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Stephanie L Yahn et al.
Neurobiology of disease, 134, 104674-104674 (2019-11-16)
Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environment including
Verena Klemis et al.
Kidney international, 91(6), 1374-1385 (2017-02-06)
Fibronectin is ubiquitously expressed in the extracellular matrix, and its accumulation in the glomerular mesangium in diabetic nephropathy is associated with deterioration of renal function in these patients. However, the exact role of fibronectin in the pathogenesis of diabetic nephropathy
Karla Rubio et al.
Nature communications, 10(1), 2229-2229 (2019-05-22)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly due to respiratory failure. Current treatments against IPF aim to ameliorate patient
Jiawen Fan et al.
Theranostics, 10(18), 7956-7973 (2020-07-30)
Rationale: The Notch and transforming growth factor-β (TGFβ) signaling pathways are two intracellular mechanisms that control fibrosis in general but whether they play a major role in retinal fibrosis is less clear. Here we study how these two signaling pathways
Joannie M Allaire et al.
International journal of cancer, 138(11), 2700-2712 (2016-01-17)
In the colon, myofibroblasts are primary contributors in the establishment of the microenvironment involved in tissue homeostasis. Alterations in myofibroblast functions lead to changes resulting in a toxic microenvironment nurturing tumorigenesis. Bone morphogenetic proteins (Bmps) are morphogens known to play
Sandrine Levet et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(25), E3207-E3215 (2015-06-10)
The transition to pulmonary respiration after birth requires rapid alterations in the structure of the mammalian cardiovascular system. One dramatic change that occurs is the closure of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood
Ashok Mittal et al.
Mechanisms of development, 127(9-12), 472-484 (2010-09-03)
Cardiac neural crest (CNC) plays a requisite role during cardiovascular development and defects in the formation of CNC-derived structures underlie several common forms of human congenital birth defects. Migration of the CNC cells to their destinations as well as expansion
Jing Qin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(41), 9925-9938 (2017-09-14)
Remyelination failure by oligodendrocytes contributes to the functional impairment that characterizes the demyelinating disease multiple sclerosis (MS). Since incomplete remyelination will irreversibly damage axonal connections, treatments effectively promoting remyelination are pivotal in halting disease progression. Our previous findings suggest that
Hernán Morales-Navarrete et al.
eLife, 8 (2019-06-18)
Functional tissue architecture originates by self-assembly of distinct cell types, following tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was pioneered by Elias in 1949. This model, however, is in contrast with the apparent
María Benito-Jardón et al.
The Journal of cell biology, 219(12) (2020-11-04)
Fibronectin (FN) is an essential glycoprotein of the extracellular matrix; binds integrins, syndecans, collagens, and growth factors; and is assembled by cells into complex fibrillar networks. The RGD motif in FN facilitates cell binding- and fibrillogenesis through binding to α5β1
Bárbara Oujo et al.
PloS one, 9(10), e110365-e110365 (2014-10-15)
Transforming growth factor-β (TGF-β) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-β co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains uncertain. Two membrane isoforms
Samuel R Beckerman et al.
Assay and drug development technologies, 13(7), 377-388 (2015-08-01)
Astrocyte phenotypes change in a process called reactive gliosis after traumatic central nervous system (CNS) injury. Astrogliosis is characterized by expansion of the glial fibrillary acidic protein (GFAP) cytoskeleton, adoption of stellate morphologies, and differential expression of some extracellular matrix
Holly C Williams et al.
Laboratory investigation; a journal of technical methods and pathology, 99(3), 399-410 (2018-10-07)
The dual specificity phosphatase slingshot homolog 1 (SSH1) contributes to actin remodeling by dephosphorylating and activating the actin-severing protein cofilin. The reorganization of the actin cytoskeleton has been implicated in chronic hypertension and the subsequent mechano-adaptive rearrangement of vessel wall
Plasma fibronectin is neuroprotective following traumatic brain injury.
Ciara C Tate, Andres J Garcia, Michelle C LaPlaca
Experimental neurology null
Alfonso Rubio-Navarro et al.
Theranostics, 6(6), 896-914 (2016-05-11)
Macrophages play an important role in rhabdomyolysis-acute kidney injury (AKI), although the molecular mechanisms involved in macrophage differentiation are poorly understood. We analyzed the expression and regulation of CD163, a membrane receptor mainly expressed by anti-inflammatory M2 macrophages, in rhabdomyolysis-AKI
null
Naohiro Yano et al.
The Biochemical journal, 423(1), 129-143 (2009-07-17)
Diabetic nephropathy is associated with mesangial ECM (extracellular matrix) accumulation. We have shown that AT-1R [Ang II (angiotensin II) type I receptor] signalling induces ECM proteins via transactivation of PI3K (phosphoinositide 3-kinase) in mesangial cells. In the present study, we
Tao-Yi Cai et al.
Molecular medicine reports, 8(5), 1323-1328 (2013-09-07)
Mesenchymal stem cells (MSCs) differentiate into numerous different cell types and thus have therapeutic potential for tissue engineering, anti‑inflammatory and immunomodulatory purposes. FGF2 may affect the biological behavior of MSCs. MSCs were transduced with either adenovirus‑null vector/green fluorescent protein (GFP)
Mohamad Azhar et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(2), 431-442 (2009-01-24)
The ligand specificity of transforming growth factor beta (TGFbeta) in vivo in mouse cardiac cushion epithelial-to-mesenchymal transition (EMT) is poorly understood. To elucidate the function of TGFbeta in cushion EMT, we analyzed Tgfb1(-/-), Tgfb2(-/-), and Tgfb3(-/-) mice between embryonic day
Martin Kragl et al.
Nature communications, 7, 13560-13560 (2016-12-21)
An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues derived from pancreatic epithelium. We find that depletion of integrin-linked kinase (ILK) in the pancreatic epithelial cells
Ting-Hein Lee et al.
Journal of biomedical science, 26(1), 37-37 (2019-05-18)
The blood-spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. Endothelial permeability is regulated by interaction between endothelial cells and ECM
Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium.
Holtz, ML; Misra, RP
BMC Developmental Biology null
D S Whitlon et al.
Neuroscience, 161(1), 227-235 (2009-03-28)
Evidence from developmental and regeneration studies of the cochlea and other tissues gives reason to hypothesize a role for nonneural cells in the growth and regeneration of cochlear spiral ganglion nerve fibers. We examined the spontaneous associations of regrowing neurites
Katsutoshi Sekine et al.
Neuron, 76(2), 353-369 (2012-10-23)
Birthdate-dependent neuronal layering is fundamental to neocortical functions. The extracellular protein Reelin is essential for the establishment of the eventual neuronal alignments. Although this Reelin-dependent neuronal layering is mainly established by the final neuronal migration step called "terminal translocation" beneath
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis.
Reticker-Flynn, NE; Malta, DF; Winslow, MM; Lamar, JM; Xu, MJ; Underhill, GH; Hynes et al.
Nature Communications null
Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling.
Yiu-Fai Chen, Ji-An Feng, Peng Li, Dongqi Xing, Namasivayam Ambalavanan, Suzanne Oparil
Life Sciences null
Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.
Chen, YF; Feng, JA; Li, P; Xing, D; Zhang, Y; Serra, R; Ambalavanan, N; Majid-Hassan, E; Oparil, S
Journal of Applied Physiology (1985)
Rut Tejero et al.
EBioMedicine, 42, 252-269 (2019-04-07)
Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducible
Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.
Li YC, Chen BM, Wu PC, Cheng TL, Kao LS, Tao MH, Lieber A, Roffler SR
Journal of immunology (Baltimore, Md. : 1950) null
Marina Theodosiou et al.
eLife, 5, e10130-e10130 (2016-01-29)
Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to activate β1 integrins
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