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c-053

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V L Yip et al.
Clinical pharmacology and therapeutics, 92(6), 757-765 (2012-11-08)
Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype. This systematic review determines the strength of these associations and
Mohammad Behbahani et al.
Journal of chromatography. A, 1308, 25-31 (2013-08-21)
A simple, rapid, and efficient method, based on surfactant assisted dispersive liquid-liquid microextraction (SA-DLLME), followed by high performance liquid chromatography (HPLC) has been developed for simultaneous preconcentration and trace detection of zonisamide and carbamazepine in biological samples. A conventional cationic
Dong Wook Kim et al.
International journal of clinical pharmacology and therapeutics, 51(10), 780-786 (2013-07-16)
Oral loading of oxcarbazepine tablet is effective and well tolerated to adequately achieve the therapeutic levels of its active metabolite, 10,11-dihydro-10-hydroxy-carbazepine (monohydroxy derivative, MHD) in epilepsy patients. The present study was performed to investigate the safety, tolerability, and pharmacokinetic profiles
Teaching video neuroimages: perioral myoclonia with absences in a 12-year-old boy.
Suvasini Sharma et al.
Neurology, 81(15), e116-e116 (2013-10-09)
PRRT2 mutation correlated with phenotype of paroxysmal kinesigenic dyskinesia and drug response.
Hong-Fu Li et al.
Neurology, 80(16), 1534-1535 (2013-03-29)
Nurcan Bektas et al.
Life sciences, 95(1), 9-13 (2013-12-24)
The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain
HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity.
S Grover et al.
Clinical pharmacology and therapeutics, 93(5), 386-387 (2013-02-28)
R Barrons et al.
Journal of clinical pharmacy and therapeutics, 35(2), 153-167 (2010-05-12)
The goal of this review is to evaluate the efficacy and safety of carbamazepine and oxcarbazepine in treatment of alcohol withdrawal syndrome (AWS) and determine the role in therapy of both agents. Relevant literature was identified through a search of
Sooyeon Jo et al.
Molecular pharmacology, 85(2), 381-387 (2013-12-10)
Voltage-gated sodium channels are inhibited by many local anesthetics, antiarrhythmics, and antiepileptic drugs. The local anesthetic lidocaine appears to be able to access its binding site in the sodium channel only from the membrane phase or from the internal face
Kousuke Nakano et al.
Epileptic disorders : international epilepsy journal with videotape, 15(3), 352-357 (2013-07-28)
We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ). Although EME is a form of early-onset epileptic encephalopathy characterised by myoclonus and focal seizures that are highly resistant
Martina Fanella et al.
Epileptic disorders : international epilepsy journal with videotape, 15(2), 181-187 (2013-06-19)
Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be underdiagnosed or misdiagnosed; in the latter case, it may be mistaken for
Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".
V L M Yip et al.
Clinical pharmacology and therapeutics, 93(5), 387-387 (2013-02-28)
Yin-Bo Chen et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 15(5), 340-342 (2013-05-17)
To investigate the clinical efficacy and safety of oxcarbazepine (OXC) suspension in children with focal epilepsy. A total of 118 children aged 2-14 years, who were newly diagnosed with focal epilepsy between October 2009 and December 2011, were randomly divided
Paul M Bradley et al.
Environmental pollution (Barking, Essex : 1987), 193, 173-180 (2014-07-20)
Pharmaceutical contamination of shallow groundwater is a substantial concern in effluent-dominated streams, due to high aqueous mobility, designed bioactivity, and effluent-driven hydraulic gradients. In October and December 2012, effluent contributed approximately 99% and 71%, respectively, to downstream flow in Fourmile
Maja Vilibić et al.
Collegium antropologicum, 37(1), 317-319 (2013-05-24)
Cobalamin deficiency is associated with a wide spectrum of hematologic, neurologic, gastroenterologic and psychiatric disorders or symptoms. We report a case of a 50-year-old man with complex partial seizures with secondary generalization, mood oscillations and psychotic symptoms alternating with confusion
Xin Yang et al.
Environmental science and pollution research international, 20(8), 5864-5875 (2013-04-24)
The occurrence and fate of eight PPCPs was studied in river waters from upstream to downstream of the three rivers in the Pearl River Delta, China. The correlations of PPCP levels and water quality parameters were also investigated. The analytes
Janneke Jentink et al.
BMJ (Clinical research ed.), 341, c6581-c6581 (2010-12-04)
To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. Review of
Huihui Chen et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 1-8 (2014-06-22)
Carbamazepine (CBZ), an anticonvulsant and mood-stabilizing pharmaceutical, is a widespread contaminant in aquatic environments. In this study, the effects of chronic exposure to environmentally relevant CBZ concentrations were investigated in freshwater clams Corbicula fluminea. Adult C. fluminea were exposed to
H N Kushwaha et al.
Drug research, 63(6), 282-288 (2013-04-06)
Coadministration of 2 or more drugs may result in unexpected toxicity. This study aimed to evaluate the effect of carbamazepine coadministration on the pharmacokinetics of CDRI-97/78, an 1,2,4-trioxane antimalarial agent. Firstly, 97/78 was administered alone and then 97/78 and carbamazepine
Sjors H W Schulpen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 311-320 (2015-05-17)
Differentiating pluripotent stem cells in vitro have proven useful for the study of developmental toxicity. Here, we studied the effects of anticonvulsant drug exposure in a human embryonic stem cell (hESC)-based neurodevelopmental toxicity test (hESTn). During neural differentiation the cells were
Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?
Subramanian Ganesan et al.
Archives of disease in childhood, 96(1), 104-106 (2010-12-21)
Jae-Sung Kim et al.
Toxicology and applied pharmacology, 273(3), 600-610 (2013-10-16)
Onset of the mitochondrial permeability transition (MPT) plays a causative role in ischemia/reperfusion (I/R) injury. Current therapeutic strategies for reducing reperfusion injury remain disappointing. Autophagy is a lysosome-mediated, catabolic process that timely eliminates abnormal or damaged cellular constituents and organelles
Waranya Rattanavipapong et al.
Epilepsia, 54(9), 1628-1638 (2013-07-31)
There is strong evidence of an association between the presence of the human leukocyte antigen (HLA)-B*15:02 and two severe adverse drug reactions-Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)-in patients taking carbamazepine (CBZ), a common treatment for patients with epilepsy
Ilya Lerman et al.
Environmental pollution (Barking, Essex : 1987), 182, 169-176 (2013-08-07)
Carbon nanotubes, organic contaminants and dissolved organic matter (DOM) are co-introduced into the environment. Thus, the interactions between these components have to be evaluated to better understand their environmental behavior. In this study, single-walled carbon nanotubes (SWCNTs) were used as
Tae Hwan Kim et al.
Epilepsia, 56(1), e6-e9 (2014-12-10)
Oxcarbazepine (OXC), widely used to treat focal epilepsy, is reported to exacerbate seizures in patients with generalized epilepsy. OXC is metabolized to monohydroxy derivatives in two enantiomeric forms: (R)-licarbazepine and (S)-licarbazepine. Eslicarbazepine acetate is a recently approved antiepileptic drug that
Maria K Swarcewicz et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(6), 1396-1402 (2013-03-20)
Carbamazepine (CBZ), nonbiodegradable pharmaceutical residue, has become an emerging pollutant in several aquatic environments. The effectiveness of the mixture of soil and fly ash (FA) in adsorbing CBZ from aqueous solution has been studied as well as agitation time, FA
Inge Anita Meijer et al.
Muscle & nerve, 49(1), 134-138 (2013-07-31)
Erythromelalgia due to heterozygous gain-of-function SCN9A mutations usually presents as a pure sensory-autonomic disorder characterized by recurrent episodes of burning pain and redness of the extremities. We describe a patient with an unusual phenotypic presentation of gross motor delay, childhood-onset
Yousheng Xiao et al.
The Cochrane database of systematic reviews, 1, CD008781-CD008781 (2012-01-20)
The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy has been well established. However, this needs to be weighed against the risk of the development of visual field defects. Whether VGB monotherapy is an effective
Sandeep Grover et al.
Pharmacogenetics and genomics, 24(2), 94-112 (2013-12-18)
A considerable heterogeneity exists in the literature on the role of different HLA alleles in carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) of varying severity among diverse ethnic groups. The aim of the present study was to understand and summarize
Robert J Hatch et al.
Epilepsia, 55(4), 601-608 (2014-03-13)
A NaV β1(C121W) mouse model of human genetic epilepsy has enhanced neuronal excitability and temperature sensitivity attributed to a decreased threshold for action potential firing in the axon initial segment. To investigate the network consequences of this neuronal dysfunction and
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