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Showing 1-30 of 44 results for "AP180P" within Papers
Natsumi Shimizu et al.
The Journal of reproduction and development, 60(3), 179-186 (2014-03-04)
In the mammalian testis, the ubiquitin-proteasome system plays important roles in the process that promotes the formation of mature sperm. We recently identified zygote-specific proteasome assembly chaperone (ZPAC), which is specifically expressed in the mouse gonads and zygote. ZPAC mediates
Shane A Liddelow et al.
PloS one, 7(3), e33554-e33554 (2012-03-30)
Exchange mechanisms across the blood-cerebrospinal fluid (CSF) barrier in the choroid plexuses within the cerebral ventricles control access of molecules to the central nervous system, especially in early development when the brain is poorly vascularised. However, little is known about
Edward A Ratovitski
Marine drugs, 14(8) (2016-08-19)
Targeting autophagic pathways might play a critical role in designing novel chemotherapeutic approaches in the treatment of human cancers, and the prevention of tumor-derived chemoresistance. Marine compounds were found to decrease tumor cell growth in vitro and in vivo. Some
Lei Xiao et al.
Nature communications, 12(1), 2617-2617 (2021-05-13)
Disruption of the transcription factor FoxP2, which is enriched in the basal ganglia, impairs vocal development in humans and songbirds. The basal ganglia are important for the selection and sequencing of motor actions, but the circuit mechanisms governing accurate sequencing
Kangsan Kim et al.
Cancer discovery, 13(1), 85-97 (2022-09-14)
Cell competition, a fitness-sensing process, is essential for tissue homeostasis. Using cancer metastatic latency models, we show that cell competition results in the displacement of latent metastatic (Lat-M) cells from the primary tumor. Lat-M cells resist anoikis and survive as
Stephanie Spannl et al.
The EMBO journal, 39(21), e101767-e101767 (2020-10-07)
Changes in cell metabolism and plasma membrane potential have been linked to shifts between tissue growth and differentiation, and to developmental patterning. How such changes mediate these effects is poorly understood. Here, we use the developing wing of Drosophila to
Season K Wyatt-Johnson et al.
Frontiers in neurology, 12, 651096-651096 (2021-06-22)
Events of status epilepticus (SE) trigger the development of temporal lobe epilepsy (TLE), a type of focal epilepsy that is commonly drug-resistant and is highly comorbid with cognitive deficits. While SE-induced hippocampal injury, accompanied by gliosis and neuronal loss, typically
Kentarou Baba et al.
eLife, 7 (2018-08-08)
Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces. Here we show that knockout mice of Shootin1 display abnormal
Elevated temperature triggers human respiratory syncytial virus F protein six-helix bundle formation.
Yunus, AS; Jackson, TP; Crisafi, K; Burimski, I; Kilgore, NR; Zoumplis, D; Allaway et al.
Virology null
Satoshi Nishikawa et al.
The Journal of reproduction and development, 59(3), 258-265 (2013-03-02)
Degradation of maternally stored mRNAs after fertilization is an essential process for mammalian embryogenesis. Maternal mRNA degradation depending on deadenylases in mammalian early embryos has been mostly speculated, rather than directly demonstrated. Previously, we found that gene expression of nocturnin
Robert E Turnbull et al.
Nature communications, 11(1), 3252-3252 (2020-06-28)
MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite implications of involvement in cell cycle regulation and in several cancers, surprisingly little is known about the
Kimiko Inoue et al.
Nature communications, 11(1), 2150-2150 (2020-05-03)
Somatic cell nuclear transfer (SCNT) in mammals is an inefficient process that is frequently associated with abnormal phenotypes, especially in placentas. Recent studies demonstrated that mouse SCNT placentas completely lack histone methylation (H3K27me3)-dependent imprinting, but how it affects placental development
Franziska Richter et al.
The Journal of comparative neurology, 515(5), 538-547 (2009-05-30)
Hemoglobin is the oxygen carrier in vertebrate blood erythrocytes. Here we report that hemoglobin chains are expressed in mammalian brain neurons and are regulated by a mitochondrial toxin. Transcriptome analyses of laser-capture microdissected nigral dopaminergic neurons in rats and striatal
Taeko Sasaki et al.
Nature communications, 15(1), 1460-1460 (2024-02-18)
Allophagy is responsible for the selective removal of paternally inherited organelles, including mitochondria, in Caenorhabditis elegans embryos, thereby facilitating the maternal inheritance of mitochondrial DNA. We previously identified two key factors in allophagy: an autophagy adaptor allophagy-1 (ALLO-1) and TBK1/IKKε
Maikel Castellano-Pozo et al.
Nature communications, 11(1), 4345-4345 (2020-08-30)
Chromosome movements and programmed DNA double-strand breaks (DSBs) promote homologue pairing and initiate recombination at meiosis onset. Meiotic progression involves checkpoint-controlled termination of these events when all homologue pairs achieve synapsis and form crossover precursors. Exploiting the temporo-spatial organisation of
Ana P Gomes et al.
Nature, 585(7824), 283-287 (2020-08-21)
The risk of cancer and associated mortality increases substantially in humans from the age of 65 years onwards1-6. Nonetheless, our understanding of the complex relationship between age and cancer is still in its infancy2,3,7,8. For decades, this link has largely been
Nicole D Schartz et al.
Physiology & behavior, 212, 112705-112705 (2019-10-20)
Status epilepticus (SE) is a prolonged and continuous seizure that lasts for at least 5 min. An episode of SE in a healthy system can lead to the development of spontaneous seizures and cognitive deficits which may be accompanied by hippocampal
Yuki Hatanaka et al.
PloS one, 8(4), e60205-e60205 (2013-04-06)
After fertilization, the sperm and oocyte genomes undergo extensive epigenetic reprogramming to form a totipotent zygote. The dynamic epigenetic changes during early embryo development primarily involve DNA methylation and demethylation. We have previously identified Gse (gonad-specific expression gene) to be
Ichiro Kawasaki et al.
Nature communications, 15(1), 792-792 (2024-01-27)
In many sexually reproducing organisms, oocytes are fundamentally fertilized with one sperm. In Caenorhabditis elegans, chitin layer formation after fertilization by the EGG complex is one of the mechanisms of polyspermy block, but other mechanisms remain unknown. Here, we demonstrate
Ultra-rare complement factor 8 coding variants in families with age-related macular degeneration.
Zelinger, et al.
iScience, 26, 106417-106417 (2023)
Kohtaro Morita et al.
The Journal of reproduction and development, 64(2), 161-171 (2018-03-06)
Antioxidant mechanisms to adequately moderate levels of endogenous reactive oxygen species (ROS) are important for oocytes and embryos to obtain and maintain developmental competence, respectively. Immediately after fertilization, ROS levels in zygotes are elevated but the antioxidant mechanisms during the
Ana P Gomes et al.
Cancer cell, 36(4), 402-417 (2019-10-01)
Metastasis is the leading cause of cancer mortality. Chromatin remodeling provides the foundation for the cellular reprogramming necessary to drive metastasis. However, little is known about the nature of this remodeling and its regulation. Here, we show that metastasis-inducing pathways
Ming Zhou et al.
Anatomical record (Hoboken, N.J. : 2007), 294(4), 729-737 (2011-02-18)
ATP sensitive K(+) (K(ATP) ) channels are important linkage of cell membrane excitability to its cellular bioenergetic state. These channels are composed of pore-forming subunits and regulatory subunits. The present study focused on the cellular expressions and localizations of these
Lucas Sagrillo-Fagundes et al.
PloS one, 14(1), e0202458-e0202458 (2019-01-11)
Melatonin has protective roles in normal cells and cytotoxic actions in cancer cells, with effects involving autophagy and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factor pathways. Hypoxia/reoxygenation (H/R) induces oxidative damage and apoptosis. These consequences activate autophagy, which degrades
Timon Eckes et al.
International journal of molecular sciences, 23(7) (2022-04-13)
S1P and its receptors have been reported to play important roles in the development of renal fibrosis. Although S1P5 has barely been investigated so far, there are indications that it can influence inflammatory and fibrotic processes. Here, we report the
Maria Cernea et al.
Journal of molecular endocrinology, 56(1), 39-46 (2015-10-23)
Adipose tissue expansion, resulting from adipocyte hyperplasia and/or hypertrophy, is a hallmark of obesity. Adipocytes are derived from mesenchymal stem cells (MSCs) through adipogenesis, a process involving three key steps: proliferation, commitment and differentiation. Although studies have elaborated on the
Anna Pezzotta et al.
Cells, 11(20) (2022-10-28)
A reduced nephron number at birth, due to critical gestational conditions, including maternal malnutrition, is associated with the risk of developing hypertension and chronic kidney disease in adulthood. No interventions are currently available to augment nephron number. We have recently
Miyoung Lee et al.
Nature communications, 13(1), 1157-1157 (2022-03-05)
The incidence of obesity is rising with greater than 40% of the world's population expected to be overweight or suffering from obesity by 2030. This is alarming because obesity increases mortality rates in patients with various cancer subtypes including leukemia.
Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model.
Aare, S; Radell, P; Eriksson, LI; Akkad, H; Chen, YW; Hoffman, EP; Larsson, L
Physiological Genomics null
Kelly Kawabata Galbraith et al.
Cell reports, 24(1), 95-106 (2018-07-05)
Dendritic filopodia of developing neurons function as environmental sensors, regulating the spatial organization of dendrites and proper targeting to presynaptic partners. Dendritic filopodia morphology is determined by the balance of F-actin assembled via two major nucleating pathways, the ARP2/3 complex
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