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[Treatment of advanced Hodgkin lymphoma].
S Kreissl et al.
Deutsche medizinische Wochenschrift (1946), 138(23), 1212-1214 (2013-05-31)
Participant-level data and the new frontier in trial transparency.
Deborah A Zarin
The New England journal of medicine, 369(5), 468-469 (2013-08-02)
Thomas Clapes et al.
Nature cell biology, 23(7), 704-717 (2021-07-14)
Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reorganization followed by increased transcription of transposable elements (TEs) during early recovery. TE
Thomas Colley et al.
Antimicrobial agents and chemotherapy, 62(5) (2018-02-15)
The antifungal effects of the novel triazole PC1244, designed for topical or inhaled administration, against Aspergillus fumigatus were tested in a range of in vitro and in vivo studies. PC1244 demonstrated potent antifungal activities against clinical A. fumigatus isolates (n
An atoll variant that mocks.
Francis X McCormack et al.
American journal of respiratory and critical care medicine, 188(1), 110-110 (2013-07-03)
Genevieve M Weir et al.
Oncoimmunology, 3(8), e953407-e953407 (2014-01-01)
In clinical trials, metronomic cyclophosphamide (CPA) is increasingly being combined with vaccines to reduce tumor-induced immune suppression. Previous strategies to modulate the immune system during vaccination have involved continuous administration of low dose chemotherapy, studies that have posed unique considerations
J Tammam et al.
British journal of pharmacology, 158(5), 1183-1195 (2009-09-25)
gamma-Secretase inhibitors (GSIs) block NOTCH receptor cleavage and pathway activation and have been under clinical evaluation for the treatment of malignancies such as T-cell acute lymphoblastic leukaemia (T-ALL). The ability of GSIs to decrease T-ALL cell viability in vitro is
No Soo Kim et al.
Journal of ethnopharmacology, 241, 112025-112025 (2019-06-13)
A rhizome of Phragmites communis Trinius has been used in traditional medicine to remove a heat, relieve vomiting and fever, nourish body fluids, and treat diseases like cancers. However, the safety of Phragmitis rhizoma has not yet been fully assessed.
STAT3 mediates multidrug resistance of Burkitt lymphoma cells by promoting antioxidant feedback
Zeng R, et al.
Biochemical and biophysical research communications, 488(1), 182-188 (2017)
Shubin Li et al.
Journal of ovarian research, 14(1), 17-17 (2021-01-23)
This study investigated the effect of recombinant human lactoferrin (rhLF) on the premature ovarian failure (POF) of rats. After cyclophosphamide treatments, the POF rats were divided into the following groups: normal control group (NC), low-dose group (LD), medium-dose group (MD)
S Chaabouni et al.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 17(3), 229-232 (2013-05-15)
The extranodal non-Hodgkin lymphomas of maxillofacial soft tissues are rare. We report two cases of maxillofacial soft tissue non-Hodgkin lymphoma treated with chemotherapy followed by localized radiotherapy with complete remission after 3 and 6 months. We study the clinical, radiological
Carlos Alexandre Lutterbeck et al.
Chemosphere, 135, 403-410 (2015-05-24)
Anti-cancer drugs are compounds that are of high environmental relevance because of their lack of specific mode of action. They can be extremely harmful to living organisms even at low concentrations. The present study evaluated the toxic effects of four
Tuğba Ekiz Yılmaz et al.
Acta histochemica, 122(2), 151470-151470 (2019-12-10)
Cyclophosphamide (CYP) is one of the alkylating chemotherapeutic agents and its adverse effects on folliculogenesis in the ovary are well-known due to the previous scientific research on this topic. Magnesium has various effects in organisms, including catalytic functions on the
Zahra Mehraban et al.
Journal of cellular biochemistry, 120(10), 17250-17257 (2019-05-29)
Alteration of free radicals (reactive oxygen species) causes mammals' sperm damage. Gallic acid (GA) is known as an antioxidant which is effective against oxidative stress. The purpose of this study was to evaluate the antioxidant effects of GA on the
Wei Li et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(2), 233-237 (2013-06-26)
To explore the inhibitory effect of Zishenshengxue capsule (ZSC) on myelosuppression in mice induced by cyclophosphamide. Kunming mice were randomly assigned into a control group, myelosuppression group, or groups for mice with myelosuppression receiving high dose ZSC, middle dose ZSC
Yi-Hu Zheng et al.
Phytotherapy research : PTR, 28(9), 1342-1348 (2014-03-07)
The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in vivo. In cell viability assays, baicalein showed significant cytotoxicity against the hepatocellular carcinoma cell lines H22, Bel-7404, and Hep G2 and moderate cytotoxicity against immortalized human
Veenu Tripathi et al.
Oncogene, 38(17), 3185-3200 (2019-01-11)
Transforming growth factor-β (TGF-β) is major inducer of epithelial-to-mesenchymal transition (EMT), which associates with cancer cell metastasis and resistance to chemotherapy and targeted drugs, through both transcriptional and non-transcriptional mechanisms. We previously reported that, in cancer cells, heightened mitogenic signaling
Thomas Colley et al.
Scientific reports, 9(1), 9482-9482 (2019-07-03)
Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using
Elna Fernandes et al.
Chemosphere, 261, 127678-127678 (2020-07-28)
The rise of cancer cases worldwide led to an increase in production and consumption of anticancer drugs, that ultimately end up in the marine environment and are accumulated in aquatic organisms. Cyclophosphamide (CP) is a cytotoxic alkylating agent frequently prescribed
Fabrice Jardin et al.
Blood, 121(22), 4433-4434 (2013-06-01)
In this issue of Blood, Li et al report mutations in the 3′ untranslated region (3′UTR) of TP53 that modify the expression of p53 and thus its effect on response to therapy in diffuse large B-cell lymphoma (DLBCL) patients.
L Verfaillie et al.
Acta clinica Belgica, 68(2), 138-139 (2013-08-24)
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a severe form of encephalitis that has been identified within the context of acute neuropsychiatric manifestations. We report the case of an 18-year-old adolescent referred for a first episode of acute psychosis. The clinical picture
Yuan Liu et al.
PloS one, 10(5), e0127361-e0127361 (2015-05-15)
Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease with a diverse range of immunological and clinical manifestations. The introduction of broad spectrum immunosuppressive therapies and better management of acute disease exacerbations have improved outcomes for lupus patients over
Wei-Ting Tseng et al.
Regulatory toxicology and pharmacology : RTP, 71(2), 148-157 (2014-12-08)
The aim of the present work was to assess the genotoxic activity and the potential for toxicity upon repeated dosing of "Vigiis 101" powder, a probiotic consisting of dried bacteria Lactobacillus paracasei subsp. paracasei NTU 101. Results of the Ames
A tritherapy combination of inactivated allogeneic leukocytes infusion and cell vaccine with cyclophosphamide in a sequential regimen enhances antitumor immunity
Tang Y, et al.
Journal of the Chinese Medical Association : JCMA, 81(4), 316-323 (2018)
A case of primary skull lymphoma: review of literature.
Sudhansu Sekhar Mishra et al.
Neurology India, 61(3), 334-336 (2013-07-19)
Light chain deposition.
Cyrus C Hsia et al.
Blood, 121(26), 5111-5111 (2013-08-24)
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators
Wu J, et al.
BMC Cancer, 16(1), 623-623 (2016)
Susmita Kundu et al.
The Indian journal of chest diseases & allied sciences, 55(1), 49-52 (2013-06-27)
We report a case of a 42-year-old patient who presented with Wegener's granulomatosis complicated by pulmonary renal syndrome, i.e., diffuse alveolar haemorrhage and rapidly progressive crescentic glomerulonephritis. The patient was treated with plasmapheresis and immunosuppressive drugs--intravenous cyclophosphamide and methyl prednisolone.
Lamprini Skriapa et al.
Journal of neuroimmunology, 276(1-2), 150-158 (2014-09-30)
Antibodies against MuSK seem to be the pathogenic factor in approximately 5-8% of myasthenia gravis (MG) patients. We aim to develop an antigen-specific therapy in which only MuSK antibodies will be removed from patients' plasma using MuSK extracellular domain (MuSK-ECD)
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