Showing 1-30 of 115 results for "A79604"
Sumit Chakraborty et al.
Science (New York, N.Y.), 339(6115), 88-91 (2012-11-03)
Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basis of target-based drug discovery. Fifty years later, PAS continues to be used to treat...
Liancai Mu et al.
Dysphagia, 30(4), 404-417 (2015-06-05)
Dysphagia is common in Parkinson's disease (PD) and causes significant morbidity and mortality. PD dysphagia has usually been explained as dysfunction of central motor control, much like other motor symptoms that are characteristic of the disease. However, PD dysphagia does...
Enrico Glaab et al.
Neurobiology of disease, 74, 1-13 (2014-12-03)
Aging is considered as one of the main factors promoting the risk for Parkinson's disease (PD), and common mechanisms of dopamine neuron degeneration in aging and PD have been proposed in recent years. Here, we use a statistical meta-analysis of...
Liliya M Yamaleyeva et al.
American journal of physiology. Endocrinology and metabolism, 309(1), E84-E94 (2015-05-15)
Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight at late gestation; however, whether uteroplacental vascular and/or hemodynamic disturbances underlie this growth-restricted phenotype is unknown. Uterine artery reactivity and flow velocities, umbilical flow velocities, trophoblast invasion, and placental...
Guan Liu et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 25, 82-87 (2014-05-27)
A Mycobacterium parascrofulaceum strain was isolated from a pneumonia patient-the first such reported case from China. The bacteriological characteristics of the strain were determined. Species identification was performed by homologue gene sequence comparison, then a series of biochemical tests was...
Yan Li et al.
Immunology, 145(4), 508-518 (2015-03-27)
Interleukin-25 (IL-25) and IL-33, which belong to distinct cytokine families, induce and promote T helper type 2 airway inflammation. Both cytokines probably play a role in asthma, but there is a lack of direct evidence to clarify distinctions between their...
Bahaa Al-Trad et al.
Diabetology & metabolic syndrome, 7, 97-97 (2015-11-20)
Previous studies reported that 17β-estradiol may influence the progression of diabetic renal disease in females. The present study was intended to provide an insight into the specific effects of progesterone, the other female sex hormone, in the diabetic renal complications....
Design, Synthesis and Biological Evaluation of Triazole-Containing 2-Phenylindole and Salicylic Acid as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa.
Srinivasarao S, et al.
ChemistrySelect, 3(32), 9170-9180 (2018)
Boglárka Erdélyi-Belle et al.
Pathology oncology research : POR, 21(4), 1059-1070 (2015-04-08)
Human embryonic stem cells can be differentiated in vitro into a wide variety of progeny cells by addition of different morphogens and growth factors. Our aim was to monitor the expression pattern of tight junction (TJ) components and various cellular...
Hong-Xing Cai et al.
International journal of clinical and experimental medicine, 8(8), 14268-14276 (2015-11-10)
Esophageal squamous cell carcinoma (ESCC) is one of the most common and deadly causes of cancer worldwide. However, to date, the mechanisms underlying its pathogenesis remain unclear. The present study investigated the gene expression profile of human esophageal cancer cell...
Hyo-Ji Kim et al.
Journal of pharmaceutical and biomedical analysis, 102, 9-16 (2014-09-15)
A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods were adopted; one using methanol...
Carolin Hartmann et al.
Immunology letters, 164(1), 44-52 (2015-01-13)
Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic...
Polymorphic ammonium salts of the antibiotic 4-aminosalicylic acid.
Andre V, et al.
Crystal Growth & Design, 12(6), 3082-3090 (2012)
Theo F J Kraus et al.
Journal of Cancer, 6(9), 832-842 (2015-08-19)
The molecular mechanisms leading to brain tumors still remain unclear. Nevertheless, there is increasing evidence that epigenetic effects play crucial roles in tumor development and progression. Thereby, 5-hydroxymethylcytosine (5hmC) represents a further base modification of cytosine besides 5-methylcytosine (5mC). In...
Daniel Lafkas et al.
Nature, 528(7580), 127-131 (2015-11-19)
Prevailing dogma holds that cell-cell communication through Notch ligands and receptors determines binary cell fate decisions during progenitor cell divisions, with differentiated lineages remaining fixed. Mucociliary clearance in mammalian respiratory airways depends on secretory cells (club and goblet) and ciliated...
Sebastian S Roeder et al.
American journal of physiology. Renal physiology, 309(2), F164-F178 (2015-05-29)
Kidney aging is accompanied by characteristic changes in the glomerulus, but little is known about the effect of aging on glomerular parietal epithelial cells (PECs), nor if the characteristic glomerular changes in humans and rats also occur in very old...
Cezary Chojnacki et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31(182), 92-96 (2011-09-23)
In order to maintain ulcerative colitis (UC) in remission, chronic use of aminosalicylates is recommended. All patients have a fear of the recurrence of symptoms, which makes their mental state and quality of life worse. Because of this a number...
L Alameda et al.
Psychological medicine, 45(13), 2727-2736 (2015-09-10)
Evidence suggests a relationship between exposure to trauma during childhood and functional impairments in psychotic patients. However, the impact of age at the time of exposure has been understudied in early psychosis (EP) patients. Two hundred and twenty-five patients aged...
Konrad Kowalski et al.
Chembiochem : a European journal of chemical biology, 16(3), 424-431 (2015-01-16)
Two complementary methods, "in solution" and "in solid state", for the synthesis of lysozyme modified with metallacarborane (cobalt bis(dicarbollide), Co(C2 B9 H11 )2 (2-) ) were developed. As metallacarborane donors, oxonium adducts of cobalt bis(dicarbollide) and 1,4-dioxane or tetrahydropyran were...
Joan Cid et al.
Platelets, 26(2), 190-194 (2014-05-29)
Platelet refractoriness (PR) due to HLA alloimmunization is a common and serious complication of patients receiving long-term packed red blood cell and platelet transfusions. Although most alloimmunized patients will respond to HLA-matched platelets, 20-50% of patients will remain refractory even...
Luciana N García et al.
Experimental biology and medicine (Maywood, N.J.), 240(7), 904-916 (2014-12-17)
Atopic asthma is a chronic allergic disease that involves T-helper type 2 (Th2)-inflammation and airway remodeling. Bronchiolar club cells (CC) and alveolar macrophages (AM) are sentinel cells of airway barrier against inhaled injuries, where allergy induces mucous metaplasia of CC...
Han-Jin Park et al.
PloS one, 10(7), e0132992-e0132992 (2015-07-16)
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding...
Anthony Vocat et al.
Antimicrobial agents and chemotherapy, 59(7), 4012-4019 (2015-04-22)
Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro...
Shaiban Jubair et al.
American journal of physiology. Heart and circulatory physiology, 309(4), H676-H684 (2015-06-14)
Accumulating evidence indicates that substance P is cardioprotective following ischemia-reperfusion primarily due to its potent coronary vasodilator actions. However, an anti-apoptotic effect of substance P has been observed in tenocytes following ischemia, which involved activation of the AKT pathway. This...
Tyler D Scherr et al.
mBio, 6(4) (2015-08-27)
The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can interfere with these responses in part by polarizing macrophages toward an anti-inflammatory profibrotic phenotype. Here we demonstrate that conditioned medium from...
Amanda S Fivian-Hughes et al.
Microbiology (Reading, England), 158(Pt 2), 308-318 (2011-10-29)
Thymidylate synthase (TS) enzymes catalyse the biosynthesis of deoxythymidine monophosphate (dTMP or thymidylate), and so are important for DNA replication and repair. Two different types of TS proteins have been described (ThyA and ThyX), which have different enzymic mechanisms and...
Dinamene Santos et al.
Biological trace element research, 152(1), 113-116 (2013-01-15)
Manganese (Mn) is an essential metal for biological systems; however, occupational or clinical exposure to high levels of Mn can produce a neurological disorder called manganism. Oxidative stress and neuroinflammation play major roles in the Mn-induced neurodegeneration leading to dysfunction...
Judy Y Ku et al.
Journal of glaucoma, 23(9), 583-588 (2013-02-23)
To qualitatively analyze anterior chamber structures imaged by ultrasound biomicroscopy (UBM) in primary angle-closure patients. Subjects diagnosed as primary angle-closure suspect (PACS), primary angle-closure glaucoma (PACG), and previous acute primary angle closure (APAC) were recruited prospectively along with a group...
Min-Jung Park et al.
Cell transplantation, 24(11), 2367-2377 (2014-12-17)
Mesenchymal stem cells (MSCs) are multipotent cells characterized by immunomodulatory properties and are therefore considered a promising tool for the treatment of autoimmune diseases. One functional B-cell subset, regulatory B cells (Bregs), has recently been shown to restrain excessive inflammatory...
A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.
Joo-Hee Kim et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(2), 118-119 (2013-01-29)

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