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Does β selectivity really affect outcome?
Jordan Field Wicker et al.
Anesthesiology, 120(5), 1286-1287 (2014-04-24)
Palash P Barman et al.
Biochemical and biophysical research communications, 432(1), 46-51 (2013-02-05)
Cardiac ventricular myocytes exhibit a protein kinase A-dependent Cl(-) current (ICl.PKA) mediated by the cystic fibrosis transmembrane conductance regulator (CFTR). There is conflicting evidence regarding the ability of the divalent cation nickel (Ni(2+)), which has been used widely in vitro
Daniel Gustavo Dos Reis et al.
Stress (Amsterdam, Netherlands), 17(4), 362-372 (2014-06-07)
Restraint stress (RS) is an experimental model to study stress-related cardiovascular responses, characterized by sustained pressor and tachycardiac responses. We used pharmacologic and surgical procedures to investigate the role played by sympathetic nervous system (SNS) and parasympathetic nervous system (PSNS)
Muhammad Alimuddin et al.
Journal of medicinal chemistry, 51(16), 5140-5142 (2008-08-01)
A method for log D (pH 7.4) measurement was developed using microfluidic liquid-liquid extraction. Values were determined for 26 compounds and compared to results obtained via shake-flask methods. Excellent correlation between the values obtained via both methods was achieved (R(2)
Verônica Lourenço Wittmer et al.
Pulmonary pharmacology & therapeutics, 30, 57-65 (2014-12-03)
Pulmonary Arterial Hypertension (PAH) is a disease associated with increased arteriolar resistance in the lungs. Due to hypoxemia, some physiological mechanisms can be posteriorly affected, including respiratory and cardiovascular reflexes, but this has not yet been fully investigated. This study
Ann Ran-Ran Qin et al.
Bioanalysis, 7(9), 1069-1079 (2015-06-04)
In early drug-discovery research, traditional techniques to analyze drug concentrations in tissues for bioanalytical needs include bead beaters and probe homogenization devices, but are not as effective for tough fibrous tissues. To prepare these tissues, the enzyme collagenase was used
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Ulisse Garbin et al.
Mediators of inflammation, 2008, 367590-367590 (2008-04-26)
The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare the effects of two beta blockers such as nebivolol and
Yong Chen et al.
Chemosphere, 194, 588-594 (2017-12-15)
Manganese dioxides are ubiquitous in natural waters, soils, and sediments and play an important role in oxidative transformation of organic pollutants. This work presents the kinetics of the oxidation of selected β-blockers, betaxolol, metoprolol, and atenolol by birnessite (δ-MnO
Kentarou Ushijima et al.
Journal of the American Society of Hypertension : JASH, 7(2), 107-117 (2013-02-12)
Daily rhythms are regulated by a master clock-system in the suprachiasmatic nucleus and by a peripheral clock-system in each organ. Because norepinephrine is one of the timekeepers for the myocardial circadian clock that influences cardiac metabolism, it is speculated that
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Gianpaolo Chiriano et al.
European journal of medicinal chemistry, 48, 206-213 (2012-01-03)
In this work, we report a rational structure-based approach aimed at the discovery of new 2-aminoimidazoles as β-secretase inhibitors. Taking advantage of a microwave-assisted synthetic protocol, a small library of derivatives was obtained and biologically evaluated. Two compounds showed promising
Selina J Hein et al.
PloS one, 10(4), e0122665-e0122665 (2015-04-09)
Translucent zebrafish larvae represent an established model to analyze genetics of cardiac development and human cardiac disease. More recently adult zebrafish are utilized to evaluate mechanisms of cardiac regeneration and by benefiting from recent genome editing technologies, including TALEN and
Pär Matsson et al.
Journal of medicinal chemistry, 48(2), 604-613 (2005-01-22)
The influence of different drug transport routes in intestinal drug permeability screening assays was studied. Three experimental models were compared: the small-intestine-like 2/4/A1 cell model, which has a leaky paracellular pathway, the Caco-2 cell model, which has a tighter paracellular
Vaidyanathan Vinoth Kumar et al.
Bioresource technology, 200, 81-89 (2015-10-18)
The present study investigated the applicability of a laccase based bioprocess for the treatment of a mixture containing 13 selected pharmaceuticals. To do so, laccase was immobilized as cross-linked enzyme aggregates (MAC-CLEAs) on amine functionalized magnetic nanoparticles using chitosan/1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
Mònica Escolà Casas et al.
Water research, 83, 293-302 (2015-07-15)
Hospital wastewater represents a significant input of pharmaceuticals into municipal wastewater. As Moving Bed Biofilm Reactors (MBBRs) appear to remove organic micro-pollutants, hospital wastewater was treated with a pilot plant consisting of three MBBRs in series. The removal of pharmaceuticals
W A Ware et al.
Journal of veterinary internal medicine, 29(2), 561-568 (2015-03-18)
A 5-year-old, healthy English Springer Spaniel died suddenly 4 months after delivering a litter of 7 puppies. Within 4 months of the dam's death, 3 offspring also died suddenly. Abnormal cardiac repolarization, caused by an inherited long QT syndrome, is thought to
Ozlem Darcansoy Işeri et al.
Pharmaceutical biology, 52(11), 1374-1381 (2014-07-16)
Propranolol, atenolol, and ICI118,551 are non-selective β-adrenergic receptor (AR), β1-AR, and β2-AR antagonists, respectively. We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocellular (HepG2) cancer cells. β-AR
M T Ubeda-Torres et al.
Journal of chromatography. A, 1380, 96-103 (2015-01-17)
In reversed-phase liquid chromatography in the absence of additives, cationic basic compounds give rise to broad and asymmetrical peaks as a result of ionic interactions with residual free silanols on silica-based stationary phases. Ionic liquids (ILs), added to the mobile
Ya-Juan Wang et al.
PLoS genetics, 10(9), e1004641-e1004641 (2014-09-19)
High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)-rs2272996-in the gene encoding vanin-1, a glycosylphosphatidylinositol (GPI)-anchored membrane pantetheinase.
[Atenolol: its cardiorespiratory effects at birth in a premature infant].
V Zanardo et al.
La Pediatria medica e chirurgica : Medical and surgical pediatrics, 19(3), 149-151 (1997-05-01)
Ronald V Lacro et al.
The New England journal of medicine, 371(22), 2061-2071 (2014-11-19)
Aortic-root dissection is the leading cause of death in Marfan's syndrome. Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective than beta-blockers, the current standard therapy in most centers. We conducted a randomized trial comparing
A Carré
Drugs, 56 Suppl 2, 23-30 (1998-11-14)
When used as first-line treatment, any monotherapy selected from one of the main classes of agents for the management of slight to moderate arterial hypertension cannot be expected to have a success rate exceeding 60%. However, this level of efficacy
In reply.
Catherine Ashes et al.
Anesthesiology, 120(5), 1287-1288 (2014-04-24)
M S Diniz et al.
The Science of the total environment, 505, 282-289 (2014-12-03)
The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and
Hsin-Hui Chiu et al.
Mayo Clinic proceedings, 88(3), 271-276 (2013-01-17)
To assess the tolerability and efficacy of the investigational use of the angiotensin II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root dilation in patients with Marfan syndrome (MFS). Between May 1, 2007, and September 31
S Veloutsou et al.
Chemosphere, 107, 180-186 (2014-03-05)
Active pharmaceutical compounds reach the wastewater treatment plants mainly through excretion and improper disposal, and, because of insufficient treating methods, they end up to surface water or even potable water in some cases. Atenolol and metoprolol are β-blockers, members of
G Riccioni et al.
Pharmacology, 91(1-2), 35-38 (2012-11-14)
No published studies have evaluated quality of life (QOL) with the 36-item Short Form Health Survey (SF-36) in subjects with chronic stable angina pectoris (CSAP). We evaluated whether a 1-month treatment with 10 mg ivabradine (IVA) or β-blockers (bisoprolol 2.5
Should atenolol still be recommended as first-line therapy for primary hypertension?
Asterios Karagiannis et al.
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese, 47(5), 298-307 (2006-12-01)
Lian-Sheng Li et al.
Bioorganic & medicinal chemistry letters, 18(11), 3446-3455 (2008-05-07)
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. Lead optimization led to the discovery of compound 3a, which displayed potent inhibitory activities in biochemical and replicon assays [IC(50) (1b)<10nM; IC(50) (1a)=22 nM; EC(50) (1b)=5nM], good stability
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