Search Within
B4126
Applied Filters:
Keyword:'B4126'
Showing 1-30 of 461 results for "B4126" within Papers
Eva Sticova et al.
World journal of gastroenterology, 19(38), 6398-6407 (2013-10-24)
Bilirubin, a major end product of heme breakdown, is an important constituent of bile, responsible for its characteristic colour. Over recent decades, our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous
Karl Walter Bock
Biochemical pharmacology, 90(1), 1-6 (2014-05-20)
Drug-metabolizing Phase I and II enzyme families, drug transporters (Phase III) and their ligand-activated transcription factors probably evolved as a system involved in homeostatic control of lipophilic endobiotics and detoxification of xenobiotics. The review is focused on CYP, UGT enzymes
John B Whitfield et al.
Alcoholism, clinical and experimental research, 39(5), 836-842 (2015-04-16)
The risk of alcohol-related liver cirrhosis increases with increasing alcohol consumption, but many people with very high intake escape from liver disease. We postulate that susceptibility to alcoholic cirrhosis has a complex genetic component and propose that this can be
Q Liu et al.
Scandinavian journal of rheumatology, 44(3), 182-191 (2014-12-03)
Progressive destruction of synovial joint cartilage and bone occurs in pathological conditions such as rheumatoid arthritis (RA) because of the overproduction of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-κB). Through the screening of NF-κB inhibitors by a
David K Stevenson et al.
Seminars in perinatology, 35(3), 121-126 (2011-06-07)
Neonatal jaundice usually occurs in the transitional period after birth, presenting as an elevation of circulating bilirubin. Bilirubin neurotoxicity can occur if the levels of bilirubin become excessive (hyperbilirubinemia). This pathologic phenotype of newborn jaundice can develop because of excessive
Flor P Castro-García et al.
Immunology, 143(4), 578-587 (2014-06-20)
Hepatitis A virus (HAV) infection is the major cause of acute liver failure in paediatric patients. The clinical spectrum of infection is variable, and liver injury is determined by altered hepatic enzyme function and bilirubin concentration. We recently reported differences
Andreas Wibmer et al.
Radiology, 269(3), 777-786 (2013-08-15)
To determine if gadoxetic acid-enhanced magnetic resonance (MR) imaging with measurement of relative liver enhancement (RLE) on hepatobiliary phase images can allow preoperative assessment of the risk of liver failure after major liver resection. The local institutional review committee approved
R Chandirasekar et al.
Clinica chimica acta; international journal of clinical chemistry, 439, 77-83 (2014-10-14)
Rheumatoid arthritis is the commonest inflammatory joint disease, affecting nearly 1% of the adult population worldwide. Early and accurate diagnosis and prognosis of rheumatoid arthritis (RA) have become increasingly important. In the present study, we aimed to elucidate the relationships
Shuqiang Jin et al.
Canadian journal of physiology and pharmacology, 93(6), 451-457 (2015-05-01)
To explore the preventative effects of prostaglandin E1 (PGE1) on a rabbit model of CCl4-induced liver fibrosis after transcatheter arterial chemoembolization (TACE), we generated a rabbit model of CCl4-induced liver fibrosis by treatment with 40% CCl4 in iodized olive oil
Guillaume Margaillan et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1331-1335 (2015-06-17)
Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study
Bruno Hagenbuch et al.
Molecular aspects of medicine, 34(2-3), 396-412 (2013-03-20)
The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of
Xingxing Li et al.
International journal of molecular medicine, 36(5), 1319-1326 (2015-09-04)
In this study, a lateral flow immunochromatographic assay (LFIA) system for the detection of immunoglobulin M (IgM) antibodies, related to TORCH [(T)oxoplasmosis, (O)ther agents, (R)ubella (also known as German Measles), (C)ytomegalovirus, and (H)erpes simplex virus infections], based on gold magnetic
Hannelore Rücker et al.
Organic & biomolecular chemistry, 13(10), 3040-3047 (2015-01-27)
Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones. In this study we
Edoardo G Giannini et al.
Cancer, 120(14), 2150-2157 (2014-04-12)
α-Fetoprotein (AFP) is a biomarker commonly used in the management of patients with hepatocellular carcinoma (HCC), although the possible determinants of its serum levels in these patients have not been adequately explored. For this study, the authors evaluated the relevance
Minghui Song et al.
Clinical therapeutics, 35(3), 286-293 (2013-03-15)
Nephrotic syndrome is associated with hyperlipidemia and low serum bilirubin. Corticosteroids and statins are routinely administered to patients with this syndrome. However, knowledge of the mechanisms that underlie hyperlipidemia is incomplete. The aim of this study was to compare the
Hiang Keat Tan et al.
Journal of gastroenterology and hepatology, 30(2), 389-395 (2014-08-30)
Transjugular intrahepatic portosystemic shunt (TIPS) is indicated for the treatment of refractory ascites in cirrhosis. The long-term outcome of TIPS for refractory ascites is unknown. The aim of this study is to describe the natural history of patients with refractory
Nicolas Istaces et al.
Clinical biochemistry, 48(10-11), 652-657 (2015-04-12)
Personalized ranges of liver fibrosis serum biomarkers such as FibroTest or hyaluronic acid could be used for early detection of fibrotic changes in patients with progressive chronic liver disease. Our aim was to generate reliable biological variation estimates for these
Karsten Geletneky et al.
Comparative medicine, 65(1), 23-35 (2015-03-03)
Parvovirus H1 (H1PV) is an autonomous parvovirus that is transmitted in rodent populations. Its natural host is rats. H1PV infection is nonpathogenic except in rat and hamster fetuses and newborns. H1PV infection of human cancer cells caused strong oncolytic effects
Jun Yang et al.
Thyroid : official journal of the American Thyroid Association, 25(3), 278-283 (2014-11-11)
Antithyroid drug (ATD)-induced severe hepatotoxicity is a rare but serious complication of ATD therapy. The characteristics of severe hepatotoxicity have been reported in only a small number of patients. Ninety patients with ATD-induced severe hepatotoxicity presenting during a 13 year
R Zant et al.
Transplantation proceedings, 46(10), 3507-3510 (2014-12-17)
In the early phase after pediatric liver transplantation (pLT) several concomitant factors may reduce the performance of established sepsis markers. To date, their clinical interpretation is hindered by a lack of information on their postoperative kinetics. To gather more information
Yan-Qing Wang et al.
Environmental toxicology and pharmacology, 38(2), 595-606 (2014-09-10)
Decabrominateddiphenyl ether (deca-BDE) and tetrabromobisphenol A (TBBPA) are known as brominated flame-retardants, which are commonly found in the environment. The binding mechanisms of deca-BDE and TBBPA with human serum albumin (HSA) are still unknown. In this report, the interactions of
Manuela R Martinefski et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1040-1048 (2013-10-15)
Intrahepatic cholestasis of pregnancy is a high-risk liver disease given the eventual deleterious consequences that may occur in the foetus. It is accepted that the abnormal accumulation of hydrophobic bile acids in maternal serum are responsible for the disease development.
Jason M Ali et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 21(4), 487-499 (2014-12-30)
Ischemia/reperfusion injury (IRI) that develops after liver implantation may prejudice long-term graft survival, but it remains poorly understood. Here we correlate the severity of IRIs that were determined by histological grading of time-zero biopsies sampled after graft revascularization with patient
Xiaoyan Chu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 851-863 (2015-03-31)
Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for
[Current state and prospects for development of systems for photodynamic therapy of neonatal hyperbilirubinemia].
V Iu Plavskiĭ
Meditsinskaia tekhnika, (2)(2), 31-35 (2013-06-26)
The temporal pattern of postoperative coagulation status in patients undergoing major liver surgery.
Gabriel Dumitrescu et al.
Thrombosis research, 136(2), 402-407 (2015-06-07)
After major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We
Gaël Piton et al.
Shock (Augusta, Ga.), 43(5), 437-442 (2015-01-08)
Small bowel damage is frequent but underdiagnosed among critically ill patients with shock. High catecholamine doses may have a deleterious effect on mesenteric blood flow. Plasma intestinal fatty acid-binding protein (I-FABP) concentration is a marker of enterocyte damage, whereas plasma
Nicolas Mano et al.
Biosensors & bioelectronics, 50, 478-485 (2013-08-06)
Bilirubin oxidases, a sub class of the Multicopper oxidases family, were discovered in 1981 by Tanaka and Murao (Murao and Tanaka, 1981) and first used for the detection of bilirubin. Since 2001 and the pioneering work of Tsujimura, these BODs
M C Benton et al.
BMC genetics, 16, 136-136 (2015-12-03)
Located in the Pacific Ocean between Australia and New Zealand, the unique population isolate of Norfolk Island has been shown to exhibit increased prevalence of metabolic disorders (type-2 diabetes, cardiovascular disease) compared to mainland Australia. We investigated this well-established genetic
Velislava Tzaneva et al.
Respiratory physiology & neurobiology, 199, 1-8 (2014-05-02)
In this study we investigated the role of heme oxygenase-1 (HO-1) in modulating the hypoxic and hyperoxic ventilatory responses of goldfish (Carassius auratus) acclimated to 7 and 25°C. HO-1 was present in the neuroepithelial cells (NECs; putative branchial O2 chemoreceptors)
Page 1 of 16