Showing 1-13 of 13 results for "AB1253"
P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
Daniel L Gustafson, Michael E Long, Erica L Bradshaw, Andrea L Merz, Patrick J Kerzic
Cancer Chemotherapy and Pharmacology null
Marta Kot et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(12), 1336-1344 (2017-09-25)
Recent studies indicated an important role of the monoaminergic nervous systems (dopaminergic, noradrenergic, and serotonergic systems) and stress in the regulation of cytochrome P450 (CYP) expression and activity in the liver. The aim of our present research was to determine...
Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues.
Debri, K, et al.
Biochemical Pharmacology, 50, 2047-2056 (1995)
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Er-Jia Wang,George Mandakas,Jairam Palamanda,Xinjie Lin,Pramila Kumari,Inhou Chu et al.
Drug and Chemical Toxicology null
Satoshi Furukawa et al.
Journal of toxicologic pathology, 30(1), 79-107 (2017-02-14)
With the aims of sharing information about the technical aspects of immunohistochemistry (IHC) and making it possible to make a suitable choice of antibody for histopathological examination, this technical report describes the results of a questionnaire administered during the period...
Alterations in P-glycoprotein expression in mouse tissues by doxorubicin: implications for pharmacokinetics in multiple dosing regimens.
D L Gustafson, M E Long
Chemico-Biological Interactions null
Stephanie E Martinez et al.
Scientific reports, 10(1), 69-69 (2020-01-11)
Greyhounds recover more slowly from certain injectable anesthetics than other dog breeds. Previous studies implicate cytochrome P450 (CYP) 2B11 as an important clearance mechanism for these drugs and suggest Greyhounds are deficient in CYP2B11. However, no CYP2B11 gene mutations have...
F P Guengerich
Annual review of pharmacology and toxicology, 39, 1-17 (1999-05-20)
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues...
Shaoqing Ni et al.
Biopharmaceutics & drug disposition, 29(9), 501-510 (2008-12-06)
Cytochrome P-450 3A (CYP3A) together with its nuclear receptors plays a critical role in drug metabolism. The present study investigated the effects of undernutrition in utero on hepatic mRNA and protein expression of the enzyme CYP3A23/3A1 and nuclear receptors including...
Masami Doi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(5), 506-514 (2019-08-14)
The inductive effects of dexamethasone on hepatic midazolam metabolism were examined in Wistar rats with acute renal failure (ARF) to clarify whether the ARF-related decrease in the hepatic expression of drug-metabolizing enzymes is caused by an impairment in the translation/polypeptide...
Kimberly C Day et al.
American journal of physiology. Lung cellular and molecular physiology, 291(1), L75-L83 (2006-02-08)
A major cause of death and illness in children under the age of five, most living in polluted cities, is respiratory disease. Previous studies have shown that neonatal animals are more susceptible to bioactivated pulmonary cytotoxicants than adults, despite lower...
Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4alpha in large-for-gestational-age neonatal rats.
Shaoqing Ni, Xiumin Wang, Jue Wang, Su Zeng, Zhengyan Zhao, Shaoqing Ni, Xiumin Wang et al.
Pharmazie null
Philip Martin et al.
Acta pharmacologica Sinica, 31(1), 51-65 (2010-01-06)
The aim of this study was to investigate the impact on expression of mRNA and protein by paradigm inducers/activators of nuclear receptors and their target genes in rat hepatic and intestinal cells. Furthermore, assess marked inter laboratory conflicting reports regarding...

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