Showing 1-30 of 157 results for "B4287"
Nikolay N Brandt et al.
Journal of biomedical optics, 20(5), 051015-051015 (2014-12-06)
The analysis of the structure-function relationship is extremely important in the study of proteins. The importance of function-related motions of large parts or subglobules of protein molecules stimulates the spectroscopic study in the low-frequency (terahertz) domain. However, only tentative assignments...
Masaaki Adachi et al.
PloS one, 4(11), e7719-e7719 (2009-11-26)
Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there have been few studies investigating...
Mr Baghaban Eslaminejad et al.
Journal of dentistry (Tehran, Iran), 7(4), 185-195 (2011-10-15)
By date investigations have indicated the presence of stem cells within the pulp tissue of both temporary and permanent human teeth. In the present study, these stem cells were compared in terms of their growth kinetics and culture requirements. Stem...
Michelle D Combs et al.
Circulation research, 105(6), 565-574 (2009-08-08)
NFATc1 (nuclear factor of activated T-cells cytoplasmic 1) activity in endocardial cushion (ECC) endothelial cells is required for normal ECC growth and extracellular matrix (ECM) remodeling during heart valve development. The mechanisms of NFATc1 activation and downstream effects on cell...
Robert W Crawford et al.
Infection and immunity, 76(11), 5341-5349 (2008-09-17)
Salmonella enterica serovar Typhi can establish a chronic, asymptomatic infection of the human gallbladder, suggesting that this bacterium utilizes novel mechanisms to mediate enhanced colonization and persistence in a bile-rich environment. Gallstones are one of the most important risk factors...
Christian Baumgartner et al.
The American journal of pathology, 175(6), 2416-2429 (2009-11-07)
Recent data suggest that the signal transducer and activator of transcription (STAT)5 contributes to differentiation and growth of mast cells. It has also been described that constitutively phosphorylated STAT5 (pSTAT5) plays a pro-oncogenic role in various myeloid neoplasms. We examined...
Christopher L Nobles et al.
Journal of microbiological methods, 118, 7-17 (2015-08-09)
Bacterial pathogens acquire host iron to power cellular processes and replication. Heme, an iron-containing cofactor bound to hemoglobin, is scavenged by bacterial proteins to attain iron. Methods to measure intracellular heme are laborious, involve complex chemistry, or require radioactivity. Such...
Zbigniew Darzynkiewicz et al.
Methods (San Diego, Calif.), 44(3), 250-254 (2008-03-04)
Activation of endonucleases that cleave chromosomal DNA preferentially at internucleosomal sections is a hallmark of apoptosis. DNA fragmentation revealed by the presence of a multitude of DNA strand breaks, therefore, is considered to be the gold standard for identification apoptotic...
Candace Kerr et al.
Molecular carcinogenesis, 57(1), 3-11 (2017-08-11)
Epidermal squamous cell carcinoma is an extremely common type of cancer. Early tumors can be successfully treated by surgery, but recurrent disease is aggressive and resistant to therapy. Cisplatin is often used as a treatment, but the outcome is rarely...
Craig Meagher et al.
Journal of immunology (Baltimore, Md. : 1950), 180(12), 7793-7803 (2008-06-05)
Autoimmune pancreatitis (AIP) is a heterogeneous autoimmune disease in humans characterized by a progressive lymphocytic and plasmacytic infiltrate in the exocrine pancreas. In this study, we report that regulatory T cell-deficient NOD.CD28KO mice spontaneously develop AIP that closely resembles the...
Noam Erez et al.
Virology journal, 6, 151-151 (2009-09-30)
Ectromelia virus, a member of the Orthopox genus, is the causative agent of the highly infectious mousepox disease. Previous studies have shown that different poxviruses induce cell-cell fusion which is manifested by the formation of multinucleated-giant cells (polykaryocytes). This phenomenon...
James C Y Dunn et al.
The Journal of surgical research, 156(2), 317-324 (2009-07-14)
The adrenal cortex may contain progenitor cells useful for tissue regeneration. Currently there are no established methods to isolate these cells. Murine adrenal cells were sorted into a Nile-red-bright (NR(bright)) and a Nile-red-dim (NR(dim)) population of cells according to their...
Eva P Browne et al.
Aquatic toxicology (Amsterdam, Netherlands), 92(4), 281-287 (2009-04-07)
Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that persist in the environment and are present in geographically widespread fish species. PBDE concentrations can be particularly high in resident Chinook salmon (Onchorhynchus tshawytscha) in the Puget Sound, Washington. Although PBDE...
Steven T Leach et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 22(5), 461-464 (2008-05-15)
The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H...
Olivia N Chuang et al.
Infection and immunity, 77(1), 539-548 (2008-10-29)
Aggregation substance proteins encoded by sex pheromone plasmids increase the virulence of Enterococcus faecalis in experimental pathogenesis models, including infectious endocarditis models. These large surface proteins may contain multiple functional domains involved in various interactions with other bacterial cells and...
Yan Jiang et al.
BMC neuroscience, 9, 42-42 (2008-04-30)
DNA-protein interactions in mature brain are increasingly recognized as key regulators for behavioral plasticity and neuronal dysfunction in chronic neuropsychiatric disease. However, chromatin assays typically lack single cell resolution, and therefore little is known about chromatin regulation of differentiated neuronal...
Haiyan Dong et al.
BMC microbiology, 8, 223-223 (2008-12-18)
The usefulness of available vaccine and serological tests for leptospirosis is limited by the low cross-reactivity of antigens from numerous serovars of pathogenic Leptospira spp. Identification of genus-specific protein antigens (GP-Ag) of Leptospira would be important for development of universal...
Matthew L Fisher et al.
Oncotarget, 8(43), 73407-73418 (2017-11-02)
Epidermal squamous cell carcinoma (SCC) is among the most common cancers. SCC can be treated by surgical excision, but recurrence of therapy-resistant disease is a major problem. We recently showed that YAP1, the Hippo signaling transcription adaptor protein, and ∆Np63α...
M Szajnik et al.
Oncogene, 28(49), 4353-4363 (2009-10-15)
Toll-like receptors (TLRs) expressed on immune cells trigger inflammatory responses. TLRs are also expressed on ovarian cancer (OvCa) cells, but the consequences of signaling by the TLR4/MyD88 pathway in these cells are unclear. Here, TLR4 and MyD88 expression in OvCa...
Malgorzata Kloc et al.
Experimental cell research, 314(17), 3245-3254 (2008-07-30)
The oocytes of many invertebrate and non-mammalian vertebrate species are not only asymmetrical but also polar in the distribution of organelles, localized RNAs and proteins, and the oocyte polarity dictates the patterning of the future embryo. Polarily located within the...
Denis A Kleymenov et al.
Frontiers in microbiology, 8, 2341-2341 (2017-12-15)
Environmental or city-scale bioaerosol surveillance can provide additional value for biodefense and public health. Efficient bioaerosol monitoring should rely on multiplex systems capable of detecting a wide range of biologically hazardous components potentially present in air (bacteria, viruses, toxins and...
Markus D Lacher et al.
Molecular cancer, 10, 91-91 (2011-07-28)
We have previously reported that RAS-MEK (Cancer Res. 2003 May 1;63(9):2088-95) and TGF-β (Cancer Res. 2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake. In the case of TGF-β, down-regulation of CAR...
Ariana Jacome et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(6), 1083-1092 (2009-03-12)
Previous clinical trials based on the genetic correction of purified CD34(+) cells with gamma-retroviral vectors have demonstrated clinical efficacy in different monogenic diseases, including X-linked severe combined immunodeficiency, adenosine deaminase deficient severe combined immunodeficiency and chronic granulomatous disease. Similar protocols...
Jonathan G Fernsler et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8131-8143 (2009-06-19)
Charged, surface-active serum proteins can severely reduce or eliminate the adsorption of lung surfactant from the subphase to the alveolar air-liquid interface via a kinetically controlled competitive adsorption process. The decreased surfactant concentration at the interface leads to higher surface...
Ashok Cattamanchi et al.
Clinical and vaccine immunology : CVI, 15(11), 1638-1643 (2008-09-12)
We conducted a double-blind, vehicle-controlled, dose escalation safety and immunogenicity trial of a candidate herpes simplex virus type 2 (HSV-2) surface glycoprotein D2 (gD2) DNA vaccine administered by use of a needle-free device. Sixty-two healthy adults were randomized using a...
Vidmantas Petraitis et al.
Antimicrobial agents and chemotherapy, 53(6), 2382-2391 (2009-03-25)
We studied the antifungal activity of anidulafungin (AFG) in combination with voriconazole (VRC) against experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits and further explored the in vitro and in vivo correlations by using Bliss independence drug interaction analysis....
Ben de Wet et al.
The Journal of biological chemistry, 286(6), 4072-4080 (2010-12-04)
Early downstream responses of T lymphocytes following T cell antigen receptor (TCR) activation are mediated by protein complexes that assemble in domains of the plasma membrane. Using stable isotope labeling with amino acids in cell culture and mass spectrometry, we...
Akihiro Naito et al.
Cancer science, 99(8), 1584-1588 (2008-08-30)
The growth of LNCaP, a human prostate adenocarcinoma cell line, and MCF-7, a human breast adenocarcinoma cell line, is initially hormone dependent. We previously demonstrated that LNrho0-8 and MCFrho0, derived from LNCaP and MCF-7 by depleting mitochondrial DNA (mtDNA), exhibited...
Lindsey A Moser et al.
Journal of virology, 82(15), 7475-7482 (2008-05-30)
Human astroviruses are nonenveloped, positive-sense single-strand RNA viruses associated with self-limiting diarrhea. Although they are recognized as a leading cause of disease in young children, the cellular factors involved in astrovirus replication are not well defined. The extracellular signal-regulated kinase...
Iwona Radziejewska et al.
Clinical and experimental medicine, 11(2), 81-88 (2010-10-19)
It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of...

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