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A8717

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Yangmei Huang et al.
Journal of Alzheimer's disease : JAD, 63(3), 1089-1107 (2018-05-02)
Reduced cerebral blood flow in Alzheimer's disease (AD) may occur in early AD, which contributes to the pathogenesis and/or pathological progression of AD. Reversing this deficit may have therapeutic potential. Certain traditional Chinese herbal medicines (e.g., Saponin and its major...
Hongsheng Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(28), 5347-5361 (2020-05-28)
Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is considered a cause of Alzheimer's disease (AD). The imbalance of Aβ production and clearance leads to Aβ accumulation and Aβ deposition. Increasing evidence indicates an important role of astrocytes...
Stefania Trazzi et al.
Human molecular genetics, 20(8), 1560-1573 (2011-01-27)
Mental retardation in Down syndrome (DS) appears to be related to severe neurogenesis impairment during critical phases of brain development. Recent lines of evidence in the cerebellum of a mouse model for DS (the Ts65Dn mouse) have shown a defective...
Angela B Clement et al.
Free radical biology & medicine, 48(9), 1236-1241 (2010-02-17)
Reactive oxygen species (ROS) have important roles as signaling molecules in the regulation of a variety of biological processes. On the other hand, chronic oxidative stress exerted by ROS is widely considered a causative factor in aging. Therefore, cells need...
Jorge Montesinos et al.
The EMBO journal, 39(20), e103791-e103791 (2020-09-01)
The link between cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationship relates to Alzheimer's disease (AD) pathogenesis, is still unknown. Cellular cholesterol levels are regulated through crosstalk between the plasma membrane (PM), where most...
Po-Min Chiang et al.
Neurobiology of aging, 33(2), 277-285 (2010-04-13)
γ-Secretase, a multisubunit transmembrane protease comprised of presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective one, participates in the regulated intramembrane proteolysis of Type I membrane proteins including the amyloid precursor protein (APP). Although Aph-1 is thought to play a...
Nancy E Caceres et al.
PloS one, 8(3), e58285-e58285 (2013-03-19)
Overexpression of multidrug transporters is a well-established mechanism of resistance to chemotherapy, but other changes may be co-selected upon exposure to drugs that contribute to resistance. Using a model of J774 macrophages made resistant to the fluoroquinolone antibiotic ciprofloxacin and...
Mikiko Ohno et al.
Neurobiology of aging, 35(1), 213-222 (2013-08-21)
Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude...
Tadashi Nakaya et al.
The FEBS journal, 276(21), 6364-6374 (2009-10-03)
FE65 is a neural adaptor protein known to interact with a number of proteins, including Alzheimer's amyloid beta-protein precursor (APP). Although several different functions have been proposed for FE65, its primary physiological role remains unclear. We previously showed that APP...
Giuseppina Minopoli et al.
The Journal of biological chemistry, 282(2), 831-835 (2006-11-24)
Fe65 interacts with the cytosolic domain of the Alzheimer amyloid precursor protein (APP). The functions of the Fe65 are still unknown. To address this point we generated Fe65 knockout (KO) mice. These mice do not show any obvious phenotype; however...
Anna Sobol et al.
Journal of cellular physiology, 230(6), 1332-1341 (2014-12-17)
We recently reported that Amyloid Precursor Protein (APP) regulates global protein synthesis in a variety of human dividing cells, including non-small cell lung cancer (NSCLC) cells. More specifically, APP depletion causes an increase of both cap- and IRES-dependent translation. Since...
Erica Butti et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(28), 5481-5492 (2019-05-30)
Myelin loss occurring in demyelinating diseases, including multiple sclerosis, is the leading cause of long-lasting neurological disability in adults. While endogenous remyelination, driven by resident oligodendrocyte precursor cells (OPCs), might partially compensate myelin loss in the early phases of demyelinating...
Yancheng Wu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 1412-1429 (2020-01-10)
Accumulation of amyloid β (Aβ) peptide, inflammation, and oxidative stress contribute to Alzheimer's disease (AD) and trigger complex pathogenesis. The ketone body β-hydroxybutyrate (BHBA) is an endogenous metabolic intermediate that protects against stroke and neurodegenerative diseases, but the underlying mechanisms...
Ye Ji Jeong et al.
Current Alzheimer research, 12(5), 481-492 (2015-05-29)
The involvement of radiofrequency electromagnetic fields (RF-EMF) in the neurodegenerative disease, especially Alzheimer's disease (AD), has received wide consideration, however, outcomes from several researches have not shown consistency. In this study, we determined whether RF-EMF influenced AD pathology in vivo...
Viviana Triaca et al.
Aging cell, 15(4), 661-672 (2016-04-15)
NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain...
Hyo-Jin Park et al.
PloS one, 12(9), e0184262-e0184262 (2017-09-07)
Abnormal accumulation of α-synuclein (αSyn) has been linked to endoplasmic-reticulum (ER) stress, defective intracellular protein/vesicle trafficking, and cytotoxicity. Targeting factors involved in ER-related protein processing and trafficking may, therefore, be a key to modulating αSyn levels and associated toxicity. Recently...
Henri J Huttunen et al.
FEBS letters, 581(8), 1688-1692 (2007-04-07)
Previous studies have shown that acyl-coenzyme A:cholesterol acyl transferase (ACAT), an enzyme that controls cellular equilibrium between free cholesterol and cholesteryl esters, modulates proteolytic processing of APP in cell-based and animal models of Alzheimer's disease. Here we report that ACAT-1...
Alessandro Castorina et al.
Neurochemical research, 36(3), 426-434 (2010-12-21)
Recently, it has been proposed that neurofibromin (NF1) forms a binding complex with amyloid precursor protein (APP) that interacts with the dopamine D(3) receptor (D(3)R). In the present study we investigated whether the absence of the D(3)R is correlated to...
Anna Doshina et al.
Scientific reports, 7(1), 370-370 (2017-03-25)
The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations regulated by Na+-K+-2Cl- cotransporter 1 (NKCC1) and neuronal K+-Cl- cotransporter 2...
Julien Chapuis et al.
Acta neuropathologica, 133(6), 955-966 (2016-12-10)
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer's disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the "post-GWAS" era. At least 123 genes are...
Chun-Yan Wang et al.
PloS one, 5(12), e15349-e15349 (2010-12-24)
Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been...
Albéna Pramatarova et al.
Molecular and cellular neurosciences, 37(1), 178-186 (2007-11-22)
The Dab1 docking protein is required for the proper organization of brain laminae and for a signal transduction pathway initiated by Reelin binding to the ApoER2 and VLDLR receptors on the cell surface of neurons. Dab1 physically interacts with APP;...
Yuichi Hashimoto et al.
Journal of neurochemistry, 130(2), 291-300 (2014-03-22)
Expression of a familial Alzheimer's disease (AD)-linked mutant of amyloid β precursor protein (APP) or the binding of transforming growth factor β2 to wild-type (wt)-APP causes neuronal death by activating an intracellular death signal (a APP-mediated intracellular death signal) in...
Yixing Wu et al.
PloS one, 16(7), e0242236-e0242236 (2021-07-23)
People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer's disease (AD). This is in part because of triplication of a chromosome 21 gene, APP. This gene encodes amyloid precursor protein...
Yawei Tong et al.
Human molecular genetics, 24(19), 5388-5403 (2015-07-15)
Phospholipid transfer protein (PLTP) is a widely expressed lipid transfer protein participating in the transport of cholesterol and other lipids in the plasma and peripheral tissues. Recently, elevated amyloid β (Aβ) in young and aged PLTP-deficient brains had been reported....
Sunmin Jung et al.
Science signaling, 13(623) (2020-03-19)
The enzyme γ-secretase generates β-amyloid (Aβ) peptides by cleaving amyloid protein precursor (APP); the aggregation of these peptides is associated with Alzheimer's disease (AD). Despite the development of various γ-secretase regulators, their clinical use is limited by coincident disruption of...
Antaripa Bhattacharya et al.
International journal of molecular sciences, 21(5) (2020-03-08)
Amyloid precursor protein (APP) is processed along both the nonamyloidogenic pathway preventing amyloid beta peptide (Aβ) production and the amyloidogenic pathway, generating Aβ, whose accumulation characterizes Alzheimer's disease. Items of evidence report that the intracellular trafficking plays a key role...
Johannes Prox et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(32), 12915-12928 (2013-08-09)
The metalloproteinase ADAM10 is of importance for Notch-dependent cortical brain development. The protease is tightly linked with α-secretase activity toward the amyloid precursor protein (APP) substrate. Increasing ADAM10 activity is suggested as a therapy to prevent the production of the...
Sara Ansaloni et al.
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research, 6(2), 411-415 (2010-12-09)
RNA interference (RNAi) is a widely used molecular biology technique to investigate the importance of specific genes in molecular pathways. Since mammalian cells are equipped with endogenous RNAi processing machinery, it has become common practice to transfect constructs that encode...
Anna A Pimenova et al.
Neurobiology of disease, 138, 104785-104785 (2020-02-08)
Mutations in APP (amyloid precursor protein), PSEN1 (presenilin 1) or PSEN2 (presenilin 2) are the main cause of early-onset familial forms of Alzheimer's disease (autosomal dominant AD or ADAD). These genes affect γ-secretase-dependent generation of Amyloid β (Aβ) peptides, the...
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