Showing 1-30 of 35 results for "


Xiaoquan Yang et al.
Optics express, 25(7), 7349-7357 (2017-04-07)
An optical-resolution photoacoustic microscope (OR-PAM) with capability of fast axial-scanning was developed by using a tunable acoustic gradient (TAG) lens. The TAG lens was designed to continuously changing the focal plane of OR-PAM by modulating its refractive power with fast-changing...
Jason Brunt et al.
Food microbiology, 51, 45-50 (2015-07-19)
Clostridium sporogenes forms highly heat resistant endospores, enabling this bacterium to survive adverse conditions. Subsequently, spores may germinate, giving rise to vegetative cells that multiply and lead to food spoilage. Electron microscopy was used to visualise changes in spore structures...
Carmen Diaz-Verdugo et al.
Current biology : CB, 29(15), 2541-2546 (2019-07-23)
Mating and flight from threats are innate behaviors that enhance species survival [1, 2]. Stimuli to these behaviors often are contemporaneous and conflicting [3, 4]. Both how such conflicts are resolved and where in the brain such decisions are made...
Joshua D Ochocki et al.
Cell metabolism, 27(6), 1263-1280 (2018-05-15)
Kidney cancer, one of the ten most prevalent malignancies in the world, has exhibited increased incidence over the last decade. The most common subtype is "clear cell" renal cell carcinoma (ccRCC), which features consistent metabolic abnormalities, such as highly elevated...
Agarose gel electrophoresis for the separation of DNA fragments
Lee PY, et al.
Journal of Visualized Experiments, (62) (2012)
Richard Kanyo et al.
Epilepsia, 61(8), 1678-1690 (2020-07-12)
Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this...
Sonja Blumenau et al.
Scientific reports, 10(1), 7103-7103 (2020-04-30)
Alzheimer's disease and small vessel ischemic disease frequently co-exist in the aging brain. However, pathogenic links between these 2 disorders are yet to be identified. Therefore we used Taqman genotyping, exome and RNA sequencing to investigate Alzheimer's disease known pathogenic...
Feng Xu et al.
PloS one, 6(4), e19344-e19344 (2011-05-10)
Decellularization and cellularization of organs have emerged as disruptive methods in tissue engineering and regenerative medicine. Porous hydrogel scaffolds have widespread applications in tissue engineering, regenerative medicine and drug discovery as viable tissue mimics. However, the existing hydrogel fabrication techniques...
Viscoelastic properties of dental pulp tissue and ramifications on biomaterial development for pulp regeneration
Erisken C, et al.
Journal of Endodontics, 41(10), 1711-1717 (2015)
Fernanda Godoy-Santos et al.
Microbiology (Reading, England), 165(7), 761-771 (2019-05-16)
Biofilms may enhance the tolerance of bacterial pathogens to disinfectants, biocides and other stressors by restricting the penetration of antimicrobials into the matrix-enclosed cell aggregates, which contributes to the recalcitrance of biofilm-associated infections. In this work, we performed real-time monitoring...
Lei Cheng et al.
PloS one, 13(10), e0204068-e0204068 (2018-11-01)
Due to its ability to induce DNA damage in a space and time controlled manner, ionising radiation is a unique tool for studying the mechanisms of DNA repair. The biological effectiveness of ionising radiation is related to the ionisation density...
Testing the Waters: New Technical Applications for the Cleaning of Acrylic Paint Films and Paper Supports
The Book and Paper Group Annual, 32, 43-51 (2013)
Anthony Murphy et al.
Oncology reports, 45(4) (2021-03-03)
Nickel (Ni) is carcinogenic to humans, and causes cancers of the lung, nasal cavity, and paranasal sinuses. The primary mechanisms of Ni‑mediated carcinogenesis involve the epigenetic reprogramming of cells and the ability for Ni to mimic hypoxia. However, the exact...
Elisabeth Butz et al.
The Journal of comparative neurology, 523(6), 963-981 (2014-12-19)
We studied the retinal cone bipolar cells of Carollia perspicillata, a microchiropteran bat of the phyllostomid family. Microchiroptera are strongly nocturnal, with small eyes and rod-dominated retinae. However, they also possess a significant cone population (2-4%) comprising two spectral types...
Marcos Mateo-Fernández et al.
Foods (Basel, Switzerland), 8(9) (2019-09-08)
Nutraceutical activity of food is analysed to promote the healthy characteristics of diet where additives are highly used. Caramel is one of the most worldwide consumed additives and it is produced by heating natural carbohydrates. The aim of this study...
A Asghari Adib et al.
Biofabrication, 12(4), 045006-045006 (2020-05-29)
We develop and characterize a biomaterial formulation and robotic methods tailored for intracorporeal tissue engineering (TE) via direct-write (DW) 3D printing. Intracorporeal TE is defined as the biofabrication of 3D TE scaffolds inside of a living patient, in a minimally...
Mamoru Takada et al.
Oncotarget, 8(4), 6787-6795 (2016-12-31)
EglN2 contributes to ERα-positive breast tumorigenesis by acting as an estrogen-inducible gene. However, the detailed molecular mechanism(s) underlying the post-transcriptional regulation of EglN2 and its potential role in Triple Negative Breast Cancer (TNBC) remains largely unclear. By using C3Tag transgenic...
Yongjae Jo et al.
Nature communications, 9(1), 4577-4577 (2018-11-06)
Fluorescent optical probes have rapidly transformed our understanding of complex biological systems by providing specific information on biological targets in the natural living state. However, their utility is often limited by insufficient brightness, photostability, and multiplexing capacity. Here, we report...
Methods in Enzymology, 135, 223-223 (1987)
Manish Sharma et al.
Autophagy, 10(9), 1637-1651 (2014-07-22)
Autophagy is a lysosomal degradative pathway that has diverse physiological functions and plays crucial roles in several viral infections. Here we examine the role of autophagy in the life cycle of JEV, a neurotropic flavivirus. JEV infection leads to induction...
Samuel Knauss et al.
Frontiers in neuroscience, 14, 576741-576741 (2020-10-20)
Numerous studies on experimental ischemic stroke use the filament middle cerebral artery occlusion (fMCAo) model in C57BL/6 mice, but lesion sizes in this strain are highly variable. A known contributor is variation in the posterior communicating artery (PcomA) patency. We...
Surfactant-induced coagulation of agarose from aqueous extract of Gracilaria dura seaweed as an energy-efficient alternative to the conventional freeze--thaw process
Meena R, et al.
Royal Society of Chemistry Advances, 4(53), 28093-28098 (2014)
Peichao Li et al.
Carcinogenesis, 42(1), 136-147 (2020-07-28)
Hexavalent chromium [Cr(VI)] is a potent human lung carcinogen. Multiple mechanisms have been proposed that contribute to Cr(VI)-induced lung carcinogenesis including oxidative stress, DNA damage, genomic instability and epigenetic modulation. However, the molecular mechanisms and pathways mediating Cr(VI) carcinogenicity have...
Line Verckist et al.
Respiratory research, 19(1), 207-207 (2018-10-28)
The microenvironment (ME) of neuroepithelial bodies (NEBs) harbors densely innervated groups of pulmonary neuroendocrine cells that are covered by Clara-like cells (CLCs) and is believed to be important during development and for adult airway epithelial repair after severe injury. Yet...
Tetsuya Kawaguchi et al.
Journal of proteome research, 19(1), 360-370 (2019-11-07)
The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly all ALS patients. Both the natural function and contribution to pathology for TDP-43...
Elliot J Stein et al.
Journal of vascular and interventional radiology : JVIR, 31(2), 352-361 (2019-11-22)
To evaluate the capability of T2-weighted magnetic resonance (MR) imaging to monitor electrolytic ablation-induced cell death in real time. Agarose phantoms arranged as an electrolytic cell were exposed to varying quantities of electric charge under constant current to create a...
In vivo imaging of zebrafish retina
Williams PR, et al.
Cold Spring Harbor Protocols, 2013(1) (2013)
Katsuhiro Kato et al.
Nature communications, 9(1), 2448-2448 (2018-06-24)
Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells. Endothelial tubules are associated with specialised mesenchymal cells, termed pericytes, which help...
Tania Merinas-Amo et al.
Journal of medicinal food, 20(3), 223-234 (2017-01-20)
The purpose of the present study was to examine the nutraceutical potential of choline as an added value to its well-known brain nutrient role. Several toxicity, antitoxicity, genotoxicity, antigenotoxicity, and longevity endpoints were checked in the somatic mutation and recombination...