Showing 1-30 of 101 results for "A9414"
Sahar I Da'as et al.
Cells, 9(8) (2020-07-31)
Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare neurological disorder hyperphosphatasia with mental retardation syndrome 4 type (HPMRS4). Here, we report a novel homozygous nonsense mutation in PGAP3 (c.265C>T-p.Gln89*), in a 3-year-old boy with unique novel...
Chiharu Tani et al.
Applied and environmental microbiology, 75(22), 7044-7050 (2009-09-22)
Arbuscular mycorrhizal (AM) fungi benefit their host plants by supplying phosphate obtained from the soil. Polyphosphate is thought to act as the key intermediate in this process, but little is currently understood about how polyphosphate is synthesized or translocated within...
Maximilian Strunz et al.
Nature communications, 11(1), 3559-3559 (2020-07-18)
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling together with lineage tracing revealed...
Freeman Lan et al.
Nature biotechnology, 35(7), 640-646 (2017-05-30)
The application of single-cell genome sequencing to large cell populations has been hindered by technical challenges in isolating single cells during genome preparation. Here we present single-cell genomic sequencing (SiC-seq), which uses droplet microfluidics to isolate, fragment, and barcode the...
Yiting Liu et al.
The Journal of comparative neurology, 523(12), 1840-1863 (2015-03-04)
Metabolic homeostasis and water balance is maintained by tight hormonal and neuronal regulation. In Drosophila, insulin-like peptides (DILPs) are key regulators of metabolism, and the neuropeptide leucokinin (LK) is a diuretic hormone that also modulates feeding. However, it is not...
Enrico Milan et al.
Autophagy, 11(7), 1161-1178 (2015-06-05)
Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating...
M F Luciani et al.
Cell death & disease, 8(1), e2528-e2528 (2017-01-06)
Cell death occurs in all eukaryotes, but it is still not known whether some core steps of the cell death process are conserved. We investigated this using the protist Dictyostelium. The dissection of events in Dictyostelium vacuolar developmental cell death...
Wioletta Skronska-Wasek et al.
American journal of respiratory and critical care medicine, 196(2), 172-185 (2017-03-01)
Chronic obstructive pulmonary disease (COPD), in particular emphysema, is characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless and INT-1 (WNT)/β-catenin signaling is reduced in COPD; however, the mechanisms thereof, specifically the role of the frizzled (FZD)...
Shigeyuki Tanaka et al.
The New phytologist, 227(1), 185-199 (2020-03-01)
The biotrophic fungus Ustilago maydis causes the smut disease of maize. The interaction with its host and induction of characteristic tumors are governed largely by secreted effectors whose function is mostly unknown. To identify effectors with a prominent role in...
Qian Zhou et al.
Molecular reproduction and development, 87(5), 550-564 (2020-03-28)
BRG1-associated factor 250a (BAF250a) is a component of the SWI/SNF adenosine triphosphate-dependent chromatin remodeling complex, which has been shown to control chromatin structure and transcription. BAF250a was reported to be a key component of the gene regulatory machinery in embryonic...
L Turrini et al.
Scientific reports, 7(1), 3025-3025 (2017-06-10)
Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs. Recently, zebrafish has become an important model for...
Marc Rollin et al.
Environmental science and pollution research international, 25(12), 11264-11280 (2017-06-19)
Gammarus fossarum is an often-abundant crustacean detritivore that contributes importantly to leaf litter breakdown in oligotrophic, mainly heterotrophic, headwater streams. This species requires large amounts of Ca to moult, thus allowing growth and reproduction. Because resource quality is tightly coupled...
Minaka Ishibashi et al.
Human genetics, 134(11-12), 1163-1182 (2015-09-05)
Protein-coding mutations in the transcription factor-encoding gene ARX cause various forms of intellectual disability (ID) and epilepsy. In contrast, variations in surrounding non-coding sequences are correlated with milder forms of non-syndromic ID and autism and had suggested the importance of...
Dominika Czaplinska et al.
Folia histochemica et cytobiologica, 56(1), 11-20 (2018-03-03)
Triple-negative breast cancer (TNBC), representing over 15% of all breast cancers, has a poorer prognosis than other subtypes. There is no effective targeted treatment available for the TNBC sufferers. Ribosomal S6 kinases (RSKs) have been previously proposed as drug targets...
Mechanical and structural contribution of non-fibrillar matrix in uniaxial tension: a collagen-agarose co-gel model
Lake SP and Barocas VH
Annals of Biomedical Engineering, 39(7), 1891-1903 (2011)
Yihan Wang et al.
Biomedical optics express, 8(8), 3778-3795 (2017-09-01)
Several attempts to achieve the quantitative photoacoustic tomography (q-PAT) have been investigated using point sources or a single-angle wide-field illumination. However, these schemes normally suffer from low signal-to-noise ratio (SNR) or poor quantification in imaging applications on large-size domains, due...
Anja Reithmeier et al.
BMC cancer, 17(1), 650-650 (2017-09-17)
Tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metastasis and was associated with clinically relevant parameters of cancer progression and cancer...
Sello Lebohang Manoto et al.
International journal of molecular sciences, 16(5), 10185-10200 (2015-05-08)
Photodynamic therapy (PDT) is phototherapeutic modality used in the treatment of neoplastic and non-neoplastic diseases. The photochemical interaction of light, photosensitizer (PS) and molecular oxygen produces singlet oxygen which induces cell death. Zinc sulfophthalocyanine (ZnPcSmix) has been shown to be...
Sonia Samtani et al.
Investigative ophthalmology & visual science, 50(11), 5098-5106 (2009-06-12)
Doxycycline, a broad-spectrum antibiotic, has certain antiangiogenic properties and can inhibit matrix metalloproteinases (MMPs/gelatinases). The authors investigated the effects of doxycycline on choroidal neovascularization (CNV) and regulation of MMP-2 and -9 and pigment epithelium-derived factor (PEDF). Doxycycline was orally administered...
Marion Robin et al.
Autophagy, 15(5), 771-784 (2018-12-20)
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently incompatible processes remains unknown. We found that Drosophila lacking p53 displayed impaired autophagic flux, higher caspase activation and...
Muhannad N Fadhel et al.
Journal of biomedical optics, 24(11), 1-8 (2019-11-11)
Solid tumors are typically supplied nutrients by a network of irregular blood vessels. By targeting these vascular networks, it might be possible to hinder cancer growth and metastasis. Vascular disrupting agents induce intertumoral hemorrhaging, making photoacoustic (PA) imaging well positioned...
Ophélie Nicolle et al.
Traffic (Copenhagen, Denmark), 16(8), 893-905 (2015-04-11)
Cryo-sectioning procedures, initially developed by Tokuyasu, have been successfully improved for tissues and cultured cells, enabling efficient protein localization on the ultrastructural level. Without a standard procedure applicable to any sample, currently existing protocols must be individually modified for each...
Liisa M Hirvonen et al.
Journal of biophotonics, 13(2), e201960099-e201960099 (2019-10-30)
We report on wide-field time-correlated single photon counting (TCSPC)-based fluorescence lifetime imaging microscopy (FLIM) with lightsheet illumination. A pulsed diode laser is used for excitation, and a crossed delay line anode image intensifier, effectively a single-photon sensitive camera, is used...
Monira M Rageh et al.
Mutation research, 828, 15-22 (2018-03-21)
The radioprotective and antioxidant activities of melanin nanoparticles (MNP) were investigated in Chinese hamster ovary (CHO) cells in vitro and BALB/C mice in vivo. The endpoints measured were cell viability, superoxide dismutase (SOD) enzyme activity, malondialdehyde (MDA) levels, DNA damage...
A simple method to recover intact high molecular weight RNA and DNA after electrophoretic separation in low gelling temperature agarose gels.
L Wieslander
Analytical biochemistry, 98(2), 305-309 (1979-10-01)
Baris N Ozbay et al.
Scientific reports, 8(1), 8108-8108 (2018-05-29)
We present a miniature head mounted two-photon fiber-coupled microscope (2P-FCM) for neuronal imaging with active axial focusing enabled using a miniature electrowetting lens. We show three-dimensional two-photon imaging of neuronal structure and record neuronal activity from GCaMP6s fluorescence from multiple...
Spindle Scaling Is Governed by Cell Boundary Regulation of Microtubule Nucleation.
Rieckhoff, et al.
Current Biology, 30, 4973-4983 (2020)
Ewa Babkiewicz et al.
Biology open, 9(7) (2020-07-23)
Numerous studies have indicated that temperature improves the visual capabilities of different ectotherms, including a variety of fish species. However, none of these studies has directly tested whether elevated temperature extends the visual detection distance - the distance from which...
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
A P Feinberg et al.
Analytical biochemistry, 137(1), 266-267 (1984-02-01)
Zhilan Li et al.
American journal of cancer research, 10(7), 2083-2099 (2020-08-11)
Anoikis resistance is an important mechanism that mediates tumor metastasis. Studies have found that Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) promotes the occurrence, development, and metastasis of nasopharyngeal carcinoma (NPC). However, the related mechanism, especially whether LMP1 is...

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