Showing 1-30 of 254 results for "C0130"
I-Chia Peng et al.
Biomaterials, 76, 76-86 (2015-11-01)
Stem cell culture is typically based on batch-type culture, which is laborious and expensive. Here, we propose a continuous harvest method for stem cells cultured on thermoresponsive nanobrush surfaces. In this method, stem cells are partially detached from the nanobrush...
Kai-Chiang Yang et al.
Materials science & engineering. C, Materials for biological applications, 110, 110733-110733 (2020-03-25)
Scaffold geometry is known a biophysical spatial cue to modulate stem cell fate. However, the effect of regulating topography on the chondrogenic differentiation of adipose-derived stem cells (ADSCs) is not fully understood. In this study, a spatial-controlled scaffold was prepared...
Serena Sagliocchi et al.
Redox biology, 24, 101228-101228 (2019-06-04)
Thyroid hormone (TH) is a key metabolic regulator that acts by coordinating short- and long-term energy needs. Accordingly, significant metabolic changes are observed depending on thyroid status. Although it is established that hyperthyroidism augments basal energy consumption, thus resulting in...
Fanny Herisson et al.
Nature neuroscience, 21(9), 1209-1217 (2018-08-29)
Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and release of leukocyte increases after stroke, it is currently unknown...
Aline Wuidart et al.
Nature cell biology, 20(6), 666-676 (2018-05-23)
The mammary gland is composed of basal cells and luminal cells. It is generally believed that the mammary gland arises from embryonic multipotent progenitors, but it remains unclear when lineage restriction occurs and what mechanisms are responsible for the switch...
Vanessa Salazar et al.
Cell reports, 26(6), 1585-1597 (2019-02-07)
Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we...
Huan Yang et al.
Carbohydrate polymers, 222, 114974-114974 (2019-07-20)
Stable hydrogels with a mechanically strong matrix microenvironment are favorable biomaterials for three-dimensional cell culture. Acidic collagen solution is commonly combined with chemical crosslinkers for rapid network formation. Herein, dialdehyde carboxymethyl cellulose (DCMC) was selected as an optimal crosslinking reagent...
P Rocheteau et al.
Nature communications, 6, 10145-10145 (2015-12-17)
Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis is caused by severe infection and is associated with mortality in 60% of cases. Morbidity due to sepsis is...
Blue B Lake et al.
Nature communications, 10(1), 2832-2832 (2019-06-30)
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (snDrop-Seq) that we use to resolve...
Limin Zhao et al.
Nature communications, 11(1), 341-341 (2020-01-19)
Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. However, the underlying molecular mechanism is less clear. Here we report that TDP-43, a RNA-binding protein, underwent positive selection in the mammalian...
Mingyue Jia et al.
Journal of genetics and genomics = Yi chuan xue bao, 46(1), 5-17 (2018-12-31)
Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored. We report here that mutations in Acsl, the...
Huiwen Song et al.
Autophagy, 11(8), 1308-1325 (2015-06-18)
Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecting the formation of autophagosomes, the post-translational modification of ATG16L1 remains elusive. Here...
Kazuto Takahashi et al.
Oncology letters, 10(3), 1463-1467 (2015-12-02)
Colorectal cancer is one of the most malignant neoplasms worldwide. Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. In the present study, the anticancer effects of fucoxanthin and its metabolite, fucoxanthinol, on 6 colorectal cancer cell lines...
Nanfei Yang et al.
EBioMedicine, 45, 473-486 (2019-07-10)
Obesity leads to the chronic inflammation in the whole body and triggers the macrophage polarization to the pro-inflammatory phenotype. Targeting macrophage polarization provides a promising therapeutic strategy for obesity-related metabolic disorders and inflammation. Here, we show that SO1989, a derivative...
Xiaoting Zou et al.
The Journal of biological chemistry, 291(5), 2181-2195 (2015-12-10)
Acetoacetate (AA) is a ketone body and acts as a fuel to supply energy for cellular activity of various tissues. Here, we uncovered a novel function of AA in promoting muscle cell proliferation. Notably, the functional role of AA in...
Lian Tian et al.
Frontiers in physiology, 9, 828-828 (2018-07-26)
Introduction: Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying RV fibrosis in PAH and the role of RV fibroblasts (RVfib) are unknown. Activation of the mitochondrial fission mediator dynamin-related protein 1 (Drp1)...
R I Dmitrieva et al.
Stem cells international, 2019, 5690345-5690345 (2019-02-06)
In heart failure (HF), metabolic alterations induce skeletal muscle wasting and decrease of exercise capacity and quality of life. The activation of skeletal muscle regeneration potential is a prospective strategy to reduce muscle wasting; therefore, the aim of this project...
Marta Sloniecka et al.
Investigative ophthalmology & visual science, 57(14), 5892-5902 (2016-11-02)
To investigate the possible antiapoptotic effect of acetylcholine (ACh) in Fas-mediated apoptosis of primary human keratocytes in vitro, and to explore the underlying mechanism. Primary human keratocytes were isolated from healthy corneas. Fas ligand (FasL) was used to induce apoptosis...
Julia Varga et al.
The Journal of experimental medicine, 217(10) (2020-08-05)
Recently, a transcriptome-based consensus molecular subtype (CMS) classification of colorectal cancer (CRC) has been established, which may ultimately help to individualize CRC therapy. However, the lack of animal models that faithfully recapitulate the different molecular subtypes impedes adequate preclinical testing...
R Foissac et al.
Chirurgie de la main, 32(4), 199-205 (2013-07-17)
Dupuytren's disease is a disorder of the palmar aponeurosis responsible for apparition of pathological collagen cords that will gradually lead to a digital retraction. These cords cause functional disability to the hand with a real handicap for the patient. No...
Effie E Bastounis et al.
Molecular biology of the cell, 29(13), 1571-1589 (2018-05-03)
Extracellular matrix stiffness (ECM) is one of the many mechanical forces acting on mammalian adherent cells and an important determinant of cellular function. While the effect of ECM stiffness on many aspects of cellular behavior has been studied previously, how...
Laurent Yvernogeau et al.
Development (Cambridge, England), 144(13), 2352-2363 (2017-05-21)
Hematopoietic stem cells (HSCs), which are responsible for blood cell production, are generated during embryonic development. Human and chicken embryos share features that position the chicken as a reliable and accessible alternative model to study developmental hematopoiesis. However, the existence...
Martin Gelbard et al.
The Journal of urology, 187(6), 2268-2274 (2012-04-17)
Collagenase Clostridium histolyticum is an investigational nonsurgical treatment for Peyronie disease. In this phase 2b, double-blind, randomized, placebo controlled study we determined the safety and efficacy of collagenase C. histolyticum and assessed a patient reported outcome questionnaire. A total of...
Fanny Guimont-Desrochers et al.
Journal of immunology (Baltimore, Md. : 1950), 182(9), 5193-5197 (2009-04-22)
The combined phenotypic expression of CD11c(low)B220(+)CD122(+)DX5(+) has been used to define a novel cell type termed IFN-producing killer dendritic cells (IKDC). IKDC readily produce IFN-gamma and demonstrate spontaneous cytotoxic activity toward tumors, suggesting that a modulation of IKDC number may...
K K Makinen et al.
The Journal of biological chemistry, 262(26), 12488-12495 (1987-09-15)
The major collagenolytic proteinase present in the culture filtrate of Bacillus cereus (strain Soc 67, isolated from the human oral cavity) has been purified to homogeneity by a procedure that comprised concentration of ultrafiltered growth medium on a Millipore PTTK00005...
Farhatullah Syed et al.
PloS one, 7(2), e31430-e31430 (2012-03-03)
Dupuytren's disease (DD) is a benign, fibroproliferative disease of the palmar fascia, with excessive extracellular matrix (ECM) deposition and over-production of cytokines and growth factors, resulting in digital fixed flexion contractures limiting hand function and patient quality of life. Surgical...
Liza Margareth Medeiros de Carvalho Sousa et al.
The Journal of endocrinology, 231(3), 223-233 (2016-11-03)
This study aimed to determine in the canine corpus luteum throughout the dioestrus (1) the influence of insulin on glucose uptake; (2) the regulation of genes potentially involved; and (3) the influence of hypoxia on glucose transporter expression and steroidogenesis...
Sun Jeong Kim et al.
International journal of molecular sciences, 21(8) (2020-04-17)
The inhibition of the aberrant differentiation of tendon-derived stem cells (TDSCs) is a major target for the regeneration of damaged tendon tissues, as tendinopathy can be caused by the aberrant differentiation of TDSCs. We investigated whether the possible aberrant differentiation...
Sasan Jalili-Firoozinezhad et al.
Advanced healthcare materials, 4(15), 2281-2290 (2015-09-17)
The availability of 3D sponges combining proper biochemical, biophysical, and biomechanical properties with enhanced capacity of in vivo engraftment and vascularization is crucial in regenerative medicine. A simple process is developed to generate macroporous scaffolds with a well-defined architecture of...
F T D Kaplan
Drugs of today (Barcelona, Spain : 1998), 47(9), 653-667 (2011-10-06)
Collagenase clostridium histolyticum is a novel treatment for Dupuytren's contracture, approved by the U.S. Food and Drug Administration in February 2010. Prior to its availability, surgery was the only treatment for contracture related to this disorder. Dupuytren's disease is a...

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