targeted drug delivery for brain tumor treatment is one of the important objectives in nanomedicine. Human glioblastoma is the most frequent and aggressive type of brain tumors. The preferential expression of membrane protein connexin 43 (Cx43) and brain-specific anion transporter
Saar Tal et al.
Virology, 468-470, 631-636 (2014-10-14)
The P4 promoter of the autonomous parvovirus Minute Virus of Mice (MVM) drives the production of its non-structural proteins, NS1 and NS2. The NS2 isoforms are without enzymatic activity but interact with cellular proteins. While NS2 is crucial to the
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.
Etchegaray, et al.
Molecular Cell, 75, 683-699 (2021)
Moonhee Lee et al.
Glia, 59(1), 152-165 (2010-11-04)
GABA is assumed to function in brain only as an inhibitory neurotransmitter. Here we report a much broader CNS role. We show that human astrocytes are GABAergic cells, and that human microglia are GABAceptive cells. We show that in adult
Katrin Brockhaus et al.
Investigative ophthalmology & visual science, 61(3), 46-46 (2020-03-25)
To scrutinize alterations in cellular interactions and cell signaling in the glaucomatous retina, mouse retinal explants were exposed to elevated pressure. Retinal explants were prepared from C57bl6 mice and cultivated in a pressure chamber under normotensive (atmospheric pressure + 0
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Zhiming Shan et al.
Molecular medicine reports, 11(3), 2062-2070 (2014-11-19)
Patients with Parkinson's disease (PD) often require surgery, and therefore may receive inhalation anesthesia. However, it is currently unknown whether inhalation anesthetics affect the prognosis of the disease. Leucine‑rich repeat kinase 2 (LRRK2) genetic mutations are the most common cause
Rongkui Zhang et al.
International journal of molecular medicine, 45(2), 578-588 (2020-01-03)
Accumulating evidence suggests that the aberrant expression of long non‑coding RNAs (lncRNAs) is involved in the initiation, development and metastasis of bladder cancer (BC). Although several differentially expressed lncRNAs have been identified via lncRNA expression profiling of BC tissues, their
Mohammad A Khanfar et al.
European journal of medicinal chemistry, 76, 414-426 (2014-03-08)
Inhibitors of sirtuin-2 deacetylase (SIRT2) have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology. The present study was directed at optimizing the potency of SIRT2 inhibitors containing
Qinghang Liu et al.
American journal of physiology. Heart and circulatory physiology, 285(1), H97-103 (2003-03-22)
Adenosine A1 receptor activation causes protein phosphatase 2a (PP2a) activation in ventricular myocytes. This attenuates beta-adrenergic functional effects in the heart (Liu Q and Hofmann PA. Am J Physiol Heart Circ Physiol 283: H1314-H1321, 2002). The purpose of the present
Moonhee Lee et al.
Brain research, 1400, 99-111 (2011-06-07)
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects
Molecular Genetics of Immunoglobulin, 17 (1987)
Stephan R Künzel et al.
FEBS open bio, 10(7), 1210-1218 (2020-05-19)
Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the underlying mechanisms is limited, which prevents effective pharmacotherapy. A deeper understanding of cardiac fibroblasts
Yuki Nakamura et al.
Nature communications, 5, 3553-3553 (2014-04-05)
Arabidopsis FT protein is a component of florigen, which transmits photoperiodic flowering signals from leaf companion cells to the shoot apex. Here, we show that FT specifically binds phosphatidylcholine (PC) in vitro. A transgenic approach to increase PC levels in
Simranjit Singh et al.
Scientific reports, 8(1), 17711-17711 (2018-12-12)
Heart failure is the most common cause of morbidity and hospitalization in the western civilization. Protein phosphatases play a key role in the basal cardiac contractility and in the responses to β-adrenergic stimulation with type-1 phosphatase (PP-1) being major contributor.
Qinghang Liu et al.
American journal of physiology. Heart and circulatory physiology, 283(4), H1314-H1321 (2002-09-18)
The ability of adenosine A(1) receptors to activate type 2a protein phosphatase (PP2a) and account for antiadrenergic effects was investigated in rat myocardial preparations. We observed that the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA) significantly reduces the isoproterenol-induced increase in
Complement-fixing IgG1 constitutes a new subclass of mouse IgG.
P L Ey et al.
Nature, 281(5731), 492-493 (1979-10-11)
Aline Raquel Voltan et al.
Medical mycology, 51(7), 759-764 (2013-04-10)
Paracoccidioidomycosis (PCM) is a chronic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis, endemic in Latin America. P. brasiliensis has been observed in epithelial cells in vivo and in vitro, as well as within the macrophages. The identification of
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