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Showing 1-30 of 77 results for "c0733" within Papers
Yu-Fan Chuang et al.
Biochemical pharmacology, 88(3), 372-383 (2014-02-21)
Inflammation and vascular perturbations are increasingly implicated in the pathogenesis of neurodegenerative diseases. Prevailing evidence suggests that valproic acid (VPA), an antiepileptic and mood stabilizer, exhibits not only neuro-protective effects, but also anti-inflammatory effects in neurodegenerative diseases. However, the underlying
A Diaz et al.
The Journal of biological chemistry, 267(15), 10816-10822 (1992-05-25)
Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. We screened a human lung fibroblast cDNA library with an ovine PGG/HS cDNA and isolated a 2.3-kilobase clone (HCO-T9). Sequence analysis of
Hippocampal dysfunction during the chronic phase following a single exposure to cranial irradiation.
Yeonghoon Son et al.
Experimental neurology, 254, 134-144 (2014-02-05)
Ionizing radiation can significantly affect brain functioning in adults. The present study assessed depression-like behaviors in adult C57BL/6 mice using the tail suspension test (TST) at 30 and 90days following a single cranial exposure to γ-rays (0, 1, or 10Gy)
W J Lukiw et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3914-3919 (1998-05-09)
To further understand the molecular mechanism of glucocorticoid action on gene expression, DNA-binding activities of the cis-acting transcription factors activator protein 1 (AP1), AP2, Egr1 (zif268), NF-kappaB, the signal transducers and activators of transcription proteins gamma interferon activation site (GAS)
Paqui G Través et al.
Journal of immunology (Baltimore, Md. : 1950), 190(8), 4226-4235 (2013-03-13)
Extracellular nucleotides have been recognized as important modulators of inflammation via their action on specific pyrimidine receptors (P2). This regulation coexists with the temporal framework of proinflammatory and proresolution mediators released by the cells involved in the inflammatory response, including
Y Takahashi et al.
Biochemical and biophysical research communications, 182(2), 433-438 (1992-01-31)
The cDNA for prostaglandin endoperoxide synthase (cyclooxygenase) was cloned from human platelets by the polymerase chain reaction amplification method, and the primary structure of the enzyme was deduced from the nucleotide sequence. The enzyme was composed of 599 amino acids
J Barnett et al.
Biochimica et biophysica acta, 1209(1), 130-139 (1994-11-16)
Human prostaglandin G/H synthase 1 and 2 were expressed in the baculovirus expression system and purified to high levels. Both enzymes were glycosylated. PGHS-1 appeared to be homogeneous by SDS-PAGE analysis but two closely migrating bands were detected in PGHS-2
Anna Z Szóstek et al.
The Journal of endocrinology, 220(3), 263-276 (2014-02-01)
This study aimed to evaluate the influence of ovarian steroids on equine endometrial epithelial and stromal cells, specifically i) prostaglandin (PG) production in a time-dependent manner, ii) specific PG synthases mRNA transcription and protein expression, and iii) cell proliferation. After
P Leclerc et al.
Scandinavian journal of immunology, 77(5), 350-360 (2013-03-16)
PGE2 is a potent lipid mediator of pain and oedema found elevated in RA. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme of the PGE2 pathway inducible by proinflammatory cytokines. mPGES-1 is markedly upregulated in RA synovial tissue despite
Maurizio Anzini et al.
Journal of medicinal chemistry, 56(8), 3191-3206 (2013-03-29)
A series of 3-substituted 1,5-diarylpyrroles bearing a nitrooxyalkyl side chain linked to different spacers were designed. New classes of pyrrole-derived nitrooxyalkyl inverse esters, carbonates, and ethers (7-10) as COX-2 selective inhibitors and NO donors were synthesized and are herein reported.
Cyclo-oxygenase isoenzymes: physiological and pharmacological role
Kam PCA and See AUL
Anaesthesia, 55(5), 442-449 (2000)
Julie E Goodman et al.
Carcinogenesis, 25(12), 2467-2472 (2004-08-17)
In the human colon, arachidonic acid is metabolized primarily by cyclooxygenase (COX) and arachidonate lipoxygenase (ALOX) to bioactive lipids, which are implicated in colon cancer risk. Several polymorphisms in ALOX and COX genes have been identified, including G-1752A, G-1699A and
Yun-Yan Xiang et al.
Anesthesiology, 118(5), 1065-1075 (2013-03-15)
Volatile anesthetics act primarily through upregulating the activity of γ-aminobutyric acid type A (GABAA) receptors. They also exhibit antiinflammatory actions in the lung. Rodent alveolar type II (ATII) epithelial cells express GABAA receptors and the inflammatory factor cyclooxygenase-2 (COX-2). The
Reiko Nishihara et al.
JAMA, 309(24), 2563-2571 (2013-06-27)
Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), suggesting that BRAF-mutant colonic cells might be less sensitive to the antitumor effects of aspirin
Vittorio Limongelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6358-6363 (2013-04-05)
A detailed description of the events ruling ligand/protein interaction and an accurate estimation of the drug affinity to its target is of great help in speeding drug discovery strategies. We have developed a metadynamics-based approach, named funnel metadynamics, that allows
D L DeWitt et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(5), 1412-1416 (1988-03-01)
Prostaglandin G/H synthase (8,11,14-icosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1) catalyzes the first step in the formation of prostaglandins and thromboxanes, the conversion of arachidonic acid to prostaglandin endoperoxides G and H. This enzyme is the site of action of nonsteroidal anti-inflammatory
The Sigma class glutathione transferase from the liver fluke Fasciola hepatica
LaCourse EJ, et al.
PLoS Neglected Tropical Diseases, 6(5), e1666-e1666 (2012)
Maria Traka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6834-6844 (2013-04-19)
The gene encoding the WD repeat-containing protein 81 (WDR81) has recently been described as the disease locus in a consanguineous family that suffers from cerebellar ataxia, mental retardation, and quadrupedal locomotion syndrome (CAMRQ2). Adult mice from the N-ethyl-N-nitrosourea-induced mutant mouse
Mary B Sevigny et al.
FEBS letters, 580(28-29), 6533-6536 (2006-11-23)
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the prostanoid biosynthesis pathway, converting arachidonic acid into prostaglandin H(2). COX-2 exists as 72 and 74kDa glycoforms, the latter resulting from an additional oligosaccharide chain at residue Asn(580). In this study, Asn(580) was
Zhuo Shao et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 581-586 (2014-01-25)
Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids (ω3LCPUFAs) through antiangiogenic metabolites of cyclooxygenase and lipoxygenase. Cytochrome P450 epoxygenases (CYP2C8) also metabolize LCPUFAs
Jinyi Han et al.
Experimental biology and medicine (Maywood, N.J.), 239(3), 272-283 (2014-02-07)
All-trans retinoic acid (ATRA) has been used for the treatment of acute promyelocytic leukemia. It remains unclear, however, whether ATRA affects cyclooxygenase-2 (COX-2; an enzyme involved in prostaglandin production), PGE2, and thromboxane A2 (TXA2) (metabolic products of COX-2) by a
Sangwon F Kim et al.
Science (New York, N.Y.), 310(5756), 1966-1970 (2005-12-24)
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic
Takaji Yanai et al.
The Journal of bone and joint surgery. American volume, 95(8), 725-728 (2013-04-19)
Glomus tumors are benign hamartomas that account for 1% to 5% of all soft-tissue tumors of the hand. Painful spasms radiating from the lesion are typical clinical signs. As the pain production mechanism is unclear, we evaluated S100 protein, substance
Xinyan Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(3), 1517-1522 (2013-03-05)
Cyclooxygenase-2 (COX-2) is a key limited enzyme of prostaglandin (PG) synthesis and has been demonstrated to be overexpressed in cancer. N-[2-(cyclohexyloxy)-4-nitropheny]-methane sulfonamide (NS-398) is a special inhibitor of COX-2 and may suppress PGE2 release and promote immune response mechanism of
S G Gregory et al.
Nature, 441(7091), 315-321 (2006-05-20)
The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chromosome 1. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes
Jayesh Mudgal et al.
Chemico-biological interactions, 210, 34-42 (2014-01-15)
Three thiazolidin-4-one derivatives were synthesized, purified and characterized by chromatographic and spectroscopic methods. In the in vitro assays, these compounds inhibited reactive oxygen species (ROS), nitrite and cytokine generation in RAW 264.7 murine macrophages and whole blood. These derivatives attenuated
Devashri Sahu et al.
Journal of toxicology and environmental health. Part A, 77(4), 177-191 (2014-02-22)
With the rapid development of nanomedicines, it is important to understand their potential immunotoxicity. Zinc oxide (ZnO) nanoparticles have several applications in the pharmaceutical and biomedicine industries. This study investigates the effect of particles size (nano and micro) of ZnO
Bor-Ren Huang et al.
Toxicology and applied pharmacology, 269(1), 43-50 (2013-03-19)
We investigated the interaction between proinflammatory and inflammatory responses caused by Staphylococcus aureus-derived lipoteichoic acid (LTA) in primary cultured microglial cells and BV-2 microglia. LTA induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels increase in a concentration-
Darshini B Trivedi et al.
Circulation research, 112(9), 1219-1229 (2013-03-26)
Abdominal aortic aneurysms (AAAs) are a chronic inflammatory vascular disease for which pharmacological treatments are not available. A mouse model of AAA formation involves chronic infusion of angiotensin II (AngII), and previous studies indicated a primary role for the AngII
Ji-Gui Yan et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(23), 4134-4137 (2014-05-06)
To study the effect of sophoridine against bone cancer pain in bone cancer pain model rats induced by W256 tumor cells and its mechanism. The rat model of bone cancer pain was reproduced by injecting W256 tumor cells into the
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