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Reduce Contamination Risks and Simplify Filtration System Design and Operation
for connecting automated integrity testing instruments to sterilizing filters -
A: connection through the filter inlet, B: connection through the AMPP on Millipak® Final Fill filters.
A B
Clamp
Integritest®5: Integrity assurance with ease and confidence
waiting for the
previous test to finish.
History and experience matter. We introduced the first commercial automated integrity tester over 25 years ago. We were the first to automate
sizing, and we developed
Technical Brief: Bubble Point Testing with Integritest®5
Introduction
The Integritest® line of automated
integrity testing instruments uses
pressure decay measurements
to determine the integrity of a
filter. Along with a system volume
measurement, one pressure
Best Practices for Integrity Testing of Viresolve®Pro Devices
considerations for integrity testing using automated
integrity testers. Before testing, the Viresolve® Pro Device
should be separated or isolated from prefilters.
Device Wetting
Complete filter wetting is
Viresolve® Barrier Filter User Guide
The integrity test may be performed using an automated
integrity tester or a manual integrity test set-up.
Automated Integrity Testing
The Integritest® Automated Integrity Test Instruments
are recommended
Integritest 4N Central Instrument Management Tool Software, DS1032EN00
4N
Filter Integrity Test
Instrument
Consistent, Effective and Reliable Integrity
Tester Instrument Management
Centralized user and instrument management of all
Integritest 4N test systems
MAS-100 Atmos® Brochure
controlled
by the instrument.
The additional safety features of the lid prevent accidental
opening while the instrument is under pressure.
Minimizes
Risk
Fully integrated software
There’s no
User Guide: Natrix® CH Bench Chromatography Membrane
The integrity test can be conducted using either an automated
integrity tester or a manual testing setup.
Automated Integrity Testing
The Integritest® Automated Integrity Test Instruments are
recommended
Buffer Preparation for Plasma Processes
if
necessary. Integrity testing can be streamlined by
using an automated filter integrity tester.
History and experience matter. We introduced the first commercial
automated integrity tester over 25
AccuSMART RFID Reader - Part of the SMART Technology Platform for the mistake free efficient exchange of critical information
your Millipore Integritest® 4
Automated Integrity Tester from the AccuSMART
Reader with a bar code reader connected to
Millipore’s Integritest 4 Instrument.
3. Attach the print-out to your log
Integrity Testing Opticap® XL 150, 300, and 600 Small-scale Capsules (SSCs) with Millipore Express® Membranes using Air/Water Diffusion and an Automatic Integrity Tester (AIT)
and prevents the use of a non-integral filter. Integrity test-
ing of sterilizing filters after a batch has been filtered, can
detect whether the integrity of the filter has been compro-
mised during
SMART Technology
using the filter specific
information stored on the RFID tag of each filter. An
on board printer prints results in alpha numeric and
bar code formats for easy input into your automated
integrity tester
Automation for Integritest ®5
communication, ensuring reliability and security of filter integrity testing.
Industrial
Automation
Types
Remote Access
• Secure access to your IT5 from
anywhere on the network
• Access from
Viresolve® NFR Filters
Viresolve NFR filters. When using the instrument,
program the diffusion stabilization time for 15 minutes.
For all other automated integrity testers, contact Millipore
for advice on optimizing test protocols
Viresolve® Pro Modus and Magnus Devices User Guide
Automated Filter
Integrity Test Instruments from Millipore are
recommended. Refer to the instrument user
guide for instructions. Contact Millipore for
guidance with other integrity testers.
If the
Viresolve® NFP Filters
Pre-use Integrity Testing
Test Viresolve NFP filters manually, or with the aid of an
automated integrity tester or a downstream flow meter.
Filters must be properly wetted prior to integrity testing
Viresolve®Pro Solution Performance Guide
described.
End-user integrity testing (the air diffusion test) can be
accomplished either manually or with automated integrity
test instrumentation. Equivalency between the two methods
was demonstrated
Designing, Developing SOPs and Validating Filter Steam Sterilization Cycles, DME83
thermocouples
- Piping design
- Monitoring instrumentation
- Filter design
11.30 • Post sterilisation pre-use integrity
testing
- Common practice
- MilliBarrier® filter
- Applications
12.30 Lunch
Course
Bio4C ACE™ Software Data Sheet
alarms and instrument
status are easily accessible.
• Data Integrity: simple data backup and restore,
and audit trails ensure data integrity.
• Process Automation: recipes automate execution
Verification of the Hamilton Microlab®STARlet for Use with the SMCxPRO and Erenna®Immunoassay Systems Powered by Single Molecule Counting (SMC) Technology
Immunoassay
System with SMC™ Immunoassays integrated onto the
Hamilton Microlab® STARlet liquid handling workstation
in order to create a hands-free, automated, assay-ready
workflow (see Workflow at end
Data Sheet: Cellicon® Cell Retention Solution for Process Scale
Release Criteria
100% Filter Integrity Tested
C5VP020A: Each filter unit exhibited an air flow rate through the
membrane of ≤ 19.9 sccm at 3 psi.
C5VP080A: Each filter unit exhibited an air flow
ADC Case Study Single-Use Technology
filtration skids
• Integritest® 4 series automated filter
integrity test instrument
Conjugation with
linker molecule
• Sterilizing-grade Aervent® filters
• Mobius® single-use mixing
solution
Cellicon® Cell Retention Solution for Process Scale
Release Criteria
100% Filter Integrity Tested
C5VP020A: Each filter unit exhibited an air flow rate through the
membrane of ≤ 19.9 sccm at 3 psi.
C5VP080A: Each filter unit exhibited an air flow
MAST® Autosampling Solution datasheet
business of Merck KGaA,
Darmstadt, Germany.
2
Benefits
Process Automation:
This sampling technique is fully automated
and minimizes the need for off-line sampling,
effectively reducing several
Steam-in-Place Sterilization of Filtration Trains containing Milligard®PES Prefilters
After SIP
sterilization, the integrity of all prefilters and sterilizing
filters was confirmed using an automated Integritest®
instrument.
Table 1: Summary of filter conditions and SIP
treatments
ADC Process Flow
filtration skids
• Integritest® 4 series automated filter
integrity test instrument
Conjugation with
linker molecule
• Sterilizing-grade Aervent® filters
• Mobius® single-use mixing
solution
Integritest® 5 OPC-UA Automation User Guide
simulator can be used to try and stage Automation. The results are simulated for each test but the
interface and methods are the same as the instrument. IT5 Instruments are licensed using an
activation key
MultiScreen HTS Vacuum Manifold
MultiScreenHTS 384 well filter plates on the
HTS manifold (n=2) versus a 384-well
plate on an “other” manifold. Average
total droplets are per 384-well plate.
Easy Integration
for Automated Sample
Processing
CELLUL AR AND PROTEIN WORKFLOW SOLUTIONS
Stericup®
Filter
Units
Muse®
Cell
Analyzer
Pure-
Proteome™
Magnetic
Beads
CellASIC®
ONIX
Microfluidic
Platform
Amicon®
Ultra
Centrifugal
Filters
Milli-Q®
Integral
Water
Purifier
Cogent® M1 TMP Control Tangential Flow Filtration System
to install.
Air Integrity Test
In order to ensure that the cassette has been installed
properly and has not sustained any damage during stor-
age and handling, integrity testing all TFF assemblies
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