Showing 1-30 of 67 results for "A9544"
Julia Karbach et al.
Cancer research, 72(17), 4304-4310 (2012-06-29)
The synthetic oligodeoxynucleotide CpG 7909, which contains unmethylated cytosine/guanine (CpG) motifs, has potent immunostimulatory effects when coadministered with NY-ESO-1 peptides or recombinant NY-ESO-1 protein, resulting in an enhanced cellular and humoral immune response against the vaccine antigen. In this study...
Antibody structure, instability, and formulation.
Wang W
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
Max Renner et al.
Nature immunology, 19(11), 1248-1256 (2018-10-17)
Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and dengue hemorrhagic fever is often associated with secondary heterologous infections. Antibody-dependent enhancement (ADE) may drive higher viral...
Yanchun Peng et al.
Nature immunology, 21(11), 1336-1345 (2020-09-06)
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease)...
Koreen Ramessar et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(10), 3727-3732 (2008-03-05)
A series of small-molecule microbicides has been developed for vaginal delivery to prevent heterosexual HIV transmission, but results from human clinical trials have been disappointing. Protein-based microbicides, such as HIV-specific monoclonal antibodies, have been considered as an alternative approach. Despite...
Sjoerd Rijpkema et al.
Biologicals : journal of the International Association of Biological Standardization, 56, 29-38 (2018-09-12)
Vi capsular polysaccharide (Vi) conjugate vaccines, which can prevent typhoid in infants and young children, are being developed. Comparative immunogenicity studies are facilitated by an International Standard (IS) for human anti-Vi IgG. 16/138, a pool of sera from volunteers which...
Wanwisa Dejnirattisai et al.
Nature immunology, 16(2), 170-177 (2014-12-17)
Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE)...
A Juhász et al.
Journal of medical virology, 64(4), 526-530 (2001-07-27)
Sera of blood donors were investigated by a peptide ELISA and indirect immunofluorescence assay to assess the prevalence of HHV-8 infection in the Hungarian population. A 14 amino acid long synthetic oligopeptide from the carboxyterminus of orf65/small virus capsid antigen...
Antibody structure, instability, and formulation.
Wang W, et al.
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
Karthik Pisupati et al.
mAbs, 9(7), 1197-1209 (2017-08-09)
Remsima™ (infliximab) is the first biosimilar monoclonal antibody (mAb) approved by the European Medical Agency and the US Food and Drug Administration. Remsima™ is highly similar to its reference product, Remicade®, with identical formulation components. The 2 products, however, are...
Wanwisa Dejnirattisai et al.
Nature immunology, 17(9), 1102-1108 (2016-06-25)
Zika virus (ZIKV) was discovered in 1947 and was thought to lead to relatively mild disease. The recent explosive outbreak of ZIKV in South America has led to widespread concern, with reports of neurological sequelae ranging from Guillain Barré syndrome...
Jake Chng et al.
mAbs, 7(2), 403-412 (2015-01-27)
Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the...
Maria Bottermann et al.
Cell host & microbe, 25(4), 617-629 (2019-03-31)
The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering microbial clearance. We demonstrate a C4-dependent antiviral mechanism...
Alexander Rouvinski et al.
Nature communications, 8, 15411-15411 (2017-05-24)
A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope protein E that is buried at the interface of the E dimers coating mature...
Elin Lunde et al.
BMC biotechnology, 10, 61-61 (2010-08-26)
Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection molecules due to molecular instability. We have investigated strategies for the production of TCR-immunoglobulin (Ig) fusion...
Initial B-cell Responses To Transmitted Human Immunodeficiency Virus Type 1: Virion-binding Immunoglobulin M (IgM) And IgG Antibodies Followed By Plasma Anti-gp41 Antibodies With Ineffective Control Of Initial Viremia.
Tomaras, G.D., et al.
J. Virol. Methods, 82, 12449-12463 (2008)
Shumaila Naz et al.
The American journal of tropical medicine and hygiene, 97(3), 851-860 (2017-07-20)
Scabies is a human skin disease due to the burrowing ectoparasite Sarcoptes scabiei var. hominis resulting in intense itching and inflammation and manifesting as a skin allergy. Because of insufficient mite material and lack of in vitro propagation system for...
Algirdas Grevys et al.
Nature communications, 9(1), 621-621 (2018-02-13)
Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based therapeutics has the potential to improve their efficacies, but there is...
Alexandra C Willcox et al.
The American journal of tropical medicine and hygiene, 99(3), 756-763 (2018-07-11)
Flaviviruses such as Zika, dengue, and yellow fever cause epidemics throughout the tropics and account for substantial global morbidity and mortality. Although malaria and other vector-borne diseases have long been appreciated in Africa, flavivirus epidemiology is incompletely understood. Despite the...
Ayşe Kübra Karaboğa Arslan et al.
Nutrients, 10(6) (2018-05-26)
The aim of this study is to investigate the potential inhibitory effect of α-chaconine and α-solanine on RL95-2 estrogen receptor (ER) positive human endometrial cancer cell line and to identify the effect of these glycoalkaloids on the Akt signaling and...
Joel R Meyerson et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(2), 513-518 (2012-12-26)
The extensive carbohydrate coat, the variability of protein structural features on HIV-1 envelope glycoproteins (Env), and the steric constraints of the virus-cell interface during infection, present challenges to the elicitation of effective full-length (~150 kDa), neutralizing antibodies against HIV. These...
Marijke C C Langenberg et al.
Nature medicine, 26(3), 326-332 (2020-02-19)
Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is insufficient to control transmission in highly endemic areas1. Novel medicines and vaccines are urgently needed2,3. An experimental human model for schistosomiasis could accelerate the development of these...
Fadil A Bidmos et al.
Frontiers in immunology, 9, 1621-1621 (2018-08-01)
The threat from invasive meningococcal disease (IMD) remains a serious source of concern despite the licensure and availability of vaccines. A limitation of current serogroup B vaccines is the breadth of coverage afforded, resulting from the capacity for extensive variation...
Esha Oommen et al.
Clinical and experimental rheumatology, 35 Suppl 103(1), 98-101 (2017-03-11)
To determine the prevalence of anti-myeloperoxidase (MPO) antibodies of IgA (IgA anti-MPO) isotype in patients with eosinophilic granulomatosis with polyangiitis (EGPA), and the association of the IgA antibodies with IgG anti-MPO and with disease activity. Serum samples from patients with...
Hadas Sar Shalom et al.
eLife, 8 (2019-01-11)
The innervation of the mammary gland is controlled by brain-derived neurotrophic factor (BDNF), and sexually dimorphic sequestering of BDNF by the truncated form of TrkB (TrkB.T1) directs male-specific axonal pruning in mice. It is unknown whether other cues modulate these...
Rasmus Lundquist et al.
Infection and immunity, 74(6), 3222-3231 (2006-05-23)
Immunoglobulins from individuals with immunity to malaria have a strong antiparasitic effect when transferred to Plasmodium falciparum malaria infected patients. One prominent target of antiparasitic antibodies is the merozoite surface antigen 3 (MSP-3). We have investigated the antibody response against...
Jose Luis Slon-Campos et al.
Nature immunology, 20(10), 1291-1298 (2019-09-04)
Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes-one to precursor membrane protein and one to the fusion loop epitope on envelope (E) protein-are recognized by cross-reactive antibodies1-3 that are not only...
Til Menge et al.
The Journal of allergy and clinical immunology, 116(2), 453-459 (2005-08-09)
Galactocerebroside, the major glycolipid of central nervous system myelin, is a known target for pathogenic demyelinating antibody responses in experimental allergic encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). To address the importance of anti-galactocerebroside (alpha-GalC) antibodies in MS...
Georgia D Tomaras et al.
Journal of virology, 82(24), 12449-12463 (2008-10-10)
A window of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through establishment of the latent pool of HIV-1-infected cells. A critical time to study the initial immune responses to...
Wanwisa Dejnirattisai et al.
Cell, 184(8), 2183-2200 (2021-03-24)
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (RBD). We...

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