Showing 1-30 of 33 results for "a5213"
Chun-Yan Wang et al.
PloS one, 5(12), e15349-e15349 (2010-12-24)
Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been...
Chia-Mei Chou et al.
Parasites & vectors, 10(1), 620-620 (2017-12-24)
Toxocariasis is a worldwide zoonotic parasitic disease mainly caused by Toxocara canis. Humans can be infected by accidental ingestion of T. canis embryonated ovum-contaminated food, water, or encapsulated larvae in paratenic hosts' viscera or meat. Since humans and mice are...
Tian Tian et al.
Nutrients, 8(9) (2016-09-13)
Alzheimer's disease (AD) is the most common type of dementia. Amyloid-β protein (Aβ) is identified as the core protein of neuritic plaques. Aβ is generated by the sequential cleavage of the amyloid precursor protein (APP) via the APP cleaving enzyme...
Zejie Zuo et al.
Neurobiology of disease, 101, 27-39 (2017-02-13)
The immune system plays a crucial role in the progression of Alzheimer's disease (AD). Recently, immune-dependent cascade induced by systemic immune activation has been verified to play a beneficial role in AD mouse models. Here, we tested whether Bacillus Calmette-Guérin...
Jared Ehrhart et al.
Journal of neuroinflammation, 2, 29-29 (2005-12-14)
Activated microglial cells have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS), and HIV dementia. It is well known that inflammatory mediators such as nitric oxide (NO), cytokines, and chemokines play an important...
Xian-Hui Dong et al.
Experimental and therapeutic medicine, 9(4), 1319-1327 (2015-03-18)
Alzheimer's disease (AD) is a neurodegenerative brain disorder and the most common cause of dementia. New treatments for AD are required due to its increasing prevalence in aging populations. The present study evaluated the effects of the active components of
Hye-Eun Han et al.
PloS one, 5(12), e15645-e15645 (2010-12-29)
The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) is responsible for the processing of the viral polyprotein into functional proteins. NIa was previously shown to possess a relatively strict substrate specificity with a preference for Val-Xaa-His-Gln↓, with...
Kendra L Puig et al.
Scientific reports, 7, 43725-43725 (2017-03-07)
It is well known that mutations in the gene coding for amyloid precursor protein are responsible for autosomal dominant forms of Alzheimer's disease. Proteolytic processing of the protein leads to a number of metabolites including the amyloid beta peptide. Although...
Zitian He et al.
Cell death & disease, 11(6), 440-440 (2020-06-10)
Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer's disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine...
Jessica F Jordão et al.
PloS one, 5(5), e10549-e10549 (2010-05-21)
Immunotherapy for Alzheimer's disease (AD) relies on antibodies directed against toxic amyloid-beta peptide (Abeta), which circulate in the bloodstream and remove Abeta from the brain. In mouse models of AD, the administration of anti-Abeta antibodies directly into the brain, in...
Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer?s disease: Implications for object recognition
Bonardi, C, et al.
Behavioural Brain Research, 313, 71-81 (2016)
Zhiwei Xing et al.
Brain, behavior, and immunity, 91, 128-141 (2020-09-22)
Immune dysfunction is implicated in Alzheimer's disease (AD), whereas systemic immune modulation may be neuroprotective. Our previous results have indicated immune challenge with Bacillus Calmette-Guerin attenuates AD pathology in animal models by boosting the systemic immune system. Similarly, independent studies...
Ji-Seon Seo et al.
Journal of ethnopharmacology, 128(1), 206-212 (2010-01-19)
Jangwonhwan, a boiled extract of 12 medicinal plants/mushroom including Korean red ginseng (Panax ginseng C.A. Meyer), has been prescribed for patients with cognitive dysfunction and are believed to induce brain activity enhancement, provide light sedation, and facilitate sound sleep. The...
Use-dependent effects of amyloidogenic fragments of β-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
Kim, J, et al.
The Journal of Neuroscience, 21(4), 1327-1333 (2001)
Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice
Tian, T, et al.
Nutrients, 8(9), 556-556 (2016)
Ji-Seon Seo et al.
Free radical biology & medicine, 50(11), 1526-1535 (2011-03-09)
Basic and clinical studies have reported that behavioral stress worsens the pathology of Alzheimer disease (AD), but the underlying mechanism has not been clearly understood. In this study, we determined the mechanism by which behavioral stress affects the pathogenesis of...
Anyang Sun et al.
Experimental neurology, 175(1), 10-22 (2002-05-16)
Chronic accumulation of beta-amyloid in the brain has been shown to result in complex molecular and cellular changes that accompany neurodegeneration in Alzheimer's disease (AD). In this study, we examined the expression of a newly identified beta-secretase, memapsin 2 (M2)...
Chun-Yan Wang et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(5), 1073-1089 (2011-02-04)
Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy. In this study, we searched for new mechanisms by which HupA could activate Wnt signaling and...
Tae-Kyung Kim et al.
Experimental & molecular medicine, 44(8), 492-502 (2012-05-31)
Adequate assessment of plaque deposition levels in the brain of mouse models of Alzheimer disease (AD) is required in many core issues of studies on AD, including studies on the mechanisms underlying plaque pathogenesis, identification of cellular factors modifying plaque...
Kendra L Puig et al.
Neurobiology of aging, 40, 22-40 (2016-03-15)
APP/PS1 double transgenic mice expressing human mutant amyloid precursor protein (APP) and presenilin-1 (PS1) demonstrate robust brain amyloid beta (Aβ) peptide containing plaque deposition, increased markers of oxidative stress, behavioral dysfunction, and proinflammatory gliosis. On the other hand, lack of...
Folic acid deficiency enhances aβ accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression
Liu, H, et al.
The Journal of Nutritional Biochemistry, 26(12), 1502-1508 (2015)
Yunjie Yang et al.
Journal of neuroinflammation, 17(1), 65-65 (2020-02-23)
Alzheimer's disease (AD) is a neurodegenerative disorder strongly correlated with a dysfunctional immune system. Our previous results demonstrated that inactivated influenza vaccine (IIV) facilitates hippocampal neurogenesis and blocks lipopolysaccharide (LPS)-induced cognitive impairment. However, whether IIV improves cognitive deficits in an...
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Tae-Kyung Kim et al.
Experimental & molecular medicine, 44(12), 740-748 (2012-11-23)
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the amyloid-β (Aβ) peptide, which contains the sequence Val-His-His-Gln in the...
R E Tanzi et al.
Nature, 331(6156), 528-530 (1988-02-11)
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. Recent molecular genetic studies...
Songhee Jeon et al.
Journal of ethnopharmacology, 137(1), 783-789 (2011-07-19)
SuHeXiang Wan (SHXW), a Chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. Previously, we reported the effects of modified SHXW essential oil mixture of the fragrance containing herbs on the...
Aneta Stachowicz et al.
International journal of molecular sciences, 18(2) (2017-02-22)
The role of different genotypes of apolipoprotein E (apoE) in the etiology of Alzheimer's disease is widely recognized. It has been shown that altered functioning of apoE may promote 4-hydroxynonenal modification of mitochondrial proteins, which may result in mitochondrial dysfunction...
Kavon Rezai-Zadeh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(38), 8807-8814 (2005-09-24)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder pathologically characterized by deposition of beta-amyloid (Abeta) peptides as senile plaques in the brain. Recent studies suggest that green tea flavonoids may be used for the prevention and treatment of a variety...
Geng Lin et al.
Frontiers in aging neuroscience, 12, 556008-556008 (2020-11-28)
Human epidemiological evidence and animal experimental data suggest that chronic manganese (Mn) exposure increases the risk of Alzheimer's disease (AD) and amyloid plaques, a hallmark of AD brain pathology, but the underlying mechanisms were not fully understood. Using the transgenic...
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