Showing 1-30 of 223 results for "B2531"
Maria A Hahn et al.
Cell reports, 3(2), 291-300 (2013-02-14)
DNA methylation in mammals is highly dynamic during germ cell and preimplantation development but is relatively static during the development of somatic tissues. 5-hydroxymethylcytosine (5hmC), created by oxidation of 5-methylcytosine (5mC) by Tet proteins and most abundant in the brain...
Chun-Ping Zhang et al.
Endocrinology, 152(6), 2437-2447 (2011-03-24)
Notch signaling is an evolutionarily conserved pathway, which regulates cell proliferation, differentiation, and apoptosis. It has been reported that the members of Notch signaling are expressed in mammalian ovaries, but the exact functions of this pathway in follicle development is...
Mengmeng Liu et al.
Journal of molecular histology, 49(5), 519-530 (2018-08-22)
During the development of mammalian cortex, late neurons generated by neuronal progenitors bypass earlier-born neurons and migrate to reach upper layers of cortical plate in an inner-to-outer fashion. Filamentous-actin (F-actin) can regulate neuronal migration, whereas Coactosin-like protein 1 (Cotl1) modulates...
Anaïs Wambecke et al.
PloS one, 14(12), e0225860-e0225860 (2019-12-12)
Epithelial ovarian cancers are insidious pathologies that give a poor prognosis due to their late discovery and the increasing emergence of chemoresistance. Development of small pharmacological anticancer molecules remains a major challenge. Ribavirin, usually used in the treatment of hepatitis...
S Krishna-Subramanian et al.
International journal of cancer, 130(12), 2771-2782 (2011-08-02)
Ursodeoxycholic acid (UDCA) attenuates colon carcinogenesis in humans and in animal models by an unknown mechanism. We investigated UDCA effects on normal intestinal epithelium in vivo and in vitro to identify the potential chemopreventive mechanism. Feeding of mice with 0.4%...
Jian-Xin Yan et al.
Photobiomodulation, photomedicine, and laser surgery, 37(1), 17-24 (2019-05-06)
Objective: The objective of the present study was to investigate the application of a carbon arc lamp on wound...
Irving Tc Ling et al.
Developmental biology, 421(2), 219-232 (2016-12-03)
Formation of the mandible requires progressive morphologic change, proliferation, differentiation and organization of chondrocytes preceding osteogenesis. The Wnt signaling pathway is involved in regulating bone development and maintenance. Chondrocytes that are fated to become bone require Wnt to polarize and...
Chuncheng Liu et al.
PloS one, 13(7), e0201551-e0201551 (2018-08-01)
MiRNAs play an important role in cell proliferation, apoptosis, and differentiation. MiR-18a is increasingly being recognized as a regulator of cancer pathogenesis. Here, we discovered that miR-18a participates in myoblasts proliferation. Expression of miR-18a was downregulated with the differentiation of...
Jésica Flores-Martín et al.
PloS one, 7(8), e44152-e44152 (2012-09-07)
StAR-related lipid transfer domain containing 7 (StarD7) is a member of the START-domain protein family whose function still remains unclear. Our data from an explorative microarray assay performed with mRNAs from StarD7 siRNA-transfected JEG-3 cells indicated that ABCG2 (ATP-binding cassette...
Dacheng Ding et al.
Acta neuropathologica communications, 2, 31-31 (2014-04-02)
Notch and Hedgehog signaling have been implicated in the pathogenesis and stem-like characteristics of glioblastomas, and inhibitors of the pathways have been suggested as new therapies for these aggressive tumors. It has also been reported that targeting both pathways simultaneously...
Dong Zhou et al.
Journal of the American Society of Nephrology : JASN, 25(10), 2187-2200 (2014-04-20)
Tubular epithelium constitutes the majority of the renal parenchyma and is the primary target of various kidney injuries. However, how the injured tubules drive interstitial fibroblast activation and proliferation remains poorly understood. Here, we investigated the role of sonic hedgehog...
Celia E Shiau et al.
Developmental biology, 348(1), 107-118 (2010-10-05)
Glypicans are conserved cell surface heparan sulfate proteoglycans expressed in a spatiotemporally regulated manner in many developing tissues including the nervous system. Here, we show that Glypican-1 (GPC1) is expressed by trigeminal placode cells as they ingress and contribute to...
Roland S.
Non-canonical Cyclic Nucleotides (2017)
Helen Williams et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(7), 1417-1424 (2016-05-21)
Increased vascular smooth muscle cell (VSMC) migration leads to intimal thickening which acts as a soil for atherosclersosis, as well as causing coronary artery restenosis after stenting and vein graft failure. Investigating factors involved in VSMC migration may enable us...
Heiko van der Kuip et al.
BMC cancer, 6, 86-86 (2006-04-11)
Sensitivity of breast tumors to anticancer drugs depends upon dynamic interactions between epithelial tumor cells and their microenvironment including stromal cells and extracellular matrix. To study drug-sensitivity within different compartments of an individual tumor ex vivo, culture models directly established...
Yi-Chao Niu et al.
Experimental and therapeutic medicine, 20(2), 1467-1479 (2020-08-04)
Dysregulation of microRNAs serves a crucial role in the chemosensitivity to cisplatin (DDP) in ovarian cancer (OVC). The abnormal expression of microRNA (miR)-654-3p has been reported in several types of human cancer. However, the association between miR-654-3p and cisplatin resistance...
Narges Pachenari et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 93, 1074-1082 (2017-07-26)
The effects of Wnt signaling modifiers on cell proliferation, seem to be cell specific. Enhancing the proliferation of subventricular zone (SVZ) progenitors has been in the focus of research in recent years. Here we investigate the effect of CHIR99021, a...
Ashwini Balakrishnan et al.
Developmental biology, 373(1), 118-129 (2012-10-20)
Teratomas are a unique class of tumors composed of ecto-, meso- and endodermal tissues, all foreign to the site of origin. In humans, the most common teratoma is the ovarian teratoma. Not much is known about the molecular and genetic...
L Latonen et al.
Oncogene, 30(7), 790-805 (2010-10-20)
The ubiquitin-proteasome pathway is essential for most cellular processes, including protein quality control, cell cycle, transcription, signaling, protein transport, DNA repair and stress responses. Hampered proteasome activity leads to the accumulation of polyubiquitylated proteins, endoplastic reticulum (ER) stress and even...
MaryClare F Rollins et al.
Journal of cell science, 123(Pt 14), 2402-2412 (2010-06-24)
Cells require ribonucleotide reductase (RNR) activity for DNA replication. In bacteria, electrons can flow from NADPH to RNR by either a thioredoxin-reductase- or a glutathione-reductase-dependent route. Yeast and plants artificially lacking thioredoxin reductases exhibit a slow-growth phenotype, suggesting glutathione-reductase-dependent routes...
Katarina Dittrich et al.
Purinergic signalling, 10(2), 327-336 (2013-11-26)
Purinergic signaling has considerable impact on the functioning of the nervous system, including the special senses. Purinergic receptors are expressed in various cell types in the retina, cochlea, taste buds, and the olfactory epithelium. The activation of these receptors by...
Jan A Kullmann et al.
Cell adhesion & migration, 9(3), 247-253 (2014-12-17)
Neuron migration defects are an important aspect of human neuropathies. The underlying molecular mechanisms of such migration defects are largely unknown. Actin dynamics has been recognized as an important determinant of neuronal migration, and we recently found that the actin-binding...
Yili Sun et al.
British journal of pharmacology, 173(18), 2793-2807 (2016-07-19)
Fingolimod (FTY-720) is the first oral therapeutic drug approved for the relapsing-remitting forms of multiple sclerosis. Neural stem cells (NSCs) are capable of continuous self-renewal and differentiation. The dentate gyrus of the hippocampus in the adult mammalian brain contains a...
Meng-Ju Lin et al.
Scientific reports, 6, 36188-36188 (2016-11-08)
A delicate balance between proliferating and differentiating signals is necessary to ensure proper growth and neuronal specification. By studying the developing zebrafish brain, we observed a specific and dynamic expression of a microtubule destabilizer gene, stathmin-like 4 (stmn4), in the...
Luz M Delgado et al.
Anatomical record (Hoboken, N.J. : 2007), 294(1), 11-15 (2010-12-16)
Neurogenesis was studied in the cerebellum of adult goldfish, to establish the phenomenon in this popular laboratory animal model. BrdU and proliferating cell nuclear antigen labeling revealed a high rate of cell proliferation within the molecular layer of the cerebellar...
Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats
Vija K, et al.
Pharmacology, Biochemistry, and Behavior, 106, 68-76 (2013)
Zahra Safaeinejad et al.
European journal of cell biology, 96(7), 665-672 (2017-09-04)
Resveratrol (RSV), a natural polyphenol component, has diverse biological properties. It has been shown that RSV regulated the self-renewal and differentiation of several types of stem cells, but the precise role of this compound on regulation of human embryonic stem...
Justin R Prigge et al.
Free radical biology & medicine, 52(4), 803-810 (2011-12-27)
Ribonucleotide reductase (RNR) activity requires an electron donor, which in bacteria, yeast, and plants is usually either reduced thioredoxin (Trx) or reduced glutaredoxin. Mice lacking glutathione reductase are viable and, although mice lacking thioredoxin reductase 1 (TrxR1) are embryonic-lethal, several...
Sarah Hulin-Curtis et al.
Molecular therapy. Methods & clinical development, 5, 191-199 (2017-05-26)
Approximately 50% of coronary artery bypass grafts using the autologous saphenous vein fail within 10 years due to intimal thickening. This study examined whether a gene therapy approach that selectively kills Wnt/β-catenin/T cell factor (TCF) activated vascular smooth muscle cells...
Yoonjin Lee et al.
Nature, 510(7506), 547-551 (2014-05-30)
Insulin constitutes a principal evolutionarily conserved hormonal axis for maintaining glucose homeostasis; dysregulation of this axis causes diabetes. PGC-1α (peroxisome-proliferator-activated receptor-γ coactivator-1α) links insulin signalling to the expression of glucose and lipid metabolic genes. The histone acetyltransferase GCN5 (general control...

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