Genes

RNF6
ring finger protein (C3H2C3 type) 6
Species:
Human RNF6 (6049), Mouse Rnf6 (74132), Rat Rnf6 (304271), Zebrafish rnf6 (100359398), chicken RNF6 (418935), Horse RNF6 (100050743), domestic cat RNF6 (101085851), dog RNF6 (477332), cow RNF6 (527056), sheep RNF6 (101115804), naked mole-rat Rnf6 (101721026), Domestic Rabbit RNF6 (100354107), domestic guinea pig Rnf6 (100730117)
Summary:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008
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