Showing 1-30 of 794 results for "A9044"
Aldrin V Gomes et al.
Journal of muscle research and cell motility, 36(6), 447-461 (2015-12-17)
In this study we aimed to provide an in-depth proteomic analysis of differentially expressed proteins in the hearts of transgenic mouse models of pathological and physiological cardiac hypertrophy using tandem mass tag labeling and liquid chromatography tandem mass spectrometry. The...
Mark A Miles et al.
Cell death & disease, 11(8), 680-680 (2020-08-23)
Most anticancer drugs provoke apoptotic signaling by damaging DNA or other means. Genotoxic therapies may enhance a patient's risk of developing "therapy-related cancers" due to the accumulation of oncogenic mutations that may occur in noncancerous cells. Mutations can also form...
Hal P Bogerd et al.
mBio, 8(1) (2017-01-18)
Analysis of the incorporation of cellular microRNAs (miRNAs) into highly purified HIV-1 virions revealed that this largely, but not entirely, mirrored the level of miRNA expression in the producer CD4+ T cells. Specifically, of the 58 cellular miRNAs detected at...
Pavlína Šimečková et al.
International journal of molecular sciences, 20(24) (2019-12-19)
Effects of airborne particles on the expression status of markers of cellular toxic stress and on the release of eicosanoids, linked with inflammation and oxidative damage, remain poorly characterized. Therefore, we proposed a set of various methodological approaches in order...
Zhishang Hu et al.
Cancer research, 68(14), 5552-5561 (2008-07-18)
The Rad9 gene is evolutionarily conserved from yeast to humans and plays crucial roles in genomic maintenance, DNA repair, and cell cycle checkpoint controls. However, the function of this gene with respect to tumorigenesis is not well-understood. A Rad9-null mutation...
Dietmar Zechner et al.
BMC cancer, 15, 51-51 (2015-04-18)
We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. Pancreatic...
Saloume Mehrlatifan et al.
Drug delivery, 23(8), 2852-2859 (2015-11-13)
One of the significant problems in vaccination projects is the lack of an effective vaccine against hepatitis C virus (HCV). The goal of the current study is to evaluate and compare two DNA constructs encoding HCV core and coreE1E2 genes...
Louis Tong et al.
Biochimica et biophysica acta, 1833(6), 1304-1315 (2013-03-08)
Migration of cells in the ocular surface underpins physiological wound healing as well as many human diseases. Transglutaminase (TG)-2 is a multifunctional cross-linking enzyme involved in the migration of skin fibroblasts and wound healing, however, its functional role in epithelial...
Chia-Mei Chou et al.
Parasites & vectors, 10(1), 620-620 (2017-12-24)
Toxocariasis is a worldwide zoonotic parasitic disease mainly caused by Toxocara canis. Humans can be infected by accidental ingestion of T. canis embryonated ovum-contaminated food, water, or encapsulated larvae in paratenic hosts' viscera or meat. Since humans and mice are...
Dianrong Li et al.
Molecular cell, 75(6), 1103-1116 (2019-08-20)
The mitochondrial pathway of apoptosis is controlled by the ratio of anti- and pro-apoptotic members of the Bcl-2 family of proteins. The molecular events underlying how a given physiological stimulus changes this ratio to trigger apoptosis remains unclear. We report...
Michael Fricker et al.
JCI insight, 3(3) (2018-02-09)
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT). Cigarette smoke (CS) exposure and chronic obstructive pulmonary disease (COPD) are risk factors for CD, although the mechanisms involved are poorly understood. We employed a mouse model...
Matthias Ebbinghaus et al.
PloS one, 15(8), e0237101-e0237101 (2020-08-21)
Mutations in the genes encoding for voltage-gated sodium channels cause profound sensory disturbances and other symptoms dependent on the distribution of a particular channel subtype in different organs. Humans with the gain-of-function mutation p.Leu811Pro in SCN11A (encoding for the voltage-gated...
Samuel Morisse et al.
Antioxidants & redox signaling, 21(9), 1271-1284 (2013-12-18)
Protein S-nitrosylation, a post-translational modification (PTM) consisting of the covalent binding of nitric oxide (NO) to a cysteine thiol moiety, plays a major role in cell signaling and is recognized to be involved in numerous physiological processes and diseases in...
Kristin M O'Brien et al.
The Journal of experimental biology, 221(Pt 5) (2018-01-24)
The unusual pattern of expression of hemoglobin (Hb) and myoglobin (Mb) among Antarctic notothenioid fishes provides an exceptional model system for assessing the impact of these proteins on oxidative stress. We tested the hypothesis that the lack of oxygen-binding proteins...
A L Guarnieri et al.
Oncogene, 37(28), 3879-3893 (2018-04-18)
Tumor-initiating cells (TIC) represent a subset of tumor cells with increased self-renewal capability. TICs display resistance to frontline cancer treatment and retain the ability to repopulate a tumor after therapy, leading to cancer relapse. NOTCH signaling has been identified as...
Yasmin ElTahir et al.
BMC molecular and cell biology, 20(1), 55-55 (2019-12-01)
Brucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis of Brucella adherence to host cells. In the present study, the possible role of Bp26 protein as an adhesin was explored. The...
Olga Ramaniuk et al.
Biomolecules, 10(8) (2020-07-28)
Cells attaching to the extracellular matrix spontaneously acquire front-rear polarity. This self-organization process comprises spatial activation of polarity signaling networks and the establishment of a protruding cell front and a non-protruding cell rear. Cell polarization also involves the reorganization of...
S A Orellana et al.
The Journal of biological chemistry, 275(28), 21233-21240 (2000-04-18)
Polycystic kidney disease is characterized by abnormal morphological development. Mechanisms that regulate cyst development may involve multiple signaling pathways. Cyst formation by Madin-Darby canine kidney (MDCK) cells in three-dimensional culture is assumed to be cyclic AMP-dependent and due to cyclic...
Lu Han et al.
Molecular cancer, 9, 67-67 (2010-03-26)
Cells are constantly exposed to stresses from cellular metabolites as well as environmental genotoxins. DNA damage caused by these genotoxins can be efficiently fixed by DNA repair in cooperation with cell cycle checkpoints. Unrepaired DNA lesions can lead to cell...
Hao Wu et al.
International journal of molecular medicine, 42(1), 346-358 (2018-04-06)
An acute reaction response (AR) following liver transplantation (LT) is caused by immune responses that are primarily mediated by T lymphocytes. Kupffer cells (KCs) are the largest antigen presenting cell (APC) group in vivo and are the primary modulators of the inflammatory...
Rita Ferreira et al.
European journal of applied physiology, 97(3), 340-346 (2006-06-14)
The comprehension of the cellular mechanisms underlying skeletal muscle atrophy has been the aim of several experimental studies. However, the majority of them focused on alterations of the myocytes induced by different experimental conditions yet disregarding the contribution of other...
Marisela Agudelo et al.
PloS one, 11(6), e0156421-e0156421 (2016-06-02)
Epigenetic mechanisms have been shown to play a role in alcohol use disorders (AUDs) and may prove to be valuable therapeutic targets. However, the involvement of histone deacetylases (HDACs) on alcohol-induced oxidative stress of human primary monocyte-derived dendritic cells (MDDCs)...
Nayoung Lee et al.
Proteomics, 19(17), e1900086-e1900086 (2019-07-19)
Mitogen-activated protein (MAP) kinase signaling is critical for various cellular responses, including cell proliferation, differentiation, and cell death. The MAP kinase cascade is conserved in the eukaryotic kingdom as a three-tiered kinase module-MAP kinase kinase kinase, MAP kinase kinase, and...
Aroa Soriano et al.
Oncotarget, 7(8), 9271-9287 (2016-01-30)
Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered...
Jeremy Stephens et al.
Temperature (Austin, Tex.), 3(2), 328-339 (2016-11-20)
Malignant hyperthermia manifests as a rapid and sustained rise in temperature in response to pharmacological triggering agents, e.g. inhalational anesthetics and the muscle relaxant suxamethonium. Other clinical signs include an increase in end-tidal CO2, increased O2 consumption, as well as...
Blanca Cáceres et al.
Cancers, 11(2) (2019-03-01)
Despite the great advances in cancer treatment, colorectal cancer has emerged as the second highest cause of death from cancer worldwide. For this type of tumor, the use of suicide gene therapy could represent a novel therapy. We recently demonstrated...
Samuel Lundt et al.
Scientific reports, 10(1), 99-99 (2020-01-11)
Nicotinamide adenine dinucleotide (NAD+) plays a critical role in energy metabolism and bioenergetic homeostasis. Most NAD+ in mammalian cells is synthesized via the NAD+ salvage pathway, where nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme, converting nicotinamide into nicotinamide mononucleotide (NMN)....
S Godefroy et al.
Infection and immunity, 73(8), 4803-4809 (2005-07-26)
The high accessibility of the skin and the presence of immunocompetent cells in the epidermis makes this surface an attractive route for needle-free administration of vaccines. However, the lining of the skin by the stratum corneum is a major obstacle...
Daichi Nagashima et al.
Archives of toxicology, 93(7), 1993-2006 (2019-05-28)
Acrylamide has been used industrially and also found in certain foods cooked at high temperatures. Previous reports described acrylamide-related human intoxication who presented with ataxia, memory impairment, and/or illusion. The aim of this study was to characterize the molecular mechanisms...
Kuang-Yu Chou et al.
Oncology reports, 45(3), 911-920 (2021-03-03)
Bladder cancer (BC), a common urologic cancer, is the fifth most frequently diagnosed tumor worldwide. hsa‑miR‑34a displays antitumor activity in several types of cancer. However, the functional mechanisms underlying hsa‑miR‑34a in BC remains largely unknown. We observed that hsa‑mir‑34a levels...

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