Showing 1-30 of 230 results for "A7627"
Sally Yu Shi et al.
Nature communications, 6, 7415-7415 (2015-06-17)
Reactive oxygen species (ROS) have been linked to a wide variety of pathologies, including obesity and diabetes, but ROS also act as endogenous signalling molecules, regulating numerous biological processes. DJ-1 is one of the most evolutionarily conserved proteins across species...
beta-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila
Zhou X, et al.
Toxins, 2(11), 2663-2679 (2010)
Aubérie Parent et al.
Nature communications, 6, 5686-5686 (2015-01-20)
Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the...
Laura Preiss et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7874-7879 (2013-04-25)
The c-rings of ATP synthases consist of individual c-subunits, all of which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. The c-ring stoichiometry determines the number of ions transferred during enzyme operation and...
Semagacestat's fall: where next for AD therapies?
Kaj Blennow et al.
Nature medicine, 19(10), 1214-1215 (2013-10-09)
Karolina Malecek et al.
Journal of immunological methods, 392(1-2), 1-11 (2013-03-19)
T cell receptors (TCRs) on T cells recognize peptide-major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells and this interaction determines the T cell immune response. Due to negative selection, naturally occurring TCRs bind self (tumor) peptides...
Industrial production of L-alanine using immobilized Escherichia coli and Pseudomonas dacunhae.
I Chibata et al.
Microbiological sciences, 1(3), 58-62 (1984-06-01)
Zhe Yang et al.
Cell research, 28(10), 1013-1025 (2018-09-14)
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that...
Riccardo Montioli et al.
Human molecular genetics, 23(22), 5998-6007 (2014-07-06)
Primary Hyperoxaluria type I (PH1) is a rare disease due to the deficit of peroxisomal alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal-5'-phosphate (PLP) enzyme present in humans as major (Ma) and minor (Mi) allele. PH1-causing mutations are mostly missense identified in...
Y Subhash et al.
International journal of systematic and evolutionary microbiology, 64(Pt 5), 1580-1586 (2014-01-31)
Two bacterial strains (JC167T and JC168) were isolated from a soil sample collected from Mandpam, Tamilnadu, India. Colonies of both strains were orange and cells Gram-stain-positive. Cells were small rods, and formed terminal endospores of ellipsoidal to oval shape. Both...
J Saklatvala
The Journal of clinical investigation, 59(5), 794-801 (1977-05-01)
A new type of enzyme hydrolyzing the elastase substrate succinyl-L-alanyl-L-alanine-4-nitroanilide has been found in cell-free rheuma todi synovial fluid. Normal plasma and osteoarthritic synovial fluid contained relatively little enzyme. The pH optimum was 8.0. Unexpectedly, the enzyme activity was not...
William A Dew et al.
Chemosphere, 112, 519-525 (2014-03-19)
The olfactory system of fish comprises several classes of olfactory sensory neurons (OSNs). The odourants L-alanine and taurocholic acid (TCA) specifically activate microvillous or ciliated OSNs, respectively, in fish. We recorded electro-olfactograms (EOG) in fathead minnows (Pimephales promelas; a laboratory-reared...
Anthony El-Khoueiry et al.
Cancer chemotherapy and pharmacology, 72(1), 53-64 (2013-05-31)
Hepatic impairment may impede tyrosine kinase inhibitor metabolism. This phase I study compared the pharmacokinetics of brivanib in patients with hepatocellular carcinoma (HCC) and varying levels of hepatic impairment with those with non-HCC malignancies and normal liver function. Patients were...
Antonio Rodríguez-Núñez et al.
Brain & development, 25(2), 102-106 (2003-02-13)
To determine the effects of meningitis on cerebral energy metabolism, cerebrospinal fluid concentrations of adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine and urate were determined by high-performance liquid chromatography, and neuron-specific enolase by an enzyme immunoassay...
Damineh Morsali et al.
Brain : a journal of neurology, 136(Pt 4), 1067-1082 (2013-03-23)
Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple sclerosis, but no therapies are known to be effective in axonal protection. Sodium channel blocking agents can provide effective protection of axons in the white...
Hunter Cuchiaro et al.
Journal of agricultural and food chemistry, 67(19), 5672-5679 (2019-04-25)
The analysis of protein in algal biomass is one of the most critical areas of commercial development of algae characterization for nutritional or other high value applications. A new rapid and accurate method is required that can be widely implemented...
Dale A Schoeller
The Journal of nutrition, 143(6), 763-765 (2013-04-26)
Light element isotope signatures have been used to study food webs in many ecological niches, including those of ancient humans, but to a far lesser extent in modern humans. A recent paper presented results from a pilot study testing the...
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be...
Seiji Ishii et al.
Biochemistry, 52(15), 2545-2555 (2013-03-29)
The ATP-binding cassette (ABC) transporter ComA is a key molecule essential for the first step of the quorum-sensing system of Streptococcus. The nucleotide binding domains (NBD) of Streptococcus mutans ComA with different N termini, NBD1 (amino acid residues 495-760), NBD2...
Cyril Basquin et al.
The EMBO journal, 34(16), 2147-2161 (2015-07-01)
Endocytosis controls many functions including nutrient uptake, cell division, migration and signal transduction. A clathrin- and caveolin-independent endocytosis pathway is used by important physiological cargos, including interleukin-2 receptors (IL-2R). However, this process lacks morphological and dynamic data. Our electron microscopy...
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with...
Barbara Milutinović et al.
Applied and environmental microbiology, 81(23), 8135-8144 (2015-09-20)
Reproduction within a host and transmission to the next host are crucial for the virulence and fitness of pathogens. Nevertheless, basic knowledge about such parameters is often missing from the literature, even for well-studied bacteria, such as Bacillus thuringiensis, an...
Chinnaiyan Mahalingam Rajesh et al.
Dalton transactions (Cambridge, England : 2003), 43(34), 12952-12960 (2014-07-16)
We are reporting structural characterization of two new hexanuclear cages (H3O)2[Cu3(μ3-OH)(μ3-NH3)(0.5)(L)3]2·8H2O (1) and (H3O)2[Cu3(μ3-OH)(μ3-H2O)(0.5)(L)3]2·8H2O (1a) where L(2-) is the dianionic form of the Schiff base of L-alanine and salicylaldehyde. The complex 1 has two C3 symmetric hydroxo bridged trinuclear halves...
L O Kristensen
The American journal of physiology, 251(5 Pt 1), G575-G584 (1986-11-01)
Alanine transport across the liver cell membrane is a regulated key process in the amino acid metabolism of the body. The majority of alanine influx in hepatocytes is Na+ dependent and is stimulated by intracellular negativity. The molar ratio between...
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine...
Sami Hraiech et al.
PloS one, 9(10), e107125-e107125 (2014-10-29)
The effectiveness of antibiotic molecules in treating Pseudomonas aeruginosa pneumonia is reduced as a result of the dissemination of bacterial resistance. The existence of bacterial communication systems, such as quorum sensing, has provided new opportunities of treatment. Lactonases efficiently quench...
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is...
Reno Winter et al.
Biological chemistry, 394(8), 951-963 (2013-04-25)
The prospective increase in life expectancy will be accompanied by a rise in the number of elderly people who suffer from ill health caused by old age. Many diseases caused by aging are protein misfolding diseases. The molecular mechanisms underlying...
Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly.
C T Walsh
The Journal of biological chemistry, 264(5), 2393-2396 (1989-02-15)
An internal sensor detects dietary amino acids and promotes food consumption in Drosophila
Zhe Yang
Nature, 1-36 (2017)

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