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Kristo Nuutila et al.
Bioactive materials, 8, 296-308 (2021-09-21)
Acute and chronic wounds affect millions of people around the world, imposing a growing financial burden on patients and hospitals. Despite the application of current wound management strategies, the physiological healing process is disrupted in many cases, resulting in impaired
Yeontaek Lee et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(15), e2100231-e2100231 (2021-06-05)
Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration
Annabel Braem et al.
ACS applied materials & interfaces, 9(10), 8533-8546 (2017-02-18)
One prominent cause of implant failure is infection; therefore, research is focusing on developing surface coatings that render the surface resistant to colonization by micro-organisms. Permanently attached coatings of antimicrobial molecules are of particular interest because of the reduced cytoxicity
Janis C Weeks et al.
International journal for parasitology. Drugs and drug resistance, 6(3), 314-328 (2016-10-19)
The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device ('chip') that records non-invasively the tiny electrophysiological signals generated
Erica D'Aguanno et al.
Life (Basel, Switzerland), 5(1), 969-996 (2015-03-21)
How did primitive living cells originate? The formation of early cells, which were probably solute-filled vesicles capable of performing a rudimentary metabolism (and possibly self-reproduction), is still one of the big unsolved questions in origin of life. We have recently
Edna Soares et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 131, 33-43 (2018-07-27)
The development of new vaccine adjuvants is urgently needed not only to enable new routes of vaccine administration but mostly to go beyond protective humoral immunity, often insufficient to fight infectious diseases. The association of two or more immunopotentiators or
Samar Damiati et al.
Biophysical chemistry, 251, 106178-106178 (2019-05-19)
Development of synthetic bioarchitectures to improve our understanding of biological systems and produce biosynthetic models with new functions has attracted substantial interest. Synthetic HDL-like phospholipid nanodiscs are a relatively new model of nanoparticles that present a promising carrier for drug
Jing Chen et al.
PLoS genetics, 10(10), e1004688-e1004688 (2014-10-31)
Spinster homolog 2 (Spns2) acts as a Sphingosine-1-phosphate (S1P) transporter in zebrafish and mice, regulating heart development and lymphocyte trafficking respectively. S1P is a biologically active lysophospholipid with multiple roles in signalling. The mechanism of action of Spns2 is still
Tine Van Bergen et al.
Investigative ophthalmology & visual science, 62(13), 18-18 (2021-10-23)
To investigate the effect of plasma kallikrein (PKal)-inhibition by THR-149 on preventing key pathologies associated with diabetic macular edema (DME) in a rat model. Following streptozotocin-induced diabetes, THR-149 or its vehicle was administered in the rat via either a single
Antonio Brante et al.
The Journal of experimental biology, 212(Pt 14), 2287-2295 (2009-06-30)
Encapsulation is a common strategy among marine invertebrate species. It has been shown that oxygen and food availability independently constrain embryo development during intracapsular development. However, it is unclear how embryos of species with different feeding strategies perceive these two
G J Wu et al.
Poultry science, 89(3), 457-463 (2010-02-26)
Earlier experimental data in our laboratory showed that introduction of an exogenous protein into early chicken embryonic blood leads to immunotolerance of hatched chicken to that protein. However, the underlying mechanism is yet unknown. In the present study, we show
Vinod Kumar et al.
Journal of neurochemistry, 158(3), 807-817 (2020-07-07)
The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are highly specialized structures that limit molecule entry from the blood and maintain homeostasis within the central nervous system (CNS). BBB and BSCB breakdown are associated with multiple neurodegenerative diseases. Given
Jimena S Gonzalez et al.
Polymers, 11(4) (2019-04-20)
Self-assembly of natural polymers constitute a powerful route for the development of functional materials. In particular, layer-by-layer (LBL) assembly constitutes a versatile technique for the nanostructuration of biobased polymers into multilayer films. Gelatin has gained much attention for its abundance
Takeyuki Miyawaki et al.
Nature communications, 11(1), 1104-1104 (2020-02-29)
Structural elucidation and molecular scrutiny of cerebral vasculature is crucial for understanding the functions and diseases of the brain. Here, we introduce SeeNet, a method for near-complete three-dimensional visualization of cerebral vascular networks with high signal-to-noise ratios compatible with molecular
Emily J Ross et al.
Scientific reports, 11(1), 14053-14053 (2021-07-09)
The kidney proximal tubule is the primary site for solute reabsorption, secretion and where kidney diseases can originate, including drug-induced toxicity. Two-dimensional cell culture systems of the human proximal tubule cells (hPTCs) are often used to study these processes. However
Molecular mechanisms of proteinuria
Molecular and Genetic Basis of Renal Disease (2008)
Sulabh Patel et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 95(Pt B), 407-417 (2015-06-03)
The stability of protein therapeutics during the residence time in the vitreous humor (VH) is an important consideration for intra ocular treatment and can possibly impact therapeutic efficacy and/or treatment intervals. Unavailability of the reliable Ex-vivo intravitreal (ExVit) model to
Stefanie Heiden et al.
Cellular and molecular life sciences : CMLS, 78(7), 3657-3672 (2021-03-03)
Apical-basal polarity is a key feature of most epithelial cells and it is regulated by highly conserved protein complexes. In mammalian podocytes, which emerge from columnar epithelial cells, this polarity is preserved and the tight junctions are converted to the
Junki Oh et al.
Polymers, 11(9) (2019-09-25)
In this work, the amine-epoxy "click" reaction is shown to be a valuable general tool in the synthesis of reactive hydrogels. The practicality of this reaction arises due to its catalyst-free nature, its operation in water, and commercial availability of
Kyomin Chae et al.
Science advances, 6(44) (2020-10-30)
Bacterial infection and infection-induced immune response have been a life-threatening risk for patients having orthopedic implant surgeries. Conventional biomaterials are vulnerable to biocontamination, which causes bacterial invasion in wounded areas, leading to postoperative infection. Therefore, development of anti-infection and immune-evasive
Jinhui Zhang et al.
PloS one, 10(3), e0122572-e0122572 (2015-03-31)
Middle ear infection (or inflammation) is the most common pathological condition that causes fluid to accumulate in the middle ear, disrupting cochlear homeostasis. Lipopolysaccharide, a product of bacteriolysis, activates macrophages and causes release of inflammatory cytokines. Many studies have shown
Katie J Schenning et al.
Physiological reports, 3(3), doi:10-doi:10 (2015-03-26)
In preclinical investigations, ischemic preconditioning (IPC) protects kidneys from ischemia/reperfusion injury. The direct effects of IPC on glomerular endothelial cells have not been studied in detail. Most investigations of IPC have focused on healthy cells and animals, and it remains
Prasanta K Dash et al.
Scientific reports, 10(1), 9746-9746 (2020-06-18)
The molecular cause(s) for early onset heart failure in people living with HIV-1 infection (PLWH) remains poorly defined. Herein, longitudinal echocardiography was used to assess whether NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice reconstituted with human hematopoietic stem cells (Hu-NSG mice) and infected with
Elsayed G E Elsakka et al.
Life sciences, 251, 117628-117628 (2020-04-06)
Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expression in the kidney tissues
Ji-Hee Kim et al.
Nature communications, 12(1), 6537-6537 (2021-11-13)
Podocyte, the gatekeeper of the glomerular filtration barrier, is a primary target for growth factor and Ca2+ signaling whose perturbation leads to proteinuria. However, the effects of insulin action on store-operated Ca2+ entry (SOCE) in podocytes remain unknown. Here, we
Simon F Merz et al.
Nature communications, 10(1), 2312-2312 (2019-05-28)
Cardioprotection by salvage of the infarct-affected myocardium is an unmet yet highly desired therapeutic goal. To develop new dedicated therapies, experimental myocardial ischemia/reperfusion (I/R) injury would require methods to simultaneously characterize extent and localization of the damage and the ensuing
Timothy S Kern et al.
Molecular pharmacology, 100(5), 470-479 (2021-08-17)
We compared monotherapies and combinations of therapies that regulate G-protein-coupled receptors (GPCRs) with respect to their abilities to inhibit early stages of diabetic retinopathy (DR) in streptozotocin-diabetic mice. Metoprolol (MTP; 0.04-1.0 mg/kg b.wt./day), bromocriptine (BRM; 0.01-0.1 mg/kg b.wt./day), doxazosin (DOX;
Alessio Fanti et al.
Integrative biology : quantitative biosciences from nano to macro, 10(1), 6-17 (2017-12-13)
A key process of protocell behaviour is their recursive growth and division. In order to be sustainable, the latter must be characterized by an even and homogeneous partition of the solute molecules initially present in the parent protocell among the
Yifan Xia et al.
Scientific reports, 10(1), 18488-18488 (2020-10-30)
The breadth of brain disorders and functions reported responsive to transcranial direct current stimulation (tDCS) suggests a generalizable mechanism of action. Prior efforts characterized its cellular targets including neuron, glia and endothelial cells. We propose tDCS also modulates the substance
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