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Jing Xu et al.
Food chemistry, 134(4), 2526-2531 (2013-02-28)
In this research, magnetic beads-based enzyme immunoassays were investigated for rapid analysis of chloramphenicol (CAP) in milk. To improve sensitivity of CAP determination, two kinds of immunomagnetic separation methods were designed and compared. Magnetic polystyrene microspheres were conjugated with anti-CAP...
Sabrina I Green et al.
Infection and immunity, 83(8), 3243-3256 (2015-06-03)
Escherichia coli is a major cause of life-threatening infections in patients with neutropenia, particularly those receiving chemotherapy for the treatment of cancer. In most cases, these infections originate from opportunistic strains living within the patient's gastrointestinal tract which then translocate...
Targeting antibacterial agents by using drug-carrying filamentous bacteriophages.
Yacoby I et al.
Antimicrobial Agents and Chemotherapy, 50, 2087-2087 (2006)
Radha Krishnakumar et al.
Nucleic acids research, 42(14), e111-e111 (2014-06-11)
Toward achieving rapid and large scale genome modification directly in a target organism, we have developed a new genome engineering strategy that uses a combination of bioinformatics aided design, large synthetic DNA and site-specific recombinases. Using Cre recombinase we swapped...
Luís França et al.
PloS one, 10(10), e0141152-e0141152 (2015-10-30)
Over a period of ten months a total of 5618 cord blood units (CBU) were screened for microbial contamination under routine conditions. The antibiotic resistance profile for all isolates was also examined using ATB strips. The detection rate for culture...
Daniel S Leventhal et al.
Nature communications, 11(1), 2739-2739 (2020-06-03)
Synthetic biology is a powerful tool to create therapeutics which can be rationally designed to enable unique and combinatorial functionalities. Here we utilize non-pathogenic E coli Nissle as a versatile platform for the development of a living biotherapeutic for the...
Robert W Behle et al.
Journal of economic entomology, 108(4), 1587-1595 (2015-10-16)
Experimental and commercial preparations of Metarhizium brunneum (Petch) strain F52 were evaluated for control of Japanese beetle, Popillia japonica Newman (Coleoptera: Scarbaeidae), larvae (white grubs) in the laboratory and under field conditions. Experimental preparations consisted of granule and liquid formulations...
Saurabh Bhattacharya et al.
Cell reports, 27(2), 334-342 (2019-04-02)
We have previously described the existence of membranous nanotubes, bridging adjacent bacteria, facilitating intercellular trafficking of nutrients, cytoplasmic proteins, and even plasmids, yet components enabling their biogenesis remain elusive. Here we reveal the identity of a molecular apparatus providing a...
Dohun Pyeon et al.
Archives of virology, 160(3), 727-737 (2015-01-07)
A central feature of HIV-1 infection is the inability of entering virus to integrate into chromosomes of resting T lymphocytes unless they are mitogenically activated. In contrast, SIVpbj1.9 replicates in initially resting T lymphocytes by activating infected cells. Previous reports...
Kanghui Yang et al.
Mini reviews in medicinal chemistry, 9(11), 1329-1341 (2009-11-26)
Chloramphenicol (CAP) is a widely used broad-spectrum antibiotic. As the precursor of CAP, chloramphenicol bases are stereochemically pure agents and could be used as resolution agents, chiral catalysts and so on. This review summarizes these applications and discusses the structural...
Takeshi Miyazawa et al.
The Journal of biological chemistry, 290(45), 26994-27011 (2015-09-18)
Understanding the biosynthetic mechanism of the atypical polyketide extender unit is important for the development of bioactive natural products. Reveromycin (RM) derivatives produced by Streptomyces sp. SN-593 possess several aliphatic extender units. Here, we studied the molecular basis of 2-alkylmalonyl-CoA...
Won Jong Kim et al.
Cell host & microbe, 26(2), 228-239 (2019-08-06)
The mucosa is colonized with commensal Neisseria. Some of these niches are sites of infection for the STD pathogen Neisseria gonorrhoeae (Ngo). Given the antagonistic behavior of commensal bacteria toward their pathogenic relatives, we hypothesized that commensal Neisseria may negatively...
Alfred Fillol-Salom et al.
Molecular cell, 75(5), 1020-1030 (2019-07-28)
Phage-inducible chromosomal islands (PICIs) represent a novel and universal class of mobile genetic elements, which have broad impact on bacterial virulence. In spite of their relevance, how the Gram-negative PICIs hijack the phage machinery for their own specific packaging and...
Jin-Won Chung et al.
Journal of leukocyte biology, 98(2), 271-281 (2015-05-17)
SAgs, produced by Staphylococcus aureus, play a major role in the pathogenesis of invasive staphylococcal diseases by inducing potent activation of the immune system. However, the role of SAgs, produced by S. aureus, associated with indwelling devices or tissues, are...
Yasuo Ono
Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 6, 131-139 (2012-11-20)
Wesley D Black
PloS one, 15(12), e0238901-e0238901 (2020-12-19)
Despite the recent increase in interest in indoor air quality regarding mould, there is no universally accepted standard media for the detection of airborne fungi, nor verification of many commonly used techniques. Commonly used media including malt-extract agar (MEA), Sabouraud...
Seung-Beom Hong et al.
Mycobiology, 43(3), 218-224 (2015-11-06)
Aspergillus is an important fungal genus used for the fermentation of Asian foods; this genus is referred to as koji mold in Japan and China. A. oryzae, A. sojae, and A. tamari are used in the production of miso and...
Flaviana Marzano et al.
Molecular biology of the cell, 26(15), 2733-2741 (2015-06-13)
The regulation of insulin-like growth factor-binding protein 3 (IGFBP3) gene expression is complex, because it can be induced by agents that both stimulate and inhibit the proliferation. The principal aim of this study was to investigate whether p73, a member...
Luhua Zhang et al.
PloS one, 10(5), e0127393-e0127393 (2015-05-20)
Haemophilus parasuis, belonging to the family Pasteurellaceae, is the causative agent of Glässer's disease leading to serious economic losses. In this study, a successive markerless mutation system for H. parasuis using two sequential steps of natural transformation was developed. By...
Stephanie Petrella et al.
Antimicrobial agents and chemotherapy, 52(10), 3725-3736 (2008-07-16)
Two clinical strains of Escherichia coli (2138) and Enterobacter cloacae (7506) isolated from the same patient in France and showing resistance to extended-spectrum cephalosporins and low susceptibility to imipenem were investigated. Both strains harbored the plasmid-contained bla(TEM-1) and bla(KPC-2) genes....
Carolin Gloger et al.
Biochimica et biophysica acta, 1847(6-7), 505-513 (2015-03-01)
Like the evolutionary related F1FO ATP synthases and V1VO ATPases, the A1AO ATP synthases from archaea are multisubunit, membrane-bound transport machines that couple ion flow to the synthesis of ATP. Although the subunit composition is known for at least two...
Kiatichai Faksri et al.
Medical mycology, 52(8), 810-818 (2014-09-19)
Invasive fungal infections (IFIs) are life threatening and associated with a high mortality rate. Here, we describe the distribution of pathogens, host risk factors, and significance of fungi isolated from patients with IFIs. The study included 861 fungal isolates recovered...
Colin Halford et al.
Antimicrobial agents and chemotherapy, 57(2), 936-943 (2012-12-12)
Precursor rRNA (pre-rRNA) is an intermediate stage in the formation of mature rRNA and is a useful marker for cellular metabolism and growth rate. We developed an electrochemical sensor assay for Escherichia coli pre-rRNA involving hybridization of capture and detector...
Jason K F Wong et al.
PloS one, 9(11), e112672-e112672 (2014-11-11)
Repaired tendons may be complicated by progressive fibrosis, causing adhesion formation or tendon softening leading to tendon rupture and subsequent reduced range of motion. There are few therapies available which improve the gliding of damaged tendons in the hand. We...
Nancy Weiland-Bräuer et al.
Applied and environmental microbiology, 81(17), 6038-6052 (2015-06-28)
The scyphozoan Aurelia aurita is recognized as a key player in marine ecosystems and a driver of ecosystem change. It is thus intensely studied to address ecological questions, although its associations with microorganisms remain so far undescribed. In the present...
J N de Almeida Júnior et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(8), 784-790 (2013-12-21)
Trichosporon spp. have recently emerged as significant human pathogens. Identification of these species is important, both for epidemiological purposes and for therapeutic management, but conventional identification based on biochemical traits is hindered by the lack of updates to the species...
[Neurotoxicity of antibacterial agents (tetracyclines, chloramphenicol, aminoglycosides, beta-lactams and others)].
K Kanemitsu et al.
Ryoikibetsu shokogun shirizu, (27 Pt 2)(27 Pt 2), 545-551 (1999-08-06)
Ivaylo Stoimenov et al.
Nucleic acids research, 43(5), e30-e30 (2014-12-10)
The rapid discovery of potential driver mutations through large-scale mutational analyses of human cancers generates a need to characterize their cellular phenotypes. Among the techniques for genome editing, recombinant adeno-associated virus (rAAV)-mediated gene targeting is suited for knock-in of single...
Ikuo Yamamiya et al.
The Journal of pharmacy and pharmacology, 66(12), 1686-1697 (2014-08-15)
Tegafur (FT), a pro-drug of 5-fluorouracil (5-FU), is a racemate consisting of two enantiomers, R and S-FT. The aim of this study was to clarify interspecies variation in the enantioselective metabolism of FT. Plasma concentrations of FT enantiomers were determined...
Nursing times, 100(48), 33-33 (2005-01-06)
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