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Matteo Gallidabino et al.
Analytical and bioanalytical chemistry, 407(23), 7123-7134 (2015-07-15)
In forensic investigation of firearm-related cases, determination of the residual amount of volatile compounds remaining inside a cartridge could be useful in estimating the time since its discharge. Published approaches are based on following the decrease of selected target compounds
Jill E Kucab et al.
Mutation research, 773, 48-62 (2015-04-08)
Somatic mutations in the tumour suppressor gene TP53 occur in more than 50% of human tumours; in some instances exposure to environmental carcinogens can be linked to characteristic mutational signatures. The Hupki (human TP53 knock-in) mouse embryo fibroblast (HUF) immortalization
Sebastian Allmann et al.
Nucleic acids research, 48(21), 12085-12101 (2020-11-10)
Transcriptional regulation of DNA repair is of outmost importance for the restoration of DNA integrity upon genotoxic stress. Here we report that the potent environmental carcinogen benzo[a]pyrene (B[a]P) activates a cellular DNA damage response resulting in transcriptional repression of mismatch
Rihui Su et al.
Journal of chromatography. A, 1405, 23-31 (2015-06-17)
In this work, polymerized high internal phase emulsion (polyHIPE) monoliths were prepared and applied as monolithic adsorbent materials for proconcentration of trace polycyclic aromatic hydrocarbons (PAHs) from large-volume water samples. The monolithic polyHIPE columns were prepared by in situ polymerization
Jill E Kucab et al.
Cell, 177(4), 821-836 (2019-04-16)
Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79 known or suspected environmental carcinogens. Forty-one yielded characteristic
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(8) (2020-04-23)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepatic and intestinal
T M A L Klem et al.
Vascular and endovascular surgery, 47(3), 213-215 (2013-02-27)
During endovenous laser ablation (EVLA) of the great saphenous vein, patients often involuntarily mention an uncomfortable "burnt" smell and taste. When applying intense heat to proteins and carbohydrates, it is inevitable that polycyclic aromatic hydrocarbons (PAHs) are formed. This group
Verena Christen et al.
Aquatic toxicology (Amsterdam, Netherlands), 150, 93-102 (2014-03-29)
UDP-Glucuronosyltransferases (Ugts) are phase II biotransformation enzymes that glucuronidate numerous endogenous and xenobiotic substrates. Based on the reported zebrafish Ugt gene repertoire, primers for the Ugt1a and Ugt1b family and for individual Ugt5a1, Ugt5a3, Ugt5a4, Ugt5a5, Ugt5c2 and Ugt5c3 were
Lilai Yuan et al.
Ecotoxicology and environmental safety, 106, 86-94 (2014-05-20)
ATP-binding cassette (ABC) transporters together with phase I and II detoxification enzymes have been considered as included in a cellular detoxification system. Previous studies have highlighted the involvement of aryl hydrocarbon receptor (AHR) and Cyp1a in PAH-induced embryo toxicity. However
Wunhak Choo et al.
Environmental health and toxicology, 32, e2017016-e2017016 (2017-10-14)
Carcinogenesis is a complex process involved in genotoxic and non-genotoxic pathways. The carcinogenic potential of silver nanoparticles (AgNPs) has been predicted by examining their genotoxic effects using several in vitro and in vivo models. However, there is no little information
Soma Banerjee et al.
The journal of physical chemistry. B, 117(14), 3726-3737 (2013-03-15)
Reactions involving electron transfer (ET) and reactive oxygen species (ROS) play a pivotal role in carcinogenesis and cancer biochemistry. Our present study emphasizes UVA radiation induced ET reaction as one of the key aspects of a potential carcinogen, benzo[a]pyrene (BP)
Isaac A Adedara et al.
Renal failure, 37(3), 497-504 (2015-01-24)
Benzo(a)pyrene (B[a]P), a polycyclic aromatic hydrocarbon generally formed from incomplete combustion of organic matter, reportedly causes renal injury and elicits a nephropathic response. The present study investigated the modulatory effect of Kolaviron, an isolated bioflavonoid from the seed of Garcinia
Sahel Pakzad Toochaei et al.
Environmental science and pollution research international, 26(25), 26090-26101 (2019-07-08)
Global DNA methylation, as an epigenetic modifications, can be a promising genomic marker for monitoring the contaminants and predicting their adverse health effects. The study aims to assess the effects of 16 PAH concentration on the altered DNA methylation levels
Lior Izhar et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1462-E1469 (2013-03-27)
DNA lesions can block replication forks and lead to the formation of single-stranded gaps. These replication complications are mitigated by DNA damage tolerance mechanisms, which prevent deleterious outcomes such as cell death, genomic instability, and carcinogenesis. The two main tolerance
M Crampon et al.
Environmental science and pollution research international, 21(13), 8133-8145 (2014-03-29)
The natural biodegradation of seven polycyclic aromatic hydrocarbons (PAHs) by native microorganisms was studied in five soils from Normandy (France) from diffusely polluted areas, which can also pose a problem in terms of surfaces and amounts of contaminated soils. Bioavailability
Celia Fernández-Blanco et al.
Toxicology letters, 235(2), 61-66 (2015-04-02)
Oxidative stress occurs as a consequence of an imbalance between the prooxidant/antioxidant systems, causing an increase of intracellular generation of reactive oxygen species. Alternariol (AOH), a mycotoxin produced by Alternaria sp. can alter the action of glutathione (GSH) and the
Kusum Rathore et al.
Cancer letters, 333(1), 113-123 (2013-01-29)
Stem-like cells and the epithelial-to-mesenchymal transition (EMT) program are postulated to play important roles in various stages of cancer development, but their roles in breast cell carcinogenesis and intervention remain to be clarified. We investigated stem-like cell- and EMT-associated properties
Xiaoli Peng et al.
Cancer prevention research (Philadelphia, Pa.), 8(6), 509-517 (2015-03-19)
Our previous study selected a promising chemopreventive agent 3,6-dihydroxyflavone (3,6-DHF) and found that 3,6-DHF significantly upregulates miR-34a and downregulates miR-21 in breast carcinogenesis, yet the upstream and downstream events of the anticancer mechanism remain unclear. The present study showed that
Yadong Wang et al.
Archives of toxicology, 89(3), 451-458 (2014-05-23)
Benzo(a)pyrene (BaP) is one of the strongest carcinogens in cigarette smoke, which is an established human carcinogen. Twist, a transcription factor of the basic helix-loop-helix class, is reported to regulate lung cancer metastasis. Evidence has shown that BaP could induce
Louisa A Hooven et al.
Bioorganic & medicinal chemistry letters, 15(5), 1283-1287 (2005-02-17)
In this study, we investigated the effects of histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) on the metabolism of polycyclic aromatic hydrocarbons (PAH) in human mammary carcinoma derived MCF-7 cells in culture. Benzo[a]pyrene (B[a]P) induces
Nisha Verma et al.
Proteomics, 12(11), 1731-1755 (2012-05-25)
Benzo[a]pyrene (BaP), a five-ring polycyclic aromatic hydrocarbon, is a well-recognized environmental pollutant. Coal-processing waste products, petroleum sludge, asphalt, creosote, and tobacco smoke, all contain high levels of BaP. Exposure to BaP elicits many adverse biological effects, including tumor formation, immunosuppression
Khuraman Mustafayeva et al.
Journal of natural products, 73(2), 99-103 (2010-01-09)
Gentiopicroside (1) is the major secoiridoid glucoside constituent of Cephalaria kotschyi roots. The mutagenicity, DNA-damaging capacities, and clastogenicity of this molecule were evaluated by the Salmonella typhimurium mutagenicity assay (Ames test) on tester strains TA97a, TA98, TA100, and TA102, the
Gizem Örs et al.
Turkish journal of biology = Turk biyoloji dergisi, 42(5), 453-462 (2019-04-02)
Benzo[a]pyrene (B[a]P) is a ubiquitous environmental pollutant that reacts with skin and induces intracellular oxidative stress through reactive oxygen species (ROS) accumulation. The antipollution properties of natural extracts, especially including antioxidants, for inhibiting ROS in cells are gaining importance, in
Francesca Vinchi et al.
Gastroenterology, 146(5), 1325-1338 (2014-02-04)
The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural
Seniyat Larai Afegbua et al.
International journal of phytoremediation, 21(3), 200-208 (2019-01-19)
Plant growth promoting bacteria (PGPB) enhanced phytoremediation (PEP) is an attractive remedial strategy for the remediation of polycyclic aromatic hydrocarbon (PAH) and heavy metal (HM) contaminated sites. The effect of PGPB; Pseudomonas putida UW4 inoculation on the phytoremediation efficiency of
Noriatsu Ozaki et al.
Water research, 80, 337-345 (2015-06-01)
The loading and removal of polycyclic aromatic hydrocarbons (PAHs) were measured and estimated in a wastewater treatment plant in a separated sewer system in a suburban area of Japan. The influent 16 PAHs concentration was 219 ± 210 ng L(-1)
Mario T Schellenberger et al.
Toxicology and applied pharmacology, 271(2), 175-183 (2013-05-21)
Benzo[a]pyrene (B[a]P) is a small molecular weight carcinogen and the prototype of polycyclic aromatic hydrocarbons (PAHs). While these compounds are primarily known for their carcinogenicity, B[a]P and its metabolites are also neurotoxic for mammalian species. To develop a prophylactic immune
Daniel J Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15837-15845 (2020-06-24)
Despite broad appreciation of their clinical utility, it has been unclear how vitamin B12 and folic acid (FA) function at the molecular level to directly prevent their hallmark symptoms of deficiency like anemia or birth defects. To this point, B12
Gisela A Umbuzeiro et al.
Environmental and molecular mutagenesis, 55(6), 510-517 (2014-03-01)
The Salmonella/microsome assay is the most used assay for the evaluation of air particulate matter (PM) mutagenicity and a positive correlation between strain TA98 responses and benzo[a]pyrene (B[a]P) levels in PM has been found. However, it seems that the major
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(7) (2020-04-15)
We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising
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