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Showing 1-30 of 591 results for "A7502" within Papers
Kitti Intuyod et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 206-215 (2014-12-03)
The pharmacological activities of herbal extracts can be enhanced by complex formation. In this study, we manipulated cyanidin and delphinidin-rich extracts to form an anthocyanin complex (AC) with turmeric and evaluated activity against inflammation and periductal fibrosis in Opisthorchis viverrini-infected
Anand Swaroop et al.
Toxicology mechanisms and methods, 24(7), 495-503 (2014-07-22)
Safety and anti-diabetic efficacy of a novel, proprietary Trigonella foenum-graecum seed extract [novel fenugreek extract (FE), Fenfuro™, CR0010810) enriched in furostanolic saponins (>60% w/w, HPLC) were assessed. Concerning safety, we undertook studies dealing with acute oral toxicity, 28-d sub-chronic toxicity
Otto O Yang et al.
Journal of virology, 89(2), 1195-1204 (2014-11-08)
Cellular immunity is pivotal in HIV-1 pathogenesis but is hampered by viral sequence diversity. An approach to minimize this diversity is to focus immunity on conserved proteome sequences; therefore, we selected four relatively conserved regions (Gag amino acids 148 to
Xin Zhou et al.
PloS one, 9(12), e115148-e115148 (2014-12-17)
We sought develop and characterize a diet-induced model of metabolic syndrome and its related diseases. The experimental animals (Spague-Dawley rats) were randomly divided into two groups, and each group was fed a different feed for 48 weeks as follows: 1)
Nikhil Baban Ghate et al.
PloS one, 10(5), e0128221-e0128221 (2015-05-27)
Free iron typically leads to the formation of excess free radicals, and additional iron deposition in the liver contributes to the oxidative pathologic processes of liver disease. Many pharmacological properties of the insectivorous plant Drosera burmannii Vahl. have been reported
Tomoki Nishikawa et al.
Organic & biomolecular chemistry, 13(47), 11426-11431 (2015-10-08)
Among l- and d-oligopeptides with multiple pyrenes as pendants, the dipeptides with two and three pyrenes showed blue-coloured circularly polarised luminescence as high as |gem|≈ (0.86-1.1) × 10(-2) at around 450 nm, reflecting from exciton couplets of twisted pyrenes.
Inka Albrecht et al.
The Journal of clinical investigation, 125(12), 4612-4624 (2015-11-10)
Mutations of the gene encoding four-and-a-half LIM domain 1 (FHL1) are the causative factor of several X-linked hereditary myopathies that are collectively termed FHL1-related myopathies. These disorders are characterized by severe muscle dysfunction and damage. Here, we have shown that
A H Amrallah et al.
Talanta, 46(4), 491-500 (2008-10-31)
The overall formation constants of 1:1:1 ternary complexes of Cu(II), Zn(II), Cd(11) with glycine, dl-alanine or dl-leucine as primary ligands and o-hydroxyphenylyazo derivatives of 2-cyanomethyl benzimidazole (ABI) and barbituric acid (ABA) as secondary ligands have been investigated potentiometrically in 40%
Satoshi Ogasawara et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(5), 318-326 (2015-10-23)
Podoplanin (PDPN) is a type-I transmembrane sialoglycoprotein that possesses a platelet aggregation-stimulating (PLAG) domain in the N-terminus. PLAG domain includes three tandem repeats of eight amino acids: PLAG1, PLAG2, and PLAG3. Among the three PLAG domains, O-glycan on Thr52 of
Przemysław Karpowicz et al.
PloS one, 10(11), e0143038-e0143038 (2015-11-18)
The proteasome is a giant protease responsible for degradation of the majority of cytosolic proteins. Competitive inhibitors of the proteasome are used against aggressive blood cancers. However, broadening the use of proteasome-targeting drugs requires new mechanistic approaches to the enzyme's
Kwang-Soo Baek et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(4), 365-372 (2015-07-15)
Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole. Thus, in the present study, we prepared two different formulas
Quentin L Sciascia et al.
PloS one, 10(7), e0134323-e0134323 (2015-08-01)
The objectives of this study were to (1) identify changes in plasma and mammary intracellular amino acid (AA) profiles in dairy cows treated with growth hormone (GH), and (2) evaluate the expression of mammary gland genes involved in the transport
Hyun Jung Lee et al.
Intervirology, 58(1), 14-21 (2015-01-17)
Interferon (IFN)-based therapy for chronic hepatitis C (CHC) is cost-effective and is associated with reduced risk of disease progression. We aimed to assess the incidence of cirrhosis and hepatocellular carcinoma (HCC) and to identify risk factors associated with disease progression.
Junming Wang et al.
Canadian journal of physiology and pharmacology, 93(6), 427-433 (2015-04-22)
Quercetin (Que) is one of main compounds in Lysimachia christinae Hance (Christina loosestrife), and has both medicinal and nutritional value. Glycosides from Tripterygium wilfordii Hook.f. (léi gōng téng [the thunder duke vine]; TG) have diverse and broad bioactivities but with
Bente Bull-Hansen et al.
Oncotarget, 6(14), 12436-12451 (2015-05-24)
HER2-targeted therapy has been shown to have limited efficacy in ovarian cancer despite frequent overexpression of this receptor. Photochemical internalization (PCI) is a modality for cytosolic drug delivery, currently undergoing clinical evaluation. In the present project we studied the application
Sally Yu Shi et al.
Nature communications, 6, 7415-7415 (2015-06-17)
Reactive oxygen species (ROS) have been linked to a wide variety of pathologies, including obesity and diabetes, but ROS also act as endogenous signalling molecules, regulating numerous biological processes. DJ-1 is one of the most evolutionarily conserved proteins across species
K Hopes et al.
The Analyst, 140(9), 3028-3038 (2015-03-10)
Experiments into the relationship between diet and health have been an area of high interest for a long time. In this study, we investigate the application of multivariate data analysis to differentiate between rat populations fed on two different diets:
Bin Shi et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 44(12), 1224-1233 (2013-07-25)
To investigate the effect of different hepatic vascular occlusion maneuvers on the growth of hepatocarcinoma after liver ischemia-reperfusion (I/R) injury. A mice hepatocarcinoma model was established by portal vein injection of H22 hepatoma cells. After 3 days, the mice underwent
Victoria Catalán et al.
Acta diabetologica, 52(2), 257-266 (2014-08-15)
The ribosomal protein S6 kinase 1 (S6K1) is a component of the insulin signalling pathway that has been proposed as a key molecular factor in insulin resistance development under conditions of nutrient overload. The aim was to evaluate the involvement
Hadar Ivanir-Dabora et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(30), 10778-10785 (2015-06-16)
Magic-angle spinning solid-state NMR spectroscopy has been applied to study the dynamics of CBM3b-Cbh9A from Clostridium thermocellum (ctCBM3b), a cellulose binding module protein. This 146-residue protein has a nine-stranded β-sandwich fold, in which 35 % of the residues are in the
Piotr Luliński et al.
Journal of chromatography. A, 1420, 16-25 (2015-10-16)
In this paper, the optimized synthesis and detailed characterization of novel imprinted material for selective extraction of 2-aminothiazoline-4-carboxylic acid (ATCA) were described. The prepolymeric system contained 1-allyl-2-thiourea and ethylene glycol dimethacrylate in methanol, tetrahydrofuran and dimethyl sulfoxide porogenic mixture and
Ji-Young Na et al.
Biochemical and biophysical research communications, 460(2), 308-313 (2015-03-19)
It has been shown that phosphatidylcholine (PC) extracted from egg yolk possesses a variety of biological activities, such as anti-inflammatory and anti-oxidant effects, and prevents oxidative stress. The aim of this study was to evaluate the hepatoprotective effects of PC
Chang Sun Sim et al.
Yonsei medical journal, 56(1), 235-243 (2014-12-17)
To determine the impact of noise on heart rate variability (HRV) in men, with a focus on the noise type rather than on noise intensity. Forty college-going male volunteers were enrolled in this study and were randomly divided into four
Hanliu Wang et al.
Biochemistry, 54(42), 6475-6481 (2015-09-30)
We report the use of hydrogen-deuterium amide exchange coupled to mass spectrometry (HDX-MS) to study the interfaces of and conformational changes accompanying CsgE oligomerization. This protein plays an important role in enteric bacteria biofilm formation. Biofilms provide protection for enteric
Marco Valente et al.
PloS one, 10(7), e0132194-e0132194 (2015-07-16)
In case of a mass casualty radiation event, there is a need to distinguish total-body irradiation (TBI) and partial-body irradiation (PBI) to concentrate overwhelmed medical resources to the individuals that would develop an acute radiation syndrome (ARS) and need hematologic
Jayadev Raju et al.
Environmental toxicology and pharmacology, 39(1), 85-92 (2014-12-05)
We recently reported that acrylamide, a known rodent and probable human carcinogen, does not increase the risk of azoxymethane (AOM)-induced rat colon precancerous lesions when administered through the diet. Here, we present toxicological data from non-AOM-injected rats. Briefly, male F344
A Di Giorgio et al.
Journal of pediatric gastroenterology and nutrition, 60(2), 159-164 (2014-10-12)
Autoimmune hepatitis (AIH) is considered an underdiagnosed cause of fulminant hepatic failure (FHF). Autoimmune FHF (AI-FHF) is believed to lead invariably to liver transplantation (LTX) or death. We aimed to describe the autoimmune features of children diagnosed as having AI-FHF
Ji Eun Moon et al.
Journal of medicinal food, 18(11), 1223-1230 (2015-10-27)
Rhus verniciflua stokes (RVS) (Anacardiaceae) has been traditionally used as a folk remedy for gastritis, several cancers, and various metabolic diseases. The present study evaluated the anti-inflammatory effect of RVS extract standardized to fustin content using lipopolysaccharide (LPS)-stimulated rats. The
Kohsuke Tsuchiya et al.
European journal of immunology, 44(12), 3696-3707 (2014-09-25)
Listeria monocytogenes induces the formation of inflammasomes and subsequent caspase-1 activation, and the adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is crucial for this response. However, the role of ASC in L. monocytogenes infection in vivo is unclear. In
Joseph Dopie et al.
Journal of cell science, 128(13), 2388-2400 (2015-05-30)
Nuclear actin plays an important role in many processes that regulate gene expression. Cytoplasmic actin dynamics are tightly controlled by numerous actin-binding proteins, but regulation of nuclear actin has remained unclear. Here, we performed a genome-wide RNA interference (RNAi) screen
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