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U Rensch et al.
Journal of food protection, 76(4), 653-656 (2013-04-12)
Few studies have been conducted on changes in the susceptibility of bacteria due to long-term use of biocides. A total of 375 avian Salmonella isolates collected in Germany from healthy or diseased animals during two time periods, 1979 through 1994...
Anna J Williams et al.
International journal of food microbiology, 215, 1-6 (2015-09-01)
The Bacteriological Analytical Manual (BAM) method currently used by the United States Food and Drug Administration (FDA) to detect Escherichia coli O157:H7 in spinach was systematically compared to a new flow cytometry based method. This Food and Drug Administration (FDA)...
Shiro Koizume et al.
Nucleic acids research, 40(12), 5389-5401 (2012-03-10)
Hypoxia-inducible factors (HIF)-1α and HIF2α are major transcription factors required for adaptive responses to hypoxia. HIFs form a complex with aryl hydrocarbon receptor nuclear translocator (ARNT) to bind to the regulatory regions of target genes. The acetylation of histones by...
Nicola Baker et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(29), 9112-9117 (2015-07-08)
Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug target. Isometamidium, for example, is a key veterinary drug that accumulates in...
Carrie A Duckworth et al.
Methods in molecular biology (Clifton, N.J.), 763, 105-114 (2011-08-30)
The intestinal barrier is formed by a monolayer of columnar epithelial cells. This barrier is effectively maintained despite the high turnover of epithelial cells in the gut. Defects in the mechanism by which barrier function is maintained are believed to...
The contribution of bacteriocin to inhibition of Listeria monocytogenes by Carnobacterium piscicola strains in cold-smoked salmon systems.
Nilsson L, et al.
Journal of Applied Microbiology, 96, 133-133 (2004)
Trudy H Grossman et al.
Antimicrobial agents and chemotherapy, 59(3), 1534-1541 (2014-12-24)
Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycobacterium tuberculosis in in vitro...
Antitumor activity of acriflavine in human hepatocellular carcinoma cells.
Lee CJ, Yue CH, Lin YY, et al.
Anticancer Research, 34(7), 3549-3556 (2014)
S E E Efem
Nigerian journal of clinical practice, 12(4), 412-415 (2010-03-25)
Chronic and non healing wounds, necrotic wounds and contused and devitalized wounds require debridement to rid the wounds of all these impediments that encourage bacterial growth and multiplications with consequent impairment of wound healing. Whereas there are several methods of...
Isolation and biotyping of Brucella melitensis from aborted sheep and goat fetuses.
Buyukcangaz E, et al.
Turkish Journal of Veterinary and Animal Sciences, 33, 311-316 (2009)
Ivan Gusarov et al.
Science (New York, N.Y.), 325(5946), 1380-1384 (2009-09-12)
Bacterial nitric oxide synthases (bNOS) are present in many Gram-positive species and have been demonstrated to synthesize NO from arginine in vitro and in vivo. However, the physiological role of bNOS remains largely unknown. We show that NO generated by...
Cathaleen Madsen et al.
Antiviral research, 112, 26-37 (2014-12-03)
Venezuelan equine encephalitis virus (VEEV) is classified as a Category B Select Agent and potential bioterror weapon for its severe disease course in humans and equines and its potential for aerosol transmission. There are no current FDA licensed vaccines or...
Santiago Ramón-García et al.
Antimicrobial agents and chemotherapy, 56(4), 2074-2083 (2012-01-11)
Efflux pumps extrude a wide variety of chemically unrelated compounds conferring multidrug resistance and participating in numerous physiological processes. Mycobacterium tuberculosis possesses many efflux pumps, and their roles in drug resistance and physiology are actively investigated. In this work we...
Nadine Fischer et al.
Biochimica et biophysica acta, 1828(2), 632-641 (2012-10-24)
Acriflavine resistance protein B acts as the active transporter in the multi-drug efflux pump Acriflavine resistance proteins A / B - Tolerance to colicins protein in Escherichia coli. Within the same reaction cycle intermediate all Acriflavine resistance protein B X-ray...
Madathilparambil V Suresh et al.
Critical care medicine, 42(10), e642-e653 (2014-07-12)
Lung contusion is a major risk factor for the development of acute respiratory distress syndrome. Hypoxia-inducible factor-1α is the primary transcription factor that is responsible for regulating the cellular response to changes in oxygen tension. We set to determine if...
Samarendra K Singh et al.
Current microbiology, 61(3), 163-168 (2010-01-30)
Acidophilic bacterium, Acidiphilium symbioticum H8, is resistant to high levels of several heavy metals, hydrophobic agents, and organic solvents. The approximately 9.6 kb plasmid pASH8, was purified, digested with HindIII, and sub-cloned in pUC19 at the respective site. Three different...
A Priyanka et al.
Free radical research, 48(10), 1206-1217 (2014-07-22)
Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance, and other obesity related complications. So the hypoxia-signalling pathway is expected to...
Jessica E S Shay et al.
Carcinogenesis, 35(5), 1067-1077 (2014-01-11)
Hypoxia-inducible factors (HIFs) accumulate in both neoplastic and inflammatory cells within the tumor microenvironment and impact the progression of a variety of diseases, including colorectal cancer. Pharmacological HIF inhibition represents a novel therapeutic strategy for cancer treatment. We show here...
Liliana Rodrigues et al.
Antimicrobial agents and chemotherapy, 57(2), 751-757 (2012-11-21)
Efflux pumps are membrane proteins capable of actively transporting a broad range of substrates from the cytoplasm to the exterior of the cell. Increased efflux activity in response to drug treatment may be the first step in the development of...
Yael Gros et al.
The Journal of biological chemistry, 285(7), 5076-5084 (2009-12-17)
The vesicular neurotransmitter transporter VMAT2 is responsible for the transport of monoamines into synaptic and storage vesicles. VMAT2 is the target of many psychoactive drugs and is essential for proper neurotransmission and survival. Here we describe a new expression system...
Jingzhang Fan et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 9571-9576 (2014-06-26)
The aim of this study was to investigate the effects of acriflavine on viability and induction of apoptosis and autophagy in human osteosarcoma cell lines MG63. Inhibition of cell proliferation by acriflavine was determined using MTT assay. Induction of apoptosis...
Carmen Chak-Lui Wong et al.
Journal of molecular medicine (Berlin, Germany), 90(7), 803-815 (2012-01-11)
Intratumoral hypoxia, a frequent finding in metastatic cancer, results in the activation of hypoxia-inducible factors (HIFs). HIFs are implicated in many steps of breast cancer metastasis, including metastatic niche formation through increased expression of lysyl oxidase (LOX) and lysyl oxidase-like...
Michel Bidet et al.
Molecular cancer research : MCR, 10(11), 1496-1508 (2012-07-04)
Most anticancer drugs fail to eradicate tumors, leading to the development of drug resistance and disease recurrence. The Hedgehog signaling plays a crucial role during embryonic development, but is also involved in cancer development, progression, and metastasis. The Hedgehog receptor...
Jun Fang et al.
Journal of biomolecular structure & dynamics, 31(4), 385-392 (2012-08-11)
The resistance-nodulation-cell division family multidrug transporter Acriflavine resistance protein B (AcrB) from Eschericha coli is an obligate homotrimer. Approximately, 45% of the inter-subunit interface is contributed by a protruding loop (also referred to as the thumb) and its corresponding binding...
Zubeyda Akin Polat et al.
Parasitology research, 112(2), 529-533 (2012-10-12)
Acanthamoeba keratitis (AK) is a potentially devastating and sight-threatening infection of the cornea caused by the ubiquitous free-living amoebae, Acanthamoeba species. Its eradication is difficult because the amoebas encyst, making it highly resistant to anti-amoebic drugs. Acriflavine neutral (ACF) has...
Gali Umschweif et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(4), 524-531 (2013-01-03)
Heat acclimation (HA), a well-established preconditioning model, confers neuroprotection in rodent models of traumatic brain injury (TBI). It increases neuroprotective factors, among them is hypoxia-inducible factor 1α (HIF-1α), which is important in the response to postinjury ischemia. However, little is...
B S Lopes et al.
Journal of medical microbiology, 60(Pt 2), 211-215 (2010-10-23)
Acinetobacter baumannii is a Gram-negative pathogenic bacterium that often exhibits a multidrug-resistant phenotype causing infections at various sites of the body and increasingly leading to septicaemic shock. This study evaluated the role of acriflavine, a frameshift mutagen, on the movement...
C Manivannan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 114, 316-322 (2013-06-20)
The interaction of acriflavine with uracils was investigated by using spectroscopic tools viz., UV-Vis absorption, steady state and time resolved fluorescence measurements. The spectroscopic data were analyzed using Stern-Volmer equation to determine the quenching process. The bimolecular quenching rate constant...
Changtao Jiang et al.
The Journal of biological chemistry, 288(6), 3844-3857 (2012-12-21)
Obesity has been identified as a major risk factor for type 2 diabetes, characterized by insulin resistance in insulin target tissues. Hypoxia-inducible factor 1α (HIF1α) regulates pathways in energy metabolism that become dysregulated in obesity. Earlier studies revealed that HIF1α...
Min-Jin Lim et al.
The international journal of biochemistry & cell biology, 44(8), 1214-1222 (2012-05-09)
Radiotherapy (RT) is one of the most effective tools in the clinical treatment of cancer. Because the tumor suppressor p53 plays a central role in radiation-mediated responses, including cell cycle-arrest and apoptosis, a number of studies have suggested that p53...
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