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A5835

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Maria Letizia Trincavelli et al.
Current topics in medicinal chemistry, 12(4), 254-269 (2011-12-30)
Anxiety disorders have been linked to alterations in γ-aminobutyric acid (GABA) neurotransmission. GABA interacts with the ligand-gated ion channels, GABAA receptor (GABAA-R) subtypes, and regulates the flow of chloride into the cell, causing neuron hyperpolarization. GABAA-Rs are assembled from a...
Zhan-Heng Qi et al.
The Journal of biological chemistry, 282(45), 33052-33063 (2007-09-19)
Ethanol enhances gamma-aminobutyrate (GABA) signaling in the brain, but its actions are inconsistent at GABA(A) receptors, especially at low concentrations achieved during social drinking. We postulated that the epsilon isoform of protein kinase C (PKCepsilon) regulates the ethanol sensitivity of...
A Rodríguez-Núñez et al.
Brain & development, 22(7), 427-431 (2000-12-05)
If febrile seizures cause significant compromise of neuronal metabolism (whether permanent or reversible), this should be reflected in an increase in the cerebrospinal fluid concentrations of neuron-specific enolase (NSE) and/or adenosine triphosphate (ATP) breakdown products. In the present study, AMP...
Gabapentin for the prophylaxis of episodic migraine in adults.
Corey D Fogleman
American family physician, 89(9), 714-715 (2014-05-03)
Thomas Gregory et al.
American journal of physical medicine & rehabilitation, 94(1), e1-e5 (2014-10-31)
A case of quadrilateral space syndrome is presented, where a large near-circumferential glenoid labrum tear led to a paralabral cyst that dissected into the quadrilateral space and caused a compressive neuropathy of the axillary nerve. This led to a 6-mo...
Marie Soukupová et al.
Experimental neurology, 257, 39-49 (2014-04-29)
The alterations in GABA release have not yet been systematically measured along the natural course of temporal lobe epilepsy. In this work, we analyzed GABA extracellular concentrations (using in vivo microdialysis under basal and high K(+)-evoked conditions) and loss of...
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Noritaka Nakamichi et al.
Journal of pharmacological sciences, 110(2), 133-149 (2009-06-02)
In this review, we will summarize our ongoing studies on the functionality of both gamma-aminobutyric acid (GABA) and glutamate receptors expressed by undifferentiated neural progenitor cells isolated from embryonic rodent brains. Cells were cultured with growth factors for the formation...
Pregabalin versus pramipexole for restless legs syndrome.
Richard P Allen
The New England journal of medicine, 370(21), 2050-2051 (2014-05-23)
J Shilpa et al.
Journal of biomedical nanotechnology, 10(4), 622-631 (2014-04-17)
Use of nanoparticulate drug delivery system for an effective therapeutic outcome against diseases gains immense hope in the study of drug delivery to partially hepatectomised rats. In the present study, partially hepatectomised rats treated with Gamma aminobutyric acid (GABA) and...
W-Y Lu et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 39(7), 956-961 (2009-04-30)
Asthma often occurs as a result of immune-based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role...
Neuroscience. Can oxytocin treat autism?
Larry J Young et al.
Science (New York, N.Y.), 347(6224), 825-826 (2015-02-24)
Richard P Allen et al.
The New England journal of medicine, 370(7), 621-631 (2014-02-14)
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment. Pregabalin may be an effective alternative. In this 52-week, randomized, double-blind trial, we assessed efficacy and...
Should anaesthetists routinely use a gabapentinoid perioperatively?
G J Sanders
British journal of hospital medicine (London, England : 2005), 75(1), 58-58 (2014-01-10)
I M Mykheĭtseva
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 78-83 (2013-05-30)
We explored the melatonin influence on the level of amino acid neurotransmitters of the retina in glaucoma neuropathy in rats. Glaucoma was caused by the prolong systemic introduction of adrenalin. In the study 3 groups were participated: control animals; the...
T Fujita et al.
Clinica chimica acta; international journal of clinical chemistry, 287(1-2), 99-109 (1999-10-06)
Pipecolic acid is regarded as a gamma-aminobutyric acid receptor agonist. Stereochemical studies of pipecolic acid were performed in patients with chronic liver diseases. Plasma D- and L-pipecolic acid were significantly elevated in 15 liver cirrhotic patients with no history of...
[Phenibut yielded withdrawal symptoms and psychosis. Drugs for cosmonauts--now marketed as dietary supplements online].
Lovisa Högberg et al.
Lakartidningen, 110(16), 825-827 (2013-05-31)
T Clayton et al.
Current medicinal chemistry, 14(26), 2755-2775 (2007-11-30)
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination...
Marie-Amélie Papon et al.
Frontiers in cellular neuroscience, 14, 214-214 (2020-08-09)
In the central nervous system, the inhibitory GABAB receptor is the archetype of heterodimeric G protein-coupled receptors (GPCRs). Receptor interaction with partner proteins has emerged as a novel mechanism to alter GPCR signaling in pathophysiological conditions. We propose here that...
Cecilia M Borghese et al.
Alcohol (Fayetteville, N.Y.), 41(3), 155-162 (2007-05-25)
The gamma-aminobutyric acid type A receptors (GABAA-Rs) display a wide variety of subunit combinations. Drugs such as benzodiazepines have shown differential effects based on GABAA-R subunit composition. Actions of alcohols and volatile anesthetics generally do not vary markedly with subunit...
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio...
Megan M Eaton et al.
Molecular pharmacology, 86(6), 647-656 (2014-09-23)
Native γ-aminobutyric acid (GABA)A receptors consisting of α4, β1-3, and δ subunits mediate responses to the low, tonic concentration of GABA present in the extracellular milieu. Previous studies on heterologously expressed α4βδ receptors have shown a large degree of variability...
Syeda Zain et al.
JPMA. The Journal of the Pakistan Medical Association, 63(1), 3-7 (2013-07-20)
To compare the efficacy and safety of topiramate with gabapentin in the prophylaxis of migraine patients. A 12-week randomised open label control trial was conducted at the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre...
Joseph E Cillo et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(10), 1909-1914 (2014-09-23)
The purpose of this study was to determine the efficacy of pre-emptive analgesia with pregabalin and celecoxib on narcotic consumption and perceived pain in adult patients undergoing maxillomandibular advancement surgery for obstructive sleep apnea. This was a prospective, randomized, double-blinded...
Gregor Hasler et al.
Biological psychiatry, 58(12), 969-973 (2005-07-27)
There is growing evidence that the brain gamma-aminobutyric acid (GABA) system is involved in depression. Lowered plasma GABA levels were identified as a traitlike abnormality found in patients with remitted unipolar depression and in healthy first-degree relatives of patients with...
Paul M Burkat et al.
Anesthesia and analgesia, 119(6), 1277-1284 (2014-09-12)
Modulation of γ-aminobutyric acid type A receptors (GABAARs) by general anesthetics may contribute to their ability to produce amnesia. Receptors containing α5 subunits, which mediate tonic and slow synaptic inhibition, are co-localized with β3 and γ2 subunits in dendritic layers...
"Seeing" how our drugs work brings translational added value.
Irene Tracey
Anesthesiology, 119(6), 1247-1248 (2013-12-18)
GABA is an effective immunomodulatory molecule.
Jin Z, Mendu SK, Birnir B.
Amino Acids, DOI: 10-DOI: 10 (2011)
Melanie M Hoefer et al.
Experimental neurology, 263, 221-234 (2014-09-24)
Methamphetamine (METH) abuse is frequent in individuals infected with human immunodeficiency virus type-1 (HIV-1) and is suspected to aggravate HIV-associated neurocognitive disorders (HAND). METH is a psychostimulant that compromises several neurotransmitter systems and HIV proteins trigger neuronal injury but the...
Satoshi Shibuta et al.
Neuroscience research, 98, 9-16 (2015-05-03)
The neurotoxic effects of anesthetics on the developing brain are a concern. Although most of the anesthetics are GABAA agonists or NMDA antagonists, the differences in these effects on prospective glutamate-neurotoxicity in the brain is not fully understood. We examined...
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