Showing 1-30 of 228 results for "AB3786"
Atanu Chakraborty et al.
Nature communications, 6, 6782-6782 (2015-04-09)
The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterized, the mechanism of activation by Ras was elusive. Here we identify the uncharacterized...
Christian C Hofer et al.
American journal of physiology. Lung cellular and molecular physiology, 308(7), L628-L638 (2015-01-18)
Influenza viruses cause acute respiratory disease of great importance to public health. Alveolar type II (ATII) respiratory epithelial cells are central to normal lung function and are a site of influenza A virus replication in the distal lung. However, the...
Tomoya Sagawa et al.
Environmental research, 195, 110722-110722 (2021-01-11)
Coronavirus disease (COVID-19) is currently a serious global issue. Epidemiological studies have identified air pollutants, including particulate matter (PM), as a risk factor for COVID-19 infection and severity of illness, in addition to numerous factors such as pre-existing conditions, aging...
Julia A Paxson et al.
PloS one, 6(8), e23232-e23232 (2011-09-14)
While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We measured the age-specific (3, 9, 24 month) effects of PNX...
Beiyun Zhou et al.
The Journal of clinical investigation, 128(3), 970-984 (2018-02-06)
Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we demonstrated that knockout of Cldn18, a claudin family member highly expressed...
Stefan Schob et al.
PloS one, 8(9), e74412-e74412 (2013-10-08)
Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system. The ability of surfactant...
Samriddha Ray et al.
Stem cell reports, 7(5), 817-825 (2016-10-25)
Recent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial. We sought to determine the cellular dynamics...
Aernoud A van Batenburg et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 66(7), 485-495 (2018-03-13)
Telomeres are small repetitive DNA sequences at the ends of chromosomes which act as a buffer in age-dependent DNA shortening. Insufficient telomere repeats will be recognized as double-strand breaks. Presently, it is becoming more evident that telomere attrition, whether or...
Andrew E Vaughan et al.
Nature, 517(7536), 621-625 (2014-12-24)
Broadly, tissue regeneration is achieved in two ways: by proliferation of common differentiated cells and/or by deployment of specialized stem/progenitor cells. Which of these pathways applies is both organ- and injury-specific. Current models in the lung posit that epithelial repair...
Wenguang Yin et al.
The European respiratory journal, 53(3) (2018-12-24)
Epithelial tubes, comprised of polarised epithelial cells around a lumen, are crucial for organ function. However, the molecular mechanisms underlying tube formation remain largely unknown. Here, we report on the function of fibrillin (FBN)2, an extracellular matrix (ECM) glycoprotein, as...
R A Morotti et al.
Human pathology, 30(6), 618-625 (1999-06-22)
Congenital cystic adenomatoid malformation of the lung (CCAM) is a rare congenital lesion whose pathogenesis is not well defined. It is generally accepted that the various types of CCAMs originate at different levels of the tracheobronchial tree. To further define...
Ah-Young Oh et al.
Cancer research, 76(16), 4791-4804 (2016-06-16)
The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this...
Melinda E Snitow et al.
Development (Cambridge, England), 142(1), 108-117 (2014-12-18)
The development of the lung epithelium is regulated in a stepwise fashion to generate numerous differentiated and stem cell lineages in the adult lung. How these different lineages are generated in a spatially and temporally restricted fashion remains poorly understood...
Katsuhiro Kato et al.
Nature communications, 9(1), 2448-2448 (2018-06-24)
Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells. Endothelial tubules are associated with specialised mesenchymal cells, termed pericytes, which help...
Shahin Rafii et al.
Nature cell biology, 17(2), 123-136 (2015-01-27)
The lung alveoli regenerate after surgical removal of the left lobe by pneumonectomy (PNX). How this alveolar regrowth/regeneration is initiated remains unknown. We found that platelets trigger lung regeneration by supplying stromal-cell-derived factor-1 (SDF-1, also known as CXCL12). After PNX...
Christian Reinke et al.
American journal of physiology. Lung cellular and molecular physiology, 300(2), L266-L273 (2010-12-07)
Obstructive sleep apnea (OSA) increases cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O(2)...
R D Nolen-Walston et al.
American journal of physiology. Lung cellular and molecular physiology, 294(6), L1158-L1165 (2008-04-01)
Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. Whereas postnatal regeneration of alveolar tissue has been attributed to type II alveolar...
Crystal N Marconett et al.
PLoS genetics, 9(6), e1003513-e1003513 (2013-07-03)
Elucidation of the epigenetic basis for cell-type specific gene regulation is key to gaining a full understanding of how the distinct phenotypes of differentiated cells are achieved and maintained. Here we examined how epigenetic changes are integrated with transcriptional activation...
Conditional overexpression of TGF?1 promotes pulmonary inflammation, apoptosis and mortality via TGF?R2 in the developing mouse lung.
Sureshbabu, A; Syed, MA; Boddupalli, CS; Dhodapkar, MV; Homer, RJ; Minoo, P; Bhandari, V
Respiratory Research null
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq.
Treutlein, B; Brownfield, DG; Wu, AR; Neff, NF; Mantalas, GL; Espinoza, FH; Desai et al.
Nature null
Correlation of apical fluid-regulating channel proteins with lung function in human COPD lungs.
Zhao, R; Liang, X; Zhao, M; Liu, SL; Huang, Y; Idell, S; Li, X; Ji, HL
Testing null
Johanna Finn et al.
Cell reports, 26(11), 2942-2954 (2019-03-14)
Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface area, are responsible for gas exchange, whereas AT2 serve multiple functions, including alveolar repair...
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice.
Santos, AM; Jung, J; Aziz, N; Kissil, JL; Pure, E
The Journal of Clinical Investigation null
Rocío Fuentes-Mateos et al.
Cell death & disease, 10(11), 838-838 (2019-11-07)
We reported previously that adult (HRAS-/-; NRAS-/-) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains...
Yao-Song Gui et al.
PloS one, 7(9), e46076-e46076 (2012-10-11)
Although several Cre-loxP-based gene knockout mouse models have been generated for the study of gene function in alveolar epithelia in the lung, their applications are still limited. In this study, we developed a SPC-Cre-ER(T2) mouse model, in which a tamoxifen-inducible...
Marco Mura et al.
The American journal of pathology, 176(4), 1725-1734 (2010-02-20)
Vascular endothelial growth factor-A (VEGF) is a potent regulator of vascular permeability, inflammatory response, and cell survival in the lung. To explore the functions of VEGF produced locally in type II pneumocytes, we generated mice with a conditional deletion of...
Aiqing Li et al.
PloS one, 8(5), e63578-e63578 (2013-05-23)
As a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors, the glucocorticoid receptor (GR) is essential for normal embryonic development. To date, the role of mesenchymal glucocorticoid signaling during development has not been fully elucidated. In the...
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal.
Rocio Sotillo,Juan-Manuel Schvartzman,Nicholas D Socci,Robert Benezra
Nature null
Geyon L Garcia et al.
The American journal of pathology, 190(3), 543-553 (2019-12-24)
Chronic obstructive pulmonary disease (COPD) and asthma remain prevalent human lung diseases. Variability in epithelial and inflammatory components that results in pathologic heterogeneity complicates the development of treatments for these diseases. Early childhood infection with parainfluenza virus or respiratory syncytial...

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