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Showing 1-30 of 82 results for "AP132C" within Papers
Jinbo Huang et al.
PloS one, 11(3), e0149586-e0149586 (2016-03-02)
Aplastic anemia (AA) is a bone marrow failure syndrome that is caused largely by profound quantitative and qualitative defects of hematopoietic stem and progenitor cells. However, the mechanisms underlying these defects remain unclear. Under conditions of stress, autophagy acts as
Metformin improves tendon degeneration by blocking translocation of HMGB1 and suppressing tendon inflammation and senescence in aging mice.
Zhang, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 41, 1162-1176 (2023)
Elisa Lupino et al.
Biochemical pharmacology, 92(2), 235-250 (2014-09-30)
Imatinib mesylate is a tyrosine kinase inhibitor with selectivity for abelson tyrosine-protein kinase 1 (c-Abl), breakpoint cluster region (Bcr)-Abl fusion protein (Bcr-Abl), mast/stem cell growth factor receptor Kit (c-Kit), and platelet-derived growth factor receptor (PDGFR). Previous studies demonstrated that imatinib
Young Me Yoon et al.
Stem cell reports, 7(5), 840-853 (2016-10-11)
Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA crosslink lesion repair. In bone marrow HSPCs, unresolved stress confers p53-dependent apoptosis and progressive cell
Baojin Ding et al.
Methods in molecular biology (Clifton, N.J.), 1018, 119-131 (2013-05-18)
Lentiviral vectors have become very useful tools for transgene delivery. Based on their ability to transduce both dividing and nondividing cells and to produce long-term transgene expression, lentiviruses have found numerous applications in the biomedical sciences, including developmental neuroscience. This
Kang Cheng et al.
Stem cell research & therapy, 1(1), 6-6 (2010-05-28)
The ability to expand organ-specific stem/progenitor cells is critical for translational applications, although uncertainties often arise in identifying the lineage of expanded cells. Therefore, superior insights into lineage maintenance mechanisms will be helpful for cell/gene therapy. We studied epithelial cells
Jin Young Shin et al.
Autophagy, 10(1), 32-44 (2013-10-24)
Current evidence suggests a central role for autophagy in Alzheimer disease (AD), and dysfunction in the autophagic system may lead to amyloid-β (Aβ) accumulation. Using in vitro and in vivo AD models, the present study investigated whether mesenchymal stem cells
Sandra Jansen et al.
Infection and immunity, 81(5), 1788-1797 (2013-03-13)
The expression and function of psoriasin in the brain have been insufficiently characterized. Here, we show the induction of psoriasin expression in the central nervous system (CNS) after bacterial and viral stimulation. We used a pneumococcal meningitis in vivo model
Zoltán Füssy et al.
mSphere, 5(5) (2020-10-23)
Most secondary nonphotosynthetic eukaryotes have retained residual plastids whose physiological role is often still unknown. One such example is Euglena longa, a close nonphotosynthetic relative of Euglena gracilis harboring a plastid organelle of enigmatic function. By mining transcriptome data from
Ramón Anadón et al.
The Journal of comparative neurology, 521(13), 3057-3082 (2013-05-01)
The glycinergic cell populations in the brain of the lesser spotted dogfish were studied by a glycine immunofluorescence method. Numerous glycine-immunoreactive (Gly-ir) neurons were observed in different brain nuclei. In the telencephalon, Gly-ir cells were observed in the olfactory bulb
Jianying Zhang et al.
Methods in molecular biology (Clifton, N.J.), 1842, 217-228 (2018-09-10)
Tendon stem/progenitor cells (TSCs) are tendon-specific adult stem cells, which play crucial roles in tendon homeostasis, repair or regeneration once tendons are injured. Additionally, their pathological role in the development of tendinopathy in response to excessive mechanical loading placed on
Sarrabeth Stone et al.
JCI insight, 5(5) (2020-02-14)
Maintaining cellular proteostasis is essential for oligodendrocyte viability and function; however, its underlying mechanisms remain unexplored. Unfolded protein response (UPR), which comprises 3 parallel branches, inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and activating transcription factor 6α (ATF6α)
Takashi Iizuka et al.
Scientific reports, 11(1), 3833-3833 (2021-02-17)
Activation-induced cytidine deaminase (AID, Aicda) is a master gene regulating class switching of immunoglobulin genes. In this study, we investigated the significance of AID expression in the ovary. Immunohistological study and RT-PCR showed that AID was expressed in murine granulosa
Ao Li et al.
JCI insight, 3(5) (2018-03-09)
Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously showed that a lack of the PKD2 gene product, PC2, increases β-catenin
Kyosuke Kagami et al.
Reproductive biology and endocrinology : RB&E, 16(1), 72-72 (2018-08-04)
Recently, we demonstrated the three-dimensional (3D) localization of murine trophoblast giant cells in the pregnant uterus using a modified Clear Unobstructed Brain Imaging Cocktails and Computational analysis (CUBIC) tissue-clearing method and hybrid construct consisting of the cytomegalovirus enhancer fused to
Paolo Chieffi et al.
Molecular reproduction and development, 65(3), 330-335 (2003-06-05)
Prolin-rich kinase 2 (PYK2) is a nonreceptor tyrosine kinase related to the focal adhesion kinase (FAK) p125(FAK). PYK2 is rapidly phosphorylated on tyrosine residues in response to various stimuli, such as tumor necrosis factor-alpha (TNF-alpha), changes in osmolarity, elevation in
Mostafa A Aboouf et al.
Scientific reports, 13(1), 7530-7530 (2023-05-10)
Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer
Eriko Tsuji et al.
Zoological science, 24(8), 836-849 (2008-01-26)
Social Hymenoptera such as ants or honeybees are known for their extensive behavioral repertories and plasticity. Neurons containing biogenic amines appear to play a major role in controlling behavioral plasticity in these insects. Here we describe the morphology of prominent
Shweta P Jadhav et al.
Journal of neurochemistry, 130(3), 388-401 (2014-04-23)
Chronic activation of microglia, the macrophages of the CNS, has been shown to enhance neuronal damage because of excessive release of proinflammatory cytokines and neurotoxic molecules in a number of neurodegenerative diseases. Recent reports showed altered microRNA (miRNA) expression in
Sandra Jansen et al.
Journal of neurochemistry, 141(1), 86-99 (2017-01-24)
Antimicrobial peptides are an important part of the innate immune defense in the central nervous system (CNS). The expression of the antimicrobial peptides psoriasin (S100A7) is up-regulated during bacterial meningitis. However, the exact mechanisms induced by psoriasin to modulate glial
Hilary C Archbold et al.
Scientific reports, 8(1), 4606-4606 (2018-03-17)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative disorders marked in most cases by the nuclear exclusion and cytoplasmic deposition of the RNA binding protein TDP43. We previously demonstrated that ALS-associated mutant TDP43 accumulates within the cytoplasm
Sarrabeth Stone et al.
JCI insight, 4(2) (2019-01-25)
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating and neurodegenerative diseases of the CNS. Although neurodegeneration is the major contributor to chronic disability in MS, mechanisms governing the viability of axons and neurons
Matthew D Keefe et al.
eLife, 9 (2020-12-11)
Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B). Current models only partially recapitulate key disease features, and pathophysiology is poorly understood.
Jun-Ichi Takino et al.
Scientific reports, 11(1), 2959-2959 (2021-02-05)
Advanced glycation end-products (AGEs) are formed by the non-enzymatic reaction of sugars and proteins. Among the AGEs, glyceraldehyde-derived toxic AGEs (TAGE) are associated with various diseases, including diabetic complications such as diabetic retinopathy (DR). The risk of developing DR is
Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury.
Baltazar-Lara, et al.
International Journal of Molecular Sciences, 23 (2022)
Jianying Zhang et al.
Journal of tissue engineering, 10, 2041731418820034-2041731418820034 (2019-02-08)
To understand the variable efficacy with platelet rich plasma (PRP) treatments for tendon injury, we determined the differential effects of proteinase-activated receptor (PAR)1- or PAR4-activated PRP (PAR1-PRP, PAR4-PRP) from humans on human patellar tendon stem/progenitor cells (TSCs) and tendon healing.
Eugenia Kress et al.
Cell communication and signaling : CCS, 15(1), 32-32 (2017-09-17)
Antimicrobial peptides are important components of the host defence with a broad range of functions including direct antimicrobial activity and modulation of inflammation. Lack of cathelin-related antimicrobial peptide (CRAMP) was associated with higher mortality and bacterial burden and impaired neutrophil
Kyoung In Kim et al.
Glia, 69(9), 2133-2145 (2021-05-07)
Our recent finding has demonstrated that astrocytes confer neuroprotection by endogenously producing ciliary neurotrophic factor (CNTF) via transient receptor potential vanilloid 1 (TRPV1) in Parkinson's disease (PD). In this study, the possible molecular target for TRPV1-mediated CNTF production and its
Mario Gössl et al.
Basic research in cardiology, 104(6), 695-706 (2009-05-22)
Vasa vasorum (VV) neovascularization is a key feature of early atherosclerosis and adds substantial endothelial exchange-surface to the coronary vessel wall. Thus, it is conceivable that VV neovascularization favors the entry of pro-inflammatory and pro-atherosclerotic blood components into the coronary
Kieu T M Pham et al.
The Journal of biological chemistry, 295(3), 729-742 (2019-12-11)
The basal body in the human parasite Trypanosoma brucei is structurally equivalent to the centriole in animals and functions in the nucleation of axonemal microtubules in the flagellum. T. brucei lacks many evolutionarily conserved centriolar protein homologs and constructs the
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