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Irene Cortés-Puch et al.
American journal of physiology. Endocrinology and metabolism, 307(11), E994-E1008 (2014-10-09)
The clinical significance and even existence of critical illness-related corticosteroid insufficiency is controversial. Here, hypothalamic-pituitary-adrenal (HPA) function was characterized in severe canine Staphylococcus aureus pneumonia. Animals received antibiotics and titrated life-supportive measures. Treatment with dexamethasone, a glucocorticoid, but not desoxycorticosterone...
Esra Gumus Bayazit et al.
International journal of clinical pharmacology and therapeutics, 51(8), 652-659 (2013-06-21)
Providing sufficient and convenient analgesia is crucial during the postoperative period after totalknee replacement (TKR) to enhance patient mobility and reduce stress response to surgery. The scope of this study is to compare the effects of levobupivacaine and levobupivacaine plus...
M V Bezruchko et al.
Klinichna khirurhiia, (3)(3), 22-25 (2013-05-31)
The results of comparison between the operation stress degree in various kinds of surgical interventions, performed for an acute cholecystitis, using determination of cortizol, prolactin and glucose content before the operation, intraoperatively and postoperatively in 50 patients, are adduced. There...
Chunming Guo et al.
Endocrinology, 155(8), 3017-3024 (2014-03-25)
Abundant evidence indicates a pivotal role of prostaglandin F2α (PGF2α) in human parturition. Both the fetal and maternal sides of the fetal membranes synthesize PGF2α. In addition to the synthesis of PGF2α from PGH2 by PGF synthase (PGFS), PGF2α can...
Guodong Zhao et al.
The Journal of surgical research, 193(1), 223-228 (2014-09-27)
To identify the effect of ulinastatin (UTI) administration on stress-induced hyperglycemia and acute insulin (INS) resistance experienced by patients undergoing partial hepatectomy. Forty-six patients undergoing partial hepatectomy were assigned randomly to the control group (group C) or UTI treatment group...
Evidence accumulating that depression may hinder survival.
Vicki Brower
Journal of the National Cancer Institute, 106(1), djt446-djt446 (2014-01-10)
Jitske Tiemensma et al.
European journal of endocrinology, 171(2), 171-182 (2014-05-08)
A high prevalence of psychological morbidity and maladaptive personality as well as impaired quality of life (QoL) is observed in patients with and without hydrocortisone dependency following (cured) Cushing's syndrome. However, it is currently unclear whether a similar pattern is...
Carla Giordano et al.
European journal of endocrinology, 170(2), 311-319 (2013-11-21)
Diabetes mellitus (DM) is one of the most frequent complications of Cushing's syndrome (CS). The aim of this study was to define the changes in insulin sensitivity and/or secretion in relation to glucose tolerance categories in newly diagnosed CS patients....
G Van den Berghe
Acta clinica Belgica, 69(6), 397-406 (2014-11-21)
Critical illness represents a major challenge for the human body, implicating that an adequate stress response is indispensable for survival. Therefore, for a long time, activation of the hypothalamic pituitary adrenal axis was assumed to be increased to respond to...
Partial hypopituitarism: a sequel of extrapontine myelinosis.
Subodh Banzal et al.
Neurology India, 61(3), 307-308 (2013-07-19)
John W Ingle et al.
The Laryngoscope, 124(4), 921-927 (2014-01-30)
Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. Our objective was to examine laryngeal secretion cytokine inflammatory profile changes associated with corticosteroid...
Janna L Friedly et al.
The New England journal of medicine, 371(1), 11-21 (2014-07-06)
Epidural glucocorticoid injections are widely used to treat symptoms of lumbar spinal stenosis, a common cause of pain and disability in older adults. However, rigorous data are lacking regarding the effectiveness and safety of these injections. In a double-blind, multisite...
Adamo Fini et al.
AAPS PharmSciTech, 9(3), 762-768 (2008-06-20)
The purpose of this research was the preparation of four formulations containing hydrocortisone acetate (HCA) for topical application, including two aqueous systems (hydrophilic microemulsion and aqueous gel) and two systems with dominant hydrophobicity (hydrophobic microemulsion and ointment). The formulations were...
Kheyrollah Khosravi Katuli et al.
Ecotoxicology and environmental safety, 106, 173-180 (2014-05-21)
Silver nanoparticles (AgNPs) are the most commonly used metallic nanoparticles in industrial applications, including medical and consumer products. In the recent years, however, concerns regarding their environmental and health impacts have emerged. Aquatic organisms are of special concern since water...
Sarita J Robinson et al.
Aviation, space, and environmental medicine, 84(6), 592-599 (2013-06-12)
During emergencies maladaptive behavior can reduce survival. This study compared the effects of a basic firefighter training course on 21 volunteers (with no firefighting experience) with age and gender-matched controls. Stress reactivity (salivary cortisol and anxiety) were monitored across the...
Gudmundur Johannsson et al.
Hormone research, 68 Suppl 5, 182-188 (2008-02-07)
Glucocorticoid (GC) deficiency is a consequence of various disorders that are by themselves rare. Because of this low prevalence, the low cost of GC replacement therapy and the belief that existing outcomes are good, there has been little interest in...
F M Penny et al.
Journal of fish biology, 84(4), 1117-1135 (2014-03-19)
This study focused on the acute physiological responses to saltwater exposure in juvenile shortnose sturgeon Acipenser brevirostrum. In two separate laboratory experiments, 2 year-old A. brevirostrum were exposed to either full (32) or half-strength (16) seawater for up to 24...
Sanda Tesanović et al.
Collegium antropologicum, 37(2), 367-371 (2013-08-15)
We conducted this study to determine the degree of obesity influence on the hypoglycemic response of growth hormone and cortisol after weight loss of 5%. A total of 45 non-diabetic, male subjects followed in the outpatient endocrinological departments were divided...
T Yada et al.
Journal of fish biology, 85(4), 1263-1278 (2014-09-30)
To clarify the regulation of expression of corticoid receptor (CR) genes during period of parr-smolt transformation of salmonids, seasonal changes in mRNA levels of glucocorticoid receptor (GR)-1, GR-2 and mineralocorticoid receptor (MR) were examined in gill, leucocytes, spleen and brain...
S S Rodrigues Gomes et al.
European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry, 14(4), 279-283 (2013-12-10)
Anxiety may influence dental treatment unfavourably, thus evaluation of the psychophysiological reactions of the child may reduce its negative effects. This study aimed to evaluate and correlate the levels of cortisol and alpha-amylase, vital signs and behaviour of children during...
Lex W Doyle et al.
Neonatology, 98(2), 111-117 (2010-02-13)
Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants....
G E Piérard
Revue medicale de Liege, 61(2), 128-130 (2006-03-29)
Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines good efficiency and reduced risk of side effects. Its topical formulations have been enriched...
Dag Sulheim et al.
JAMA pediatrics, 168(4), 351-360 (2014-02-05)
Chronic fatigue syndrome (CFS) is a disabling condition with unknown disease mechanisms and few treatment options. To explore the pathophysiology of CFS and assess clonidine hydrochloride pharmacotherapy in adolescents with CFS by using a hypothesis that patients with CFS have...
Spyros D Mentzelopoulos et al.
JAMA, 310(3), 270-279 (2013-07-19)
Among patients with cardiac arrest, preliminary data have shown improved return of spontaneous circulation and survival to hospital discharge with the vasopressin-steroids-epinephrine (VSE) combination. To determine whether combined vasopressin-epinephrine during cardiopulmonary resuscitation (CPR) and corticosteroid supplementation during and after CPR...
K Kahveci et al.
Nigerian journal of clinical practice, 17(4), 523-527 (2014-06-10)
The aim of this study was to investigate the effect of different types of anesthesia on stress hormones. The study was included 60 ASAI-II cases scheduled for major lower extremity surgery. The cases were randomized into 2 groups: The EA...
Federico Raveglia et al.
The Journal of thoracic and cardiovascular surgery, 147(1), 469-473 (2013-11-05)
Pain control after thoracotomy prevents postsurgical complications and improves respiratory function. The gold standard for post-thoracotomy analgesia is the epidural catheter. The aim of this study was to compare it with a new technique that involves placement of a catheter...
Olivier Chabre
Presse medicale (Paris, France : 1983), 43(4 Pt 1), 376-392 (2014-03-25)
The most frequent cause of Cushing's syndrome is iatrogenic, as Cushing's syndrome is the unavoidable consequence of long-term glucocorticoid treatment using more than 7.5 mg prednisone per day. The most frequent cause of endogenous Cushing's syndrome is Cushing's disease (CD), which...
Simone Henderson
Dental update, 41(4), 342-344 (2014-06-17)
Patients with primary adrenal insufficiency (Addison's disease) lack the endogenous steroid hormones cortisol and aldosterone and require daily steroid therapy (usually hydrocortisone and fludrocortisone) to replace them. These patients are unable to adapt physiologically to stress and may need supplemental...
Tim Vanuytsel et al.
Gut, 63(8), 1293-1299 (2013-10-25)
Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on...
Chun-Ju Lin et al.
Biochemical pharmacology, 90(3), 288-296 (2014-05-31)
Inhibition of 17α-hydroxylase/17,20-lyase (CYP17), which dictates the proceeding of androgen biosynthesis, is recommended as an effective treatment for androgen-dependent diseases. However, androgen depletion by selective CYP17 inhibition is accompanied with corticosteroid elevation, which increases risk of cardiovascular diseases. In this...
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