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Apoptosis Detection
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Apoptosis Inducers
Activation and Inhibition of Apoptosis
Apoptosis Inducers
Apoptosis Inducers
F 6627 5-Fluorouracil See p53 Regulators, page
Biotin-Asp(OMe)- Glu(OMe)- Val-Asp(OMe)- fluoromethyl ketone (B1807)
suppress induced caspase-3
activation and apoptosis.1 Activation of caspase-3 is
the first step in the execution phase of apoptosis.
DEVD-FMK can block increases in caspase-3 activity
and significantly reduce
Data Sheet - I7528
caspases is essential for its function
during apoptosis. J. Biol. Chem., 273, 28549-28552
(1998).
6. Wolf, B.B., et al., Caspase-3 is the primary activator
of apoptotic DNA fragmentation via DNA fragmen
Apoptosis - Antibodies, Reagents and Kits
to form active Caspase 8. Activated Caspase 8
activates pro-Caspase 3; active Caspase 3 is a
principle effector caspase of apoptosis. Caspase 8
also activates the protein Bid, which activates Bak
and
Data Sheet - F0427
pro-caspase 8 leading to the activation of
caspase 8. Activated caspase 8 then cleaves
(activates) nine other procaspases, a process that
ultimately leads to apoptosis.
B cell antigen receptor
Data Sheet - S8689
and pro-caspase 8 leading to the activation of
caspase 8. Activated caspase 8 cleaves (activates)
nine other procaspases, a process that ultimately leads
to apoptosis. B cell antigen receptor signaling
Monoclonal Anti-Caspase 7 antibody produced in rat (C1104)
has a role in inflammation as well as in apoptosis; these
proteases may also be indirectly involved in apoptosis
as activators of other caspases (upstream activity).
Caspase-8 and -10 are involved in death
Data Sheet - I7653
caspases is essential for its function
during apoptosis. J. Biol. Chem., 273, 28549-28552
(1998).
6. Wolf, B.B., et al., Caspase-3 is the primary activator
of apoptotic DNA fragmentation via DNA fragmen
Data Sheet - C7852
caspases is essential for its function
during apoptosis. J. Biol. Chem., 273, 28549 –
28552 (1998).
6. Wolf, B.B., et al., Caspase-3 is the primary activator
of apoptotic DNA fragmentation via DNA
fragmentation
Data Sheet - F0552
pro-caspase 8 leading to the activation of
caspase 8. Activated caspase 8 then cleaves
(activates) nine other procaspases, a process that
ultimately leads to apoptosis.
B cell antigen receptor
Data Sheet - A8469
designated Apaf1 (apoptosis
protease-activating factor1).1,2 Apaf1 is a protein that
participates in activation of caspase-3, a deoxy-
ribonuclease which is activated during apoptosis to
degrade nucleic
Data Sheet - D3438
caspases is essential for its function
during apoptosis. J. Biol. Chem., 273, 28549-28552
(1998).
6. Wolf, B.B., et al., Caspase-3 is the primary activator
of apoptotic DNA fragmentation via DNA fragmen
Data Sheet - D3313
Cleavage of CAD inhibitor in
CAD activation and DNA degradation during
apoptosis. Nature, 391, 96-99 (1998).
6. Wolf, B.B., et al., Caspase-3 is the primary activator
of apoptotic DNA fragmentation
Data Sheet - S5941
role in
the commitment of cells to apoptosis. Release of
cytochrome c from the mitochondria into the cytosol, in
response to apoptosis signals, results in the activation
of caspase 9 and the downstream
Data Sheet - A5851
kinase (JNK) or
stress-activated kinase (SAPK), pathway and the p38
kinase pathway.
ASK1 (Apoptosis Signal-regulating Kinase 1) also
known as MAPKKK5 (Mitogen activated protein kinase
kinase kinase
Data Sheet - D9438
to DR5, sharing 55% sequence homology. DR4
induces apoptosis in a variety of human tumor cell lines
but not in normal cells. In addition, it activates NF-κB.2,3
DR4 is expressed in most human tissues
Data Sheet - T5694
and DR4 induce
FADD-dependent apoptosis and activate the NF-κB
pathway. Immunity 7:821-830 (1997).
6. Tollefson, A.E., et al., Inhibition of trail-induced
apoptosis and forced internalization of trail
Data Sheet - C9484
converting enzyme, ICE) is
involved in the production of proinflammatory cytokines
and in apoptosis.1
Apoptosis or programmed cell death (PCD) plays an
essential role in development, homeostasis, and
Data Sheet - R4277
receptor 1), mediates TNFR1
induced apoptosis, and attenuates RIP and TNFR1
induced NF-B activation. Overexpression of RIP3
induces apoptosis and NF-B activation. The
messenger RNA of RIP3 is expressed
Data Sheet - M2189
kinase SLK releases and activates
an apoptosis-inducing kinase domain and an actin-
disassembling region. Mol. Cell. Biol., 20, 684-696
(2000).
4. Watabe, M. et al., Activation of MST/Krs and c-Jun
N-
Product Information Sheet - CS0310
Smac/DIABLO
regulates caspase activity and apoptosis. Nature,
410, 112-116 (2001).
8. Marsden, V. S., et al., Apoptosis initiated by Bcl-2-
regulated caspase activation independently of the
cytochrome
Product Information Sheet - CASPASSYRO
determination of caspases activity in microplates, which is especially use-
ful for high throughput screening.
Test Principle-
Basic Steps
Application During apoptosis, the activation of specific proteases
Data Sheet - C8487
17-19 kDa (p17, p18) and 12 kDa (p12) active
subunits only when cells undergo apoptosis.
4,5
Many
key proteins are cleaved by caspase 3 during
apoptosis, including poly (ADP-ribose) polymerase
Product Information Sheet - H8787
nonpeptide Bcl-2 ligand, which antagonizes the
function of Bcl-2 and induces apoptosis.[1-5].
Bcl-2 is a potent suppressor of apoptosis originally
described as the chromosomal breakpoint (t(14:18)) in
B-cell
Data Sheet - P9993
suppression, apoptosis and cell
cycle progression.3,6,7,8 PKR has been identified as the
signal transducer in cell stress signaling pathways
leading to NFκB activation.9,10 PKR mediates the
activation of signal
Data Sheet - P0244
suppression, apoptosis and cell
cycle progression.3,6-8 PKR has been identified as the
signal transducer in cell stress signaling pathways
leading to NFκB activation.9,10 PKR mediates the
activation of signal
Data Sheet - F1926
Many cells can be activated to undergo apoptosis
following the interaction of selected ligands with cell
surface receptors. The most well-studied receptors are
CD95/Fas/Apo-1 (apoptosis inducing protein
Data Sheet - F8799
receptors involved in apoptosis are
CD95/Fas/Apo-1 (apoptosis inducing protein 1) and
TNF receptor I (TNF RI). Apoptosis mediated by both
signaling cascades results in activation of a family of
cysteine
MONOCLONAL ANTI-CASPASE 9 CLONE CAS9 Purified Mouse Immunoglobulin
has a role in inflammation as well as in apoptosis; these
proteases may also be indirectly involved in apoptosis
as activators of other caspases (upstream activity).
Caspase-8 and -10 are involved in death
User Guide-APT173
proteases/caspases initiates apoptosis in mammalian cells. The Chemicon® Caspase-9
Colorimetric Activity Assay Kits provide a simple and convenient means for assaying the activity of caspases that
recognize
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