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Srinivasa R Penumutchu et al.
PloS one, 9(8), e103947-e103947 (2014-08-02)
The S100P protein is a member of the S100 family of calcium-binding proteins and possesses both intracellular and extracellular functions. Extracellular S100P binds to the cell surface receptor for advanced glycation end products (RAGE) and activates its downstream signaling cascade
Chrissy M Leopold Wager et al.
Infection and immunity, 83(12), 4513-4527 (2015-09-10)
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an opportunistic fungal pathogen that primarily affects AIDS patients and patients undergoing immunosuppressive therapy. In immunocompromised individuals, C. neoformans can lead to life-threatening meningoencephalitis. Studies using a virulent strain of C.
Y Yin et al.
Letters in applied microbiology, 61(6), 580-587 (2015-09-24)
(+)-Terrein shows multiple bioactivities, however, its mass production is a big challenge. Aspergillus terreus strain PF26 derived from South China Sea sponge Phakellia fusca has been cultured to produce (+)-terrein successfully, but artificial sea water (ASW) of high salinity used
Niels A J Cremers et al.
International journal of molecular sciences, 15(10), 17974-17999 (2014-10-10)
Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injury. Heme oxygenase (HO) generates the cytoprotective effector molecules biliverdin/bilirubin, carbon
Rainer Nikolay et al.
Nucleic acids research, 42(12), e100-e100 (2014-05-06)
While the structure of mature ribosomes is analyzed in atomic detail considerably less is known about their assembly process in living cells. This is mainly due to technical and conceptual hurdles. To analyze ribosome assembly in vivo, we designed and
F Vela-Soria et al.
Talanta, 129, 209-218 (2014-08-17)
The population is continuously exposed to endocrine disrupting chemicals (EDCs). This has influenced an increase in diseases and syndromes that are more frequent nowadays. Therefore, it is necessary to develop new analytical procedures to evaluate the exposure with the ultimate
Allison Sang et al.
PloS one, 9(8), e102151-e102151 (2014-08-06)
The breakdown in tolerance of autoreactive B cells in the lupus-prone NZM2410-derived B6.Sle1.Sle2.Sle3 (TC) mice results in the secretion of autoantibodies. TC dendritic cells (DCs) enhance B cell proliferation and antibody secretion in a cytokine-dependent manner. However, the specific cytokine
Magdalena Jarosz-Biej et al.
Archivum immunologiae et therapiae experimentalis, 63(6), 451-464 (2015-03-25)
Tumor progression depends on tumor milieu, which influences neovasculature formation and immunosuppression. Combining immunotherapy with antiangiogenic/antivascular therapy might be an effective therapeutic approach. The aim of our study was to elaborate an anticancer therapeutic strategy based on the induction of
Sukhwan Yoon et al.
Applied and environmental microbiology, 81(10), 3510-3517 (2015-03-15)
Shewanella loihica strain PV-4 harbors both a functional denitrification (NO3 (-)→N2) and a respiratory ammonification (NO3 (-)→NH4 (+)) pathway. Batch and chemostat experiments revealed that NO2 (-) affects pathway selection and the formation of reduced products. Strain PV-4 cells grown
Maria C Whelan et al.
PloS one, 9(5), e97602-e97602 (2014-05-17)
Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour growth advantage. We investigated the utilisation of regulatory
Yang Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(34), 12516-12521 (2014-08-13)
Middle East respiratory syndrome coronavirus (MERS-CoV) currently spreads in humans and causes ∼ 36% fatality in infected patients. Believed to have originated from bats, MERS-CoV is genetically related to bat coronaviruses HKU4 and HKU5. To understand how bat coronaviruses transmit
Nilufar Mohebbi et al.
PloS one, 8(1), e55286-e55286 (2013-02-06)
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of
Effat Alizadeh et al.
Chemical biology & drug design, 85(3), 268-279 (2014-07-26)
MicroRNAs are small non-coding RNAs that regulate key processes of the stem cells. Although, microRNAs have emerged as powerful regulators of differentiation, few studies have been focused on the post-transcriptional regulation of hepatic differentiation in mesenchymal stem cells (MSCs) by
Fahad N Almajhdi et al.
PloS one, 9(11), e113461-e113461 (2014-11-26)
Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop
Shuang-Bai Zhou et al.
Transplantation, 98(10), 1048-1055 (2014-11-19)
Unpredictable survival rate of transplanted fat is an obstacle in application of fat grafting. Although recent researches have suggested that adipose-derived stromal vascular fraction (SVF) could promote grafted fat survival, there has been seldom reports on tracing the dynamic change
Sergio C Nanita et al.
Analytica chimica acta, 768, 1-11 (2013-03-12)
A sample extraction and purification procedure that uses ammonium-salt-induced acetonitrile/water phase separation was developed and demonstrated to be compatible with the recently reported method for pesticide residue analysis based on fast extraction and dilution flow injection mass spectrometry (FED-FI-MS). The
Kari L Roberts et al.
Journal of virology, 89(3), 1537-1549 (2014-11-28)
In the extracellular environment, cell-free virions seek out naive host cells over long distances and between organisms. This is the primary mechanism of spread for most viruses. Here we provide evidence for an alternative pathway previously undescribed for orthomyxoviruses, whereby
Ruiping Zhou et al.
PloS one, 9(8), e104392-e104392 (2014-08-08)
Mesenchymal stem cells (MSCs) have exhibited therapeutic effects in multiple animal models so that are promising liver substitute for transplantation treatment of end-stage liver diseases. However, it has been shown that over-manipulation of these cells increased their tumorigenic potential, and
Francesca Veronesi et al.
Age (Dordrecht, Netherlands), 36(3), 9647-9647 (2014-04-02)
Osteoporosis due to estrogen deficiency is an increasing bone health issue worldwide: new strategies are being studied for regenerative medicine of bone pathologies in these patients. The most commonly used cells for tissue engineering therapy are the bone marrow mesenchymal
Diego G Ogando et al.
American journal of physiology. Cell physiology, 305(7), C716-C727 (2013-07-19)
Slc4a11, a member of the solute linked cotransporter 4 family that is comprised predominantly of bicarbonate transporters, was described as an electrogenic 2Na(+)-B(OH)4(-) (borate) cotransporter and a Na(+)-2OH(-) cotransporter. The goal of the current study was to confirm and/or clarify
Joshua D Doyle et al.
PLoS pathogens, 11(3), e1004693-e1004693 (2015-03-05)
Reovirus is a nonenveloped mammalian virus that provides a useful model system for studies of viral infections in the young. Following internalization into host cells, the outermost capsid of reovirus virions is removed by endosomal cathepsin proteases. Determinants of capsid
J Marcus et al.
Physical chemistry chemical physics : PCCP, 17(48), 32528-32538 (2015-11-26)
We study the addition of electrolytes to surfactant-free microemulsions in the domain where polydisperse pre-Ouzo aggregates are present. As in previous studies, the microemulsion is the ternary system water/ethanol/1-octanol, where ethanol acts as co-solvent. Addition of electrolytes modifies the static
Lena Grave et al.
Protein expression and purification, 86(2), 142-150 (2012-10-13)
Using a codon-optimized gene fragment, we report remarkable yields for extracellular domain of human NK cell receptor (NKp30ex) when produced on M9 minimal medium, even with low (2g/L) glucose concentration. The yields were identical using media containing (15)NH(4)Cl or (15)NH(4)Cl
Hiroyuki Yamamoto et al.
Nature communications, 6, 6429-6429 (2015-03-11)
Angiogenic blood vessel growth requires several distinct but integrated cellular activities. Endothelial cell sprouting and proliferation lead to the expansion of the vasculature and give rise to a highly branched, immature plexus, which is subsequently reorganized into a mature and
Lan Wei-LaPierre et al.
The Journal of biological chemistry, 288(15), 10567-10577 (2013-03-05)
Superoxide flashes are transient bursts of superoxide production within the mitochondrial matrix that are detected using the superoxide-sensitive biosensor, mitochondria-targeted circularly permuted YFP (mt-cpYFP). However, due to the pH sensitivity of mt-cpYFP, flashes were suggested to reflect transient events of
Jonathan M Berman et al.
American journal of physiology. Cell physiology, 304(7), C604-C613 (2013-01-25)
Electrophysiological techniques make use of Ag/AgCl electrodes that are in direct contact with cells or bath. In the bath, electrodes are exposed to numerous experimental conditions and chemical reagents that can modify electrode voltage. We examined voltage offsets created in
Xiaoxiao Zhang et al.
Nucleic acids research, 42(21), 13430-13439 (2014-11-13)
Many ribosome-interacting GTPases, with proposed functions in ribosome biogenesis, are also implicated in the cellular regulatory coupling between ribosome assembly process and various growth control pathways. EngA is an essential GTPase in bacteria, and intriguingly, it contains two consecutive GTPase
Nadiah Abu et al.
Drug design, development and therapy, 9, 1401-1417 (2015-04-04)
Flavokawain B (FKB) is a naturally occurring chalcone that can be isolated through the root extracts of the kava-kava plant (Piper methysticum). It can also be synthesized chemically to increase the yield. This compound is a promising candidate as a
Sherezade Fuentes-Julián et al.
PloS one, 10(3), e0117945-e0117945 (2015-03-03)
The effect of local and systemic injections of mesenchymal stem cells derived from adipose tissue (AD-MSC) into rabbit models of corneal allograft rejection with either normal-risk or high-risk vascularized corneal beds was investigated. The models we present in this study
Yu-Sen Zhong et al.
Journal of ethnopharmacology, 144(3), 761-767 (2012-11-06)
Orthosiphon stamineus (OS) popularly known as "diuretic agent" are traditionally used in folk medicine in the treatment of hyperuricemia, rheumatism, gout, nephritis, nephrolithiasis, urethritis and cystitis. To evaluate prophylactic potentials of total flavonoids, total phenolics and polysaccharides from OS on
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