Showing 1-30 of 108 results for "

aminooxyacetic acid

Fen Ye et al.
Life sciences, 261, 118348-118348 (2020-08-30)
3,3'-Diindolylmethane (DIM) has limited anti-cancer effects in gastric cancer. Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter...
K Tsukamoto et al.
Neuropharmacology, 32(6), 575-579 (1993-06-01)
The effect of injection of inhibitors of GABA-transaminase into the nucleus tractus solitarius (NTS) on arterial pressure was examined in anesthetized rats. Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS...
S K Hong et al.
Toxicology and applied pharmacology, 147(1), 115-125 (1997-11-14)
A halogenated derivative of 4-aminophenol, 4-amino-2, 6-dichlorophenol (ADCP), is a potent nephrotoxicant and a weak hepatotoxicant in Fischer 344 rats. Although the mechanism of ADCP nephrotoxicity is unknown, ADCP could undergo oxidation to a reactive intermediate, such as a 4-amino-2,6-dichlorophenoxy...
Kirsten Bagh et al.
Plant physiology and biochemistry : PPB, 42(10), 803-809 (2004-12-15)
In vivo (15)N nuclear magnetic resonance (NMR) as well as (15)N solid-state magic angle spinning (MAS) NMR spectroscopy were used to investigate nitrogen metabolism in cultured white spruce (Picea glauca) buds. Long-term as well as short-term experiments were carried out...
Influence of aminooxyacetic acid, a gamma-aminobutyrate transaminase inhibitor, on hereditary spastic defect in the mouse.
C K CHAI et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 109, 491-495 (1962-03-01)
Joseph T Dever et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(11), 2252-2260 (2008-08-09)
L-methionine-dl-sulfoxide (MetO) is an L-methionine (Met) metabolite, but its role in Met metabolism and toxicity is not clear. In this study, MetO uptake, metabolism to Met, cytotoxicity, and glutathione (GSH) and glutathione disulfide (GSSG) status were characterized in freshly isolated...
Ru-Yi Zhu et al.
Journal of the American Chemical Society, 139(45), 16080-16083 (2017-11-01)
We report Pd(II)-catalyzed β-C(sp
W Löscher et al.
Naunyn-Schmiedeberg's archives of pharmacology, 349(3), 270-278 (1994-03-01)
Drugs which elevate brain levels of the inhibitory amino acid neurotransmitter GABA by inhibiting the GABA catabolizing enzyme GABA transaminase (GABA-T) have been developed for treatment of brain disease, such as epilepsy. Among all GABA-T inhibitors available, vigabatrin is thought...
Zhanwei Xu et al.
The Journal of organic chemistry, 77(16), 7114-7118 (2012-08-02)
An efficient method for the synthesis of indolylglycine derivatives is described. The oxidative coupling reactions of ethyl 2-(disubstituted amino)acetates with indoles proceeded smoothly in the presence of meta-chloroperoxybenzoic acid (mCPBA) under ambient conditions to produce indolylglycine derivatives in satisfactory to...
Y T Yang et al.
The International journal of biochemistry, 14(4), 335-340 (1982-01-01)
1. Isolated ovine adipocytes, unlike rat adipose tissue, could utilize lactate at a high rate. 2. When the rate of fatty acid synthesis was attenuated with 5-(tetradecyloxy)-2-furoic acid, a fatty acid synthesis inhibitor, there was a good positive correlation between...
Lili Yang et al.
The Journal of biological chemistry, 283(32), 21978-21987 (2008-06-12)
We conducted a study coupling metabolomics and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. Rat livers were perfused with lactate or pyruvate +/- aminooxyacetate or mercaptopicolinate in the presence of 40% enriched NaH(13)CO(3). Other livers were perfused...
S Nagaki et al.
Life sciences, 46(22), 1587-1595 (1990-01-01)
Immunoreactive somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) contents in the rat brain were investigated to study chronic effects of the treatment with anticonvulsants, carbamazepine (CBZ), valproic acid (VPA) and phenytoin (PHT). Decreased IR-SRIF levels were found in several brain regions...
R B Hamat et al.
Metabolism: clinical and experimental, 31(6), 548-552 (1982-06-01)
An "in vitro" model of one type of lactic acidosis was produced in rat hemi-diaphragms with inhibitors of pyruvate oxidation. In order to obtain this inhibition in the absence of hypoxia, two actions were sought; inhibiting the mitochondrial pyruvate transporter...
[Neurochemical aspects of the pharmacology of GABAergic substances].
K S Raevskiĭ
Farmakologiia i toksikologiia, 44(5), 517-529 (1981-09-01)
R Svarna et al.
Neurochemical research, 21(5), 603-608 (1996-05-01)
The effect of aminooxyacetic acid (AOAA), NH4+, phenylsuccinate (Phs), ketone bodies (KB) and glutamine (Gln), that might interfere with the biosynthesis of neurotransmitter glutamate on the K(+)-evoked Ca(2+)-dependent release of D-[3H]aspartate from rat cerebellar slices was studied. Therefore slices were...
Mechanism of action of oxfenicine on muscle metabolism.
A J Higgins et al.
Biochemical and biophysical research communications, 100(1), 291-296 (1981-05-15)
E A Bulantseva et al.
Prikladnaia biokhimiia i mikrobiologiia, 47(2), 201-208 (2011-03-01)
The treatment of apple and banana fruits with 2-CEFA and ethacyde induced the production of ethylene and accelerated the ripening and accumulation of ACC in apple fruits. Inhibitors AOA, AVG, and CoCl2 acted at the different steps of ethylene biosynthesis...
K Yamada et al.
Biological & pharmaceutical bulletin, 24(9), 1068-1071 (2001-09-18)
The effect of alkylpyrazine derivatives on pentobarbital-induced sleeping time, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in mouse brain were studied. The duration of pentobarbital-induced sleep in mice was dose-dependently increased by 2,5-dimethylpyrazine (DMP). The duration of pentobarbital-induced sleep was...
Preethi Korangath et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(14), 3263-3273 (2015-03-31)
Glutamine addiction in c-MYC-overexpressing breast cancer is targeted by the aminotransferase inhibitor, aminooxyacetate (AOA). However, the mechanism of ensuing cell death remains unresolved. A correlation between glutamine dependence for growth and c-MYC expression was studied in breast cancer cell lines....
Heyu Chen et al.
Neurochemical research, 40(6), 1311-1318 (2015-05-23)
NADH shuttles mediate the transfer of the reducing equivalents of cytosolic NADH into mitochondria. Cumulating evidence has suggested that malate-aspartate shuttle (MAS), one of the two types of NADH shuttles, plays significant roles in such biological processes as glutamate synthesis...
I E O'Neill et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 83(3), 595-598 (1986-01-01)
Isolated kidney tubules synthesize glucose actively from fructose, lactate, glycerol and pyruvate and, to a lesser extent, from a variety of amino acids. Ethanol stimulated gluconeogenesis from pyruvate and inhibited it from lactate. The aminotransferase inhibitor, aminooxyacetate, greatly reduced synthesis...
L H Lash et al.
The Journal of biological chemistry, 261(28), 13076-13081 (1986-10-05)
S-(1,2-Dichlorovinyl)glutathione (DCVG) and S-(1,2-dichlorovinyl)-L-cysteine (DCVC) produced time- and concentration-dependent cell death in isolated rat kidney proximal tubular cells. AT-125 blocked and glycylglycine potentiated DCVG toxicity, indicating that metabolism by gamma-glutamyltransferase is required. S-(1,2-Dichlorovinyl)-L-cysteinylglycine, a putative metabolite of DCVG, also produced...
Makiko Ogata et al.
Biochemical and biophysical research communications, 421(1), 20-26 (2012-04-03)
Mitochondrial pH is a key determinant of mitochondrial energy metabolism. We have developed a new fluorescence-based ratiometric pH biosensor using a chloride-insensitive and hydrogen-sensitive probe for direct, quantitative and bleaching-free measurement in a living cell. Fusing this biosensor with a...
Alexander Roy et al.
American journal of hypertension, 25(1), 74-81 (2011-08-26)
Hydrogen sulfide (H(2)S), an endogenous vasoactive agent, is produced by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS) enzymes. This study was conducted to evaluate the relative contribution of these enzymes in regulating systemic arterial pressure. Sprague-Dawley rats were chronically treated...
G Palaiologos et al.
Neurochemical research, 14(4), 359-366 (1989-04-01)
Evoked release of glutamate and aspartate from cultured cerebellar granule cells was studied after preincubation of the cells in tissue culture medium with glucose (6.5 mM), glutamine (1.0 mM), D[3H] aspartate and in some cases aminooxyacetate (5.0 mM) or phenylsuccinate...
Megan Mitchell et al.
Biology of reproduction, 80(2), 295-301 (2008-10-31)
The nutrient requirements and metabolic pathways used by the developing embryo transition from predominantly pyruvate during early cleavage stages to glucose at the blastocyst; however, the complexities involved in the regulation of metabolism at different developmental stages are not clear....
A F Rowe et al.
Molecular and biochemical parasitology, 21(1), 17-24 (1986-10-01)
The amino acid pool sizes of Trichomonas vaginalis are reported. Alanine, glutamic acid, proline and leucine account for 72% of the measured amino acids. Growth of T. vaginalis was unaffected by gostatin, an irreversible inhibitor of aspartate aminotransferase, when the...
G Palaiologos et al.
Journal of neurochemistry, 51(1), 317-320 (1988-07-01)
Based on the selective inhibition of glutamate release in cerebellar granule cells in primary cultures by the aspartate aminotransferase inhibitor, aminooxyacetic acid, and by the ketodicarboxylate carrier inhibitor, phenylsuccinate, a novel model for synthesis of transmitter glutamate is suggested: Glutamate...
P S Callery et al.
Journal of neurochemistry, 45(3), 946-948 (1985-09-01)
Intraperitoneal injection of the cyclic imine 1-piperideine in mice resulted in measurable quantities of 5-aminopentanoic acid in brain. 5-Aminopentanoic acid is a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. 5-Aminopentanoic acid formed in the periphery...
Marina Casimir et al.
The Biochemical journal, 424(3), 459-466 (2009-09-22)
Transfer of reducing equivalents between cytosolic compartments and the mitochondrial matrix is mediated by NADH shuttles. Among these, the malate-aspartate shuttle has been proposed to play a major role in beta-cells for the control of glucose-stimulated insulin secretion. AGC1 or...