Showing 1-30 of 3294 results for "biomaterials"
Alvin Bacero Bello et al.
Tissue engineering. Part B, Reviews, 26(2), 164-180 (2020-01-08)
Health care and medicine were revolutionized in recent years by the development of biomaterials, such as stents, implants, personalized drug delivery systems, engineered grafts, cell sheets, and other transplantable materials. These materials not only support the growth of cells before...
Natalia S Fagali et al.
Colloids and surfaces. B, Biointerfaces, 160, 238-246 (2017-09-25)
The interactions that could be built between the biomaterials and tissue- microenvironments are very complex, especially in case of degradable metals that generate a broad variety of degradation products. The interfacial problems are particularly relevant for Fe-based materials that have...
Alexander M Tatara et al.
Journal of biomedical materials research. Part A, 107(9), 1867-1874 (2019-03-19)
Cutaneous fungal infection is a challenging condition to treat that primarily afflicts immunocompromised patients. Local antifungal therapy may permit the delivery of high concentrations of antifungals directly to wounds while minimizing systemic toxicities. However, the field currently lacks suitable in...
Yoon Kyung Kim et al.
Advanced healthcare materials, 3(7), 989-994 (2014-02-28)
A biomaterial inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.
Thanga Bhuvanesh Vijaya Bhaskar et al.
Clinical hemorheology and microcirculation, 61(2), 119-133 (2015-10-08)
Silicones are widely used as biomaterials for medical devices such as extracorporeal equipments. However, there is often conflicting evidence about their supposed cell- and histocompatibility. Macrophages could mediate silicone-induced adverse responses such as foreign body reaction and fibrous encapsulation. The...
Ulises Gómez-Pinedo et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 107(1), 190-196 (2018-03-25)
Repair of central nervous system (CNS) lesions is difficulted by the lack of ability of central axons to regrow, and the blocking by the brain astrocytes to axonal entry. We hypothesized that by using bridges made of porous biomaterial and...
Dibakar Mondal et al.
Journal of the mechanical behavior of biomedical materials, 104, 103653-103653 (2020-03-17)
In this study, single filaments of acrylated epoxidized soybean oil (AESO)/polyethylene glycol diacrylate (PEGDA)/nanohydroxyapatite (nHA)-based nanocomposites intended for bone defect repair have displayed significant improvement of their mechanical properties when extruded through smaller needle gauges before UV curing. These nanocomposite...
Nora Bloise et al.
Frontiers in bioengineering and biotechnology, 8, 292-292 (2020-04-23)
Coronary artery disease is a severe ischemic condition characterized by the reduction of blood flow in the arteries of the heart that results in the dysfunction and death of cardiac tissue. Despite research over several decades on how to reduce...
Antonio Conde-González et al.
Materials science & engineering. C, Materials for biological applications, 108, 110489-110489 (2020-01-12)
Three dimensional synthetic polymer scaffolds have remarkable chemical and mechanical tunability in addition to biocompatibility. However, the chemical and physical space is vast in view of the number of variables that can be altered e.g. chemical composition, porosity, pore size...
Mafalda Bessa-Gonçalves et al.
Acta biomaterialia, 114, 471-484 (2020-07-21)
Macrophage behavior upon biomaterial implantation conditions the inflammatory response and subsequent tissue repair. The hypothesis behind this work was that fibrinogen (Fg) and magnesium (Mg) biomaterials, used in combination (FgMg) could act synergistically to modulate macrophage activation, promoting a pro-regenerative...
Wen-Cheng Lo et al.
Cell transplantation, 29, 963689720947348-963689720947348 (2020-08-08)
Besides inhalation, a few studies have indicated that the uptake of nicotine through air or clothing may be a significant pathway of its exposure among passive smokers. Nicotine is well known to exert various physiological impacts, including stimulating sympathetic nervous...
Björn Binnewerg et al.
Materials science & engineering. C, Materials for biological applications, 109, 110566-110566 (2020-04-02)
Marine demosponges of the Verongiida order are considered a gold-mine for bioinspired materials science and marine pharmacology. The aim of this work was to simultaneously isolate selected bromotyrosines and unique chitinous structures from A. aerophoba and to propose these molecules...
Michael J Mitchell et al.
Biomaterials, 56, 179-186 (2015-05-03)
The metastatic spread of cancer cells from the primary tumor to distant sites leads to a poor prognosis in cancers originating from multiple organs. Increasing evidence has linked selectin-based adhesion between circulating tumor cells (CTCs) and endothelial cells of the...
Leila Lotfi et al.
Journal of biomedical materials research. Part A, 107(11), 2425-2446 (2019-06-30)
Schwann cells, in addition to forming myelin sheaths, have pivotal roles in regeneration of injured axons in the peripheral nervous system such as producing a natural permissive conduit between distal and proximal stumps and secreting nerve growth factors. Due to...
Anna E Engberg et al.
Biomaterials, 36, 55-65 (2014-10-09)
Inappropriate complement activation is often responsible for incompatibility reactions that occur when biomaterials are used. Complement activation is therefore a criterion included in legislation regarding biomaterials testing. However, no consensus is yet available regarding appropriate complement-activation-related test parameters. We examined...
Anne-Sophie Mertgen et al.
ACS applied materials & interfaces, 12(19), 21342-21367 (2020-04-15)
In the human body, cells in a tissue are exposed to signals derived from their specific extracellular matrix (ECM), such as architectural structure, mechanical properties, and chemical composition (proteins, growth factors). Research on biomaterials in tissue engineering and regenerative medicine...
Jason I Kilpatrick et al.
Advanced healthcare materials, 4(16), 2456-2474 (2015-07-23)
The behavior and mechanical properties of cells are strongly dependent on the biochemical and biomechanical properties of their microenvironment. Thus, understanding the mechanical properties of cells, extracellular matrices, and biomaterials is key to understanding cell function and to develop new...
John G Hardy et al.
International journal of molecular sciences, 16(9), 20511-20522 (2015-09-08)
Tissues in the body are hierarchically structured composite materials with tissue-specific properties. Urea self-assembles via hydrogen bonding interactions into crystalline supracolloidal assemblies that can be used to impart macroscopic pores to polymer-based tissue scaffolds. In this communication, we explain the...
Qiong Liu et al.
Biomaterials, 263, 120327-120327 (2020-09-15)
While nanoscale modification of a biomaterial surface is known to influence various cell behaviors, it is unclear whether there is an optimal nanospacing of a bioactive ligand with respect to cell migration. Herein, we investigated the effects of nanospacing of...
Alba Córdoba et al.
Advanced healthcare materials, 4(4), 540-549 (2014-10-23)
Flavonoids are small polyphenolic molecules of natural origin with antioxidant, anti-inflammatory, and antibacterial properties. Here, a bioactive surface based on the covalent immobilization of flavonoids taxifolin and quercitrin on titanium substrates is presented, using (3-aminopropyl)triethoxysilane (APTES) as coupling agent. FTIR...
R Hedayati et al.
Journal of biomedical materials research. Part A, 106(7), 1798-1811 (2018-02-23)
Magnesium and its alloys have the intrinsic capability of degrading over time in vivo without leaving toxic degradation products. They are therefore suitable for use as biodegradable scaffolds that are replaced by the regenerated tissues. One of the main concerns...
Armin Mooranian et al.
Pharmaceutical development and technology, 23(2), 145-150 (2017-04-21)
Ideal cell-containing microcapsules should be capable of maintaining cell viability and exhibit significant structural stability to support cellular functionality. To date, such microcapsules remain unavailable; thus, this study used our well-established microencapsulating methods to examine a total of 32 different...
Atsushi Tamura et al.
Beilstein journal of organic chemistry, 12, 2883-2892 (2017-02-02)
Cyclodextrin (CD)-threaded polyrotaxanes (PRXs) with reactive functional groups at the terminals of the axle polymers are attractive candidates for the design of supramolecular materials. Herein, we describe a novel and simple synthetic method for end-reactive PRXs using bis(2-amino-3-phenylpropyl) poly(ethylene glycol)...
Wen-Cheng Lo et al.
Cell transplantation, 29, 963689720947348-963689720947348 (2020-08-08)
Besides inhalation, a few studies have indicated that the uptake of nicotine through air or clothing may be a significant pathway of its exposure among passive smokers. Nicotine is well known to exert various physiological impacts, including stimulating sympathetic nervous...
A M Ostdiek et al.
Biomaterials, 65, 175-183 (2015-07-15)
Currently vascular repairs are treated using synthetic or biologic patches, however these patches have an array of complications, including calcification, rupture, re-stenosis, and intimal hyperplasia. An active patch material composed of decellularized tissue conjugated to gold nanoparticles (AuNPs) was developed...
Ali Moshiri et al.
Iranian journal of basic medical sciences, 23(11), 1426-1438 (2020-11-26)
We investigated the role of various biomaterials on cell viability and in healing of an experimentally induced femoral bone hole model in rats. Cell viability and cytotoxicity of gelatin (Gel; 50 µg/µl), chitosan (Chi; 20 µg/µl), hydroxyapatite (HA; 50 µg/µl)...
A Herrero-Mendez et al.
Journal of tissue engineering and regenerative medicine, 11(4), 989-1001 (2015-03-03)
Most new advances in tissue engineering (TE) focus on the creation of adequate microenvironments that may accelerate the repair processes of damaged tissues. Extracellular matrix (ECM) of Wharton's jelly (WJ) from umbilical cords is very rich in sulphated GAGs (sGAGs)...
Ruud A Bank et al.
Tissue engineering. Part A, 23(19-20), 1078-1087 (2017-01-17)
Macrophages are pivotal cells during the foreign body reaction (FBR), as they orchestrate the proinflammatory microenvironment inside and around biomaterials by secretion of inflammatory mediators. Furthermore, they are responsible for the degradation of biomaterials and are thought to instruct the...
Charlotte Grenade et al.
Cytotechnology, 68(6), 2437-2448 (2016-03-27)
In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was...
Mahetab H Amer et al.
Stem cell research & therapy, 9(1), 39-39 (2018-02-23)
Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This study investigated the effects of varying administration and formulation parameters of injection-based...

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