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Yolanda Gilaberte et al.
The Journal of investigative dermatology, 134(9), 2428-2437 (2014-04-11)
Photodynamic therapy (PDT) is widely used to treat non-melanoma skin cancer. However, some patients affected with squamous cell carcinoma (SCC) do not respond adequately to PDT with methyl-δ-aminolevulinic acid (MAL-PDT) and the tumors acquire an infiltrative phenotype and became histologically
Naghmeh Varghayee et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(1), 79-91 (2013-04-06)
Cardiac hypertrophy in myocytes is in part regulated by changes in expression of a novel Ang II type 2 receptor (AT2-receptor) interacting protein identified as ATIP. The role of the AT2-receptor in cardiac hypertrophy is controversial, with some reports indicating
Azusa Yoneshige et al.
Respiratory research, 16, 90-90 (2015-08-02)
Lung alveolar epithelial cell (AEC) apoptosis has attracted attention as an early pathogenic event in the development of idiopathic interstitial pneumonia (IIP); however, the causative mechanism remains unclear. Cell adhesion molecule 1 (CADM1) is an AEC adhesion molecule in the
Mariann Kremlitzka et al.
Cellular and molecular life sciences : CMLS, 72(11), 2223-2236 (2014-12-30)
B cells are efficiently activated by CpG oligodeoxynucleotides (ODNs) to produce pro-inflammatory cytokines and antibody (Ab). Here, we describe a so far unidentified, spleen tyrosine kinase (Syk)-dependent pathway, which is indispensable for CpG-induced human B cell activation. We show that
R Novaković et al.
Molecular human reproduction, 21(6), 545-551 (2015-03-10)
The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study
Simona Infantino et al.
Science signaling, 7(338), ra77-ra77 (2014-08-15)
Maintenance of an appropriate number of plasma cells, long-lived antibody-producing cells that are derived from B cells, is essential for maintaining immunological memory while limiting disease. Plasma cell survival relies on extrinsic factors, the limited availability of which determines the
Angela G Hückelhoven et al.
Journal of acquired immune deficiency syndromes (1999), 69(5), 528-535 (2015-04-23)
It has been reported that HIV-1-specific cytotoxic T cells (CTL) recognizing the HLA-A2-restricted p17 epitope SLYNTVATL (SL9) can cross-react with the HLA-A2-restricted influenza matrix epitope GILGFVFTL (GL9). So far, the prevalence of GL9-cross-reacting HIV-1-specific CTL in larger cohorts of HIV-1-infected
Surendra Singh et al.
Biochemical and biophysical research communications, 463(4), 768-773 (2015-06-19)
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a mitochondrial enzyme sharing 65% and 72% sequence identity with ALDH1A1 and ALDH2 proteins, respectively. Compared to the latter two ALDH isozymes, little is known about the physiological functions of ALDH1B1. Studies in humans indicate
Liye Suo et al.
Experimental biology and medicine (Maywood, N.J.), 240(5), 618-623 (2014-11-02)
Alopecia areata (AA) is an autoimmune hair loss disease caused by a cell-mediated immune attack of the lower portion of the cycling hair follicle. Feeding mice 3-7 times the recommended level of dietary vitamin A accelerated the progression of AA
Xiang-Yu Wang et al.
PloS one, 10(8), e0136888-e0136888 (2015-09-01)
Due to the enormous capacity of Staphylococcus aureus to acquire antibiotic resistance, it becomes imperative to develop vaccines for decreasing the risk of its life-threatening infections. Peptidoglycan (PGN) is a conserved and major component of S. aureus cell wall. However
Simone P Zehntner et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(10), 873-880 (2008-06-25)
Quantitative analysis of digitized IHC-stained tissue sections is increasingly used in research studies and clinical practice. Accurate quantification of IHC staining, however, is often complicated by conventional tissue counterstains caused by the color convolution of the IHC chromogen and the
Renata C Pereira et al.
PloS one, 10(3), e0120856-e0120856 (2015-03-17)
Osteocytic protein expression is dysregulated in CKD and is affected by changes in mineral metabolism; however the effects of active vitamin D sterol therapy on osteocyte protein expression in advanced CKD is unknown. Eleven pediatric patients with end stage kidney
David De Wilde et al.
Molecular imaging, 14 (2015-06-06)
Recently, an apolipoprotein E-deficient (ApoE-/-) mouse model with a mutation (C1039G+/-) in the fibrillin-1 (Fbn1) gene (ApoE-/-Fbn1C1039G+/- mouse model) was developed showing vulnerable atherosclerotic plaques, prone to rupture, in contrast to the ApoE-/- mouse model, where mainly stable plaques are
Anders Elm Pedersen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(7), 547-555 (2015-04-25)
TL1A is a TNF-like cytokine which has been shown to co-stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is
L Jordaens et al.
Theriogenology, 84(6), 899-910 (2015-06-30)
Elevated non-esterified fatty acids (NEFAs) have been recognized as an important link between lipolytic metabolic conditions and impaired fertility in high-yielding dairy cows. However, NEFA effects on the oviductal micro-environment currently remain unknown. We hypothesize that elevated NEFAs may contribute
Pamela J Skinner et al.
PloS one, 10(7), e0131993-e0131993 (2015-07-03)
Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment. The pathology of these diseases involves the conversion of a protease sensitive
Katherine M Harris et al.
Frontiers in immunology, 11, 575977-575977 (2020-10-31)
Human Parainfluenza Virus-3 (HPIV3) causes severe respiratory illness in immunocompromised patients and lacks approved anti-viral therapies. A phase I study of adoptively transferred virus-specific T-cells (VSTs) targeting HPIV3 following bone marrow transplantation is underway (NCT03180216). We sought to identify immunodominant
Martin Wartenberg et al.
Oncotarget, 6(6), 4190-4201 (2015-02-12)
Here we explore the role of the interplay between host immune response and epithelial-mesenchymal-transition (EMT)-Type tumor-budding on the outcome of pancreatic adenocarcinoma (PDAC). CD4+, CD8+, and FOXP3+T-cells as well as iNOS+ (M1) and CD163+-macrophages (M2) were assessed on multipunch tissue-microarrays
Anita Mangia et al.
Cancer biology & therapy, 16(8), 1140-1147 (2015-07-01)
Cellular resistance in advanced gastric cancer (GC) might be related to function of multidrug resistance (MDR) proteins. The adaptor protein NHERF1 (Na(+)/H(+) exchanger regulatory factor) is an important player in cancer progression for a number of solid malignancies, even if
Milton Maciel et al.
PLoS neglected tropical diseases, 9(4), e0003693-e0003693 (2015-04-16)
Attenuated yellow fever (YF) virus 17D/17DD vaccines are the only available protection from YF infection, which remains a significant source of morbidity and mortality in the tropical areas of the world. The attenuated YF virus vaccine, which is used worldwide
Giuseppe Lofano et al.
Journal of immunology (Baltimore, Md. : 1950), 195(4), 1617-1627 (2015-07-15)
Induction of persistent protective immune responses is a key attribute of a successful vaccine formulation. MF59 adjuvant, an oil-in-water emulsion used in human vaccines, is known to induce persistent high-affinity functional Ab titers and memory B cells, but how it
Meirong Bi et al.
Immunopharmacology and immunotoxicology, 37(1), 26-34 (2014-12-19)
Although it is recognized that thrombin plays a key role in airway remodeling during chronic asthma. In a previous study, we have proved that thrombin promotes airway remodeling via PAR-1 in OVA-allergic rats, but little is known about intracellular signaling
Assessment of substrates for horseradish peroxidase in enzyme immunoassay.
E Al-Kaissi et al.
Journal of immunological methods, 58(1-2), 127-132 (1983-03-11)
Iresha N Ambepitiya Wickramasinghe et al.
PloS one, 10(6), e0128893-e0128893 (2015-06-04)
The initial interaction between viral attachment proteins and the host cell is a critical determinant for the susceptibility of a host for a particular virus. To increase our understanding of avian pathogens and the susceptibility of poultry species, we developed
O Brugière et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(2), 461-471 (2014-12-10)
Human leukocyte antigen G (HLA-G) expression is thought to be associated with a tolerance state following solid organ transplantation. In a lung transplant (LTx) recipient cohort, we assessed (1) the role of HLA-G expression as a predictor of graft acceptance
Han Kang et al.
Immunology, 143(4), 661-669 (2014-06-27)
The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction
Cédric Seignez et al.
Oncotarget, 5(22), 11442-11451 (2014-10-28)
Management of advanced colorectal cancer is challenging due to the lack of efficient therapy. The lipid A, OM-174 exhibited antitumor activity in colorectal cancer. We explored the anticancer efficacy of this compound in rats bearing large colorectal tumors in combination
Tommi Pätilä et al.
PloS one, 10(4), e0123963-e0123963 (2015-04-11)
Although cell therapy of the failing heart by intramyocardial injections of myoblasts to results in regenerative benefit, it has also been associated with undesired and prospectively fatal arrhythmias. We hypothesized that intramyocardial injections of myoblasts could enhance inflammatory reactivity and
Ying-Chyi Song et al.
Scientific reports, 5, 12578-12578 (2015-07-29)
The toll-like receptor 9 (TLR9) agonists CpG oligodeoxynucleotides (CpG ODNs) have been recognized as promising adjuvants for vaccines against infectious diseases and cancer. However, the role of TLR9 signaling in the regulation of antigen uptake and presentation is not well
J R Shainoff et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1(4-5), 479-484 (1990-10-01)
A novel electrophoretic procedure enabling multiple, direct immunoprobing of electrophoregrams without depending on Western blotting is described, and applied to the identification of the derivatives formed in the early stages of clot stabilization. Multicolour immunostainings for positive identification of cross-linked
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