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Showing 1-30 of 53 results for "AB1128" within Papers
Krist Helen Antunes et al.
Scientific reports, 9(1), 17766-17766 (2019-11-30)
Respiratory syncytial virus (RSV) is a common cause of childhood lower respiratory tract infections. The recent failure of a vaccine candidate based on recombinant F protein underlines the urgent need to better understand the protective human memory immune response against
Krist Helen Antunes et al.
Frontiers in immunology, 13, 867022-867022 (2022-05-24)
Respiratory syncytial virus (RSV) is a seasonal pathogen responsible for the highest percentage of viral bronchiolitis in pediatric patients. There are currently no vaccine available and therapeutic methods to mitigate the severity of RSV bronchiolitis are limited. OM-85, an oral
An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25.
Van Royen, et al.
Journal of virology, 96, e0129722-e0129722 (2022)
Shingo Umemoto et al.
NPJ vaccines, 8(1), 106-106 (2023-07-25)
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins of RSV (proteins F and G) have been tested; however, they
M P Rubach et al.
Transplant infectious disease : an official journal of the Transplantation Society, 15(4), E152-E156 (2013-06-04)
We describe a case of pericarditis and large pericardial effusion in a 63-year-old African-American man undergoing autologous hematopoietic stem cell transplant for multiple myeloma. Pericardial tissue biopsy demonstrated fibrinous pericarditis, and immunohistochemistry stains were positive for respiratory syncytial virus. The
Respiratory syncytial virus represses glucocorticoid receptor-mediated gene activation.
Hinzey, A; Alexander, J; Corry, J; Adams, KM; Claggett, AM; Traylor, ZP; Davis et al.
Endocrinology null
Sarhad Alnajjar et al.
PloS one, 16(3), e0235026-e0235026 (2021-03-12)
Respiratory syncytial virus (RSV) is the primary cause of viral bronchiolitis resulting in hospitalization and a frequent cause of secondary respiratory bacterial infection, especially by Streptococcus pneumoniae (Spn) in infants. While murine studies have demonstrated enhanced morbidity during a viral/bacterial
Eigo Kawahara et al.
Frontiers in immunology, 14, 1282016-1282016 (2024-01-04)
Respiratory syncytial virus (RSV) vaccines targeting the fusion glycoprotein (F protein) are highly effective clinically in preventing RSV challenges. The attachment glycoprotein (G protein) is a potentially effective vaccine antigen candidate, as it is important for cell adhesion during infection.
Protein kinase C-alpha activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells.
San-Juan-Vergara, H; Peeples, ME; Lockey, RF; Mohapatra, SS
Journal of virology null
Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cells.
Che, et al.
Molecular Biology Reports, 50, 4261-4272 (2023)
IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent.
K K Tekkanat, H F Maassab, D S Cho, J J Lai, A John, A Berlin, M H Kaplan, N W Lukacs et al.
Journal of immunology (Baltimore, Md. : 1950) (1950)
Karen J Gonzalez et al.
Nature communications, 15(1), 1335-1335 (2024-02-14)
Many pathogenic viruses rely on class I fusion proteins to fuse their viral membrane with the host cell membrane. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion state to an
Iebe Rossey et al.
Nature communications, 8, 14158-14158 (2017-02-15)
Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection. The prefusion conformation
Casey Ward et al.
PloS one, 12(10), e0184629-e0184629 (2017-10-14)
Human Respiratory Syncytial Virus (HRSV) is a leading cause of bronchopneumonia in infants and the elderly. To date, knowledge of viral and host protein interactions within HRSV is limited and are critical areas of research. Here, we show that HRSV
Loes van Schie et al.
mAbs, 15(1), 2210709-2210709 (2023-05-22)
As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of VHHs, we explored the VHH scaffold in
Pooja Munnilal Tiwari et al.
Nature communications, 9(1), 3999-3999 (2018-10-03)
The lung is a critical prophylaxis target for clinically important infectious agents, including human respiratory syncytial virus (RSV) and influenza. Here, we develop a modular, synthetic mRNA-based approach to express neutralizing antibodies directly in the lung via aerosol, to prevent
Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.
De Baets, S; Schepens, B; Sedeyn, K; Schotsaert, M; Roose, K; Bogaert, P; Fiers, W; Saelens, X
Journal of virology null
Respiratory syncytial virus (RSV) suppression of glucocorticoid receptor phosphorylation does not account for repression of transactivation.
Webster Marketon, JI; Corry, J
FEBS Open Bio null
Molly K Roe et al.
The Journal of infectious diseases, 227(1), 50-60 (2022-10-26)
Respiratory syncytial virus (RSV) is a leading viral respiratory pathogen in infants. The objective of this study was to generate RSV live-attenuated vaccine (LAV) candidates by removing the G-protein mucin domains to attenuate viral replication while retaining immunogenicity through deshielding
Respiratory syncytial virus glycoproteins uptake occurs through clathrin-mediated endocytosis in a human epithelial cell line.
Abel Gutierrez-Ortega,Carla Sanchez-Hernandez,Beatriz Gomez-Garcia
Virology Journal null
Crystal Passmore et al.
Human vaccines & immunotherapeutics, 10(3), 615-622 (2013-12-12)
Respiratory Syncytial Virus (RSV) is a ubiquitous virus that infects almost all people by age two and is a major source of respiratory illness in infants, the elderly and others with compromised immune systems. Currently there is no available vaccine.
Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice.
Stokes, KL; Chi, MH; Sakamoto, K; Newcomb, DC; Currier, MG; Huckabee, MM; Lee et al.
Journal of virology null
Zhaolong Li et al.
EMBO reports, 21(1), e47528-e47528 (2019-12-05)
SAMHD1 possesses multiple functions, but whether cellular factors regulate SAMHD1 expression or its function remains not well characterized. Here, by investigating why cultured RD and HEK293T cells show different sensitivity to enterovirus 71 (EV71) infection, we demonstrate that SAMHD1 is
Sujin Lee et al.
Antiviral research, 111, 129-135 (2014-09-23)
Respiratory syncytial virus (RSV) is the most important pathogen for lower respiratory tract illness in infants and a high priority for vaccine development. We previously reported that RSV virus-like particles (VLPs) expressing either the fusion (F) or attachment (G) glycoprotein
Nanobodies? specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion.
Schepens, B; Iba?ez, LI; De Baets, S; Hultberg, A; Bogaert, P; De Bleser, P; Vervalle et al.
The Journal of Infectious Diseases null
Recurrent respiratory syncytial virus infections in allergen-sensitized mice lead to persistent airway inflammation and hyperresponsiveness.
H Matsuse, A K Behera, M Kumar, H Rabb, R F Lockey, S S Mohapatra
Journal of immunology (Baltimore, Md. : 1950) (1950)
Julien Sourimant et al.
Science advances, 8(25), eabo2236-eabo2236 (2022-06-25)
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections in infants and the immunocompromised, yet no efficient therapeutic exists. We have identified the AVG class of allosteric inhibitors of RSV RNA synthesis. Here, we demonstrate through biolayer
Krist Helen Antunes et al.
Nature communications, 10(1), 3273-3273 (2019-07-25)
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral
Zhaolong Li et al.
Journal of virology, 94(21) (2020-08-17)
Guanylate binding protein 5 (GBP5) belongs to the GTPase subfamily, which is mainly induced by interferon gamma (IFN-γ) and is involved in many important cellular processes, including inflammasome activation and innate immunity against a wide variety of microbial pathogens. However
Weidong Zhang et al.
Nature medicine, 11(1), 56-62 (2004-12-28)
Respiratory syncytial virus (RSV) infection is one of the major causes of respiratory tract infection for which no vaccine or antiviral treatment is available. The RSV NS1 protein seems to antagonize the host interferon (IFN) response; however, its mechanism is
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