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A3803

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PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling
Thomopoulos S, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 25(10), 1358-1368 (2007)
Guiehdani Villalobos et al.
Pathogens (Basel, Switzerland), 9(6) (2020-06-18)
More than 180 mammalian species have been found naturally infected with Trypanosoma cruzi. Many of them play an important role in the maintenance of this parasite. In particular, new studies have appeared which indicate that some species of Procyonidae family...
Masako Abe et al.
BMC cancer, 11, 51-51 (2011-02-03)
CD26 (dipeptidyl peptidase IV, DPPIV) is a 110 kDa surface glycoprotein expressed in most normal tissues, and is a potential novel therapeutic target for selected cancers. Our work evaluates the mechanism involved in confluence-dependent CD26 expression in colon cancer. Colon...
Ine Rombouts et al.
Scientific reports, 5, 12210-12210 (2015-07-21)
Thermolysin hydrolyzates of freshly isolated, extensively stored (6 years, 6 °C, dry) and heated (60 min, 90 °C, in excess water) bovine serum albumin (BSA) samples were analyzed with liquid chromatography (LC) electrospray ionization (ESI) tandem mass spectrometry (MS/MS) using alternating electron-transfer...
Stefan Jean-Pierre Haas et al.
Journal of anatomy, 212(1), 19-30 (2007-11-27)
Neural progenitor cell grafting is a promising therapeutic option in the treatment of Parkinson's disease. In previous experiments we grafted temperature-sensitive immortalized CSM14.1 cells, derived from the ventral mesencephalon of E14-rats, bilaterally in the caudate putamen of adult hemiparkinsonian rats....
Ignacio Izeddin et al.
PloS one, 6(1), e15611-e15611 (2011-01-26)
The actin cytoskeleton of dendritic spines plays a key role in morphological aspects of synaptic plasticity. The detailed analysis of the spine structure and dynamics in live neurons, however, has been hampered by the diffraction-limited resolution of conventional fluorescence microscopy....
Xuemei Yu et al.
Antimicrobial agents and chemotherapy, 53(10), 4311-4319 (2009-07-22)
A major obstacle in the treatment of chronic hepatitis C virus (HCV) infection has been the lack of effective, well-tolerated therapeutics. Notably, the recent development of the HCV cell culture infection system now allows not only for the study of...
Gang Li et al.
Microbial cell factories, 7, 38-38 (2009-01-01)
Pyrethroids and pyrethrins are widely used insecticides. Extensive applications not only result in pest resistance to these insecticides, but also may lead to environmental issues and human exposure. Numerous studies have shown that very high exposure to pyrethroids might cause...
Frank Tavassol et al.
Head & neck oncology, 3, 10-10 (2011-02-25)
Oral squamous cell carcinoma (OSCC) is characterized by an aggressive growth pattern, local invasiveness, and spread to cervical lymph nodes. Overall survival rates have not improved, primarily due to locoregional tumor recurrences and distant metastasis. To date, no trustworthy or...
Joyce Besheer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(30), 9582-9591 (2009-07-31)
The interoceptive effects of alcohol are major determinants of addiction liability. Metabotropic glutamate (mGlu) receptors are widely expressed in striatal circuits known to modulate drug-seeking. Given that the interoceptive effects of drugs can be important determinants of abuse liability, we...
Brooke E Gilliam et al.
Pediatric rheumatology online journal, 9, 8-8 (2011-03-29)
Several studies have noted the significance of measuring anti-cyclic citrullinated peptide (CCP) antibodies in juvenile idiopathic arthritis (JIA) as an important indicator for destructive disease, as is the case in rheumatoid arthritis (RA). While the role of anti-CCP antibodies in...
Brian K Bednarski et al.
PloS one, 4(9), e6992-e6992 (2009-09-12)
The ability of the transcription factor NF-kappaB to upregulate anti-apoptotic proteins has been linked to the chemoresistance of solid tumors to standard chemotherapy. In contrast, recent studies have proposed that, in response to doxorubicin, NF-kappaB can be pro-apoptotic through repression...
Ying Zou et al.
Molecular and cellular biology, 29(9), 2390-2397 (2009-02-19)
The molecular distinctions between mortality stages 1 (M1; senescence) and 2 (M2; crisis) of human replicative aging are ill defined. We demonstrate a qualitative difference between telomeric end associations at M1 and the end fusions that produce dicentric chromosomes and...
Jun-Bean Park et al.
PloS one, 6(11), e28327-e28327 (2011-12-06)
The role and underlying mechanisms of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, on myocardial infarction are poorly understood. We investigated the effects of this PPAR-γ agonist on the expression of tissue factor (TF), a primary molecule for thrombosis, and...
Thomas R Cheever et al.
PloS one, 6(3), e17768-e17768 (2011-03-30)
The proper localization of ß-actin mRNA and protein is essential for growth cone guidance and axon elongation in cultured neurons. In addition, decreased levels of ß-actin mRNA and protein have been identified in the growth cones of motor neurons cultured...
Ping Ye et al.
BMC cell biology, 10, 2-2 (2009-01-14)
Control of intercellular penetration of microbial products is critical for the barrier function of oral epithelia. We demonstrated that CD24 is selectively and strongly expressed in the cells of the epithelial attachment to the tooth and the epithelial lining of...
Mi Yang et al.
Theriogenology, 148, 68-75 (2020-03-08)
Spermatogonial stem cells (SSCs) are defined as the tissue-specific stem cells in the testes that produce sperm and support life-long spermatogenesis. A culture microenvironment could convert mouse SSCs from unipotent to pluripotent states; however, the underlying mechanism is unclear. NANOG...
Mano Sivaganesan et al.
BMC bioinformatics, 9, 120-120 (2008-02-27)
In real-time quantitative PCR studies using absolute plasmid DNA standards, a calibration curve is developed to estimate an unknown DNA concentration. However, potential differences in the amplification performance of plasmid DNA compared to genomic DNA standards are often ignored in...
Kwok Ki Ho et al.
Biochemical pharmacology, 76(5), 690-696 (2008-07-24)
Cyclophosphamides are pro-drugs whose killing agent is produced from an aldehyde that is formed by the action of a P450 oxidation step. The mustard from the aldehyde can destroy bone marrow cells as well as the tumor. Aldehyde dehydrogenase (EC...
Liping Guo et al.
Breast cancer research and treatment, 175(2), 459-472 (2019-02-20)
Breast cancer is a heterogeneous disease, and although advances in molecular subtyping have been achieved in recent years, most subtyping strategies target individual genes independent of one another and primarily concentrate on proliferative markers. The contributions of biological processes and...
Natalie C Johnson et al.
Environmental science & technology, 42(15), 5772-5778 (2008-08-30)
The projected increase in the use of compact fluorescent lamps (CFLs) motivates the development of methods to manage consumer exposure to mercury and its environmental release at the end of lamp life. This work characterizes the time-resolved release of mercury...
Katherine Leon et al.
Nature communications, 11(1), 194-194 (2020-01-12)
Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key functions in diverse biological processes including neurodevelopment, embryogenesis, and tumorigenesis. However, their structures and mechanisms of action...
Kerstin Harnack et al.
Nutrition & metabolism, 6, 8-8 (2009-02-21)
Conversion of linoleic acid (LA) and alpha-linolenic acid (ALA) to their higher chain homologues in humans depends on the ratio of ingested n6 and n3 fatty acids. In order to determine the most effective ratio with regard to the conversion...
Justin A Boddey et al.
Traffic (Copenhagen, Denmark), 10(3), 285-299 (2008-12-06)
The intracellular survival of Plasmodium falciparum within human erythrocytes is dependent on export of parasite proteins that remodel the host cell. Most exported proteins require a conserved motif (RxLxE/Q/D), termed the Plasmodium export element (PEXEL) or vacuolar targeting sequence (VTS)...
Ying Liu et al.
PloS one, 6(7), e21930-e21930 (2011-07-15)
Multiple myeloma (MM) is a disease of cell cycle dysregulation while cell cycle modulation can be a target for MM therapy. In this study we investigated the effects and mechanisms of action of a sesquiterpene lactone 6-O-angeloylplenolin (6-OAP) on MM...
Eun Na Lee et al.
Anatomy & cell biology, 44(1), 14-24 (2011-04-27)
The thymus is a central lymphoid organ for T cell development. Thymic epithelial cells (TECs) constitute a major component of the thymic stroma, which provides a specialized microenvironment for survival, proliferation, and differentiation of immature T cells. In this study...
Christopher R Bethel et al.
Antimicrobial agents and chemotherapy, 52(9), 3135-3143 (2008-06-19)
The partnering of a beta-lactam with a beta-lactamase inhibitor is a highly effective strategy that can be used to combat bacterial resistance to beta-lactam antibiotics mediated by serine beta-lactamases (EC 3.2.5.6). To this end, we tested two novel penem inhibitors...
Ayna Alfadhli et al.
Journal of virology, 83(23), 12196-12203 (2009-09-25)
The human immunodeficiency virus type 1 (HIV-1) matrix (MA) protein targets HIV-1 precursor Gag (PrGag) proteins to assembly sites at plasma membrane (PM) sites that are enriched in cholesterol and phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)]. MA is myristoylated, which enhances membrane binding, and...
Robert Kumagai et al.
Free radical biology & medicine, 47(5), 600-607 (2009-06-09)
Although the glycocalyx has been implicated in wall shear stress (WSS) mechanotransduction, the role of glycocalyx components in nitric oxide (NO) and reactive oxygen species (ROS) production remains unclear. Here, we tested the hypothesis that glycocalyx is implicated in both...
Marina L Mokrishcheva et al.
BMC evolutionary biology, 11, 35-35 (2011-02-05)
The discovery of restriction endonucleases and modification DNA methyltransferases, key instruments of genetic engineering, opened a new era of molecular biology through development of the recombinant DNA technology. Today, the number of potential proteins assigned to type II restriction enzymes...
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