Showing 1-30 of 198 results for "C-006"
Is it farewell to codeine?
Brian J Anderson
Archives of disease in childhood, 98(12), 986-988 (2013-08-27)
K R Crews et al.
Clinical pharmacology and therapeutics, 95(4), 376-382 (2014-01-25)
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity. Polymorphisms are a major cause of CYP2D6 variability. We summarize evidence from...
Chen Liang et al.
Journal of separation science, 38(10), 1680-1690 (2015-03-18)
A liquid chromatography with tandem mass spectrometry method was developed for the simultaneous screening of 34 drugs and poisons in forensic cases. Blood (0.5 mL, diluted 1:1 with water) or 1.0 mL of urine was purified by solid-phase extraction. Gastric...
Jun Bu et al.
Journal of analytical toxicology, 37(3), 166-174 (2013-01-15)
Heroin is a highly addictive drug, and heroin abuse is considered to be a serious criminal act. The major metabolite of heroin, morphine, can usually be detected as evidence of heroin abuse. However, it is difficult to determine heroin use...
Codeine for children: weighing the risks.
Lisa D Watt et al.
Nursing, 43(11), 62-63 (2013-10-22)
Yanguang Cao et al.
Journal of pharmacokinetics and pharmacodynamics, 39(6), 711-723 (2012-11-28)
Conventional mammillary models are frequently used for pharmacokinetic (PK) analysis when only blood or plasma data are available. Such models depend on the quality of the drug disposition data and have vague biological features. An alternative minimal-physiologically-based PK (minimal-PBPK) modeling...
Paediatric codeine use after adenotonsillectomy.
K W Tan et al.
Anaesthesia, 69(10), 1179-1180 (2014-09-11)
Andrea E Steuer et al.
Forensic science international, 244, 92-101 (2014-09-15)
In the context of driving under the influence of drugs (DUID), not only common drugs of abuse may have an influence, but also medications with similar mechanisms of action. Simultaneous quantification of a variety of drugs and medications relevant in...
Codeine in mothers and children: where are we now?
A Palanisamy et al.
Anaesthesia, 69(7), 655-660 (2014-05-07)
Ynze Mengerink et al.
Bioanalysis, 7(16), 2095-2104 (2015-09-04)
DBS cards have been a big promise for decades. However, blood with low hematocrit (Ht) values results on regular cellulose-based DBS cards in larger spot sizes, compared with blood with high Ht-values. A new material has been developed to solve...
Natalie Cortes et al.
Life sciences, 122, 42-50 (2014-12-23)
Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced toxicity has been lacking. Thus, the purpose of this study...
Nathaly Reyes-Garcés et al.
Journal of chromatography. A, 1374, 40-49 (2014-12-03)
Simple, fast and efficient sample preparation approaches that allow high-throughput isolation of various compounds from complex matrices are highly desired in bioanalysis. Particularly sought are methods that can, without sacrificing time, easily remove matrix interferences capable of inducing ionization suppression/enhancement...
C Mattia et al.
Minerva medica, 105(6), 501-513 (2014-11-14)
Acute pain of mild to moderate intensity is one of the problems most frequently encountered in primary care and emergency medicine and is a major reason of request for visit by patients. In recent years the focus has been more...
Douglas M McMillan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7), 1804-1812 (2015-01-30)
CYP2D metabolically activates codeine to morphine, which is required for codeine analgesia. Permeability across the blood-brain barrier, and active efflux, suggests that initial morphine in the brain after codeine is due to brain CYP2D metabolism. Human CYP2D is higher in...
Wei Liu et al.
Journal of ethnopharmacology, 162, 79-86 (2015-01-06)
Aerial parts of Peganum harmala Linn (APP) is used as traditional medical herb in Uighur medicine in China, and it is traditionally used for treatment of cough and asthma.The aim of the present study is to evaluate the antitussive, expectorant...
Christine M Marsh et al.
Journal of analytical toxicology, 38(6), 360-367 (2014-05-02)
The discovery of two cocaine-N-oxide (CNO) diastereomers, syn- and anti-CNO, is reported for the first time. Prior to this study, only one structural form of CNO was known to exist and has not been analyzed in hair before. CNO is...
Sheena Derry et al.
The Cochrane database of systematic reviews, (4)(4), CD008099-CD008099 (2010-04-16)
Codeine is an opioid metabolised to active analgesic compounds, including morphine. It is widely available by prescription, and combination drugs including low doses of codeine are commonly available without prescription. To assess the efficacy, the time to onset of analgesia...
What is the best non-codeine postadenotonsillectomy pain management for children?
Robert F Yellon et al.
The Laryngoscope, 124(8), 1737-1738 (2014-05-29)
FDA: No codeine after tonsillectomy for children.
Bridget M Kuehn
JAMA, 309(11), 1100-1100 (2013-03-21)
J Leysen et al.
Cytometry. Part B, Clinical cytometry, 84(2), 65-70 (2013-01-29)
Immunoglubulin E antibody-mediated allergic reactions to opioids are rare and difficult to document correctly. Assessment of the basophil activation test in the diagnosis of IgE-mediated allergy to the antitussive pholcodine and associated sensitizations to neuromuscular blocking agents (NMBA). Three patients...
Rajeev Subramanyam et al.
International journal of pediatric otorhinolaryngology, 77(2), 194-199 (2012-11-20)
Although commonly performed, pediatric tonsillectomy is not necessarily a low risk procedure due to potentially life threatening perioperative complications. There is paucity of literature on lethal anesthesia and surgical complications of tonsillectomy. In this article, we have reviewed both minor...
Dilek Battal et al.
Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)
Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative...
Peter V Dicpinigaitis et al.
The Journal of pharmacology and experimental therapeutics, 352(3), 448-454 (2014-12-20)
Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough...
A K Tang et al.
East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan, 22(4), 154-159 (2012-12-29)
OBJECTIVES. Cough mixture is the third most commonly abused substance in patients attending the Prince of Wales Hospital Substance Abuse Clinic. The content of the local cough mixture is not well researched. Paranoid psychosis manifesting as persecutory delusions and derogatory...
Hirokazu Toubou et al.
Legal medicine (Tokyo, Japan), 16(5), 308-313 (2014-06-01)
A simple and precise drug screening method was developed for the detection of abused drugs in whole blood by using the Oratect® III device that is usually employed for the detection of drugs in saliva. Whole blood was acidified with...
Cynthia A Prows et al.
The Laryngoscope, 124(5), 1242-1250 (2013-10-15)
To prospectively determine factors associated with codeine's adverse drug reactions (ADRs) at home in a large homogenous population of children undergoing outpatient tonsillectomy. Prospective, genotype blinded, observational study with a single group and repeated ADR measures documented by parents at...
Jian-Rong Zhou et al.
Pharmacology, 95(1-2), 36-41 (2015-01-17)
We studied the antitussive effects of suplatast, a Th2 cytokine inhibitor, and compared them with the effects of codeine using an experimental cough model in guinea pigs. Suplatast and codeine dose-dependently inhibited cough caused by mechanical stimulation of the larynx...
Arik Dahan et al.
Journal of pharmaceutical sciences, 103(6), 1592-1600 (2014-05-03)
The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly...
Toshiyuki Iwata et al.
PloS one, 10(11), e0141823-e0141823 (2015-11-19)
Cough affects all individuals at different times, and its economic burden is substantial. Despite these widespread adverse effects, cough research relies on animal models, which hampers our understanding of the fundamental cause of cough. Postnasal drip is speculated to be...
Liyan Chen et al.
PloS one, 8(3), e59263-e59263 (2013-04-05)
Detection for cough in mice has never yielded clearly audible sounds, so there is still a great deal of debates as to whether mice can cough in response to tussive stimuli. Here we introduce an approach for detection of mouse...

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.