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Xing Han et al.
Journal of biomaterials applications, 35(3), 371-384 (2020-06-24)
Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore the relationship between the zwitterionic...
Lihua Gu et al.
Biomedical materials (Bristol, England), 15(3), 035012-035012 (2020-02-08)
Gelatin cryogels are good candidate scaffolds for tissue engineering because of their interconnected macroporous structure. For bone regeneration, inorganic components are chosen to reinforce gelatin cryogels: (i) to mimic the compositions of natural bone tissue and (ii) to meet the...
Michael Bachmann et al.
Journal of cell science, 133(9) (2020-03-21)
αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates. However, in tissues, cells experience highly complex and changing environments. To better understand integrin...
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
Liu W, et al.
Journal of the American Chemical Society, 132(2), 472-483 (2009)
Shan Jiang et al.
Journal of chromatography. A, 1412, 75-81 (2015-08-25)
Mass spectrometry (MS) coupled to sample preparation and separation techniques has become a primary tool for proteomics studies. However, due to sample complexity, it is often challenging to achieve fast and efficient sample preparation prior to MS analysis. In recent...
Mahmoud Farrag et al.
Cells, 7(10) (2018-10-20)
A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs)...
Raja Zaidatul Akhmar Raja Jamaluddin et al.
Sensors (Basel, Switzerland), 18(5) (2018-04-28)
A new biosensor for the analysis of nitrite in food was developed based on hemoglobin (Hb) covalently immobilized on the succinimide functionalized poly(n-butyl acrylate)-graphene [poly(nBA)-rGO] composite film deposited on a carbon-paste screen-printed electrode (SPE). The immobilized Hb on the poly(nBA)-rGO...
Fred Y Shen et al.
Nature communications, 11(1), 4632-4632 (2020-09-17)
Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost...
Xiaoxun Han et al.
Journal of chromatographic science, 57(2), 116-121 (2018-10-03)
In this work, two kinds of monolith-based immobilized enzyme microreactors (IMER) were compared in terms of monolith properties and digestion performance. Two monoliths were prepared involving poly (tetraethoxysiLane-co-3-aminopropyltriethoxysilane) (poly (TEOS-co-APTES)) monolith and poly (N-acryloxysuccinimide-co-acrylamide-co-ethylene dimethacrylate) (poly (NAS-co-AA-co-EDMA)) monolith for covalent...
Farshad Oveissi et al.
Biomaterials science, 7(3), 926-937 (2018-12-07)
Novel hydrogels with tunable mechanical properties similar to human soft tissue have increasing applications in biomedicine, soft robotics, and biocompatible electronics. However, most of these materials require multiple-step fabrication, are not robust, and compromise bioactivity. Thus, aiming to address these...
Nan Zhao et al.
ACS applied materials & interfaces, 12(22), 24599-24610 (2020-05-10)
Mesenchymal stem cells (MSCs) have a very low survival rate after in vivo delivery, which limits their great promise for treating human diseases. Various strategies have been studied to overcome this challenge. However, an overlooked but important potential is to...
Nan Zhao et al.
ACS applied materials & interfaces, 11(20), 18123-18132 (2019-04-27)
In situ injectable hydrogels hold great potential for in vivo applications such as drug delivery and regenerative medicine. However, it is challenging to ensure stable sequestration and sustained release of loaded biomolecules in these hydrogels. As aptamers have high binding...
Lauren Baugh et al.
American journal of physiology. Heart and circulatory physiology, 317(7), H26-H36 (2019-04-06)
The lack of pharmaceutical targets available to treat patients with calcific aortic valve disease (CAVD) necessitates further research into the specific mechanisms of the disease. The significant changes that occur to the aortic valves extracellular matrix (ECM) during the progression...
Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells.
Kim J, et al.
Biomaterials, 28(10), 1830-1837 (2007)
Juntao Zhang et al.
International journal of biological macromolecules, 128, 885-892 (2019-02-04)
Side chain modification of collagen provides an attractive way to enhance their structure and functions, which is highly desirable for the development of promising biomaterials. However, the impact of structural change of side chains on the intrinsic self-assembly property of...
Hui Pan et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 44(2), 116-125 (2016-01-07)
Hyaluronic acid (HA) hydrogel has been used as a carrier of recombinant human bone morphogenetic protein (rhBMP)-2 for sustained delivery. To enhance peri-implant osteogenesis, a dried coating of rhBMP-2 HA hydrogel (BMP-HAH) on dental implants was designed; this approach provides...
Jinxie Zhang et al.
Theranostics, 6(12), 2099-2113 (2016-10-05)
The inner membrane vesicle system is a complex transport system that includes endocytosis, exocytosis and autophagy. However, the details of the intracellular trafficking pathway of nanoparticles in cells have been poorly investigated. Here, we investigate in detail the intracellular trafficking...
Iman Manavitehrani et al.
Macromolecular bioscience, 18(12), e1800201-e1800201 (2018-11-06)
The manufacture of a biocompatible carrier for controlled delivery of bioactive compounds is described. This carrier is composed of a mesoporous silica nanoparticle as core that is homogenously distributed in an injectable hydrogel. For the synthesis of nanoparticles, a one...
Sylvia L Natividad-Diaz et al.
Biomaterials, 194, 73-83 (2018-12-26)
Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex process of angiogenesis and the endothelial cell response to biomaterial and biophysical changes in a defined microenvironment. We present a...
So Jeong Yoon et al.
Journal of bioscience and bioengineering, 118(4), 461-468 (2014-05-27)
Hydrogel has been used for regenerating myocardial infraction (MI) as a delivery vehicle for cells and growth factors. This study showed that injectable hyaluronic acid (HA)-based hydrogels alone would effectively regenerate the damaged infarcted heart tissue. We found that there...
Protein-reactive, thermoresponsive copolymers with high flexibility and biodegradability.
Guan J, et al.
Biomacromolecules, 9(4), 1283-1292 (2008)
Shane Browne et al.
PloS one, 13(3), e0194679-e0194679 (2018-03-23)
Cell-based strategies for the treatment of ischemic diseases are at the forefront of tissue engineering and regenerative medicine. Cell therapies purportedly can play a key role in the neovascularization of ischemic tissue; however, low survival and poor cell engraftment with...
Elena Garreta et al.
Nature materials, 18(4), 397-405 (2019-02-20)
The generation of organoids is one of the biggest scientific advances in regenerative medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were exposed to a three-dimensional microenvironment, and by applying defined renal inductive signals, we generated...
Avin Ramaiya et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(41), 10894-10899 (2017-10-05)
Cytoskeletal motors drive many essential cellular processes. For example, kinesin-1 transports cargo in a step-wise manner along microtubules. To resolve rotations during stepping, we used optical tweezers combined with an optical microprotractor and torsion balance using highly birefringent microspheres to...
Jun-Bao Fan et al.
Cancer discovery, 10(3), 382-393 (2020-01-25)
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the ISG UBA7 is a...
Heemin Kang et al.
Biomaterials, 149, 12-28 (2017-10-11)
Cellular behaviors, such as differentiation, are regulated by complex ligation processes involving cell surface receptors, which can be activated by various divalent metal cations. The design of nanoparticle for co-delivery of ligand and ligation activator can offer a novel strategy...
L Przybyla et al.
Methods (San Diego, Calif.), 94, 101-113 (2015-09-08)
The way cells are organized within a tissue dictates how they sense and respond to extracellular signals, as cues are received and interpreted based on expression and organization of receptors, downstream signaling proteins, and transcription factors. Part of this microenvironmental...
Sogol Motallebi Tala Tapeh et al.
Materials science & engineering. C, Materials for biological applications, 119, 111517-111517 (2020-12-17)
One of the major challenges in cardiac cell therapy is cell death and low rate of cardiac differentiation. In this regard, a series of thermosensitive and injectable hydrogels with similar physicomechanical properties of cardiac tissue can be an ideal candidate...
Hang Li et al.
Annals of biomedical engineering, 42(7), 1456-1469 (2013-10-17)
Neural stem/progenitor cells (NSPCs) are able to differentiate into the primary cell types (neurons, oligodendrocytes and astrocytes) of the adult nervous system. This attractive property of NSPCs offers a potential solution for neural regeneration. 3D implantable scaffolds should mimic the...
Akira Tsuchiya et al.
Colloids and surfaces. B, Biointerfaces, 160, 60-64 (2017-09-17)
Sonoporation is a promising method to intracellularly deliver synthetic gene carriers that have lower endocytotic uptake than viral carriers. Here, we applied sonoporation to deliver genes via polyethylene glycol (PEG)-grafted polymeric carriers that specifically respond to hyperactivated protein kinase A...
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