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Md Kaimul Ahsan et al.
American journal of physiology. Gastrointestinal and liver physiology, 319(2), G121-G132 (2020-06-23)
Nongenomic glucocorticoid (GC) and serum- and glucocorticoid-inducible kinase 1 (SGK1) signaling regulate ion transport, but CFTR has not been investigated in the intestine. We examined GC, SGK1, and phosphatidylinositol 3-kinase (PI3K) kinase signaling of CFTR ion transport in native intestine
Julia Dolinina et al.
American journal of physiology. Renal physiology, 311(5), F984-F990 (2016-09-30)
There is increasing evidence that the permeability of the glomerular filtration barrier (GFB) is partly regulated by a balance between the bioavailability of nitric oxide (NO) and that of reactive oxygen species (ROS). It has been postulated that normal or
Rabindra Nath Das et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(19), 6008-6014 (2012-03-31)
Transparent self-standing supramolecular hydrogels were readily prepared by the potassium-ion-mediated self-organization of guanosine and 8-bromoguanosine whilst the individual components precipitated within a few hours. VT-NMR spectroscopy showed that bromoguanosine was a superior gelator compared to guanosine. XRD analysis showed that
Astrid Weyerbrock et al.
Neuro-oncology, 13(2), 203-211 (2010-11-03)
Nitric oxide (NO) signaling in tumors and endothelial cells regulates vascular permeability and blood flow and therefore influences tumor uptake and response to therapeutic compounds. As delivery and efficacy of chemotherapy is impaired in CNS neoplasms due to a partially
Oli Sarkar et al.
PloS one, 12(7), e0179301-e0179301 (2017-07-12)
Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit decreased levels of nitric oxide (NO) that may be responsible for the overexpression of Giα proteins that has been shown as a contributing factor for the pathogenesis of hypertension
Leishmania amazonensis infection is reduced in macrophages treated with guanine ribonucleosides.
S Giorgio et al.
Acta tropica, 70(1), 119-122 (1998-08-26)
J H Nascimento et al.
American journal of physiology. Cell physiology, 281(4), C1251-C1258 (2001-09-08)
The effects of a monoclonal antibody (B8E5) directed against the second extracellular loop of the muscarinic M(2) receptor were studied on the L-type Ca(2+) currents (I(Ca,L)) of guinea pig ventricular myocytes using the whole cell patch-clamp technique. Similar to carbachol
M G Goodman et al.
Cellular immunology, 123(2), 417-426 (1989-10-15)
The mechanism of action of a group of synthetic lymphokine-like molecules, the C8-substituted guanine ribonucleosides, was studied. Among their pleiotropic effects on B cells are the increased expression of surface Ia antigens, induction of polyclonal immunoglobulin secretion, enhancement of thymus-dependent
Peng Li et al.
Cancer research, 77(18), 5095-5106 (2017-09-17)
High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal (GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and morbidity and mortality in nuclear disasters. No approved prophylaxis or therapy exists for
Joyce E Heckman et al.
Biochemistry, 44(11), 4148-4156 (2005-03-16)
The hammerhead ribozyme has been intensively studied for approximately 15 years, but its cleavage mechanism is not yet understood. Crystal structures reveal a Y-shaped molecule in which the cleavage site is not ideally aligned for an S(N)2 reaction and no
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes.
Fusi, et al.
Biochemical Pharmacology, 182, 114263-114263 (2021)
Narumi Hashikawa-Hobara et al.
Biochemical and biophysical research communications, 478(2), 970-975 (2016-08-16)
We investigated whether Angiotensin II type 2 (AT2) receptor activation was involved in NGF-induced nerve regeneration. NGF-mediated neurite outgrowth in cultured dorsal root ganglia (DRG) cells was significantly inhibited by AT2 receptor antagonist (PD123,319) treatment. AT2 receptor knockdown also inhibited
Yung-hyo Koh et al.
Nucleosides, nucleotides & nucleic acids, 23(1-2), 501-507 (2004-03-27)
A series of 2,6,8-trisubstituted purine nucleoside libraries was prepared by parallel solid-phase synthesis using 8-bromoguanosine as a common synthetic precursor. Polystyrene-methoxytrityl chloride resin was linked to the N2 or O5' position of the guanosine analogues. 8-Bromoguanosine was derivatized at the
Soichiro Akashi et al.
Biochemistry, 55(5), 751-761 (2016-01-20)
8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is a nitrated derivative of guanosine 3',5'-cyclic monophosphate (cGMP) formed endogenously under conditions associated with production of both reactive oxygen species and nitric oxide. It acts as an electrophilic second messenger in the regulation of cellular
Sandra Cristina Barão et al.
Chemotherapy, 49(4), 159-162 (2003-07-30)
In this study, we investigated the effect of 8-bromoguanosine (8Brguo), an immunostimulatory compound, in a murine model of experimental cutaneous leishmaniasis. The results indicated that treatment by intraperitoneal administration of 8Brguo (150 mg/kg once daily for 1 week and thereafter
M G Goodman
Cellular immunology, 129(2), 377-384 (1990-09-01)
C8-substituted guanine ribonucleosides activate B cells by a novel pathway that apparently is independent of GTP-binding proteins and protein kinase C. B lymphocytes from SJL mice are hyporesponsive to antigen-independent inductive signals transmitted by these nucleosides. In the current studies
Aline M S Yamashita et al.
American journal of physiology. Cell physiology, 313(1), C11-C26 (2017-04-07)
Nitric oxide (NO) contributes to myogenesis by regulating the transition between myoblast proliferation and fusion through cGMP signaling. NO can form S-nitrosothiols (RSNO), which control signaling pathways in many different cell types. However, neither the role of RSNO content nor
T Yoneyama et al.
Archives of biochemistry and biophysics, 388(1), 67-73 (2001-05-22)
GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates the feedback inhibition of GTP cyclohydrolase I activity by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) through protein complex formation. Since guanine and BH4 have a common pyrimidine ring structure, we examined the inhibitory effect of guanine
Ian Mutton et al.
Journal of chromatography. A, 1218(23), 3711-3717 (2011-05-06)
The development of a seven-component test mixture designed for use with a generic gradient and a reversed-phase high performance liquid chromatography-mass spectrometry (RP-HPLC-MS) system is discussed. Unlike many test mixtures formulated in order to characterise column quality at neutral pH
Adriana Buskin et al.
Nature communications, 9(1), 4234-4234 (2018-10-14)
Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non-syndromic retinal disease. Here, we generate transcriptome profiles from RP11 (PRPF31-mutated) patient-derived retinal organoids and retinal pigment epithelium
Carla B Mellough et al.
Stem cells translational medicine, 8(7), 694-706 (2019-03-28)
A major goal in the stem cell field is to generate tissues that can be utilized as a universal tool for in vitro models of development and disease, drug development, or as a resource for patients suffering from disease or
Long Bai et al.
Endocrinology, 158(9), 2813-2825 (2017-09-16)
Lithium chloride (LiCl) is widely prescribed for the treatment of bipolar disorders and is associated with a higher incidence of reproductive adverse effects. Cyclooxygenase (COX)-2 and its derivative, prostaglandin E2 (PGE2), play regulatory roles in the human ovulatory process. Whether
Lin Yan et al.
Clinical and experimental pharmacology & physiology, 30(12), 943-950 (2003-12-18)
1. We tested the hypothesis that the cGMP-dependent protein kinase has major negative functional effects in cardiac myocytes and that the importance of this pathway is reduced in thyroxine (T4; 0.5 mg/kg per day for 16 days) hypertrophic myocytes. 2.
Stefanie Gnipp et al.
Scientific reports, 8(1), 10969-10969 (2018-07-22)
Allergic airway inflammation is accompanied by excessive generation of nitric oxide (NO). Beside its detrimental activity due to the generation of reactive nitrogen species, NO was found to modulate immune responses by activating the NO-sensitive Guanylyl Cyclases (NO-GCs) thereby mediating
S Watanabe et al.
Visual neuroscience, 14(4), 609-615 (1997-07-01)
Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in
V M Ferreira et al.
Alcoholism, clinical and experimental research, 23(12), 1898-1904 (2000-01-12)
Nitric oxide (NO) is a neuromodulator and an intercellular and retrograde messenger that mediates several functions in the central nervous system. The effects of ethanol (EtOH) on neuronal NO-dependent pathways have been the focus of recent research. Most studies have
Kazuhiro Nagayama et al.
In vitro cellular & developmental biology. Animal, 55(1), 45-51 (2018-11-07)
Osteocytes regulate bone remodeling, especially in response to mechanical loading and unloading of bone, with nitric oxide reported to play an important role in that process. In the present study, we found that 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), a second messenger
Puneet Sodhi et al.
The Journal of physiology, 592(19), 4201-4220 (2014-07-20)
Adenosine is an established neuromodulator in the mammalian retina, with A1 adenosine receptors being especially prevalent in the innermost ganglion cell layer. Activation of A1 receptors causes inhibition of adenylate cyclase, decreases in intracellular cyclic AMP (cAMP) levels and inhibition
Daniel Pecher et al.
Molecules (Basel, Switzerland), 23(7) (2018-07-19)
Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations between levels of TP
Rieko Yajima et al.
Chemistry & biology, 14(1), 23-30 (2007-01-27)
Recent studies indicate that RNA function can be enhanced by the incorporation of conformationally restricted nucleotides. Herein, we use 8-bromoguanosine, a nucleotide analog with an enforced syn conformation, to elucidate the catalytic relevance of ribozyme structures. We chose to study
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