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A4034

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Sławomir Tokarski et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 35(207), 136-140 (2013-11-15)
One of the main after-effects of chemotherapy used in cancer treatment is an augmented production of reactive oxygen species (ROS). In turn ROS become a source of unwanted side effects of chemotherapy, often forcing the discontinuation of the therapy. Ascorbic...
Eugenio Jose Garcia et al.
The European journal of esthetic dentistry : official journal of the European Academy of Esthetic Dentistry, 7(2), 154-162 (2012-05-31)
It is generally not recommended that bonded restoration treatment should be carried out immediately after bleaching treatment. However, the use of antioxidants such as sodium ascorbate can be useful to avoid a waiting period. This article is a brief review...
J Bautista-Ortega et al.
Poultry science, 93(4), 979-988 (2014-04-08)
The effects of l-Arg, vitamin C (VC), and vitamin E (VE) on xanthine- (XO) and NAD(P)H-oxidase (NOX) activities, and nitric oxide (NO) availability of hypoxic broilers were evaluated. Chickens were kept in wire cages with free access to feed and...
Marina A Kozuleva et al.
FEBS letters, 588(23), 4364-4368 (2014-10-15)
O2 reduction was investigated in photosystem I (PSI) complexes isolated from cyanobacteria Synechocystis sp. PCC 6803 wild type (WT) and menB mutant strain, which is unable to synthesize phylloquinone and contains plastoquinone at the quinone-binding site A1. PSI complexes from...
Che-Fan Huang et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(2), 114-119 (2015-01-06)
Protein oxidation by reactive oxygen species has been associated with aging and neurodegenerative disorders, and histidine is one of the major oxidation targets due to its metal-chelating property and susceptibility to metal-catalyzed oxidation. 2-Oxohistidine, the major product of histidine oxidation...
Hiroyuki Katayama et al.
Cell, 181(5), 1176-1187 (2020-05-22)
Dysfunctional mitochondria accumulate in many human diseases. Accordingly, mitophagy, which removes these mitochondria through lysosomal degradation, is attracting broad attention. Due to uncertainties in the operational principles of conventional mitophagy probes, however, the specificity and quantitativeness of their readouts are...
Melissa A Erlandson et al.
PloS one, 10(7), e0132008-e0132008 (2015-07-03)
The organization of cortical networks can be investigated functionally in brain slices. Laser scanning photostimulation (LSPS) with glutamate-uncaging allows for a rapid survey of all connections impinging on single cells recorded in patch-clamp. We sought to develop a variant of...
Olivier Fain
La Revue du praticien, 63(8), 1091-1096 (2013-12-05)
Vitamin C is a water soluble vitamin which is mainly fresh fruits and vegetables foodborne. Vitamin C deficiency is most often due to a lack of daily amount. Scurvy is characterized by the occurrence of fatigue, myalgia, arthralgia, purpura, bleeding...
Xuan Ming et al.
Cell research, 30(11), 980-996 (2020-06-26)
Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell identity. Whether DNA methylation pattern in different genomic contexts can all be faithfully maintained is an open question. A replication-coupled DNA methylation maintenance model was...
Curt T Dellavalle et al.
International journal of cancer, 134(12), 2917-2926 (2013-11-19)
Nitrate and nitrite are precursors of endogenously formed N-nitroso compounds (NOC), known animal carcinogens. Nitrosation reactions forming NOCs can be inhibited by vitamin C and other antioxidants. We prospectively investigated the association between dietary nitrate and nitrite intake and risk...
A A Akinlolu et al.
African journal of medicine and medical sciences, 41 Suppl, 149-155 (2013-05-18)
This study investigated the neurotoxic effects of the combined intramuscular administration of Artemether (0.5 mg/kg/b.w.), Quinine (5.14 mg/kg/b.w.) and Ascorbic acid (0.21 mg/kg/b.w) on the cerebellum, trapezoid nuclei and behavioural functions in male Wistar rats for a period of seven...
Allegra Vit et al.
Chembiochem : a European journal of chemical biology, 16(10), 1490-1496 (2015-06-17)
The ubiquitous sulfur metabolite ergothioneine is biosynthesized by oxidative attachment of a sulfur atom to the imidazole ring of Nα-trimethylhistidine. Most actinobacteria, including Mycobacterium tuberculosis, use γ-glutamyl cysteine as a sulfur donor. In subsequent steps the carbon scaffold of γ-glutamyl...
Jonathan C Y Tang et al.
Nature neuroscience, 18(9), 1334-1341 (2015-08-11)
There are many transgenic GFP reporter lines that allow the visualization of specific populations of cells. Using such lines for functional studies requires a method that transforms GFP into a molecule that enables genetic manipulation. We developed a method that...
Benedict Tan et al.
STAR protocols, 1(2), 100074-100074 (2020-10-29)
The peroxidase APEX2 has been used widely for proximity biotinylation and subsequent proteomics analyses. However, the poor membrane permeability of the biotin phenol substrate and the inhibitory effect of peroxide on the enzyme's activity has hampered proximity labeling in certain...
D U A Kumara et al.
Journal of wound care, 24(1), 5-10 (2014-12-30)
Antiseptics are widely used in wound management to prevent or treat wound infections due to their proven wound healing properties regardless of their cytotoxicity. The objective of this study was to determine the bactericidal effects of three antiseptics on pathogens...
Laure Magnan et al.
Acta biomaterialia, 105, 111-120 (2020-01-31)
In the field of tissue engineering, many groups have come to rely on the extracellular matrix produced by cells as the scaffold that provides structure and strength to the engineered tissue. We have previously shown that sheets of Cell-Assembled extracellular...
Aleksander Hinek et al.
Journal of dermatological science, 75(3), 173-182 (2014-07-13)
Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis. Present studies explored whether and how the L-ascorbic acid derivative (+) sodium L-ascorbate (SA) would affect production of collagen and elastic...
Tran Thi Nhung et al.
Journal of nanoscience and nanotechnology, 13(8), 5346-5350 (2013-07-26)
Flowerlike gold nanostructure was facilely prepared by the seed-mediated growth of gold nanoparticles in chitosan-TPP template films. Firstly, chitosan nanoparticles, spontaneously formed by inter and/or intra cross-linking with TPP, were transformed into gel-type of chitosan-TPP films under strong sonication process....
Peng Sun et al.
Science advances, 6(12), eaaz0368-eaaz0368 (2020-03-29)
Adhesion G protein-coupled receptor G6 (Adgrg6; also named GPR126) single-nucleotide polymorphisms are associated with human height in multiple populations. However, whether and how GPR126 regulates body height is unknown. In this study, we found that mouse body length was specifically...
Sevnur Serim et al.
Organic & biomolecular chemistry, 13(8), 2293-2299 (2015-01-03)
Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging, allowing the visualization of dynamic enzyme activation by fluorescent microscopy....
Beata Jabłonowska-Lietz et al.
Roczniki Panstwowego Zakladu Higieny, 64(1), 43-48 (2013-06-26)
The health benefits arising from antioxidant vitamins A, C and E are well recognised and their recommended dietary intake for the general population have been established. However, there is still a need for assessing antioxidant vitamin intake in different population...
Hong Seok Choi et al.
Diseases of the colon and rectum, 57(10), 1220-1227 (2014-09-10)
Many patients report discomfort because of the unpleasant taste of bowel preparation solutions. This study aimed to determine whether adding orange juice to 2 L of polyethylene glycol plus ascorbic acid is effective for reducing patient discomfort and improving palatability...
Kerrie B Collins et al.
The Journal of cell biology, 219(2) (2019-12-23)
Podosomes are compartmentalized actin-rich adhesions, defined by their ability to locally secrete proteases and remodel extracellular matrix. Matrix remodeling by endothelial podosomes facilitates invasion and thereby vessel formation. However, the mechanisms underlying endothelial podosome formation and function remain unclear. Here...
Tomoharu Takeuchi et al.
Biological & pharmaceutical bulletin, 38(3), 482-486 (2015-03-12)
Interferon-stimulated gene 15 kDa (ISG15) is a protein upregulated by interferon-β that negatively regulates osteoclastogenesis. We investigated the role of ISG15 in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenic differentiation of murine RAW264 cells. RANKL stimulation induced ISG15 expression in...
Jia-Dong Pang et al.
Materials science & engineering. C, Materials for biological applications, 49, 485-492 (2015-02-18)
Although amylose as a naturally-occurring helical polysaccharide has been widely used for biomedical applications, few studies have dealt with its chemical modification for non-viral gene delivery. In this work, the click modification of amylose by poly(l-lysine) dendrons was carried out...
Xi Su et al.
Journal of experimental & clinical cancer research : CR, 40(1), 34-34 (2021-01-21)
BRAFV600E mutation is the most common mutation in thyroid cancer. It strongly activates MAPK/ERK pathway and indicates an invasive subtype of thyroid cancer. PLX4032 is a selective oral inhibitor of the BRAFV600 kinase although with limited effect in treating this...
Tim J Wigle et al.
Journal of biomolecular screening, 20(6), 810-820 (2015-03-11)
Demethylation of histones by lysine demethylases (KDMs) plays a critical role in controlling gene transcription. Aberrant demethylation may play a causal role in diseases such as cancer. Despite the biological significance of these enzymes, there are limited assay technologies for...
Christopher M Stephenson et al.
Cancer chemotherapy and pharmacology, 72(1), 139-146 (2013-05-15)
This phase I clinical trial evaluated the safety, tolerability, and pharmacokinetics of high-dose intravenous (i.v.) ascorbic acid as a monotherapy in patients with advanced solid tumors refractory to standard therapy. Five cohorts of three patients received i.v. ascorbic acid administered...
A L Althaus et al.
Journal of neurophysiology, 113(4), 1184-1194 (2014-11-28)
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability...
Andrew Fulton et al.
Journal of chromatography. A, 1389, 128-132 (2015-03-10)
Monoclonal antibodies (mAbs) are one of the fastest growing drug molecules targeting the treatment of diseases ranging from arthritis, immune disorders, and infectious diseases to cancer. Due to its unique application principle, antibodies are commonly produced in large quantities. Plants...
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