Search Within
ab152
Applied Filters:
Keyword:'ab152'
Showing 1-30 of 1252 results for "ab152" within Papers
Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.
Hennis, MR; Marvin, MA; Taylor, CM; Goldberg, MS
Neurobiology of Disease null
Dusti Shay et al.
International journal of molecular sciences, 25(11) (2024-06-19)
Declining estrogen (E2) leads to physical inactivity and adipose tissue (AT) dysfunction. Mechanisms are not fully understood, but E2's effects on dopamine (DA) activity in the nucleus accumbens (NAc) brain region may mediate changes in mood and voluntary physical activity
Pascale Malapert et al.
iScience, 27(4), 109396-109396 (2024-03-21)
The recent development of single-cell and single-nucleus RNA sequencing has highlighted the extraordinary diversity of dorsal root ganglia neurons. However, the few available genetic tools limit our understanding of the functional significance of this heterogeneity. We generated a new mouse
Li-Hsien Lin et al.
The Journal of physiology, 590(15), 3545-3559 (2012-06-13)
Despite numerous studies it remains controversial whether nitric oxide (NOĀ·) synthesized by neuronal NOS (nNOS) plays an excitatory or inhibitory role in transmission of baroreflex signals in the nucleus tractus solitarii (NTS). In the current studies we sought to test
Jungwoo Wren Kim et al.
Cell stem cell, 27(4), 633-645 (2020-08-28)
The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via dysregulated protein translation, although how alterations in protein synthesis contribute to neurodegeneration in human neurons
Stephen X Zhang et al.
Nature, 597(7875), 245-249 (2021-08-27)
Transient neuromodulation can have long-lasting effects on neural circuits and motivational states1-4. Here we examine the dopaminergic mechanisms that underlie mating drive and its persistence in male mice. Brief investigation of females primes a male's interest to mate for tens
Joanne Ng et al.
Science translational medicine, 13(594) (2021-05-21)
Most inherited neurodegenerative disorders are incurable, and often only palliative treatment is available. Precision medicine has great potential to address this unmet clinical need. We explored this paradigm in dopamine transporter deficiency syndrome (DTDS), caused by biallelic loss-of-function mutations in
Alexandra Tallafuss et al.
eNeuro, 9(2) (2022-03-30)
Finding the link between behaviors and their regulatory molecular pathways is a major obstacle in treating neuropsychiatric disorders. The immediate early gene (IEG) EGR1 is implicated in the etiology of neuropsychiatric disorders, and is linked to gene pathways associated with
Susan van Erp et al.
Experimental neurology, 339, 113594-113594 (2021-01-16)
Regeneration capacity is reduced as CNS axons mature. Using laser-mediated axotomy, proteomics and puromycin-based tagging of newly-synthesized proteins in a human embryonic stem cell-derived neuron culture system that allows isolation of axons from cell bodies, we show here that efficient
Maria HernƔndez et al.
Investigative ophthalmology & visual science, 51(12), 6793-6802 (2010-07-31)
Leber congenital amaurosis (LCA) is a group of childhood-onset retinal diseases characterized by severe visual impairment or blindness. One form is caused by mutations in the RPE65 gene, which encodes the retinal pigment epithelium (RPE) isomerase. In this study, the
Properties and modulation of excitatory inputs to the locus coeruleus.
Barcomb, et al.
The Journal of physiology, 600, 4897-4916 (2023)
Sheng Song et al.
Scientific reports, 10(1), 15054-15054 (2020-09-16)
This study examined the genetic mutation and toxicant exposure in producing gut microbiota alteration and neurotoxicity. Homozygous Ī±-synuclein mutant (SNCA) mice that overexpress human A53T protein and littermate wild-type mice received a single injection of LPS (2Ā mg/kg) or a selective
Casey L Mahoney-Crane et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(3), 501-521 (2023-01-15)
The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutations GBA1, which encodes for the lysosomal enzyme, glucocerebrosidase. Reduced glucocerebrosidase activity associates with an accumulation of abnormal Ī±-synuclein (Ī±-syn) called Lewy pathology, which characterizes PD. PD patients
Abdulaziz H Almuhanna et al.
Equine veterinary journal, 53(6), 1188-1198 (2020-12-19)
Horses are affected by various peripheral nerve disorders but defining their aetiology and pathophysiology is hampered by limited understanding of associated morphological and pathological changes and involvement of specific axonal types. To investigate the hypothesis that selected antibody markers, used
Patrick C Kerstein et al.
Cell reports, 33(7), 108382-108382 (2020-11-19)
Our understanding of nervous system function is limited by our ability to identify and manipulate neuronal subtypes within intact circuits. We show that the Gbx2CreERT2-IRES-EGFP mouse line labels two amacrine cell (AC) subtypes in the mouse retina that have distinct
Hui Dong et al.
Current biology : CB, 32(3), 600-613 (2022-01-13)
Patients with Parkinson's disease (PD) suffer from severe sleep disorders. Pathophysiology of the basal ganglia (BG) underlies PD, and the dorsal striatum represents the major input pathway of the BG. However, the roles and mechanisms of the dorsal striatum in
Rahul Sachdeva et al.
Journal of neurotrauma, 37(18), 1963-1970 (2020-05-13)
Individuals living with chronic spinal cord injury (SCI) often exhibit impairments in cognitive function, which impede their rehabilitation and transition into the community. Although a number of clinical studies have demonstrated the impact of impaired cardiovascular control on cognitive impairment
Tommi P KilpelƤinen et al.
Journal of medicinal chemistry, 66(11), 7475-7496 (2023-05-30)
Prolyl oligopeptidase (PREP) is a widely distributed serine protease in the human body cleaving proline-containing peptides; however, recent studies suggest that its effects on pathogenic processes underlying neurodegeneration are derived from direct protein-protein interactions (PPIs) and not from its regulation
Bjƶrn Reinius et al.
Frontiers in behavioral neuroscience, 9, 71-71 (2015-04-15)
The striatum serves as the main input to the basal ganglia, and is key for the regulation of motor behaviors, compulsion, addiction, and various cognitive and emotional states. Its deterioration is associated with degenerative disorders such as Huntington's disease. Despite
Francisco Javier Maza et al.
The Journal of comparative neurology, 529(3), 501-523 (2020-06-03)
The hypothesis of a common origin for high-order memory centers in bilateral animals presents the question of how different brain structures, such as the vertebrate hippocampus and the arthropod mushroom bodies, are both structurally and functionally comparable. Obtaining evidence to
Thomas Steinkellner et al.
ACS chemical neuroscience, 12(4), 626-639 (2021-02-02)
Communication between neurons relies on the release of diverse neurotransmitters, which represent a key-defining feature of a neuron's chemical and functional identity. Neurotransmitters are packaged into vesicles by specific vesicular transporters. However, tools for labeling and imaging synapses and synaptic
Matthew L Neal et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 1679-1694 (2020-01-10)
Increased pro-inflammatory cytokine levels and proliferation of activated microglia have been found in Parkinson's disease (PD) patients and animal models of PD, suggesting that targeting of the microglial inflammatory response may result in neuroprotection in PD. Microglial proliferation is regulated
Fares J P Sayegh et al.
Nature communications, 15(1), 4100-4100 (2024-05-22)
In most models of neuronal plasticity and memory, dopamine is thought to promote the long-term maintenance of Long-Term Potentiation (LTP) underlying memory processes, but not the initiation of plasticity or new information storage. Here, we used optogenetic manipulation of midbrain
Lithium protects against oxidative stress-mediated cell death in ?-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease.
Kim, YH; Rane, A; Lussier, S; Andersen, JK
Journal of Neuroscience Research null
Tina Schubert et al.
Journal of the Endocrine Society, 6(6), bvac062-bvac062 (2022-05-21)
Steroid 21-hydroxylase is an enzyme of the steroid pathway that is involved in the biosynthesis of cortisol and aldosterone by hydroxylation of 17Ī±-hydroxyprogesterone and progesterone at the C21 position. Mutations in CYP21A2, the gene encoding 21-hydroxylase, cause the most frequent
Giampaolo Bosi et al.
Animals : an open access journal from MDPI, 10(9) (2020-08-28)
On the basis of trophic behavior, fish are classified as herbivores, carnivores, omnivores, or detritivores. Epithelial mucous cells secrete mucin types specific to diet and digestive function. Mucus secretion is regulated mainly by molecular modulators produced by epithelial endocrine cells
Elena Kotsyuba et al.
Biology, 13(1) (2024-01-22)
This article presents recent findings as regards distribution of cells producing serotonin and dopamine in the larval central nervous system at different developmental stages, including four pelagic larval stages (zoea I-IV), a semibenthic postlarval stage glaucothoe (megalopa), benthic juveniles, and
S Qiu et al.
Anatomia, histologia, embryologia, 42(2), 144-150 (2012-07-06)
The distribution of adrenal chromaffin cells in the control beagle dog was investigated. The presence of chromaffin cells in the adrenal medulla, three zones of the adrenal cortex and capsule was identified by staining with H&E, chromium salts and TH
Abubakar Atiq et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Trolox is a potent antioxidant and a water-soluble analog of vitamin E. It has been used in scientific studies to examine oxidative stress and its impact on biological systems. Trolox has been shown to have a neuroprotective effect against ischemia
Maxime FougĆØre et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(43) (2021-10-22)
In Parkinson's disease (PD), the loss of midbrain dopaminergic cells results in severe locomotor deficits, such as gait freezing and akinesia. Growing evidence indicates that these deficits can be attributed to the decreased activity in the mesencephalic locomotor region (MLR)
Page 1 of 42