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Giuliana Pellegrino et al.
The Journal of comparative neurology, 526(9), 1419-1443 (2017-12-13)
The adult brain contains niches of neural stem cells that continuously add new neurons to selected circuits throughout life. Two niches have been extensively studied in various mammalian species including humans, the subventricular zone of the lateral ventricles and the
Lianwu Fu et al.
Journal of molecular and cellular cardiology, 89(Pt B), 241-250 (2015-11-26)
In a pure volume overloaded (VO) heart, interstitial collagen loss is degraded by matrix metalloproteinases (MMPs) that leads to left ventricular (LV) dilatation and heart failure. Cardiac fibroblasts are the primary source of extracellular matrix proteins that connect cardiomyocytes. The
Yue J Wang et al.
PloS one, 9(11), e113127-e113127 (2014-11-19)
The role of miRNA processing in the maintenance of adult pancreatic acinar cell identity and during the initiation and progression of pancreatic neoplasia has not been studied in detail. In this work, we deleted Dicer specifically in adult pancreatic acinar
Gábor Wittmann et al.
Endocrinology, 155(5), 2009-2019 (2014-03-08)
Thyroid hormone regulates immune functions and has antiinflammatory effects. In promoter assays, the thyroid hormone-activating enzyme, type 2 deiodinase (D2), is highly inducible by the inflammatory transcription factor nuclear factor-κ B (NF-κB), but it is unknown whether D2 is induced
Christopher S Morrow et al.
Cell stem cell, 26(4), 558-568 (2020-02-29)
Maintaining a healthy proteome throughout life is critical for proper somatic stem cell function, but the complexities of the stem cell response to increases in damaged or aggregated proteins remain unclear. Here we demonstrate that adult neural stem cells (NSCs)
Yanina L Petracca et al.
Development (Cambridge, England), 143(5), 880-891 (2016-02-04)
Considerable progress has been made in understanding the mechanisms that control the production of specialized neuronal types. However, how the timing of differentiation contributes to neuronal diversity in the developing spinal cord is still a pending question. In this study
Malin Olsen et al.
Molecular imaging and biology, 20(4), 605-614 (2018-01-04)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-beta (Aβ) deposition, hyperphosphorylation of tau, and neuroinflammation. Astrocytes, the most abundant glial cell type in the nervous system, respond to neurodegenerative disorders through astrogliosis, i.e., converting to a reactive inflammatory
Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.
Aguilera, KY; Rivera, LB; Hur, H; Carbon, JG; Toombs, JE; Goldstein, CD; Dellinger et al.
Cancer Research null
Mayuko Kano et al.
Endocrinology, 160(7), 1701-1718 (2019-05-29)
Tanycytes have recently been accepted as neural stem/progenitor cells in the postnatal hypothalamus. Persistent retina and anterior neural fold homeobox (Rax) expression is characteristic of tanycytes in contrast to its transient expression of whole hypothalamic precursors. In this study, we
Marie A Bentsen et al.
Nature communications, 11(1), 4458-4458 (2020-09-09)
In rodent models of type 2 diabetes (T2D), sustained remission of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1), and the mediobasal hypothalamus (MBH) was recently implicated as the brain area responsible
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Spike, BT; Engle, DD; Lin, JC; Cheung, SK; La, J; Wahl, GM
Cell Stem Cell null
Bong Ihn Koh et al.
Nature communications, 11(1), 3866-3866 (2020-08-02)
Upon severe head injury (HI), blood vessels of the meninges and brain parenchyma are inevitably damaged. While limited vascular regeneration of the injured brain has been studied extensively, our understanding of meningeal vascular regeneration following head injury is quite limited.
Amy M Bittel et al.
Scientific reports, 8(1), 4590-4590 (2018-03-17)
Multicolor microscopy tools necessary to localize and visualize the complexity of subcellular systems are limited by current fluorophore technology. While commercial fluorophores cover spectral space from the ultraviolet to the near infrared region and are optimized for conventional bandpass based
Ricardo Ceriani et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Recently, it has been shown in adult mammals that the hypothalamus can generate new cells in response to metabolic changes, and tanycytes, putative descendants of radial glia, can give rise to neurons. Previously we have shown in vitro that neurospheres
Jeonghoon Choi et al.
Development (Cambridge, England), 141(5), 1151-1160 (2014-02-08)
Layer-specific cortical neurons are essential components of local, intracortical and subcortical circuits and are specified by complex signaling pathways acting on cortical progenitors. However, whether extrinsic signals contribute to postmitotic cortical neuronal development is unclear. Here we show in mice
Kristel Martínez-Lagunas et al.
Cell death and differentiation, 27(4), 1398-1414 (2019-10-02)
Despite the great progress on the cell biology of programmed cell death (PCD), its incidence and exact time course during embryonic and particular heart development are still unclear. This is also due to the lack of models enabling to directly
Martin Marsala et al.
Stem cells translational medicine, 9(2), 177-188 (2019-12-05)
Neural precursor cells (NSCs) hold great potential to treat a variety of neurodegenerative diseases and injuries to the spinal cord. However, current delivery techniques require an invasive approach in which an injection needle is advanced into the spinal parenchyma to
Alejandra Palma-Chavez et al.
Frontiers in endocrinology, 10, 647-647 (2019-10-18)
The endocannabinoid system (ECS) is composed of a group of Gi-coupled protein receptors and enzymes, producing and degrading the endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoyl-ethanolamine (AEA). Endocannabinoid-mediated signaling modulates brain functions, such as pain, mood, memory, and feeding behavior. The activation
Alexandre N Ermilov et al.
PLoS genetics, 12(11), e1006442-e1006442 (2016-11-29)
For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions. To investigate a role for Hedgehog/GLI signaling in adult taste organs we used a panel of conditional mouse models to
Alexandria N Early et al.
Journal of neuroinflammation, 17(1), 115-115 (2020-04-16)
Older-age individuals are at the highest risk for disability from a traumatic brain injury (TBI). Astrocytes are the most numerous glia in the brain, necessary for brain function, yet there is little known about unique responses of astrocytes in the
Laura A B Elias et al.
Nature, 448(7156), 901-907 (2007-08-24)
Radial glia, the neuronal stem cells of the embryonic cerebral cortex, reside deep within the developing brain and extend radial fibres to the pial surface, along which embryonic neurons migrate to reach the cortical plate. Here we show that the
Andreia V Pinho et al.
Nature communications, 9(1), 5083-5083 (2018-12-07)
Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost while Robo1 expression becomes
Tissue-Type Plasminogen Activator Controlled Corticogenesis Through a Mechanism Dependent of NMDA Receptors Expressed on Radial Glial Cells.
Pasquet, et al.
Cerebral Cortex, 29, 2482-2498 (2020)
Geraldine M Jowett et al.
Nature materials, 20(2), 250-259 (2020-09-09)
Organoids can shed light on the dynamic interplay between complex tissues and rare cell types within a controlled microenvironment. Here, we develop gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed
Jinar Rostami et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11835-11853 (2017-11-02)
Many lines of evidence suggest that the Parkinson's disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from
Zaman Mirzadeh et al.
Nature communications, 8, 13759-13759 (2017-01-10)
Multiciliated ependymal (E1) cells line the brain ventricles and are essential for brain homeostasis. We previously identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and unique basal bodies. Here we show that E2 cells
Eloy Cuadrado et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3623-3633 (2015-03-15)
Aicardi-Goutières syndrome (AGS) is a monogenic inflammatory encephalopathy caused by mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, or MDA5. Mutations in those genes affect normal RNA/DNA intracellular metabolism and detection, triggering an autoimmune response with an increase in cerebral
Marlena Zyśk et al.
Journal of Alzheimer's disease : JAD, 72(1), 161-180 (2019-09-29)
Alzheimer's disease (AD) is the leading cause of dementia worldwide, affecting over 10% of the elderly population. Epidemiological evidence indicates that traumatic brain injury (TBI) is an important risk factor for developing AD later in life. However, which injury-induced processes
Karen Oprych et al.
Brain structure & function, 222(4), 1877-1895 (2016-10-09)
The in situ immunocytochemical properties of olfactory ensheathing cells (OECs) have been well studied in several small to medium sized animal models including rats, mice, guinea pigs, cats and canines. However, we know very little about the antigenic characteristics of OECs
Jinkyoung Chung et al.
Scientific reports, 11(1), 10511-10511 (2021-05-20)
Understanding the platelet activation molecular pathways by characterizing specific protein clusters within platelets is essential to identify the platelet activation state and improve the existing therapies for hemostatic disorders. Here, we employed various state-of-the-art super-resolution imaging and quantification methods to
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